PL1912976T3 - Pochodne indol-3-ilokarbonylopiperydynobenzoimidazolu jako antagoniści receptora V1a - Google Patents

Pochodne indol-3-ilokarbonylopiperydynobenzoimidazolu jako antagoniści receptora V1a

Info

Publication number
PL1912976T3
PL1912976T3 PL06777681T PL06777681T PL1912976T3 PL 1912976 T3 PL1912976 T3 PL 1912976T3 PL 06777681 T PL06777681 T PL 06777681T PL 06777681 T PL06777681 T PL 06777681T PL 1912976 T3 PL1912976 T3 PL 1912976T3
Authority
PL
Poland
Prior art keywords
indol
piperidin
carbonyl
receptor antagonists
benzoimidazole derivatives
Prior art date
Application number
PL06777681T
Other languages
English (en)
Inventor
Caterina Bissantz
Christophe Grundschober
Hasane Ratni
Mark Rogers-Evans
Patrick Schnider
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PL1912976T3 publication Critical patent/PL1912976T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL06777681T 2005-07-21 2006-07-11 Pochodne indol-3-ilokarbonylopiperydynobenzoimidazolu jako antagoniści receptora V1a PL1912976T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05106695 2005-07-21
EP05110506 2005-11-09
EP06777681A EP1912976B1 (en) 2005-07-21 2006-07-11 Indol-3-yl-carbonyl-piperidin-benzoimidazole derivatives as v1a receptor antagonists
PCT/EP2006/064075 WO2007009906A1 (en) 2005-07-21 2006-07-11 Indol-3-yl-carbonyl-piperidin-benzoimidazol derivatives as v1a receptor antagonists

Publications (1)

Publication Number Publication Date
PL1912976T3 true PL1912976T3 (pl) 2009-04-30

Family

ID=37192471

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06777681T PL1912976T3 (pl) 2005-07-21 2006-07-11 Pochodne indol-3-ilokarbonylopiperydynobenzoimidazolu jako antagoniści receptora V1a

Country Status (21)

Country Link
US (2) US7803815B2 (pl)
EP (1) EP1912976B1 (pl)
JP (1) JP4839374B2 (pl)
KR (1) KR100984893B1 (pl)
CN (1) CN101268067A (pl)
AR (1) AR056188A1 (pl)
AT (1) ATE414078T1 (pl)
AU (1) AU2006271804B2 (pl)
BR (1) BRPI0613656A2 (pl)
CA (1) CA2616063A1 (pl)
DE (1) DE602006003666D1 (pl)
DK (1) DK1912976T3 (pl)
ES (1) ES2314941T3 (pl)
IL (1) IL188722A (pl)
MX (1) MX2008000886A (pl)
NO (1) NO20080291L (pl)
PL (1) PL1912976T3 (pl)
PT (1) PT1912976E (pl)
RU (1) RU2415139C2 (pl)
TW (1) TWI324601B (pl)
WO (1) WO2007009906A1 (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007014851A2 (en) * 2005-07-29 2007-02-08 F. Hoffmann-La Roche Ag Indol-3-yl-carbonyl-piperidin and piperazin derivatives
ES2345132T3 (es) 2006-12-08 2010-09-15 F. Hoffmann-La Roche Ag Indoles que actuan como agonistas del receptor v1a.
PE20081401A1 (es) * 2006-12-28 2008-10-24 Hoffmann La Roche Derivados de indol como antagonistas de receptores vasopresina
MY153609A (en) * 2008-01-31 2015-02-27 Sanofi Aventis Cyclic azaindole-3-carboxamides, their preparation and their use as pharmaceuticals
HUP1000598A2 (en) 2010-11-05 2012-09-28 Richter Gedeon Nyrt Indole derivatives
EP2548864B1 (en) 2011-07-22 2014-02-19 Université Joseph Fourier Novel bis-indolic derivatives, a process for preparing the same and their uses as a drug
MX2020002436A (es) * 2017-09-05 2020-07-13 Blackthorn Therapeutics Inc Antagonistas del receptor de vasopresina y productos y metodos relacionados a los mismos.
HU231206B1 (hu) 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek
TW201938171A (zh) 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素V1a受體拮抗劑之三環化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686624A (en) * 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
AUPP150098A0 (en) * 1998-01-27 1998-02-19 Fujisawa Pharmaceutical Co., Ltd. Benzamide derivatives
AU2002243419A1 (en) * 2000-10-27 2002-07-24 Ortho-Mcneil Pharmaceutical, Inc. Substituted benzimidazol-2-ones as vasopressin receptor antagonists and neuropeptide y modulators
TWI317634B (en) * 2001-12-13 2009-12-01 Nat Health Research Institutes Aroyl indoles compounds

Also Published As

Publication number Publication date
MX2008000886A (es) 2008-03-18
CA2616063A1 (en) 2007-01-25
AR056188A1 (es) 2007-09-26
TW200740792A (en) 2007-11-01
DK1912976T3 (da) 2009-01-26
ES2314941T3 (es) 2009-03-16
RU2008100780A (ru) 2009-08-27
IL188722A0 (en) 2008-08-07
US20100256140A1 (en) 2010-10-07
US7803815B2 (en) 2010-09-28
RU2415139C2 (ru) 2011-03-27
KR100984893B1 (ko) 2010-10-01
KR20080027950A (ko) 2008-03-28
AU2006271804A1 (en) 2007-01-25
US20070021463A1 (en) 2007-01-25
JP2009501757A (ja) 2009-01-22
PT1912976E (pt) 2009-01-07
CN101268067A (zh) 2008-09-17
AU2006271804B2 (en) 2011-03-31
DE602006003666D1 (de) 2008-12-24
EP1912976A1 (en) 2008-04-23
ATE414078T1 (de) 2008-11-15
WO2007009906A1 (en) 2007-01-25
EP1912976B1 (en) 2008-11-12
JP4839374B2 (ja) 2011-12-21
IL188722A (en) 2012-12-31
NO20080291L (no) 2008-03-06
BRPI0613656A2 (pt) 2011-01-25
TWI324601B (en) 2010-05-11

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