ES2525298T3

ES2525298T3 - Compuestos heterocíclicos como agonistas del S1P1 para el tratamiento de enfermedades autoinmunes y vasculares

Compuestos heterocíclicos como agonistas del S1P1 para el tratamiento de enfermedades autoinmunes y vasculares Download PDF

Info

Publication number: ES2525298T3
Authority: ES; Spain
Prior art keywords: acid; phenyl; trifluoromethyl; isoxazol; chroman
Prior art date: 2010-11-03
Legal status : Active

Application number

ES11782723.8T

Other languages

English (en)

Spanish (es)

Inventor

Robert J. Cherney

Zhongyu Wang

Current Assignee

Bristol Myers Squibb Co

Original Assignee

Bristol Myers Squibb Co

Priority date

2010-11-03

Filing date

2011-11-02

Publication date

2014-12-19

2011-11-02 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2014-12-19 Application granted granted Critical

2014-12-19 Publication of ES2525298T3 publication Critical patent/ES2525298T3/es

Status Active legal-status Critical Current

2031-11-02 Anticipated expiration legal-status Critical

Links

238000011282 treatment Methods 0.000 title claims description 27
208000023275 Autoimmune disease Diseases 0.000 title claims description 16
230000001363 autoimmune Effects 0.000 title description 15
ZZMYWYZPNZRYPX-SANMLTNESA-N (2r)-2-amino-2-[5-[4-[2-(4-phenylphenyl)ethoxy]-3-(trifluoromethyl)phenyl]-1h-imidazol-2-yl]propan-1-ol Chemical compound N1C([C@@](N)(CO)C)=NC=C1C(C=C1C(F)(F)F)=CC=C1OCCC1=CC=C(C=2C=CC=CC=2)C=C1 ZZMYWYZPNZRYPX-SANMLTNESA-N 0.000 title description 10
208000019553 vascular disease Diseases 0.000 title description 9
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-1 - CN Chemical group 0.000 claims abstract description 327
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125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 14
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NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 claims description 11
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ILFIAVWHTRZJRF-SUMWQHHRSA-N (3s,4r)-3-amino-7-[5-[3-phenyl-4-(trifluoromethyl)-1,2-oxazol-5-yl]-1,2,4-oxadiazol-3-yl]-3,4-dihydro-2h-chromen-4-ol Chemical compound C([C@@H]([C@@H](C1=CC=2)O)N)OC1=CC=2C(N=1)=NOC=1C(=C1C(F)(F)F)ON=C1C1=CC=CC=C1 ILFIAVWHTRZJRF-SUMWQHHRSA-N 0.000 claims description 3
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