JP2002508347A5 - - Google Patents
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- Publication number
- JP2002508347A5 JP2002508347A5 JP2000538977A JP2000538977A JP2002508347A5 JP 2002508347 A5 JP2002508347 A5 JP 2002508347A5 JP 2000538977 A JP2000538977 A JP 2000538977A JP 2000538977 A JP2000538977 A JP 2000538977A JP 2002508347 A5 JP2002508347 A5 JP 2002508347A5
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- JP
- Japan
- Prior art keywords
- compound
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- solvates
- salts
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 description 44
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 10
- 150000003839 salts Chemical class 0.000 description 10
- 239000012453 solvate Substances 0.000 description 10
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 8
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 6
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 6
- 102000005348 Neuraminidase Human genes 0.000 description 4
- 108010006232 Neuraminidase Proteins 0.000 description 4
- 239000003937 drug carrier Substances 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6955397P | 1997-12-12 | 1997-12-12 | |
| US60/069,553 | 1997-12-12 | ||
| PCT/US1998/026327 WO1999031047A1 (en) | 1997-12-12 | 1998-12-10 | Cyclohexene carboxylates as neuraminidase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002508347A JP2002508347A (ja) | 2002-03-19 |
| JP2002508347A5 true JP2002508347A5 (enExample) | 2006-01-12 |
| JP4422895B2 JP4422895B2 (ja) | 2010-02-24 |
Family
ID=22089760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000538977A Expired - Lifetime JP4422895B2 (ja) | 1997-12-12 | 1998-12-10 | ノイラミニダーゼインヒビターとしてのシクロヘキセンカルボキシレート |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6111132A (enExample) |
| EP (1) | EP1040095B1 (enExample) |
| JP (1) | JP4422895B2 (enExample) |
| AR (1) | AR015493A1 (enExample) |
| AT (1) | ATE237582T1 (enExample) |
| AU (1) | AU1722699A (enExample) |
| CA (1) | CA2313638C (enExample) |
| DE (1) | DE69813616T2 (enExample) |
| ES (1) | ES2196636T3 (enExample) |
| TW (2) | TW477783B (enExample) |
| WO (1) | WO1999031047A1 (enExample) |
| ZA (1) | ZA9811314B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859284A (en) * | 1996-08-23 | 1999-01-12 | Gilead Sciences, Inc. | Preparation of carbocyclic compounds |
| US6518438B2 (en) | 1996-08-23 | 2003-02-11 | Gilead Sciences, Inc. | Preparation of cyclohexene carboxylate derivatives |
| US5994377A (en) | 1996-10-21 | 1999-11-30 | Gilead Sciences, Inc. | Piperidine compounds |
| US20040053999A1 (en) * | 1997-09-17 | 2004-03-18 | Bischofberger Norbert W. | Novel compounds and methods for synthesis and therapy |
| US6518305B1 (en) | 1998-04-23 | 2003-02-11 | Abbott Laboratories | Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases |
| US6455571B1 (en) | 1998-04-23 | 2002-09-24 | Abbott Laboratories | Inhibitors of neuraminidases |
| US6593314B1 (en) | 1999-10-19 | 2003-07-15 | Abbott Laboratories | Neuraminidase inhibitors |
| WO2001028981A1 (en) * | 1999-10-19 | 2001-04-26 | Abbott Laboratories | 1-cyclohexene-1-carboxylic acid and 1-cyclohexene-1-carboxylates as neuraminidase inhibitors |
| US6383037B2 (en) * | 2000-01-17 | 2002-05-07 | Harting Automotive Gmbh & Co., Kg | Safety disconnector |
| WO2003034071A2 (en) * | 2001-10-15 | 2003-04-24 | Therascope Ag | A method of forming a dynamic combinatorial library using a scaffold |
| US6964784B2 (en) * | 2002-03-07 | 2005-11-15 | Optigenex, Inc. | Method of preparation and composition of a water soluble extract of the bioactive component of the plant species uncaria for enhancing immune, anti-inflammatory, anti-tumor and dna repair processes of warm blooded animals |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| DK2318832T3 (da) | 2008-07-15 | 2014-01-20 | Academia Sinica | Glycan-arrays på PTFE-lignende aluminiumcoatede objektglas og relaterede fremgangsmåder |
| BRPI1010981A2 (pt) | 2009-05-15 | 2018-12-04 | Redx Pharma Ltd | "derivados de fármaco redox" |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| CN102964267B (zh) * | 2011-09-01 | 2015-06-10 | 中山大学 | 一种具有流感病毒神经氨酸酶抑制活性的环己烯化合物及其制备方法以及其应用 |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| US9914956B2 (en) | 2012-08-18 | 2018-03-13 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| CN103224464B (zh) * | 2013-04-15 | 2016-05-04 | 广州市恒诺康医药科技有限公司 | 环己烯类衍生物或其药学上可接受的盐及其用途 |
| WO2014210397A1 (en) | 2013-06-26 | 2014-12-31 | Academia Sinica | Rm2 antigens and use thereof |
| EP3013347B1 (en) | 2013-06-27 | 2019-12-11 | Academia Sinica | Glycan conjugates and use thereof |
| EP3041484B1 (en) | 2013-09-06 | 2021-03-03 | Academia Sinica | Human inkt cell activation using glycolipids with altered glycosyl groups |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| KR20160104727A (ko) | 2014-01-16 | 2016-09-05 | 아카데미아 시니카 | 암의 치료 및 검출을 위한 조성물 및 방법 |
| TWI797430B (zh) | 2014-03-27 | 2023-04-01 | 中央研究院 | 反應性標記化合物及其用途 |
| EP4116329A1 (en) | 2014-05-27 | 2023-01-11 | Academia Sinica | Anti-her2 glycoantibodies and uses thereof |
| KR20170010003A (ko) | 2014-05-27 | 2017-01-25 | 아카데미아 시니카 | 박테로이드 기원의 푸코시다제 및 이의 사용 방법 |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| JP2017518989A (ja) | 2014-05-27 | 2017-07-13 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 抗ｃｄ２０糖操作抗体群およびその使用 |
| JP7063538B2 (ja) | 2014-05-28 | 2022-05-09 | アカデミア シニカ | 抗ＴＮＦα糖操作抗体群およびその使用 |
| GB2532178A (en) * | 2014-06-09 | 2016-05-18 | Redx Pharma Plc | Antiviral compounds |
| EP3191500A4 (en) | 2014-09-08 | 2018-04-11 | Academia Sinica | HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| AU2015378564A1 (en) | 2015-01-24 | 2017-07-13 | Academia Sinica | Novel glycan conjugates and methods of use thereof |
| CN109195996A (zh) | 2016-03-08 | 2019-01-11 | 中央研究院 | N-聚醣及其阵列的模组化合成方法 |
| CN107325040B (zh) * | 2016-04-28 | 2019-05-03 | 广州市恒诺康医药科技有限公司 | 环己烯类衍生物或其药学上可接受的盐及其用途 |
| CA3034057A1 (en) | 2016-08-22 | 2018-03-01 | CHO Pharma Inc. | Antibodies, binding fragments, and methods of use |
| CN106496100B (zh) * | 2016-09-09 | 2021-01-22 | 广州市恒诺康医药科技有限公司 | 环己烯类化合物及其用途 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968788A (en) * | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
| US5206400A (en) * | 1986-07-07 | 1993-04-27 | Ohio State University | Diastereomeric mono- and di-substituted diamino cyclohexane compounds and the method of preparation thereof |
| US5175273A (en) * | 1988-07-01 | 1992-12-29 | Genentech, Inc. | Nucleic acid intercalating agents |
| US5270340A (en) * | 1988-12-27 | 1993-12-14 | Bayer Aktiengesellschaft | Substituted 2-cyclohexen-1-yl-amine fungicidal and herbicidal agents |
| SK282950B6 (sk) * | 1990-04-24 | 2003-01-09 | Biota Scientific Management Pty Ltd | Deriváty alfa-D-neuramínovej kyseliny, spôsob ich prípravy, ich použitie a farmaceutické prípravky na ich báze |
| WO1992006691A1 (en) * | 1990-10-19 | 1992-04-30 | Biota Scientific Management Pty. Ltd. | Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus |
| DE4033415A1 (de) * | 1990-10-20 | 1992-04-23 | Bayer Ag | Antimikrobielle mittel sowie substituierte 2-cyclohexan-1-yl-amin-derivate und deren herstellung |
| DE4131311A1 (de) * | 1991-09-20 | 1993-04-01 | Basf Ag | Dihydropyranderivate und diese enthaltende pflanzenschutzmittel |
| AU659501B2 (en) * | 1991-10-23 | 1995-05-18 | Biota Scientific Management Pty Ltd | Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-D-neuraminic acid |
| GB9126725D0 (en) * | 1991-12-17 | 1992-02-12 | Glaxo Group Ltd | Process |
| FR2687674B1 (fr) * | 1992-02-07 | 1995-05-19 | Roussel Uclaf | Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
| US5292938A (en) * | 1992-04-13 | 1994-03-08 | Associated Universities, Inc. | Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging |
| US5633360A (en) * | 1992-04-14 | 1997-05-27 | Gilead Sciences, Inc. | Oligonucleotide analogs capable of passive cell membrane permeation |
| GB9220241D0 (en) * | 1992-09-25 | 1992-11-11 | Glaxo Group Ltd | Process |
| GB9220327D0 (en) * | 1992-09-25 | 1992-11-11 | Glaxo Group Ltd | Process |
| US5514798A (en) * | 1993-06-02 | 1996-05-07 | Gilead Sciences, Inc. | Method and cyclic carbonates for nucleotide analogues |
| GB9311892D0 (en) * | 1993-06-09 | 1993-07-28 | Glaxo Wellcome Australia Ltd | Device |
| GB9311873D0 (en) * | 1993-06-09 | 1993-07-28 | Glaxo Group Ltd | Process |
| GB9312531D0 (en) * | 1993-06-17 | 1993-08-04 | Glaxo Group Ltd | Process |
| GB9325841D0 (en) * | 1993-12-17 | 1994-02-23 | Glaxo Group Ltd | Chemical compounds |
| GB9400206D0 (en) * | 1994-01-07 | 1994-03-02 | Glaxo Group Ltd | Chemical compound |
| AUPM354694A0 (en) * | 1994-01-27 | 1994-02-17 | Biota Scientific Management Pty Ltd | Chemical compounds |
| US5985859A (en) * | 1994-04-14 | 1999-11-16 | The University Of Alabama | Methods of inhibiting bacterial sialidase |
| GB9410817D0 (en) * | 1994-05-28 | 1994-07-20 | Glaxo Group Ltd | Medicaments |
| AUPM725794A0 (en) * | 1994-08-03 | 1994-08-25 | Biota Scientific Management Pty Ltd | Chemical compounds |
| US5556963A (en) * | 1994-08-05 | 1996-09-17 | Oklahoma Medical Research Foundation | Synthesis of 4-alkoxy-N-acetylneuraminic acid |
| US5512596A (en) * | 1994-09-02 | 1996-04-30 | Gilead Sciences, Inc. | Aromatic compounds |
| EP0789695A2 (en) * | 1994-11-04 | 1997-08-20 | Gilead Sciences, Inc. | Thiepane compounds inhibiting and detecting hiv protease |
| US5866601A (en) * | 1995-02-27 | 1999-02-02 | Gilead Sciences, Inc. | Carbocyclic compounds |
| CN100409844C (zh) * | 1995-02-27 | 2008-08-13 | 吉里德科学公司 | 神经氨酸苷酶抑制剂 |
| US5602277A (en) * | 1995-03-30 | 1997-02-11 | Biocryst Pharmaceuticals, Inc. | Substituted benzene derivatives useful as neuraminidase inhibitors |
| US5714509A (en) * | 1995-05-03 | 1998-02-03 | The University Of Alabama | Inhibitors of bacterial sialidase and methods of making and using the same |
| GB9525389D0 (en) | 1995-12-12 | 1996-02-14 | Biota Scient Management Ltd | Chemical compounds |
| GB9510141D0 (en) | 1995-05-19 | 1995-07-12 | Biota Scient Management | Chemical compounds |
| ATE206116T1 (de) * | 1995-05-19 | 2001-10-15 | Biota Scient Management | 6-carboxamido-dihydropyran-derivate |
| GB9516276D0 (en) * | 1995-08-08 | 1995-10-11 | Biota Scient Management | Chemical compounds |
| US5763483A (en) * | 1995-12-29 | 1998-06-09 | Gilead Sciences, Inc. | Carbocyclic compounds |
-
1998
- 1998-12-08 TW TW087120362A patent/TW477783B/zh not_active IP Right Cessation
- 1998-12-08 TW TW090111328A patent/TW480247B/zh not_active IP Right Cessation
- 1998-12-10 WO PCT/US1998/026327 patent/WO1999031047A1/en not_active Ceased
- 1998-12-10 DE DE69813616T patent/DE69813616T2/de not_active Expired - Lifetime
- 1998-12-10 AT AT98962059T patent/ATE237582T1/de not_active IP Right Cessation
- 1998-12-10 ES ES98962059T patent/ES2196636T3/es not_active Expired - Lifetime
- 1998-12-10 EP EP98962059A patent/EP1040095B1/en not_active Expired - Lifetime
- 1998-12-10 AU AU17226/99A patent/AU1722699A/en not_active Abandoned
- 1998-12-10 US US09/208,646 patent/US6111132A/en not_active Expired - Lifetime
- 1998-12-10 ZA ZA9811314A patent/ZA9811314B/xx unknown
- 1998-12-10 CA CA002313638A patent/CA2313638C/en not_active Expired - Lifetime
- 1998-12-10 JP JP2000538977A patent/JP4422895B2/ja not_active Expired - Lifetime
- 1998-12-11 AR ARP980106313A patent/AR015493A1/es active IP Right Grant
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