SI2045241T1 - Fluor substituirani cikloalkanoindoli in njihova uporaba kot prostaglandin d receptorski antagonisti - Google Patents

Fluor substituirani cikloalkanoindoli in njihova uporaba kot prostaglandin d receptorski antagonisti

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Publication number
SI2045241T1
SI2045241T1 SI200332197T SI200332197T SI2045241T1 SI 2045241 T1 SI2045241 T1 SI 2045241T1 SI 200332197 T SI200332197 T SI 200332197T SI 200332197 T SI200332197 T SI 200332197T SI 2045241 T1 SI2045241 T1 SI 2045241T1
Authority
SI
Slovenia
Prior art keywords
prostaglandin
receptor antagonists
fluoro substituted
cycloalkanoindoles
substituted cycloalkanoindoles
Prior art date
Application number
SI200332197T
Other languages
English (en)
Inventor
Carl Berthelette
Nicolas Lachance
Lianhai Li
Claudio Sturino
Zhaoyin Wang
Original Assignee
Merck Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Canada Inc filed Critical Merck Canada Inc
Publication of SI2045241T1 publication Critical patent/SI2045241T1/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
SI200332197T 2002-01-24 2003-01-22 Fluor substituirani cikloalkanoindoli in njihova uporaba kot prostaglandin d receptorski antagonisti SI2045241T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35138402P 2002-01-24 2002-01-24
EP08105552A EP2045241B1 (en) 2002-01-24 2003-01-22 Fluoro substituted cycloalkanoindoles and their use as prostaglandin D2 receptor antagonists

Publications (1)

Publication Number Publication Date
SI2045241T1 true SI2045241T1 (sl) 2012-11-30

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Family Applications (2)

Application Number Title Priority Date Filing Date
SI200332197T SI2045241T1 (sl) 2002-01-24 2003-01-22 Fluor substituirani cikloalkanoindoli in njihova uporaba kot prostaglandin d receptorski antagonisti
SI200331470T SI1470107T1 (sl) 2002-01-24 2003-01-22 Fluoro substituirani cikloalkanoidoli in njihova uporaba kot prostaglandin d2 receptor antagonisti

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200331470T SI1470107T1 (sl) 2002-01-24 2003-01-22 Fluoro substituirani cikloalkanoidoli in njihova uporaba kot prostaglandin d2 receptor antagonisti

Country Status (39)

Country Link
US (6) US20030158246A1 (sl)
EP (3) EP2045241B1 (sl)
JP (2) JP4008885B2 (sl)
KR (2) KR20070056166A (sl)
CN (3) CN101851191A (sl)
AR (1) AR038136A1 (sl)
AT (1) ATE414690T1 (sl)
AU (1) AU2003202343B2 (sl)
BR (1) BR0307050A (sl)
CA (1) CA2471952C (sl)
CY (3) CY1108841T1 (sl)
DE (2) DE122009000022I1 (sl)
DK (2) DK2045241T3 (sl)
DO (1) DOP2003000566A (sl)
EA (1) EA006134B1 (sl)
EC (1) ECSP045203A (sl)
EG (1) EG24978A (sl)
ES (2) ES2316717T3 (sl)
FR (1) FR09C0010I2 (sl)
GE (1) GEP20074078B (sl)
HR (1) HRP20040665B1 (sl)
IL (3) IL162825A0 (sl)
IS (2) IS2633B (sl)
JO (1) JO2481B1 (sl)
LU (1) LU91534I2 (sl)
MX (1) MXPA04007167A (sl)
MY (1) MY137040A (sl)
NL (1) NL300377I2 (sl)
NO (3) NO327322B1 (sl)
NZ (1) NZ533786A (sl)
PE (1) PE20030982A1 (sl)
PL (1) PL208527B1 (sl)
PT (2) PT1470107E (sl)
RS (2) RS20100338A (sl)
SI (2) SI2045241T1 (sl)
TW (1) TWI259080B (sl)
UA (1) UA75520C2 (sl)
WO (1) WO2003062200A2 (sl)
ZA (1) ZA200404999B (sl)

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