EA200500178A1 - Новые соединения, содержащие их фармацевтические композиции и способы их применеия - Google Patents

Новые соединения, содержащие их фармацевтические композиции и способы их применеия

Info

Publication number
EA200500178A1
EA200500178A1 EA200500178A EA200500178A EA200500178A1 EA 200500178 A1 EA200500178 A1 EA 200500178A1 EA 200500178 A EA200500178 A EA 200500178A EA 200500178 A EA200500178 A EA 200500178A EA 200500178 A1 EA200500178 A1 EA 200500178A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkylaryl
arylalkyl
cycloalkyl
alkenyl
aryl
Prior art date
Application number
EA200500178A
Other languages
English (en)
Other versions
EA013371B1 (ru
Inventor
Фрэнсис П. Кухаджа
Сьюзен М. Медгалчи
Джилл М. Макфэдден
Джаган Тхупари
Крэйг А. Таунсенд
Original Assignee
Фасджен, Ллс.
Дзе Джонс Хопкинс Юниверсити
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фасджен, Ллс., Дзе Джонс Хопкинс Юниверсити filed Critical Фасджен, Ллс.
Publication of EA200500178A1 publication Critical patent/EA200500178A1/ru
Publication of EA013371B1 publication Critical patent/EA013371B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Фармацевтическая композиция, содержащая фармацевтический разбавитель и соединение формулы IV, в котором R=H, C-Cалкил, циклоалкил, алкенил, арил, арилалкил или алкиларил, -CHOR, -C(O)R, -CO(O)R, -C(O)NRR, -CHC(O)Rили -CHC(O)NHR, где каждый из Rи Rнезависимо представляет собой H, C-Cалкил, циклоалкил, алкенил, арил, арилалкил или алкиларил, необязательно содержащий один или более атомов галогена. R=-OH, -OR, -OCHC(O)R, -OCHC(O)NHR, -OC(O)R, -OC(O)OR, -OC(O)NHNH-Rили -OC(O)NRR, где каждый из Rи Rнезависимо представляет собой H, C-Cалкил, циклоалкил, алкенил, арил, арилалкил или алкиларил и где каждый из Rи Rможет необязательно содержать атомы галогена; Rи Rявляются одинаковыми или отличаются друг от друга и представляют собой C-Cалкил, циклоалкил, алкенил, арил, арилалкил или алкиларил. Раскрыты также способы применения таких композиций для лечения рака, снижения веса, лечения инфекций, вызванных микробами, для ингибирования нейропептида-Y и/или синтазы жирных кислот и для стимуляции CPT-1.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500178A 2002-07-09 2003-07-09 Новые соединения, содержащие их фармацевтические композиции и способы их применения EA013371B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39458502P 2002-07-09 2002-07-09
PCT/US2003/021700 WO2004005277A1 (en) 2002-07-09 2003-07-09 Novel compunds, pharmaceutical compositions containing same, and methods of use for same

Publications (2)

Publication Number Publication Date
EA200500178A1 true EA200500178A1 (ru) 2006-02-24
EA013371B1 EA013371B1 (ru) 2010-04-30

Family

ID=30115739

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500178A EA013371B1 (ru) 2002-07-09 2003-07-09 Новые соединения, содержащие их фармацевтические композиции и способы их применения

Country Status (14)

Country Link
US (2) US7649012B2 (ru)
EP (3) EP2386550A1 (ru)
JP (3) JP2005533835A (ru)
KR (1) KR101087559B1 (ru)
CN (2) CN100513404C (ru)
AU (1) AU2003265267B2 (ru)
BR (1) BRPI0312649A2 (ru)
CA (2) CA2491802C (ru)
EA (1) EA013371B1 (ru)
HK (1) HK1083835A1 (ru)
IL (2) IL166108A0 (ru)
MX (1) MXPA05000365A (ru)
SG (1) SG169236A1 (ru)
WO (1) WO2004005277A1 (ru)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003215111A1 (en) 2002-02-08 2003-09-02 The Johns Hopkins University School Of Medicine Stimulation of cpt-1 as a means to reduce weight
BRPI0312649A2 (pt) * 2002-07-09 2017-05-16 Fasgen Llc compostos, composições farmacêuticas contendo os mesmos, e processos de uso para os mesmos.
EA200500177A1 (ru) * 2002-07-09 2005-12-29 Фасджен, Ллс. Способы лечения микробных инфекций у людей и животных
AU2005249437A1 (en) * 2004-05-26 2005-12-15 Fasgen, Llc Novel compounds, pharmaceutical compositions containing same, and methods of use for same
EP2061767B1 (de) 2006-08-08 2014-12-17 Sanofi Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung
CN101611017A (zh) * 2006-11-08 2009-12-23 法斯根有限责任公司 新化合物、包含该化合物的药物组合物以及该化合物的使用方法
WO2008059214A1 (en) * 2006-11-13 2008-05-22 Astrazeneca Ab Bisamlde derivatives and use thereof as fatty acid synthase inhibitors
JP2011521978A (ja) * 2008-06-02 2011-07-28 ファスジェン， インコーポレイテッド 新規化合物、それを含む医薬組成物、およびこれらの使用方法
TW201014822A (en) 2008-07-09 2010-04-16 Sanofi Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
US8729239B2 (en) 2009-04-09 2014-05-20 Nuclea Biotechnologies, Inc. Antibodies against fatty acid synthase
US9149445B2 (en) 2009-07-27 2015-10-06 The Trustees Of Princeton University Inhibition of glycerol-3-phosphate acyltransferase (GPAT) and associated enzymes for treatment of viral infections
DK2470552T3 (en) 2009-08-26 2014-02-17 Sanofi Sa NOVEL, CRYSTALLINE, heteroaromatic FLUORGLYCOSIDHYDRATER, MEDICINES COVERING THESE COMPOUNDS AND THEIR USE
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
EP2566853B1 (en) 2010-05-05 2017-01-25 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
WO2012120051A1 (de) 2011-03-08 2012-09-13 Sanofi Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120058A1 (de) 2011-03-08 2012-09-13 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120057A1 (de) 2011-03-08 2012-09-13 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120050A1 (de) 2011-03-08 2012-09-13 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US9056851B2 (en) 2011-03-25 2015-06-16 The Research Foundation For The State University Of New York Thiolactone antibiotics
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9750758B2 (en) 2012-06-25 2017-09-05 Thomas Jefferson University Compositions and methods for treating cancer with aberrant lipogenic signaling
JP6285442B2 (ja) * 2012-09-07 2018-02-28 ヤンセン ファーマシューティカ エヌ．ベー． がん治療用の脂肪酸合成酵素（ｆａｓｎ）阻害剤として有用なイミダゾリン−５−オン誘導体
DK2968316T3 (da) 2013-03-13 2019-10-07 Forma Therapeutics Inc 2-hydroxy-1-{4-[(4-phenylphenyl)carbonyl]piperazin-1-yl}ethan-1-on-derivater og relaterede forbindelser som fedtsyresyntase (fasn)-inhibitorer til behandlingen af cancer
EP3220901B1 (en) 2014-11-20 2020-02-19 VIB vzw Means and methods for treatment of early-onset parkinson's disease
US10793554B2 (en) 2018-10-29 2020-10-06 Forma Therapeutics, Inc. Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone
CN114480521A (zh) * 2020-11-13 2022-05-13 中国科学院青岛生物能源与过程研究所 一种三氮菌素c的制备方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3496187A (en) * 1967-03-20 1970-02-17 American Home Prod N-(heterocyclyl)aconamides
US3472878A (en) * 1969-01-27 1969-10-14 American Home Prod N-(hydroxyaryl)aconamides
JPS5859920A (ja) * 1981-10-05 1983-04-09 Chugai Pharmaceut Co Ltd 生体防禦能賦活剤
US4565699A (en) * 1983-07-18 1986-01-21 The Upjohn Company Composition of matter and process
US4720503A (en) * 1985-08-02 1988-01-19 Merck & Co., Inc. N-substituted fused-heterocyclic carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors
CH667655A5 (de) * 1986-09-24 1988-10-31 Lonza Ag Verfahren zur herstellung von 4-alkoxy-2(5h)-thiophenonen.
US4753871A (en) * 1986-12-12 1988-06-28 Eastman Kodak Company Cyan dye-forming couplers and photographic materials containing same
WO1988004652A1 (en) * 1986-12-17 1988-06-30 Nippon Soda Co., Ltd. Heterocyclic compounds having triketo skeleton
US5665874A (en) * 1989-01-17 1997-09-09 John Hopkins University Cancer related antigen
US5759791A (en) * 1989-01-17 1998-06-02 The Johns Hopkins University Cancer related antigen
US5759837A (en) 1989-01-17 1998-06-02 John Hopkins University Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway
US5679801A (en) * 1991-04-12 1997-10-21 American Home Products Corporation Tetronic and thiotetronic acid derivatives as phospholipase A2 inhibitors
US5614551A (en) 1994-01-24 1997-03-25 The Johns Hopkins University Inhibitors of fatty acid synthesis as antimicrobial agents
CN1131209C (zh) * 1995-05-09 2003-12-17 拜尔公司 可用作杀虫剂和除草剂的烷基－二卤代苯基取代的酮烯醇
US5981575A (en) 1996-11-15 1999-11-09 Johns Hopkins University, The Inhibition of fatty acid synthase as a means to reduce adipocyte mass
JPH10212284A (ja) * 1996-11-27 1998-08-11 Sagami Chem Res Center テトロン酸−３−カルボン酸誘導体、その製造方法、製造中間体、抗がん剤、及び蛋白脱リン酸化酵素阻害剤
US6391912B1 (en) * 1996-12-12 2002-05-21 Bayer Aktiengesellschaft Substituted phenylketoenols
CO4970714A1 (es) * 1997-09-05 2000-11-07 Boehringer Mannheim Gmbh Derivados ureido y tioureido de 4-amino-2(5h)-furanonas y 4-amino-2(5h) tiofenonas como agentes antitumorales
HN2000000051A (es) * 1999-05-19 2001-02-02 Pfizer Prod Inc Derivados heterociclicos utiles como agentes anticancerosos
IT1315267B1 (it) * 1999-12-23 2003-02-03 Novuspharma Spa Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale
GB0000131D0 (en) * 2000-01-06 2000-02-23 Univ Cardiff Thiolactomycin analogues,compositions containing the same and uses thereof
US6376682B1 (en) * 2000-02-01 2002-04-23 Takama System, Ltd. Compound with α-glucosidase inhibiting action and method for producing the same
MY134040A (en) * 2001-05-02 2007-11-30 Univ New York Inhibition of pigmentation by inhibition of fatty acid synthase
AU2003215111A1 (en) * 2002-02-08 2003-09-02 The Johns Hopkins University School Of Medicine Stimulation of cpt-1 as a means to reduce weight
EA200500177A1 (ru) * 2002-07-09 2005-12-29 Фасджен, Ллс. Способы лечения микробных инфекций у людей и животных
BRPI0312649A2 (pt) * 2002-07-09 2017-05-16 Fasgen Llc compostos, composições farmacêuticas contendo os mesmos, e processos de uso para os mesmos.
US9690894B1 (en) 2015-11-02 2017-06-27 Altera Corporation Safety features for high level design

Also Published As

Publication number Publication date
JP2013189464A (ja) 2013-09-26
AU2003265267B2 (en) 2010-03-11
EA013371B1 (ru) 2010-04-30
CN101602756A (zh) 2009-12-16
IL190218A0 (en) 2008-11-03
EP1539730A1 (en) 2005-06-15
EP2386550A1 (en) 2011-11-16
CA2491802A1 (en) 2004-01-15
IL166108A0 (en) 2006-01-15
CN101602756B (zh) 2014-11-12
KR101087559B1 (ko) 2011-11-29
AU2003265267A1 (en) 2004-01-23
CA2767092A1 (en) 2004-01-15
EP1539730A4 (en) 2007-03-28
CA2491802C (en) 2012-04-10
KR20060002007A (ko) 2006-01-06
CA2767092C (en) 2013-10-15
CN100513404C (zh) 2009-07-15
WO2004005277A1 (en) 2004-01-15
MXPA05000365A (es) 2005-09-20
BRPI0312649A2 (pt) 2017-05-16
SG169236A1 (en) 2011-03-30
JP2011037881A (ja) 2011-02-24
EP2386551A1 (en) 2011-11-16
US20100120901A1 (en) 2010-05-13
CN1675192A (zh) 2005-09-28
JP2005533835A (ja) 2005-11-10
US20060247302A1 (en) 2006-11-02
HK1083835A1 (en) 2006-07-14
US7649012B2 (en) 2010-01-19

Similar Documents

Publication Publication Date Title
EA200500178A1 (ru) Новые соединения, содержащие их фармацевтические композиции и способы их применеия
DK0705254T3 (da) Phenylheterocykliske forbindelser som cyclooxygenase-2-inhibitorer
RU95108387A (ru) Дикетопиперазин, способ его получения, фармацевтическая композиция, применение дикетопиперазина
IL174471A (en) A method for making quinolinone compounds and preparations containing such compounds
SE9203825D0 (sv) Dual inhibitors of no synthase and cyclooxygenase, process for their preparation and therapeutical compositions containing them
TW200612920A (en) Novel imidazolidine derivatives
EA200500312A1 (ru) Новые спироконденсированные хиназолиноны и их применение в качестве ингибиторов фосфодиэстераз
EA200870321A1 (ru) Способ получения 4-оксохинолинового соединения
CY1107403T1 (el) Μια μεθοδος δια την παρασκευη υπερινδοπριλης,των αναλογων ενωσεων αυτης και των αλατων αυτων με χρησιμοποιηση ενδιαμεσων ενωσεων 2,5-διοξο-οξαζολιδινης
CR10974A (es) Inhibidores de carboxipeptidasa b plasmatica (divisional)
EA200500122A1 (ru) Новые соединения, фармацевтические композиции, содержащие их, и способы их использования
WO2005117590A3 (en) Novel compounds, pharmaceutical compositions containing same, and methods of use for same
EA200501530A1 (ru) Новые соединения бензотиадиазина, способ их получения и фармацевтические композиции, которые их содержат
FI942928A0 (fi) Fenyleenidialkanoaattien aromaattiset esterit ihmisen neutrofiili-elastaasin inhibiittoreina
YU47219B (sh) Antivirusna tetrahidroimidazo (1,4) benzodiazepin-2-tiona jedinjenja i postupak za njihovo dobijanje
BR8504542A (pt) Processo para preparar um composto,aplicacao de tal composto,processo para combater insetos e representantes da ordem acarina,bem como composicao praguicida
HRP20030797B1 (en) Fungicide compositions
RS51504B (en) FUNGICID COMPOSITIONS BASED ON PIRIDYL METHYLBENZAMIDE DERIVATIVES AND PROPAMOCARB
EA200600551A1 (ru) Соединения пиперазина, способ их получения и фармацевтические композиции, которые их содержат
SE7903687L (sv) Cyklohexylkarboxylsyraderivat och sett att framstella desamma
EA200501696A1 (ru) Новые соединения тиадиазина, способ их получения и фармацевтические композиции, которые их содержат
EA200000068A2 (ru) Новые цианоиндольные соединения, являющиеся ингибиторами повторного захвата серотонина, способ их получения и фармацевтические композиции, содержащие их
EA200100644A1 (ru) Фунгицидная смесь
EA200300458A1 (ru) Новые соединения аминотриазолона, способ их получения и фармацевтические композиции, содержащие их
EA200400756A1 (ru) Новые соединения бензотиазина и бензотиадиазина, способ их получения и фармацевтические композиции, которые их содержат

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU