CN103298807A - 作为用于治疗自身免疫性疾病和血管疾病的s1p1激动剂的杂环化合物 - Google Patents

作为用于治疗自身免疫性疾病和血管疾病的s1p1激动剂的杂环化合物 Download PDF

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Publication number
CN103298807A
CN103298807A CN2011800639683A CN201180063968A CN103298807A CN 103298807 A CN103298807 A CN 103298807A CN 2011800639683 A CN2011800639683 A CN 2011800639683A CN 201180063968 A CN201180063968 A CN 201180063968A CN 103298807 A CN103298807 A CN 103298807A
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CN
China
Prior art keywords
phenyl
trifluoromethyl
oxadiazol
chroman
isoxazol
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Pending
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CN2011800639683A
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English (en)
Chinese (zh)
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R.J.彻尼
王中玉
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of CN103298807A publication Critical patent/CN103298807A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2011800639683A 2010-11-03 2011-11-02 作为用于治疗自身免疫性疾病和血管疾病的s1p1激动剂的杂环化合物 Pending CN103298807A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40968210P 2010-11-03 2010-11-03
US61/409,682 2010-11-03
PCT/US2011/058891 WO2012061459A1 (en) 2010-11-03 2011-11-02 Heterocyclic compounds as s1p1 agonists for the treatment of autoimmune and vascular diseases

Publications (1)

Publication Number Publication Date
CN103298807A true CN103298807A (zh) 2013-09-11

Family

ID=44983720

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800639683A Pending CN103298807A (zh) 2010-11-03 2011-11-02 作为用于治疗自身免疫性疾病和血管疾病的s1p1激动剂的杂环化合物

Country Status (6)

Country Link
US (1) US8629282B2 (enExample)
EP (1) EP2635573B1 (enExample)
JP (1) JP2013544811A (enExample)
CN (1) CN103298807A (enExample)
ES (1) ES2525298T3 (enExample)
WO (1) WO2012061459A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018014862A1 (zh) * 2016-07-22 2018-01-25 南京明德新药研发股份有限公司 S1p1激动剂及其应用
WO2019141245A1 (zh) * 2018-01-18 2019-07-25 南京明德新药研发股份有限公司 一种三并环化合物的晶型、盐型及其制备方法
CN115038437A (zh) * 2019-11-20 2022-09-09 艾尼纳制药公司 治疗与s1p1受体相关的病症的方法

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JP5869579B2 (ja) 2010-09-24 2016-02-24 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 置換オキサジアゾール化合物およびそれらのｓ１ｐ１アゴニストとしての使用
TWI613182B (zh) 2013-02-21 2018-02-01 必治妥美雅史谷比公司 雙環化合物
TWI689487B (zh) 2014-08-20 2020-04-01 美商必治妥美雅史谷比公司 經取代雙環化合物
IL271149B2 (en) 2017-06-14 2024-05-01 Trevena Inc Compounds for modulating s1p1 activity and methods of using the same
EP4061352A4 (en) * 2019-11-19 2024-02-28 Trevena, Inc. Compounds and methods of preparing compounds s1p1 modulators

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018014862A1 (zh) * 2016-07-22 2018-01-25 南京明德新药研发股份有限公司 S1p1激动剂及其应用
CN109661391A (zh) * 2016-07-22 2019-04-19 石家庄智康弘仁新药开发有限公司 S1p1激动剂及其应用
US11192886B2 (en) 2016-07-22 2021-12-07 Medshine Discovery Inc. S1P1 agonist and application thereof
CN109661391B (zh) * 2016-07-22 2022-04-19 南京明德新药研发有限公司 S1p1激动剂及其应用
WO2019141245A1 (zh) * 2018-01-18 2019-07-25 南京明德新药研发股份有限公司 一种三并环化合物的晶型、盐型及其制备方法
CN111683946A (zh) * 2018-01-18 2020-09-18 石家庄智康弘仁新药开发有限公司 一种三并环化合物的晶型、盐型及其制备方法
US11465995B2 (en) 2018-01-18 2022-10-11 Medshine Discovery Inc. Crystal and salt forms of tricyclic compound and preparation process thereof
CN115038437A (zh) * 2019-11-20 2022-09-09 艾尼纳制药公司 治疗与s1p1受体相关的病症的方法
TWI895298B (zh) * 2019-11-20 2025-09-01 美商艾尼納製藥公司 受體相關之病況的方法

Also Published As

Publication number Publication date
JP2013544811A (ja) 2013-12-19
WO2012061459A1 (en) 2012-05-10
EP2635573A1 (en) 2013-09-11
ES2525298T3 (es) 2014-12-19
EP2635573B1 (en) 2014-10-01
US20130237566A1 (en) 2013-09-12
US8629282B2 (en) 2014-01-14

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