EA200000068A2 - Новые цианоиндольные соединения, являющиеся ингибиторами повторного захвата серотонина, способ их получения и фармацевтические композиции, содержащие их - Google Patents

Новые цианоиндольные соединения, являющиеся ингибиторами повторного захвата серотонина, способ их получения и фармацевтические композиции, содержащие их

Info

Publication number
EA200000068A2
EA200000068A2 EA200000068A EA200000068A EA200000068A2 EA 200000068 A2 EA200000068 A2 EA 200000068A2 EA 200000068 A EA200000068 A EA 200000068A EA 200000068 A EA200000068 A EA 200000068A EA 200000068 A2 EA200000068 A2 EA 200000068A2
Authority
EA
Eurasian Patent Office
Prior art keywords
group
optionally substituted
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
EA200000068A
Other languages
English (en)
Other versions
EA200000068A3 (ru
EA003146B1 (ru
Inventor
Жильбер Лавиелль
Оливье Мюллер
Бернар Симетьер
Марк Миллан
Ален Гобер
Жан-Мишель Риве
Original Assignee
Адир Э Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Адир Э Компани filed Critical Адир Э Компани
Publication of EA200000068A2 publication Critical patent/EA200000068A2/ru
Publication of EA200000068A3 publication Critical patent/EA200000068A3/ru
Publication of EA003146B1 publication Critical patent/EA003146B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Соединение формулы (I)в которой Rи R, независимо друг от друга, каждый представляет атом водорода или алкильную группу; A представляет алкиленовую, алкениленовую или алкиниленовую группу; Gпредставляет группув которой Rи R, независимо друг от друга, каждый представляет атом водорода, алкильную группу, циклоалкильную группу, циклоалкилалкильную группу, необязательно замещенную арильную группу или необязательно замещенную арилалкильную группу; или Gпредставляет гетероциклоалкильную группу, необязательно замещенную алкильной группой, циклоалкильной группой, циклоалкилалкильной группой, нитрильной группой, карбоксигруппой, алкоксикарбонильной группой, карбамоильной группой, необязательно замещенной арильной группой, необязательно замещенной арилалкильной группой, необязательно замещенной гетероарильной группой или необязательно замещенной гетероарилалкильной группой. Лекарственные средства.
EA200000068A 1999-01-26 2000-01-25 Новые цианоиндольные соединения, являющиеся ингибиторами повторного захвата серотонина, способ их получения и фармацевтические композиции, содержащие их EA003146B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9900801A FR2788772B1 (fr) 1999-01-26 1999-01-26 Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
EA200000068A2 true EA200000068A2 (ru) 2000-08-28
EA200000068A3 EA200000068A3 (ru) 2000-10-30
EA003146B1 EA003146B1 (ru) 2003-02-27

Family

ID=9541208

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000068A EA003146B1 (ru) 1999-01-26 2000-01-25 Новые цианоиндольные соединения, являющиеся ингибиторами повторного захвата серотонина, способ их получения и фармацевтические композиции, содержащие их

Country Status (22)

Country Link
US (1) US6239129B1 (ru)
EP (1) EP1023898B1 (ru)
JP (1) JP2000212162A (ru)
KR (1) KR100445389B1 (ru)
CN (1) CN1155570C (ru)
AT (1) ATE234093T1 (ru)
AU (1) AU761084B2 (ru)
BR (1) BR0000158A (ru)
CA (1) CA2297279C (ru)
DE (1) DE60001591T2 (ru)
DK (1) DK1023898T3 (ru)
EA (1) EA003146B1 (ru)
ES (1) ES2193923T3 (ru)
FR (1) FR2788772B1 (ru)
HK (1) HK1029584A1 (ru)
HU (1) HUP0000308A2 (ru)
MX (1) MXPA00000856A (ru)
NO (1) NO314801B1 (ru)
NZ (1) NZ502494A (ru)
PL (1) PL338027A1 (ru)
SI (1) SI1023898T1 (ru)
ZA (1) ZA200000336B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001247562A (ja) * 2000-03-07 2001-09-11 Daicel Chem Ind Ltd アミド化合物及びその製造方法
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
CA2448729A1 (en) * 2000-11-20 2002-05-23 Biovitrum Ab Piperazinyl and piperidyl substituted heterocyclic compounds
CZ20032644A3 (en) 2001-03-29 2004-06-16 Bristol-Myers Squibb Company Cyclopropylindole derivatives as selective serotonin reuptake inhibitors
RU2327685C2 (ru) * 2002-09-17 2008-06-27 Ф.Хоффманн-Ля Рош Аг 2,7-замещенные индолы и фармацевтическая композиция, проявляющая антагонистическую активность по отношению к 5-гт6 рецептору
US7129264B2 (en) * 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
EP1689389A4 (en) * 2003-12-04 2009-06-17 Nat Health Research Institutes Indole compounds
FR2884251B1 (fr) * 2005-04-08 2007-07-13 Servier Lab Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK181190D0 (da) * 1990-07-30 1990-07-30 Lundbeck & Co As H 3-aryl-indol- eller 3-aryl-indazolderivater
TW270114B (ru) * 1993-10-22 1996-02-11 Hoffmann La Roche
DE19500689A1 (de) * 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
US5912256A (en) * 1996-06-20 1999-06-15 Eli Lilly And Company Compounds having effects on serotonin-related systems
WO1998030548A1 (fr) * 1997-01-13 1998-07-16 Yamanouchi Pharmaceutical Co., Ltd. AGONISTES DU RECEPTEUR 5-HT2c ET DERIVES D'AMINOALKYLINDAZOLE

Also Published As

Publication number Publication date
ES2193923T3 (es) 2003-11-16
ATE234093T1 (de) 2003-03-15
HUP0000308A2 (en) 2002-06-29
DE60001591T2 (de) 2003-12-24
FR2788772A1 (fr) 2000-07-28
SI1023898T1 (en) 2003-06-30
NO314801B1 (no) 2003-05-26
CN1266057A (zh) 2000-09-13
AU1355300A (en) 2000-07-27
US6239129B1 (en) 2001-05-29
EA200000068A3 (ru) 2000-10-30
HU0000308D0 (en) 2000-03-28
AU761084B2 (en) 2003-05-29
NO20000373D0 (no) 2000-01-25
EA003146B1 (ru) 2003-02-27
MXPA00000856A (es) 2002-03-08
KR100445389B1 (ko) 2004-08-25
EP1023898A1 (fr) 2000-08-02
HK1029584A1 (en) 2001-04-06
NO20000373L (no) 2000-07-27
CA2297279C (fr) 2004-05-18
NZ502494A (en) 2001-06-29
CA2297279A1 (fr) 2000-07-26
FR2788772B1 (fr) 2001-03-02
BR0000158A (pt) 2000-09-19
KR20010006587A (ko) 2001-01-26
DE60001591D1 (de) 2003-04-17
PL338027A1 (en) 2000-07-31
EP1023898B1 (fr) 2003-03-12
CN1155570C (zh) 2004-06-30
JP2000212162A (ja) 2000-08-02
DK1023898T3 (da) 2003-06-10
ZA200000336B (en) 2000-08-15

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU