PL1833791T3 - Pochodne 2,3,4,9-tetrahydro-1H-karbazolu jako antagonisty receptora CRTH2 - Google Patents
Pochodne 2,3,4,9-tetrahydro-1H-karbazolu jako antagonisty receptora CRTH2Info
- Publication number
- PL1833791T3 PL1833791T3 PL05850906T PL05850906T PL1833791T3 PL 1833791 T3 PL1833791 T3 PL 1833791T3 PL 05850906 T PL05850906 T PL 05850906T PL 05850906 T PL05850906 T PL 05850906T PL 1833791 T3 PL1833791 T3 PL 1833791T3
- Authority
- PL
- Poland
- Prior art keywords
- tetrahydro
- receptor antagonists
- carbazole derivatives
- crth2 receptor
- crth2
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2004014719 | 2004-12-27 | ||
| EP05850906A EP1833791B1 (en) | 2004-12-27 | 2005-12-22 | 2,3,4,9-tetrahydro-1h-carbazole derivatives as crth2 receptor antagonists |
| PCT/IB2005/054380 WO2006070325A2 (en) | 2004-12-27 | 2005-12-22 | 2,3,4,9-tetrahydro-1h-carbazole derivatives as crth2 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1833791T3 true PL1833791T3 (pl) | 2011-12-30 |
Family
ID=36499938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL05850906T PL1833791T3 (pl) | 2004-12-27 | 2005-12-22 | Pochodne 2,3,4,9-tetrahydro-1H-karbazolu jako antagonisty receptora CRTH2 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8039474B2 (pl) |
| EP (1) | EP1833791B1 (pl) |
| JP (1) | JP5137240B2 (pl) |
| KR (1) | KR101329903B1 (pl) |
| CN (1) | CN101084190B (pl) |
| AR (1) | AR052549A1 (pl) |
| AT (1) | ATE518834T1 (pl) |
| AU (1) | AU2005320964B2 (pl) |
| BR (1) | BRPI0519280A2 (pl) |
| CA (1) | CA2594280C (pl) |
| CY (1) | CY1112376T1 (pl) |
| DK (1) | DK1833791T3 (pl) |
| ES (1) | ES2369782T3 (pl) |
| HR (1) | HRP20110773T1 (pl) |
| IL (1) | IL184233A0 (pl) |
| MX (1) | MX2007007691A (pl) |
| MY (1) | MY144897A (pl) |
| NO (1) | NO20073059L (pl) |
| NZ (1) | NZ556657A (pl) |
| PL (1) | PL1833791T3 (pl) |
| PT (1) | PT1833791E (pl) |
| RU (1) | RU2404163C2 (pl) |
| SI (1) | SI1833791T1 (pl) |
| TW (1) | TW200633978A (pl) |
| WO (1) | WO2006070325A2 (pl) |
| ZA (1) | ZA200705085B (pl) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2387652C2 (ru) | 2004-03-11 | 2010-04-27 | Актелион Фармасьютиклз Лтд | Производные тетрагидропиридоиндола |
| KR101411820B1 (ko) | 2006-08-07 | 2014-06-24 | 액테리온 파마슈티칼 리미티드 | (3-아미노-1,2,3,4-테트라하이드로-9ｈ-카르바졸-9-일)-아세트산 유도체 |
| BRPI0907364A2 (pt) | 2008-02-01 | 2015-07-14 | Amira Pharmaceuticals Inc | Antagonistas aminoalquilbifenil n,n-disubstituídos de receptores d2 de prostaglandina |
| WO2009108720A2 (en) | 2008-02-25 | 2009-09-03 | Amira Pharmaceuticals, Inc. | Antagonists of prostaglandin d2 receptors |
| EP2300425A4 (en) | 2008-06-24 | 2012-03-21 | Panmira Pharmaceuticals Llc | PROSTAGLANDIN D2 RECEPTOR CYCLOALCANEÝBINDLUCK ANTAGONISTS |
| GB2463788B (en) | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| US8378107B2 (en) | 2008-10-01 | 2013-02-19 | Panmira Pharmaceuticals, Llc | Heteroaryl antagonists of prostaglandin D2 receptors |
| WO2010042652A2 (en) | 2008-10-08 | 2010-04-15 | Amira Pharmaceuticals, Inc. | Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors |
| GB2465062B (en) * | 2008-11-06 | 2011-04-13 | Amira Pharmaceuticals Inc | Cycloalkane(B)azaindole antagonists of prostaglandin D2 receptors |
| EP2492267B1 (en) * | 2009-02-24 | 2014-11-26 | Merck Sharp & Dohme Corp. | Indole derivatives as CRTH2 receptor antagonists in combination with a second active ingredient |
| EP2461809A4 (en) | 2009-07-31 | 2013-06-19 | Panmira Pharmaceuticals Llc | OPHTHALMIC PHARMACEUTICAL COMPOSITIONS OF DP2 RECEPTOR ANTAGONSITES |
| EP2462110A4 (en) | 2009-08-05 | 2013-04-03 | Panmira Pharmaceuticals Llc | DP2 ANTAGONIST AND USES THEREOF |
| WO2011117798A1 (en) | 2010-03-22 | 2011-09-29 | Actelion Pharmaceuticals Ltd | 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators |
| US8927559B2 (en) | 2010-10-11 | 2015-01-06 | Merck Sharp & Dohme Corp. | Quinazolinone-type compounds as CRTH2 antagonists |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| MY165623A (en) | 2011-04-14 | 2018-04-18 | Idorsia Pharmaceuticals Ltd | 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators |
| WO2012174176A1 (en) * | 2011-06-17 | 2012-12-20 | Merck Sharp & Dohme Corp. | Cycloalkyl-fused tetrahydroquinolines as crth2 receptor modulators |
| HRP20181555T1 (hr) | 2014-03-17 | 2018-11-30 | Idorsia Pharmaceuticals Ltd | Derivati azaindol-octene kiseline i njihova uporaba kao modulatora receptora prostaglandina d2 |
| RU2016140708A (ru) | 2014-03-18 | 2018-04-18 | Идорсиа Фармасьютиклз Лтд | Производные азаиндол уксусной кислоты и их применение в качестве модуляторов рецептора простагландина d2 |
| PL3350179T3 (pl) | 2015-09-15 | 2021-08-02 | Idorsia Pharmaceuticals Ltd | Krystaliczne postacie |
| CN117143007B (zh) * | 2023-08-31 | 2026-01-09 | 陕西科技大学 | 一种四氢咔唑衍生物及其光催化合成方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687969A (en) * | 1970-06-02 | 1972-08-29 | Sterling Drug Inc | 9-aroyl-1,2,3,4-tetrahydrocarbazole-3,3-dicarboxylic acids |
| GB1335228A (en) * | 1970-06-02 | 1973-10-24 | Sterling Drug Inc | Tetrahydrocarbazoles |
| US3941805A (en) * | 1972-11-17 | 1976-03-02 | Sterling Drug Inc. | 3-Halomethylcarbonyl-9-benzoyl-1,2,3,4-tetrahydrocarbazoles |
| US4808608A (en) | 1986-01-23 | 1989-02-28 | Merck & Co., Inc. | Tetrahydrocarbazole 1-alkanoic acids, pharmaceutical compositions and use |
| CA2106642C (en) * | 1992-10-14 | 2005-08-16 | Peter Bod | Carbazolone derivatives and process for preparing the same |
| US20010047027A1 (en) | 2000-04-12 | 2001-11-29 | Marc Labelle | Prostaglandin D2 receptor antagonists |
| ES2272712T3 (es) | 2001-05-23 | 2007-05-01 | Merck Frosst Canada Ltd. | Derivados de dihidropirrolo-1,2-aiindol y tetrahidropirido -1,2-aiindol como antagonistas de receptores de prostaglandina d2. |
| BR0214958A (pt) * | 2001-12-14 | 2004-12-28 | Zentaris Gmbh | Derivados de tetraidrocarbazol como ligandos para receptores acoplados à proteìna-g (gpcr) |
| AR038136A1 (es) * | 2002-01-24 | 2004-12-29 | Merck Frosst Canada Inc | Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento |
| SE0200356D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| SE0200411D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| JP4484108B2 (ja) * | 2002-05-16 | 2010-06-16 | 塩野義製薬株式会社 | Ｐｇｄ２受容体拮抗作用を有する化合物 |
| JPWO2003097042A1 (ja) | 2002-05-16 | 2005-09-15 | 塩野義製薬株式会社 | Ｐｇｄ２受容体拮抗剤 |
| GB2388540A (en) * | 2002-05-17 | 2003-11-19 | Bayer Ag | New use of Ramatroban |
| TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
| SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
| SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
| MXPA05004715A (es) | 2002-10-30 | 2005-08-03 | Merck Frosst Canada Inc | Derivados de piridopirrolizina y piridoindolizina. |
| US20060089353A1 (en) | 2003-03-06 | 2006-04-27 | Maki Iwahashi | Indole derivative compounds and drugs containing the compounds as the active ingredient |
| WO2004103970A1 (en) | 2003-05-20 | 2004-12-02 | Merck Frosst Canada Ltd. | Fluoro-methanesulfonyl-substituted cycloalkanoindoles and their use as prostaglandin d2 antagonists |
| SE0301569D0 (sv) | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
| WO2004111047A2 (en) | 2003-06-12 | 2004-12-23 | Merck Frosst Canada Ltd. | Cycloalkanepyrrolopyridines as dp receptor antagonists |
| SE0302232D0 (sv) | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
| CA2542716A1 (en) | 2003-10-14 | 2005-05-06 | Oxagen Limited | Compounds having crth2 antagonist activity |
| WO2005040112A1 (en) | 2003-10-14 | 2005-05-06 | Oxagen Limited | Compounds with pgd2 antagonist activity |
| GB2407318A (en) | 2003-10-23 | 2005-04-27 | Oxagen Ltd | Substituted Indol-3-yl acetic acid derivatives |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| SE0303180D0 (sv) | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
| US7019022B2 (en) | 2003-12-15 | 2006-03-28 | Merck Frosst Canada & Co. | Substituted tetrahydrocarbazole and cyclopentanoindole derivatives |
| NZ548396A (en) | 2004-01-31 | 2010-06-25 | Actimis Pharmaceuticals Inc | Imidazo[1,2-C]pyrimidinylacetic acid derivatives |
| RU2387652C2 (ru) | 2004-03-11 | 2010-04-27 | Актелион Фармасьютиклз Лтд | Производные тетрагидропиридоиндола |
| WO2005094816A1 (en) | 2004-03-11 | 2005-10-13 | Actelion Pharmaceuticals Ltd | Indol-1-yl-acetic acid derivatives |
| CN101052397B (zh) | 2004-08-26 | 2011-07-06 | 埃科特莱茵药品有限公司 | 2-硫烷基-苯并咪唑-1-基-乙酸衍生物 |
| KR101411820B1 (ko) | 2006-08-07 | 2014-06-24 | 액테리온 파마슈티칼 리미티드 | (3-아미노-1,2,3,4-테트라하이드로-9ｈ-카르바졸-9-일)-아세트산 유도체 |
-
2005
- 2005-12-22 PL PL05850906T patent/PL1833791T3/pl unknown
- 2005-12-22 RU RU2007128736/04A patent/RU2404163C2/ru not_active IP Right Cessation
- 2005-12-22 JP JP2007547781A patent/JP5137240B2/ja not_active Expired - Fee Related
- 2005-12-22 CN CN2005800438848A patent/CN101084190B/zh not_active Expired - Fee Related
- 2005-12-22 WO PCT/IB2005/054380 patent/WO2006070325A2/en not_active Ceased
- 2005-12-22 AT AT05850906T patent/ATE518834T1/de active
- 2005-12-22 ES ES05850906T patent/ES2369782T3/es not_active Expired - Lifetime
- 2005-12-22 HR HR20110773T patent/HRP20110773T1/hr unknown
- 2005-12-22 AU AU2005320964A patent/AU2005320964B2/en not_active Ceased
- 2005-12-22 PT PT05850906T patent/PT1833791E/pt unknown
- 2005-12-22 BR BRPI0519280-3A patent/BRPI0519280A2/pt not_active IP Right Cessation
- 2005-12-22 DK DK05850906.8T patent/DK1833791T3/da active
- 2005-12-22 CA CA2594280A patent/CA2594280C/en not_active Expired - Fee Related
- 2005-12-22 MX MX2007007691A patent/MX2007007691A/es active IP Right Grant
- 2005-12-22 US US11/722,095 patent/US8039474B2/en not_active Expired - Fee Related
- 2005-12-22 SI SI200531395T patent/SI1833791T1/sl unknown
- 2005-12-22 NZ NZ556657A patent/NZ556657A/en not_active IP Right Cessation
- 2005-12-22 EP EP05850906A patent/EP1833791B1/en not_active Expired - Lifetime
- 2005-12-22 KR KR1020077017341A patent/KR101329903B1/ko not_active Expired - Fee Related
- 2005-12-23 MY MYPI20056197A patent/MY144897A/en unknown
- 2005-12-26 TW TW094146581A patent/TW200633978A/zh unknown
- 2005-12-27 AR ARP050105557A patent/AR052549A1/es not_active Application Discontinuation
-
2007
- 2007-06-13 ZA ZA200705085A patent/ZA200705085B/xx unknown
- 2007-06-15 NO NO20073059A patent/NO20073059L/no not_active Application Discontinuation
- 2007-06-26 IL IL184233A patent/IL184233A0/en not_active IP Right Cessation
-
2011
- 2011-11-02 CY CY20111101047T patent/CY1112376T1/el unknown
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