JP2005511592A5 - - Google Patents
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- Publication number
- JP2005511592A5 JP2005511592A5 JP2003541824A JP2003541824A JP2005511592A5 JP 2005511592 A5 JP2005511592 A5 JP 2005511592A5 JP 2003541824 A JP2003541824 A JP 2003541824A JP 2003541824 A JP2003541824 A JP 2003541824A JP 2005511592 A5 JP2005511592 A5 JP 2005511592A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- branched
- alkyl
- numbers
- linear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 30
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 10
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 3
- 229930184725 Lipoxin Natural products 0.000 claims 2
- 208000019693 Lung disease Diseases 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 150000002639 lipoxins Chemical class 0.000 claims 2
- 210000004072 lung Anatomy 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33886201P | 2001-11-06 | 2001-11-06 | |
| US39104902P | 2002-06-24 | 2002-06-24 | |
| US10/289,654 US20030166716A1 (en) | 2001-11-06 | 2002-11-06 | Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
| PCT/US2002/035860 WO2003039533A1 (en) | 2001-11-06 | 2002-11-06 | Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005320216A Division JP2006063084A (ja) | 2001-11-06 | 2005-11-02 | 喘息および炎症性気道疾患の治療におけるリポキシンおよびアスピリン誘発リポキシンおよびそれらの安定な類似物 |
| JP2010207350A Division JP2010275329A (ja) | 2001-11-06 | 2010-09-15 | 喘息および炎症性気道疾患の治療におけるリポキシンおよびアスピリン誘発リポキシンおよびそれらの安定な類似物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005511592A JP2005511592A (ja) | 2005-04-28 |
| JP2005511592A5 true JP2005511592A5 (enExample) | 2006-01-05 |
| JP4652685B2 JP4652685B2 (ja) | 2011-03-16 |
Family
ID=27403915
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003541824A Expired - Fee Related JP4652685B2 (ja) | 2001-11-06 | 2002-11-06 | 喘息および炎症性気道疾患の治療におけるリポキシンおよびアスピリン誘発リポキシンおよびそれらの安定な類似物 |
| JP2005320216A Pending JP2006063084A (ja) | 2001-11-06 | 2005-11-02 | 喘息および炎症性気道疾患の治療におけるリポキシンおよびアスピリン誘発リポキシンおよびそれらの安定な類似物 |
| JP2010207350A Withdrawn JP2010275329A (ja) | 2001-11-06 | 2010-09-15 | 喘息および炎症性気道疾患の治療におけるリポキシンおよびアスピリン誘発リポキシンおよびそれらの安定な類似物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005320216A Pending JP2006063084A (ja) | 2001-11-06 | 2005-11-02 | 喘息および炎症性気道疾患の治療におけるリポキシンおよびアスピリン誘発リポキシンおよびそれらの安定な類似物 |
| JP2010207350A Withdrawn JP2010275329A (ja) | 2001-11-06 | 2010-09-15 | 喘息および炎症性気道疾患の治療におけるリポキシンおよびアスピリン誘発リポキシンおよびそれらの安定な類似物 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20030166716A1 (enExample) |
| EP (1) | EP1441715B1 (enExample) |
| JP (3) | JP4652685B2 (enExample) |
| AU (1) | AU2008216965B9 (enExample) |
| CA (1) | CA2465117C (enExample) |
| WO (1) | WO2003039533A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2246230T3 (es) | 1999-03-18 | 2006-02-16 | The Brigham And Women's Hospital, Inc. | Compuestos de lipoxina y su utilizacion. |
| EP1586550A1 (en) * | 1999-03-18 | 2005-10-19 | The Brigham And Women's Hospital, Inc. | Lipoxin compounds and their use |
| IL151299A0 (en) | 2000-02-16 | 2003-04-10 | Brigham & Womens Hospital | Aspirin-triggered lipid mediators |
| EP1268393A2 (en) * | 2000-03-20 | 2003-01-02 | Trustees Of Boston University | Lipoxin analogs and methods for the treatment of periodontal disease |
| CA2465117C (en) * | 2001-11-06 | 2012-01-03 | Brigham And Women's Hospital, Inc. | Lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
| CA2467580C (en) | 2001-12-18 | 2012-10-30 | Brigham And Women's Hospital | Use of lipoxin analogs to promote cell defense against gram-negative infections |
| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
| US7902257B2 (en) * | 2002-04-01 | 2011-03-08 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid |
| US7759395B2 (en) * | 2002-08-12 | 2010-07-20 | The Brigham And Women's Hospital, Inc. | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma |
| DK2216318T3 (en) * | 2002-08-12 | 2018-12-10 | Brigham & Womens Hospital | Resolvins: Bio templates for therapeutic interventions |
| WO2004078143A2 (en) * | 2003-03-05 | 2004-09-16 | The Brigham And Women's Hospital Inc. | Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs |
| WO2004110426A1 (en) * | 2003-06-01 | 2004-12-23 | Petasis Nicos A | Modulation of airway inflammation in patients with cystic fibrosis and related diseases |
| EP1755537A4 (en) * | 2004-04-14 | 2009-12-09 | Univ Boston | METHOD AND COMPOSITIONS FOR PREVENTING OR TREATING PERIODONTOPATHIA |
| WO2007041440A2 (en) | 2005-10-03 | 2007-04-12 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers |
| US7687539B1 (en) | 2005-11-07 | 2010-03-30 | Alcon Research, Ltd. | Method of treating ocular allergy |
| WO2007061783A1 (en) * | 2005-11-18 | 2007-05-31 | Trustees Of Boston University | Treatment and prevention of bone loss using resolvins |
| EP2679224A1 (en) | 2007-08-01 | 2014-01-01 | University of Pittsburgh of the Commonwealth System of Higher Education | Nitro oleic acid modulation of type II diabetes |
| GB0802116D0 (en) * | 2008-02-05 | 2008-03-12 | Natural Enviromental Res Counc | Treatment |
| DK2280928T3 (en) | 2008-05-01 | 2018-11-05 | Complexa Inc | Vinyl-substituted fatty acids |
| US20140024713A1 (en) | 2008-06-19 | 2014-01-23 | University Of Utah Research Foundation | Use of nitrated lipids for treatment of side effects of toxic medical therapies |
| US20120122816A1 (en) * | 2009-02-05 | 2012-05-17 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for organ preservation |
| CA2769624C (en) * | 2009-07-31 | 2018-09-11 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Electrophilic fatty acid derivatives as anti-inflammatory agents |
| WO2011041639A2 (en) | 2009-10-02 | 2011-04-07 | Miller Raymond A | Heteroatom containing substituted fatty acids |
| US20120220658A1 (en) * | 2009-10-21 | 2012-08-30 | University Of Medicine And Dentistry Of New Jersey | Method for Treating Sepsis or Septic Shock |
| EP2744491B1 (en) | 2011-08-19 | 2020-07-29 | The University of Utah Research Foundation | Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system |
| US20150253327A1 (en) * | 2012-09-07 | 2015-09-10 | Brigham And Women's Hospital, Inc. | Diagnosis and treatment of aspirin-exacerbated respiratory disease (aerd) |
| CA2990521C (en) | 2015-07-07 | 2023-10-10 | H. Lundbeck A/S | Pde9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases |
| CN113440506A (zh) | 2015-10-02 | 2021-09-28 | 康普莱克夏公司 | 使用治疗有效量的活化脂肪酸预防、治疗和逆转疾病 |
| KR102437682B1 (ko) | 2016-06-03 | 2022-08-29 | 테티스 파마수티컬스 엘엘씨 | 특화된 사전 해소 매개체의 염에 관한 조성물 및 방법 |
| US11519911B2 (en) | 2017-01-31 | 2022-12-06 | The Brigham And Women's Hospital, Inc. | ALX receptor ligands define a biochemical endotype for inflammation-based diseases |
| US11439615B2 (en) | 2017-03-09 | 2022-09-13 | University Health Network | Lipoxin and lipoxin analogue mediated neuroprotection and treatments |
| BR112020024019A2 (pt) | 2018-05-25 | 2021-02-23 | Imara Inc. | monoidrato e formas cristalinas de 6-[(3s,4s)-4-metil-1-(pirimidin-2-ilmetil)pirrolidin-3-il]-3-tetra-hidropiran-4-il-7h-imidazo[1,5-a]pirazin-8-ona |
| KR20250108770A (ko) | 2018-08-31 | 2025-07-15 | 카듀리온 파마슈티칼스, 인크. | 겸상 세포 질환의 치료를 위한 pde9 억제제 |
| CA3114750A1 (en) | 2018-10-09 | 2020-04-16 | University Of Rochester | Treatment of vulvovaginal disorders |
| KR20240150603A (ko) | 2022-03-03 | 2024-10-15 | 테티스 파마수티컬스 엘엘씨 | 특수화된 해소촉진 매개체의 시클로덱스트린 복합체 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4560514A (en) * | 1984-05-04 | 1985-12-24 | Bengt Samuelsson | Inflammatory lipoxin A and anti-anflammatory lipoxin B compounds |
| US4576758A (en) * | 1984-06-01 | 1986-03-18 | The Upjohn Company | Anti-inflammatory lipoxin B analogs |
| US4780281A (en) * | 1985-06-14 | 1988-10-25 | Wayne State University | Method for assay of peroxidase enzyme or reducing substrate activity |
| US5385938B1 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of using glycolic acid for treating wrinkles |
| CA1329809C (en) * | 1987-07-08 | 1994-05-24 | Nissan Chemical Industries, Ltd. | Optically active allyl alcohol and process for producing leucotriene b_ using thereof |
| US5079261A (en) * | 1989-04-28 | 1992-01-07 | Brigham And Women's Hospital | Use of lipoxin a4 and its derivatives as antagonists for slow-reacting substances of anaphylaxis |
| US5322699A (en) * | 1991-02-04 | 1994-06-21 | The Rockefeller University | Leukocyte-derived CR3 modulator, integrin modulating factor-1 (IMF-1) |
| US5650435A (en) * | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| EP0703897B1 (en) * | 1993-06-15 | 2008-08-20 | The Brigham And Women's Hospital, Inc. | Lipoxin compounds with prolonged half-life |
| US5441951A (en) * | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| US6048897A (en) * | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
| WO1995001179A1 (en) | 1993-06-29 | 1995-01-12 | Brigham & Women's Hospital | Modulation of inflammation related to columnar epithelia |
| US5837699A (en) * | 1994-01-27 | 1998-11-17 | Schering Corporation | Use of mometasone furoate for treating upper airway passage diseases |
| US5674483A (en) * | 1995-01-31 | 1997-10-07 | National Jewish Medical And Research Center | Treatment for diseases involving inflammation |
| US5998487A (en) * | 1998-04-08 | 1999-12-07 | Colgate-Palmolive Company | Anti-inflammatory and antibacterial benzyl phenol agents and their use in oral compositions |
| ATE324105T1 (de) | 1998-09-08 | 2006-05-15 | Cornell Res Foundation Inc | Verwendung von cyclooxygenase-2-inhibitoren zur behandlung von entzündungserkrankungen von kopf und nacken |
| ES2249257T3 (es) * | 1999-03-18 | 2006-04-01 | The Brigham And Women's Hospital, Inc. | Utilizacion de compuestos de lipoxina para la inhibicion de la respuesta de los neutrofilos inducida por tnf-alfa. |
| JP4392473B2 (ja) * | 1999-03-18 | 2010-01-06 | ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド | ホスホリパーゼｄの活性の調節 |
| ES2246230T3 (es) * | 1999-03-18 | 2006-02-16 | The Brigham And Women's Hospital, Inc. | Compuestos de lipoxina y su utilizacion. |
| EP1268393A2 (en) | 2000-03-20 | 2003-01-02 | Trustees Of Boston University | Lipoxin analogs and methods for the treatment of periodontal disease |
| US6495596B1 (en) * | 2001-03-23 | 2002-12-17 | Biozibe Laboratories, Inc. | Compounds and methods for inhibition of phospholipase A2 and cyclooxygenase-2 |
| CA2465117C (en) * | 2001-11-06 | 2012-01-03 | Brigham And Women's Hospital, Inc. | Lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
| US6831186B2 (en) * | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
-
2002
- 2002-11-06 CA CA2465117A patent/CA2465117C/en not_active Expired - Fee Related
- 2002-11-06 US US10/289,654 patent/US20030166716A1/en not_active Abandoned
- 2002-11-06 WO PCT/US2002/035860 patent/WO2003039533A1/en not_active Ceased
- 2002-11-06 JP JP2003541824A patent/JP4652685B2/ja not_active Expired - Fee Related
- 2002-11-06 EP EP02789515A patent/EP1441715B1/en not_active Expired - Lifetime
-
2005
- 2005-11-02 JP JP2005320216A patent/JP2006063084A/ja active Pending
- 2005-11-17 US US11/281,132 patent/US8119691B2/en not_active Expired - Fee Related
-
2007
- 2007-08-13 US US11/837,674 patent/US20080064746A1/en not_active Abandoned
-
2008
- 2008-09-11 AU AU2008216965A patent/AU2008216965B9/en not_active Ceased
-
2010
- 2010-09-15 JP JP2010207350A patent/JP2010275329A/ja not_active Withdrawn
-
2012
- 2012-02-21 US US13/401,519 patent/US20120149771A1/en not_active Abandoned
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