JP2005533835A - 新規の化合物、それを含有する医薬組成物、およびその使用方法 - Google Patents

新規の化合物、それを含有する医薬組成物、およびその使用方法 Download PDF

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Publication number
JP2005533835A
JP2005533835A JP2004520132A JP2004520132A JP2005533835A JP 2005533835 A JP2005533835 A JP 2005533835A JP 2004520132 A JP2004520132 A JP 2004520132A JP 2004520132 A JP2004520132 A JP 2004520132A JP 2005533835 A JP2005533835 A JP 2005533835A
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alkyl
compound
subject
aryl
alkylaryl
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Japanese (ja)
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JP2005533835A5 (enExample
Inventor
クハジャ,フランシス,ピー.
メドガルチ,スーザン,エム.
マックファーデン,ジル,エム.
サパリ,ジェイガン
タウンセンド,クレイグ,エー.
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Johns Hopkins University
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Johns Hopkins University
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Publication of JP2005533835A publication Critical patent/JP2005533835A/ja
Publication of JP2005533835A5 publication Critical patent/JP2005533835A5/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30Hetero atoms other than halogen
    • C07D333/32Oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2004520132A 2002-07-09 2003-07-09 新規の化合物、それを含有する医薬組成物、およびその使用方法 Pending JP2005533835A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39458502P 2002-07-09 2002-07-09
PCT/US2003/021700 WO2004005277A1 (en) 2002-07-09 2003-07-09 Novel compunds, pharmaceutical compositions containing same, and methods of use for same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010228956A Division JP2011037881A (ja) 2002-07-09 2010-10-08 新規の化合物、それを含有する医薬組成物、およびその使用方法

Publications (2)

Publication Number Publication Date
JP2005533835A true JP2005533835A (ja) 2005-11-10
JP2005533835A5 JP2005533835A5 (enExample) 2007-10-04

Family

ID=30115739

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2004520132A Pending JP2005533835A (ja) 2002-07-09 2003-07-09 新規の化合物、それを含有する医薬組成物、およびその使用方法
JP2010228956A Pending JP2011037881A (ja) 2002-07-09 2010-10-08 新規の化合物、それを含有する医薬組成物、およびその使用方法
JP2013117677A Pending JP2013189464A (ja) 2002-07-09 2013-06-04 新規の化合物、それを含有する医薬組成物、およびその使用方法

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JP2010228956A Pending JP2011037881A (ja) 2002-07-09 2010-10-08 新規の化合物、それを含有する医薬組成物、およびその使用方法
JP2013117677A Pending JP2013189464A (ja) 2002-07-09 2013-06-04 新規の化合物、それを含有する医薬組成物、およびその使用方法

Country Status (13)

Country Link
US (2) US7649012B2 (enExample)
EP (3) EP1539730A4 (enExample)
JP (3) JP2005533835A (enExample)
KR (1) KR101087559B1 (enExample)
CN (2) CN101602756B (enExample)
AU (1) AU2003265267B2 (enExample)
BR (1) BRPI0312649A2 (enExample)
CA (2) CA2491802C (enExample)
EA (1) EA013371B1 (enExample)
IL (2) IL166108A0 (enExample)
MX (1) MXPA05000365A (enExample)
SG (1) SG169236A1 (enExample)
WO (1) WO2004005277A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011521978A (ja) * 2008-06-02 2011-07-28 ファスジェン, インコーポレイテッド 新規化合物、それを含む医薬組成物、およびこれらの使用方法

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CA2474884A1 (en) 2002-02-08 2003-08-14 John Hopkins University School Of Medicine Stimulation of cpt-1 as a means to reduce weight
AU2003265267B2 (en) * 2002-07-09 2010-03-11 Fasgen, Llc Novel compounds, pharmaceutical compositions containing same, and methods of use for same
CN101721412A (zh) * 2002-07-09 2010-06-09 法斯根有限责任公司 治疗人和动物中微生物感染的方法
MXPA06013687A (es) * 2004-05-26 2007-10-18 Fasgen Llc Compuestos novedosos, composiciones farmaceuticas que los contienen y metodos para utilizar los mismos.
AU2007283113A1 (en) 2006-08-08 2008-02-14 Sanofi-Aventis Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
CA2668840A1 (en) * 2006-11-08 2008-05-15 Fasgen Llc Novel compounds, pharmaceutical compositions containing same, and methods of use for same
WO2008059214A1 (en) * 2006-11-13 2008-05-22 Astrazeneca Ab Bisamlde derivatives and use thereof as fatty acid synthase inhibitors
US8470841B2 (en) 2008-07-09 2013-06-25 Sanofi Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
WO2010118324A2 (en) 2009-04-09 2010-10-14 Nuclea Biotechnologies, LLC Antibodies against fatty acid synthase
US9149445B2 (en) 2009-07-27 2015-10-06 The Trustees Of Princeton University Inhibition of glycerol-3-phosphate acyltransferase (GPAT) and associated enzymes for treatment of viral infections
JP2013503135A (ja) 2009-08-26 2013-01-31 サノフイ 新規な結晶性複素芳香族フルオログリコシド水和物、その化合物を含んでなる医薬及びその使用
WO2011140296A1 (en) 2010-05-05 2011-11-10 Infinity Pharmaceuticals Triazoles as inhibitors of fatty acid synthase
CA2798330A1 (en) 2010-05-05 2011-11-10 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
EP2683703B1 (de) 2011-03-08 2015-05-27 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120058A1 (de) 2011-03-08 2012-09-13 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120054A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8809324B2 (en) 2011-03-08 2014-08-19 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
EP2683698B1 (de) 2011-03-08 2017-10-04 Sanofi Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012135027A2 (en) * 2011-03-25 2012-10-04 The Research Foundation Of State University Of New York Thiolactone antibiotics
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
JP6228198B2 (ja) * 2012-06-25 2017-11-08 トーマス・ジェファーソン・ユニバーシティThomas Jefferson University 異常な脂質生合成シグナル伝達を有するがんを処置するための組成物および方法
CA2884355C (en) * 2012-09-07 2022-05-17 Janssen Pharmaceutica Nv Imidazolin-5-one derivative useful as fasn inhobitors for the treatment of cancer
CN112521369A (zh) 2013-03-13 2021-03-19 福马治疗股份有限公司 用于抑制fasn的化合物及组合物
US11202795B2 (en) 2014-11-20 2021-12-21 Vib Vzw Means and methods for treatment of early-onset Parkinson's disease
WO2020092395A1 (en) 2018-10-29 2020-05-07 Forma Therapeutics, Inc. SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE
CN114480521B (zh) * 2020-11-13 2024-07-26 中国科学院青岛生物能源与过程研究所 一种三氮菌素c的制备方法

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JPS5859920A (ja) * 1981-10-05 1983-04-09 Chugai Pharmaceut Co Ltd 生体防禦能賦活剤
JPS6041492A (ja) * 1983-07-18 1985-03-05 ジ アツプジヨン カンパニ− 微生物ストレプトミセス・チオラクトヌス(nrrl 15439)の生物学的に純粋な培養基、及びそれからつくられる抗生物質
WO1988004652A1 (fr) * 1986-12-17 1988-06-30 Nippon Soda Co., Ltd. Composes heterocycliques possedant un squelette triketo
JPH11505220A (ja) * 1995-05-09 1999-05-18 バイエル・アクチエンゲゼルシヤフト 有害生物防除剤及び除草剤として有用なアルキルジハロゲン化フェニル置換ケトエノール
WO2001049278A2 (en) * 2000-01-06 2001-07-12 University College Cardiff Consultants Limited Compounds and compositions for use in inhibiting endoparasitic fatty acid biosynthesis

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JPS5859920A (ja) * 1981-10-05 1983-04-09 Chugai Pharmaceut Co Ltd 生体防禦能賦活剤
JPS6041492A (ja) * 1983-07-18 1985-03-05 ジ アツプジヨン カンパニ− 微生物ストレプトミセス・チオラクトヌス(nrrl 15439)の生物学的に純粋な培養基、及びそれからつくられる抗生物質
WO1988004652A1 (fr) * 1986-12-17 1988-06-30 Nippon Soda Co., Ltd. Composes heterocycliques possedant un squelette triketo
JPH11505220A (ja) * 1995-05-09 1999-05-18 バイエル・アクチエンゲゼルシヤフト 有害生物防除剤及び除草剤として有用なアルキルジハロゲン化フェニル置換ケトエノール
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011521978A (ja) * 2008-06-02 2011-07-28 ファスジェン, インコーポレイテッド 新規化合物、それを含む医薬組成物、およびこれらの使用方法

Also Published As

Publication number Publication date
US20100120901A1 (en) 2010-05-13
EP1539730A4 (en) 2007-03-28
CN101602756A (zh) 2009-12-16
CA2767092C (en) 2013-10-15
HK1083835A1 (zh) 2006-07-14
KR101087559B1 (ko) 2011-11-29
EP2386550A1 (en) 2011-11-16
AU2003265267B2 (en) 2010-03-11
JP2013189464A (ja) 2013-09-26
JP2011037881A (ja) 2011-02-24
EP2386551A1 (en) 2011-11-16
CN100513404C (zh) 2009-07-15
IL166108A0 (en) 2006-01-15
US7649012B2 (en) 2010-01-19
SG169236A1 (en) 2011-03-30
MXPA05000365A (es) 2005-09-20
WO2004005277A1 (en) 2004-01-15
EA200500178A1 (ru) 2006-02-24
CA2767092A1 (en) 2004-01-15
BRPI0312649A2 (pt) 2017-05-16
US20060247302A1 (en) 2006-11-02
EA013371B1 (ru) 2010-04-30
IL190218A0 (en) 2008-11-03
CN101602756B (zh) 2014-11-12
CA2491802A1 (en) 2004-01-15
KR20060002007A (ko) 2006-01-06
EP1539730A1 (en) 2005-06-15
CA2491802C (en) 2012-04-10
AU2003265267A1 (en) 2004-01-23
CN1675192A (zh) 2005-09-28

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