JP2002539159A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2002539159A5 JP2002539159A5 JP2000604843A JP2000604843A JP2002539159A5 JP 2002539159 A5 JP2002539159 A5 JP 2002539159A5 JP 2000604843 A JP2000604843 A JP 2000604843A JP 2000604843 A JP2000604843 A JP 2000604843A JP 2002539159 A5 JP2002539159 A5 JP 2002539159A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- branched
- straight
- alkyl
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims description 120
- 125000000217 alkyl group Chemical group 0.000 claims description 56
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 40
- 229930184725 Lipoxin Natural products 0.000 claims description 24
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 24
- 229910052736 halogen Inorganic materials 0.000 claims description 24
- 150000002367 halogens Chemical class 0.000 claims description 24
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 24
- 125000003342 alkenyl group Chemical group 0.000 claims description 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 16
- 150000002639 lipoxins Chemical class 0.000 claims description 16
- 229910052760 oxygen Inorganic materials 0.000 claims description 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
- 229910052717 sulfur Inorganic materials 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 11
- 208000001840 Dandruff Diseases 0.000 claims description 8
- 201000004624 Dermatitis Diseases 0.000 claims description 8
- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- 125000002947 alkylene group Chemical group 0.000 claims description 8
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 8
- 238000002372 labelling Methods 0.000 claims description 8
- -1 lipoxin compound Chemical class 0.000 claims description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
- 239000002453 shampoo Substances 0.000 claims description 8
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims description 7
- 208000008742 seborrheic dermatitis Diseases 0.000 claims description 7
- 206010061218 Inflammation Diseases 0.000 claims description 5
- 230000004054 inflammatory process Effects 0.000 claims description 5
- 210000003622 mature neutrocyte Anatomy 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 102000003777 Interleukin-1 beta Human genes 0.000 claims 1
- 108090000193 Interleukin-1 beta Proteins 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 3
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12520599P | 1999-03-18 | 1999-03-18 | |
| US60/125,205 | 1999-03-18 | ||
| PCT/US2000/006582 WO2000054767A1 (en) | 1999-03-18 | 2000-03-14 | Use of lipoxin compounds for inhibiting of tnf-(alfa) initiated neutrophil response |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002539159A JP2002539159A (ja) | 2002-11-19 |
| JP2002539159A5 true JP2002539159A5 (enExample) | 2006-05-18 |
| JP4440481B2 JP4440481B2 (ja) | 2010-03-24 |
Family
ID=22418647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000604843A Expired - Fee Related JP4440481B2 (ja) | 1999-03-18 | 2000-03-14 | ＴＮＦ−αにより開始される好中球応答を阻害するためのリポキシン化合物の使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US6387953B1 (enExample) |
| EP (1) | EP1165066B1 (enExample) |
| JP (1) | JP4440481B2 (enExample) |
| AT (1) | ATE310512T1 (enExample) |
| AU (1) | AU775140B2 (enExample) |
| CA (3) | CA2615917C (enExample) |
| DE (1) | DE60024242T2 (enExample) |
| DK (1) | DK1165066T3 (enExample) |
| ES (1) | ES2249257T3 (enExample) |
| HK (1) | HK1043307B (enExample) |
| WO (1) | WO2000054767A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650435A (en) | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| US6387953B1 (en) * | 1999-03-18 | 2002-05-14 | Brigham And Women's Hopsital | Inhibition of TNF-(α)-initiated neutrophil response |
| ES2344138T3 (es) | 1999-03-18 | 2010-08-19 | The Brigham And Women's Hospital, Inc. | Analogos de 16-fenoxi-lipoxina para utilizacion medica. |
| ATE303355T1 (de) * | 1999-03-18 | 2005-09-15 | Brigham & Womens Hospital | Lipoxinverbindungen und ihre anwendung |
| ATE344226T1 (de) | 2000-02-16 | 2006-11-15 | Brigham & Womens Hospital | Aspirin-ausgelöste lipidmediatoren |
| WO2001070664A2 (en) * | 2000-03-20 | 2001-09-27 | Trustees Of Boston University | Lipoxin analogs and methods for the treatment of periodontal disease |
| GB2362140B (en) * | 2000-05-12 | 2003-03-05 | Autoliv Dev | Improvements in or relating to an apparatus for a method of folding an air-bag |
| PT1406698E (pt) * | 2001-03-02 | 2009-01-12 | Brigham & Womens Hospital | Análogos de lipoxina como novos inibidores da angiogénese |
| US8722654B2 (en) | 2001-03-02 | 2014-05-13 | The Brigham And Women's Hospital, Inc. | Lipoxin analogs as novel inhibitors of angiogenesis |
| CA2465117C (en) * | 2001-11-06 | 2012-01-03 | Brigham And Women's Hospital, Inc. | Lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
| US6831186B2 (en) * | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
| EP1911448B1 (en) * | 2001-11-06 | 2013-01-02 | The Brigham and Women's Hospital, Inc. | Lipoxins and Aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
| US20030195248A1 (en) | 2001-12-18 | 2003-10-16 | Serhan Charles N. | Novel approach to anti-microbial host defense with molecular shields with lipoxin compounds |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7902257B2 (en) | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| EP2216318B1 (en) * | 2002-08-12 | 2018-10-10 | Brigham And Women's Hospital | Resolvins: Biotemplates for therapeutic interventions |
| US7759395B2 (en) * | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| CN1946734B (zh) * | 2004-02-26 | 2012-07-18 | 贝勒研究院 | 系统性治疗关节炎的组合物和方法 |
| WO2005105025A1 (en) * | 2004-04-14 | 2005-11-10 | Boston University | Methods and compositions for preventing or treating periodontal diseases |
| WO2007041440A2 (en) | 2005-10-03 | 2007-04-12 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers |
| WO2007061783A1 (en) * | 2005-11-18 | 2007-05-31 | Trustees Of Boston University | Treatment and prevention of bone loss using resolvins |
| US7906678B2 (en) | 2006-12-04 | 2011-03-15 | Bayer Schering Pharma Aktiengesellschaft | Crystalline potassium salt of lipoxin A4 analogs |
| WO2011050126A1 (en) * | 2009-10-21 | 2011-04-28 | University Of Medicine And Dentistry Of New Jersey | Method for treating sepsis or septic shock |
| EP3576843A4 (en) | 2017-01-31 | 2020-11-11 | The Brigham and Women's Hospital, Inc. | ALX RECEIVER LIGANDS DEFINING A BIOCHEMICAL ENDOTYPE FOR INFLAMMATION-BASED DISEASES |
| CA3114750A1 (en) | 2018-10-09 | 2020-04-16 | University Of Rochester | Treatment of vulvovaginal disorders |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5441951A (en) * | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| US6048897A (en) * | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
| CA2164951C (en) | 1993-06-15 | 2004-02-10 | Charles N. Serhan | Lipoxin compounds |
| WO1995001179A1 (en) * | 1993-06-29 | 1995-01-12 | Brigham & Women's Hospital | Modulation of inflammation related to columnar epithelia |
| ES2344138T3 (es) * | 1999-03-18 | 2010-08-19 | The Brigham And Women's Hospital, Inc. | Analogos de 16-fenoxi-lipoxina para utilizacion medica. |
| US6387953B1 (en) * | 1999-03-18 | 2002-05-14 | Brigham And Women's Hopsital | Inhibition of TNF-(α)-initiated neutrophil response |
| ATE303355T1 (de) * | 1999-03-18 | 2005-09-15 | Brigham & Womens Hospital | Lipoxinverbindungen und ihre anwendung |
-
2000
- 2000-03-14 US US09/525,291 patent/US6387953B1/en not_active Expired - Fee Related
- 2000-03-14 DK DK00917903T patent/DK1165066T3/da active
- 2000-03-14 CA CA2615917A patent/CA2615917C/en not_active Expired - Fee Related
- 2000-03-14 JP JP2000604843A patent/JP4440481B2/ja not_active Expired - Fee Related
- 2000-03-14 DE DE60024242T patent/DE60024242T2/de not_active Expired - Lifetime
- 2000-03-14 CA CA002367909A patent/CA2367909C/en not_active Expired - Fee Related
- 2000-03-14 HK HK02104452.1A patent/HK1043307B/en not_active IP Right Cessation
- 2000-03-14 CA CA2747376A patent/CA2747376A1/en not_active Abandoned
- 2000-03-14 WO PCT/US2000/006582 patent/WO2000054767A1/en not_active Ceased
- 2000-03-14 AT AT00917903T patent/ATE310512T1/de active
- 2000-03-14 ES ES00917903T patent/ES2249257T3/es not_active Expired - Lifetime
- 2000-03-14 EP EP00917903A patent/EP1165066B1/en not_active Expired - Lifetime
- 2000-03-14 AU AU38806/00A patent/AU775140B2/en not_active Ceased
-
2002
- 2002-01-11 US US10/044,499 patent/US6703423B2/en not_active Expired - Fee Related
- 2002-01-11 US US10/044,740 patent/US6710084B2/en not_active Expired - Fee Related
-
2004
- 2004-03-05 US US10/794,153 patent/US7132451B2/en not_active Expired - Fee Related
-
2006
- 2006-09-14 US US11/531,921 patent/US20080312323A1/en not_active Abandoned
-
2007
- 2007-12-03 US US11/837,964 patent/US20080081838A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2002539159A5 (enExample) | ||
| JP2002539156A5 (enExample) | ||
| JP2005511592A5 (enExample) | ||
| JP2002539181A5 (enExample) | ||
| JP2005533835A5 (enExample) | ||
| RU2000132188A (ru) | Производные эпотилонов, их синтез и применение | |
| CA2645558A1 (en) | Regulation of phospholipase d activity | |
| CA2465117A1 (en) | Lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases | |
| EP0909560A3 (en) | Treatment o tumors with compounds having RXR retinoid receptor agoinst activity | |
| KR970706818A (ko) | 뉴로펩티드 y와 관련된 상태의 억제 방법(methods of inhibiting conditions associated with neuropeptide) | |
| RU2005107314A (ru) | Пиримидопроизводные, характеризующиеся антипролиферативной активностью | |
| JP2002502874A5 (enExample) | ||
| KR950704330A (ko) | 면역억제제로서의 라파마이신 카보네이트 에스테르(Rapamycin carbonate esters as immunosuppressant agents) | |
| CA2747376A1 (en) | Use of lipoxin compounds for inhibiting of tnf-(alpha) initiated neutrophil response | |
| JP2002505323A5 (enExample) | ||
| RU94037235A (ru) | Ингибитор фиброза матки | |
| JP2002527474A5 (ja) | 躁病および双極性障害の治療のための医薬 | |
| RU2002101622A (ru) | Нафтохиноновые производные и их использование для лечения и борьбы с туберкулезом | |
| KR950016727A (ko) | 트롬보모듈린 발현을 증가시키는 방법 | |
| KR960017663A (ko) | 결합 수용체 길항물질 | |
| RU98104276A (ru) | Новые конденсированные изохинолины в качестве лигандов для допаминовых рецепторов | |
| JP2003509494A5 (enExample) | ||
| KR910000647A (ko) | 나프틸아미노-및 나프틸옥시- 피리딘아민 및 관련된 화합물, 이의 제조방법 및 이의 피부소염제로서의 용도 | |
| KR920000715A (ko) | 신규의 n- 벤질-n1- 페닐-및- 펜알킬- 티오우레아류 | |
| JP2002523458A5 (enExample) |