TW201002696A - Novel compounds 409 - Google Patents
Novel compounds 409 Download PDFInfo
- Publication number
- TW201002696A TW201002696A TW098120291A TW98120291A TW201002696A TW 201002696 A TW201002696 A TW 201002696A TW 098120291 A TW098120291 A TW 098120291A TW 98120291 A TW98120291 A TW 98120291A TW 201002696 A TW201002696 A TW 201002696A
- Authority
- TW
- Taiwan
- Prior art keywords
- mixture
- ethyl
- compound
- phenylethoxy
- cyclohexyl
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 253
- 238000000034 method Methods 0.000 claims abstract description 51
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 11
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 268
- -1 propanamide compound Chemical class 0.000 claims description 174
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 claims description 134
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 107
- 125000000109 phenylethoxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])O* 0.000 claims description 102
- 150000003839 salts Chemical class 0.000 claims description 59
- 239000003112 inhibitor Substances 0.000 claims description 38
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 33
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 24
- 201000010099 disease Diseases 0.000 claims description 23
- 239000003814 drug Substances 0.000 claims description 21
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- 229910052757 nitrogen Inorganic materials 0.000 claims description 17
- 229940079593 drug Drugs 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 208000006673 asthma Diseases 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 11
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- 150000003431 steroids Chemical class 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 7
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- 239000002671 adjuvant Substances 0.000 claims description 5
- 125000004429 atom Chemical group 0.000 claims description 5
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000004593 Epoxy Substances 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
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- 230000009286 beneficial effect Effects 0.000 claims description 3
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- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims description 3
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 3
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- 208000027866 inflammatory disease Diseases 0.000 claims description 3
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- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 70
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- 238000010828 elution Methods 0.000 description 31
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Classifications
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
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| WO2011048409A1 (en) | 2009-10-20 | 2011-04-28 | Astrazeneca Ab | Cyclic amine derivatives having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| WO2011073662A1 (en) | 2009-12-17 | 2011-06-23 | Astrazeneca Ab | Combination of a benzoxazinone and a further agent for treating respiratory diseases |
| CN102993116A (zh) * | 2012-12-04 | 2013-03-27 | 常州大学 | 一种苯并噁嗪类激动剂的制备方法 |
| CA2953655C (en) * | 2014-06-30 | 2020-05-12 | Astrazeneca Ab | Benzoxazinone amides as mineralocorticoid receptor modulators |
| CN104496920A (zh) * | 2014-12-04 | 2015-04-08 | 北京理工大学 | 一种n-烯丙基-二取代四唑及其制备方法和检测方法 |
| CN107188865B (zh) * | 2016-03-14 | 2019-08-27 | 益方生物科技（上海）有限公司 | 苯并噁嗪化合物及其制备方法和用途 |
| PL424609A1 (pl) * | 2018-02-16 | 2019-08-26 | Uniwersytet Przyrodniczy we Wrocławiu | Zastosowanie 6-(tert-butylo)-3-dodecylo-3,4-dihydro-2H-benzo[e][1,3]oxazyny |
| CN110028521B (zh) * | 2019-05-27 | 2020-07-14 | 湖南科技大学 | 11-芳基-1,4-苯并恶嗪酮并咪唑啉类化合物及其制备方法和用途 |
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| AR040962A1 (es) | 2002-08-09 | 2005-04-27 | Novartis Ag | Compuestos derivados de tiazol 1,3-2-ona, composicion farmaceutica y proceso de preparacion del compuesto |
| GB0225540D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Medicinal compounds |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| GB0303396D0 (en) | 2003-02-14 | 2003-03-19 | Glaxo Group Ltd | Medicinal compounds |
| JP4767842B2 (ja) | 2003-04-01 | 2011-09-07 | セラヴァンス， インコーポレーテッド | β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有するジアリールメチル化合物および関連化合物 |
| TW200526547A (en) | 2003-09-22 | 2005-08-16 | Theravance Inc | Amino-substituted ethylamino β2 adrenergic receptor agonists |
| GB0324654D0 (en) | 2003-10-22 | 2003-11-26 | Glaxo Group Ltd | Medicinal compounds |
| GB0324886D0 (en) | 2003-10-24 | 2003-11-26 | Glaxo Group Ltd | Medicinal compounds |
| JP2005187357A (ja) | 2003-12-25 | 2005-07-14 | Nippon Suisan Kaisha Ltd | 選択的なβ２受容体アゴニスト活性を有するベンゾチアゾロン誘導体の製造方法 |
| TW200531692A (en) | 2004-01-12 | 2005-10-01 | Theravance Inc | Aryl aniline derivatives as β2 adrenergic receptor agonists |
| GB0402797D0 (en) | 2004-02-09 | 2004-03-10 | Novartis Ag | Organic compounds |
| WO2005092861A1 (en) | 2004-03-11 | 2005-10-06 | Pfizer Limited | Quinolinone derivatives pharmaceutical compositions containing them and their use |
| EP1577306A1 (de) | 2004-03-17 | 2005-09-21 | Boehringer Ingelheim Pharma GmbH & Co.KG | Neue Benzoxazinonderivate als langwirksame Betamimetika zur Behandlung von Atemwegserkrankungen |
| WO2005092841A1 (en) | 2004-03-23 | 2005-10-06 | Pfizer Limited | Compounds having beta-agonist activity |
| WO2005110990A1 (de) | 2004-05-13 | 2005-11-24 | Boehringer Ingelheim International Gmbh | Hydroxy-substituierte benzkondensierte heterozyklen als betaagonisten zur behandlung von atemwegserkrankungen |
| EP1595873A1 (de) | 2004-05-13 | 2005-11-16 | Boehringer Ingelheim Pharma GmbH & Co.KG | Substituierte Cycloalkylderivate zur Behandlung von Atemswegerkrankungen |
| DE102004024453A1 (de) | 2004-05-14 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue langwirksame Bronchodilatoren zur Behandlung von Atemwegserkrankungen |
| RU2006146042A (ru) | 2004-06-03 | 2008-07-20 | Тереванс | Диаминные агонисты 2-адренергических рецепторов |
| EP1778638A1 (en) | 2004-07-21 | 2007-05-02 | Theravance, Inc. | Diaryl ether beta2 adrenergic receptor agonists |
| WO2006023460A2 (en) | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| WO2006023457A1 (en) | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| EP1786762A2 (en) | 2004-09-10 | 2007-05-23 | Theravance, Inc. | Amidine substituted aryl aniline compounds |
| GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
| CA2594484A1 (en) | 2005-01-11 | 2006-07-20 | Glaxo Group Limited | Cinnamate salts of a beta-2 adrenergic agonist |
| GB0511066D0 (en) | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
| EP1907356A2 (en) | 2005-07-18 | 2008-04-09 | Pfizer Limited | Process for the preparation of sulfonamide derivatives |
| TW200738658A (en) | 2005-08-09 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| TW200738659A (en) | 2005-08-29 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| TW200740781A (en) * | 2005-08-29 | 2007-11-01 | Astrazeneca Ab | Novel compounds |
| TW200745084A (en) | 2006-03-08 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| TW200745067A (en) | 2006-03-14 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| WO2008041914A1 (en) | 2006-10-06 | 2008-04-10 | Astrazeneca Ab | 5-(2-AMINO-L-HYDROXYETHYL)-8-HYDROXY-2-OXOQUINOLINE DERIVATIVES AND OTHER COMPOUNDS AS β2 -ADRENERGIC AGONISTS |
| TW200833670A (en) | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
| TW200835686A (en) * | 2006-12-20 | 2008-09-01 | Astrazeneca Ab | Novel compounds 621 |
| GB0702459D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 669 |
| GB0702456D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | New combination |
| GB0702457D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | New combination 666 |
| GB0702458D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 668 |
| GB0704000D0 (en) | 2007-03-01 | 2007-04-11 | Astrazeneca Ab | Salts 670 |
| GB0703999D0 (en) | 2007-03-01 | 2007-04-11 | Astrazeneca Ab | New combination 667 |
| WO2009037503A2 (en) | 2007-09-18 | 2009-03-26 | Astrazeneca Ab | New combination - 012 for the treatment of respiratory diseases |
| WO2009154557A1 (en) | 2008-06-18 | 2009-12-23 | Astrazeneca Ab | Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders |
| KR20110022611A (ko) | 2008-06-20 | 2011-03-07 | 아스트라제네카 아베 | 베타２－아드레날린수용체 활성의 조절을 위한, ４－히드록시－２－옥소－２,３－디히드로－１,３－벤조티아졸－７－일 화합물을 포함하는 제약 조성물 |
-
2009
- 2009-06-17 WO PCT/SE2009/050749 patent/WO2009154557A1/en not_active Ceased
- 2009-06-17 KR KR1020117001144A patent/KR20110017456A/ko not_active Withdrawn
- 2009-06-17 BR BRPI0915428A patent/BRPI0915428A2/pt not_active IP Right Cessation
- 2009-06-17 AU AU2009260899A patent/AU2009260899B2/en not_active Ceased
- 2009-06-17 MX MX2010013477A patent/MX2010013477A/es active IP Right Grant
- 2009-06-17 EP EP09766947A patent/EP2303873A4/en not_active Withdrawn
- 2009-06-17 CN CN2009801320729A patent/CN102124003A/zh active Pending
- 2009-06-17 EA EA201001747A patent/EA201001747A1/ru unknown
- 2009-06-17 TW TW098120291A patent/TW201002696A/zh unknown
- 2009-06-17 JP JP2011514537A patent/JP2011524896A/ja active Pending
- 2009-06-17 CA CA2726746A patent/CA2726746A1/en not_active Abandoned
- 2009-06-17 UY UY0001031905A patent/UY31905A/es unknown
- 2009-06-18 US US12/486,854 patent/US8017602B2/en not_active Expired - Fee Related
- 2009-06-18 AR ARP090102225A patent/AR072189A1/es unknown
-
2010
- 2010-11-29 CO CO10150418A patent/CO6321269A2/es not_active Application Discontinuation
- 2010-12-02 IL IL209731A patent/IL209731A0/en unknown
- 2010-12-09 ZA ZA2010/08886A patent/ZA201008886B/en unknown
- 2010-12-17 EC EC2010010694A patent/ECSP10010694A/es unknown
- 2010-12-17 CR CR11856A patent/CR11856A/es not_active Application Discontinuation
- 2010-12-17 CL CL2010001459A patent/CL2010001459A1/es unknown
- 2010-12-17 DO DO2010000389A patent/DOP2010000389A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0915428A2 (pt) | 2015-11-03 |
| CL2010001459A1 (es) | 2011-09-23 |
| ECSP10010694A (es) | 2011-01-31 |
| IL209731A0 (en) | 2011-02-28 |
| CO6321269A2 (es) | 2011-09-20 |
| EP2303873A1 (en) | 2011-04-06 |
| AU2009260899B2 (en) | 2012-02-23 |
| KR20110017456A (ko) | 2011-02-21 |
| WO2009154557A1 (en) | 2009-12-23 |
| EA201001747A1 (ru) | 2011-08-30 |
| AR072189A1 (es) | 2010-08-11 |
| US8017602B2 (en) | 2011-09-13 |
| CN102124003A (zh) | 2011-07-13 |
| EP2303873A4 (en) | 2012-01-04 |
| CA2726746A1 (en) | 2009-12-23 |
| UY31905A (es) | 2010-01-29 |
| AU2009260899A1 (en) | 2009-12-23 |
| CR11856A (es) | 2011-02-25 |
| US20100105642A1 (en) | 2010-04-29 |
| JP2011524896A (ja) | 2011-09-08 |
| DOP2010000389A (es) | 2011-01-15 |
| MX2010013477A (es) | 2010-12-21 |
| ZA201008886B (en) | 2011-08-31 |
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