CN109661391A - S1p1激动剂及其应用 - Google Patents
S1p1激动剂及其应用 Download PDFInfo
- Publication number
- CN109661391A CN109661391A CN201780044927.7A CN201780044927A CN109661391A CN 109661391 A CN109661391 A CN 109661391A CN 201780044927 A CN201780044927 A CN 201780044927A CN 109661391 A CN109661391 A CN 109661391A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
Description
Claims (44)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610583286X | 2016-07-22 | ||
CN201610583286 | 2016-07-22 | ||
PCT/CN2017/093808 WO2018014862A1 (zh) | 2016-07-22 | 2017-07-21 | S1p1激动剂及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109661391A true CN109661391A (zh) | 2019-04-19 |
CN109661391B CN109661391B (zh) | 2022-04-19 |
Family
ID=60991955
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201780044927.7A Active CN109661391B (zh) | 2016-07-22 | 2017-07-21 | S1p1激动剂及其应用 |
Country Status (11)
Country | Link |
---|---|
US (1) | US11192886B2 (zh) |
EP (1) | EP3492465B1 (zh) |
JP (1) | JP6883882B2 (zh) |
KR (1) | KR102481328B1 (zh) |
CN (1) | CN109661391B (zh) |
BR (1) | BR112019001153A2 (zh) |
CA (1) | CA3034796A1 (zh) |
ES (1) | ES2877686T3 (zh) |
RU (1) | RU2754845C2 (zh) |
WO (1) | WO2018014862A1 (zh) |
ZA (1) | ZA201901089B (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3026074A1 (en) | 2016-06-01 | 2017-12-07 | M3 Biotechnology, Inc. | N-hexanoic-l-tyrosine-l-isoleucine-(6)-aminohexanoic amide compounds and their use to treat neurodegenerative diseases |
RU2020127083A (ru) * | 2018-01-18 | 2022-02-18 | Медшайн Дискавери Инк. | Кристаллическая и солевая формы трициклического соединения и способ их получения |
KR102333564B1 (ko) * | 2019-11-28 | 2021-12-01 | 동방에프티엘(주) | 광학 활성 다이아민 유도체 및 티아졸 유도체의 생산을 위한 새로운 합성경로 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101622234A (zh) * | 2007-03-06 | 2010-01-06 | 诺瓦提斯公司 | 适于治疗炎性或变应性病症的二环有机化合物 |
CN102099333A (zh) * | 2008-01-10 | 2011-06-15 | 阿勒根公司 | 具有1-磷酸鞘氨醇(s1p)受体拮抗剂生物学活性的6-取代吲哚-3-羧酸酰胺化合物 |
CN102762100A (zh) * | 2009-11-13 | 2012-10-31 | 瑞塞普托斯公司 | 选择性的1-磷酸鞘氨醇受体调节剂及手性合成方法 |
CN103298807A (zh) * | 2010-11-03 | 2013-09-11 | 百时美施贵宝公司 | 作为用于治疗自身免疫性疾病和血管疾病的s1p1激动剂的杂环化合物 |
CN103380112A (zh) * | 2010-11-24 | 2013-10-30 | 阿勒根公司 | 作为s1p受体调节剂的吲哚衍生物 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2701B1 (en) * | 2006-12-21 | 2013-03-03 | جلاكسو جروب ليميتد | Vehicles |
EP2210890A1 (en) * | 2009-01-19 | 2010-07-28 | Almirall, S.A. | Oxadiazole derivatives as S1P1 receptor agonists |
WO2011005290A1 (en) * | 2009-06-23 | 2011-01-13 | Arena Pharmaceuticals, Inc. | Disubstituted oxadiazole derivatives useful in the treatment of autoimmune and inflammatory disorders |
CA2780433C (en) * | 2009-11-13 | 2018-01-02 | Receptos, Inc. | Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis |
JP2013514287A (ja) * | 2009-12-17 | 2013-04-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | スフィンゴシンキナーゼの阻害薬 |
CN103261157B (zh) * | 2010-12-14 | 2015-12-09 | 先正达参股股份有限公司 | strigolactam衍生物及其作为植物生长调节剂的用途 |
WO2012158550A2 (en) | 2011-05-13 | 2012-11-22 | Receptos, Inc. | Selective heterocyclic sphingosine 1 phosphate receptor modulators |
GB201121803D0 (en) * | 2011-12-16 | 2012-02-01 | Syngenta Participations Ag | Plant growth regulating compounds |
ES2698359T3 (es) * | 2013-02-20 | 2019-02-04 | Lg Chemical Ltd | Agonistas del receptor de la esfingosina-1-fosfato, métodos para preparar los mismos y composiciones farmacéuticas que los contienen como agentes activos |
-
2017
- 2017-07-21 JP JP2019524500A patent/JP6883882B2/ja active Active
- 2017-07-21 KR KR1020197005385A patent/KR102481328B1/ko active IP Right Grant
- 2017-07-21 CA CA3034796A patent/CA3034796A1/en active Pending
- 2017-07-21 ES ES17830496T patent/ES2877686T3/es active Active
- 2017-07-21 WO PCT/CN2017/093808 patent/WO2018014862A1/zh unknown
- 2017-07-21 US US16/319,491 patent/US11192886B2/en active Active
- 2017-07-21 RU RU2019104953A patent/RU2754845C2/ru active
- 2017-07-21 CN CN201780044927.7A patent/CN109661391B/zh active Active
- 2017-07-21 EP EP17830496.0A patent/EP3492465B1/en active Active
- 2017-07-21 BR BR112019001153-6A patent/BR112019001153A2/pt active Search and Examination
-
2019
- 2019-02-20 ZA ZA2019/01089A patent/ZA201901089B/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101622234A (zh) * | 2007-03-06 | 2010-01-06 | 诺瓦提斯公司 | 适于治疗炎性或变应性病症的二环有机化合物 |
CN102099333A (zh) * | 2008-01-10 | 2011-06-15 | 阿勒根公司 | 具有1-磷酸鞘氨醇(s1p)受体拮抗剂生物学活性的6-取代吲哚-3-羧酸酰胺化合物 |
CN102762100A (zh) * | 2009-11-13 | 2012-10-31 | 瑞塞普托斯公司 | 选择性的1-磷酸鞘氨醇受体调节剂及手性合成方法 |
CN103298807A (zh) * | 2010-11-03 | 2013-09-11 | 百时美施贵宝公司 | 作为用于治疗自身免疫性疾病和血管疾病的s1p1激动剂的杂环化合物 |
CN103380112A (zh) * | 2010-11-24 | 2013-10-30 | 阿勒根公司 | 作为s1p受体调节剂的吲哚衍生物 |
Non-Patent Citations (1)
Title |
---|
田育林 等: "选择性鞘胺醇-1-磷酸受体1激动剂研究进展", 《药学学报》 * |
Also Published As
Publication number | Publication date |
---|---|
ES2877686T3 (es) | 2021-11-17 |
WO2018014862A1 (zh) | 2018-01-25 |
JP2019522059A (ja) | 2019-08-08 |
ZA201901089B (en) | 2022-04-28 |
RU2019104953A3 (zh) | 2020-08-24 |
JP6883882B2 (ja) | 2021-06-09 |
CA3034796A1 (en) | 2018-01-25 |
CN109661391B (zh) | 2022-04-19 |
EP3492465A1 (en) | 2019-06-05 |
KR102481328B1 (ko) | 2022-12-26 |
US11192886B2 (en) | 2021-12-07 |
KR20190029729A (ko) | 2019-03-20 |
BR112019001153A2 (pt) | 2019-04-30 |
EP3492465B1 (en) | 2021-03-24 |
RU2019104953A (ru) | 2020-08-24 |
US20210300908A1 (en) | 2021-09-30 |
EP3492465A4 (en) | 2020-03-04 |
RU2754845C2 (ru) | 2021-09-08 |
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