NO20000373L - Nye cyano-indol serotinin-reopptaks-inhibitorforbindelser, fremgangsmÕte for deres fremstilling og farmasøytiske sammensetninger inneholdende dem - Google Patents

Nye cyano-indol serotinin-reopptaks-inhibitorforbindelser, fremgangsmÕte for deres fremstilling og farmasøytiske sammensetninger inneholdende dem

Info

Publication number
NO20000373L
NO20000373L NO20000373A NO20000373A NO20000373L NO 20000373 L NO20000373 L NO 20000373L NO 20000373 A NO20000373 A NO 20000373A NO 20000373 A NO20000373 A NO 20000373A NO 20000373 L NO20000373 L NO 20000373L
Authority
NO
Norway
Prior art keywords
alkyl
indole
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
NO20000373A
Other languages
English (en)
Other versions
NO314801B1 (no
NO20000373D0 (no
Inventor
Gilbert Lavielle
Olivier Muller
Bernard Cimetiere
Mark Millan
Alain Gobert
Jean-Michel Rivet
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of NO20000373D0 publication Critical patent/NO20000373D0/no
Publication of NO20000373L publication Critical patent/NO20000373L/no
Publication of NO314801B1 publication Critical patent/NO314801B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20000373A 1999-01-26 2000-01-25 Nye cyanoindol serotonin-reopptaks-inhibitorforbindelser og farmasöytiske sammensetninger inneholdende dem NO314801B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9900801A FR2788772B1 (fr) 1999-01-26 1999-01-26 Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
NO20000373D0 NO20000373D0 (no) 2000-01-25
NO20000373L true NO20000373L (no) 2000-07-27
NO314801B1 NO314801B1 (no) 2003-05-26

Family

ID=9541208

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20000373A NO314801B1 (no) 1999-01-26 2000-01-25 Nye cyanoindol serotonin-reopptaks-inhibitorforbindelser og farmasöytiske sammensetninger inneholdende dem

Country Status (22)

Country Link
US (1) US6239129B1 (no)
EP (1) EP1023898B1 (no)
JP (1) JP2000212162A (no)
KR (1) KR100445389B1 (no)
CN (1) CN1155570C (no)
AT (1) ATE234093T1 (no)
AU (1) AU761084B2 (no)
BR (1) BR0000158A (no)
CA (1) CA2297279C (no)
DE (1) DE60001591T2 (no)
DK (1) DK1023898T3 (no)
EA (1) EA003146B1 (no)
ES (1) ES2193923T3 (no)
FR (1) FR2788772B1 (no)
HK (1) HK1029584A1 (no)
HU (1) HUP0000308A2 (no)
MX (1) MXPA00000856A (no)
NO (1) NO314801B1 (no)
NZ (1) NZ502494A (no)
PL (1) PL338027A1 (no)
SI (1) SI1023898T1 (no)
ZA (1) ZA200000336B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001247562A (ja) * 2000-03-07 2001-09-11 Daicel Chem Ind Ltd アミド化合物及びその製造方法
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
CA2448729A1 (en) * 2000-11-20 2002-05-23 Biovitrum Ab Piperazinyl and piperidyl substituted heterocyclic compounds
CZ20032644A3 (en) 2001-03-29 2004-06-16 Bristol-Myers Squibb Company Cyclopropylindole derivatives as selective serotonin reuptake inhibitors
RU2327685C2 (ru) * 2002-09-17 2008-06-27 Ф.Хоффманн-Ля Рош Аг 2,7-замещенные индолы и фармацевтическая композиция, проявляющая антагонистическую активность по отношению к 5-гт6 рецептору
US7129264B2 (en) * 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
EP1689389A4 (en) * 2003-12-04 2009-06-17 Nat Health Research Institutes Indole compounds
FR2884251B1 (fr) * 2005-04-08 2007-07-13 Servier Lab Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK181190D0 (da) * 1990-07-30 1990-07-30 Lundbeck & Co As H 3-aryl-indol- eller 3-aryl-indazolderivater
TW270114B (no) * 1993-10-22 1996-02-11 Hoffmann La Roche
DE19500689A1 (de) * 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
US5912256A (en) * 1996-06-20 1999-06-15 Eli Lilly And Company Compounds having effects on serotonin-related systems
WO1998030548A1 (fr) * 1997-01-13 1998-07-16 Yamanouchi Pharmaceutical Co., Ltd. AGONISTES DU RECEPTEUR 5-HT2c ET DERIVES D'AMINOALKYLINDAZOLE

Also Published As

Publication number Publication date
ES2193923T3 (es) 2003-11-16
ATE234093T1 (de) 2003-03-15
HUP0000308A2 (en) 2002-06-29
DE60001591T2 (de) 2003-12-24
FR2788772A1 (fr) 2000-07-28
SI1023898T1 (en) 2003-06-30
NO314801B1 (no) 2003-05-26
CN1266057A (zh) 2000-09-13
EA200000068A2 (ru) 2000-08-28
AU1355300A (en) 2000-07-27
US6239129B1 (en) 2001-05-29
EA200000068A3 (ru) 2000-10-30
HU0000308D0 (en) 2000-03-28
AU761084B2 (en) 2003-05-29
NO20000373D0 (no) 2000-01-25
EA003146B1 (ru) 2003-02-27
MXPA00000856A (es) 2002-03-08
KR100445389B1 (ko) 2004-08-25
EP1023898A1 (fr) 2000-08-02
HK1029584A1 (en) 2001-04-06
CA2297279C (fr) 2004-05-18
NZ502494A (en) 2001-06-29
CA2297279A1 (fr) 2000-07-26
FR2788772B1 (fr) 2001-03-02
BR0000158A (pt) 2000-09-19
KR20010006587A (ko) 2001-01-26
DE60001591D1 (de) 2003-04-17
PL338027A1 (en) 2000-07-31
EP1023898B1 (fr) 2003-03-12
CN1155570C (zh) 2004-06-30
JP2000212162A (ja) 2000-08-02
DK1023898T3 (da) 2003-06-10
ZA200000336B (en) 2000-08-15

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