JP2013544811A5 - - Google Patents

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Publication number
JP2013544811A5
JP2013544811A5 JP2013537774A JP2013537774A JP2013544811A5 JP 2013544811 A5 JP2013544811 A5 JP 2013544811A5 JP 2013537774 A JP2013537774 A JP 2013537774A JP 2013537774 A JP2013537774 A JP 2013537774A JP 2013544811 A5 JP2013544811 A5 JP 2013544811A5
Authority
JP
Japan
Prior art keywords
phenyl
isoxazol
trifluoromethyl
chroman
oxadiazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2013537774A
Other languages
English (en)
Japanese (ja)
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JP2013544811A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/058891 external-priority patent/WO2012061459A1/en
Publication of JP2013544811A publication Critical patent/JP2013544811A/ja
Publication of JP2013544811A5 publication Critical patent/JP2013544811A5/ja
Ceased legal-status Critical Current

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JP2013537774A 2010-11-03 2011-11-02 自己免疫疾患および血管疾患の治療用のs1p1アゴニストとしての複素環式化合物 Ceased JP2013544811A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40968210P 2010-11-03 2010-11-03
US61/409,682 2010-11-03
PCT/US2011/058891 WO2012061459A1 (en) 2010-11-03 2011-11-02 Heterocyclic compounds as s1p1 agonists for the treatment of autoimmune and vascular diseases

Publications (2)

Publication Number Publication Date
JP2013544811A JP2013544811A (ja) 2013-12-19
JP2013544811A5 true JP2013544811A5 (enExample) 2014-11-06

Family

ID=44983720

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013537774A Ceased JP2013544811A (ja) 2010-11-03 2011-11-02 自己免疫疾患および血管疾患の治療用のs1p1アゴニストとしての複素環式化合物

Country Status (6)

Country Link
US (1) US8629282B2 (enExample)
EP (1) EP2635573B1 (enExample)
JP (1) JP2013544811A (enExample)
CN (1) CN103298807A (enExample)
ES (1) ES2525298T3 (enExample)
WO (1) WO2012061459A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012012477A1 (en) 2010-07-20 2012-01-26 Bristol-Myers Squibb Company Substituted 3-phenyl-1,2,4-oxadiazole compounds
EP2619190B1 (en) 2010-09-24 2015-08-12 Bristol-Myers Squibb Company Substituted oxadiazole compounds and their use as s1p1 agonists
TWI613182B (zh) 2013-02-21 2018-02-01 必治妥美雅史谷比公司 雙環化合物
MA40082B1 (fr) 2014-08-20 2019-09-30 Bristol Myers Squibb Co Nouveau compose de substitution sphingosine phosphate utile traitement maladie rhumatisme
RU2754845C2 (ru) * 2016-07-22 2021-09-08 Медшайн Дискавери Инк. Агонист s1p1 и его применение
EP3638235A4 (en) 2017-06-14 2021-06-09 Trevena, Inc. COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING IT
CN111683946B (zh) * 2018-01-18 2022-04-05 南京明德新药研发有限公司 一种三并环化合物的晶型、盐型及其制备方法
JP2023502123A (ja) * 2019-11-19 2023-01-20 トレベナ・インコーポレイテッド S1p1モジュレーター化合物及び化合物を調製する方法
EP4061358B1 (en) * 2019-11-20 2025-05-28 Arena Pharmaceuticals, Inc. Etrasimod for use in the treatment of eosinophilic esophagitis

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AU2004277947A1 (en) * 2003-10-01 2005-04-14 Merck & Co., Inc. 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as S1P receptor agonists
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JP2012515789A (ja) * 2009-01-23 2012-07-12 ブリストル−マイヤーズ スクイブ カンパニー スフィンゴシン−1−リン酸アゴニストとしてのピラゾール−1,2,4−オキサジアゾール誘導体
WO2010085582A1 (en) * 2009-01-23 2010-07-29 Bristol-Myers Squibb Company Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
EP2382212B1 (en) * 2009-01-23 2014-07-16 Bristol-Myers Squibb Company Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
US8399451B2 (en) * 2009-08-07 2013-03-19 Bristol-Myers Squibb Company Heterocyclic compounds
MX336881B (es) 2009-10-29 2016-02-04 Bristol Myers Squibb Co Compuestos heterociclicos triciclicos.
US8835470B2 (en) 2010-04-23 2014-09-16 Bristol-Myers Squibb Company Mandelamide heterocyclic compounds
WO2012012477A1 (en) 2010-07-20 2012-01-26 Bristol-Myers Squibb Company Substituted 3-phenyl-1,2,4-oxadiazole compounds
EP2619190B1 (en) 2010-09-24 2015-08-12 Bristol-Myers Squibb Company Substituted oxadiazole compounds and their use as s1p1 agonists

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