BR0000158A - Compostos inibidores de reabsorção de ciano-indol serotonina, processo para sua preparação e composições farmacêuticas contendo os mesmos - Google Patents

Compostos inibidores de reabsorção de ciano-indol serotonina, processo para sua preparação e composições farmacêuticas contendo os mesmos

Info

Publication number
BR0000158A
BR0000158A BR0000158-9A BR0000158A BR0000158A BR 0000158 A BR0000158 A BR 0000158A BR 0000158 A BR0000158 A BR 0000158A BR 0000158 A BR0000158 A BR 0000158A
Authority
BR
Brazil
Prior art keywords
group
optionally substituted
preparation
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
BR0000158-9A
Other languages
English (en)
Inventor
Gilbert Lavielle
Olivier Muller
Bernard Cimetiere
Mark Millan
Alain Gobert
Jean-Michel Rivet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR et Cie
Original Assignee
ADIR et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR et Cie filed Critical ADIR et Cie
Publication of BR0000158A publication Critical patent/BR0000158A/pt
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Patente de Invenção: <B>"COMPOSTOS INIBIDORES DE REABSORçãO DE CIANO-INDOL SEROTONINA, PROCESSO PARA SUA PREPARAçãO E COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS"<D>. A presente invenção refere-se a compostos de fórmula (I): onde: <sym> R~ 1~ e R~ 2~ cada um independentemente de outro representa um átomo de hidrogênio ou um grupo alquila, <sym> A representa um alquileno, alquenileno ou um grupo alquinileno, <sym> G~ 1~ representa um grupamento onde R~ 3~ e R~ 4~ independentemente um do outro representam um átomo de hidrogênio, um grupo alquila, um grupo cicloalquila, um grupo cicloalquilalquila, um grupo arila opcionalmente substituído ou um grupo arilalquila opcionalmente substituído, ou G~ 1~ representa um grupo heterocicloalquila opcionalmente substituído por um grupo alquila, um grupo cicloalquila, um grupo cicloalquilalquila, um grupo nitrila, um grupo carbóxi, um grupo alcoxi-carbonila, um grupo carbamoíla, um grupo arila opcionalmente substituído, um grupo arilalquila opcionalmente substituído, um grupo heteroarila opcionalmente substituído ou um grupo heteroarilalquila opcionalmente substituído. Medicamentos.
BR0000158-9A 1999-01-26 2000-01-25 Compostos inibidores de reabsorção de ciano-indol serotonina, processo para sua preparação e composições farmacêuticas contendo os mesmos Withdrawn BR0000158A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9900801A FR2788772B1 (fr) 1999-01-26 1999-01-26 Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BR0000158A true BR0000158A (pt) 2000-09-19

Family

ID=9541208

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0000158-9A Withdrawn BR0000158A (pt) 1999-01-26 2000-01-25 Compostos inibidores de reabsorção de ciano-indol serotonina, processo para sua preparação e composições farmacêuticas contendo os mesmos

Country Status (22)

Country Link
US (1) US6239129B1 (pt)
EP (1) EP1023898B1 (pt)
JP (1) JP2000212162A (pt)
KR (1) KR100445389B1 (pt)
CN (1) CN1155570C (pt)
AT (1) ATE234093T1 (pt)
AU (1) AU761084B2 (pt)
BR (1) BR0000158A (pt)
CA (1) CA2297279C (pt)
DE (1) DE60001591T2 (pt)
DK (1) DK1023898T3 (pt)
EA (1) EA003146B1 (pt)
ES (1) ES2193923T3 (pt)
FR (1) FR2788772B1 (pt)
HK (1) HK1029584A1 (pt)
HU (1) HUP0000308A2 (pt)
MX (1) MXPA00000856A (pt)
NO (1) NO314801B1 (pt)
NZ (1) NZ502494A (pt)
PL (1) PL338027A1 (pt)
SI (1) SI1023898T1 (pt)
ZA (1) ZA200000336B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001247562A (ja) * 2000-03-07 2001-09-11 Daicel Chem Ind Ltd アミド化合物及びその製造方法
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
ATE470662T1 (de) * 2000-11-20 2010-06-15 Biovitrum Ab Publ Piperazinylpyrazinverbindungen als agonisten oder antagonisten am serotonin-5ht-2-rezeptor
SK12012003A3 (en) * 2001-03-29 2004-10-05 Bristol Myers Squibb Co Cyclopropylindole derivatives as selective serotonin reuptake inhibitors
DK1587788T3 (da) * 2002-09-17 2007-09-24 Hoffmann La Roche 2,7-substituerede indoler og anvendelsen deraf som 5-HT6-modulatorer
US7129264B2 (en) * 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
EP1689389A4 (en) * 2003-12-04 2009-06-17 Nat Health Research Institutes Indole compounds
FR2884251B1 (fr) * 2005-04-08 2007-07-13 Servier Lab Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK181190D0 (da) * 1990-07-30 1990-07-30 Lundbeck & Co As H 3-aryl-indol- eller 3-aryl-indazolderivater
TW270114B (pt) * 1993-10-22 1996-02-11 Hoffmann La Roche
DE19500689A1 (de) * 1995-01-12 1996-07-18 Merck Patent Gmbh Indolpiperidin-Derivate
US5912256A (en) * 1996-06-20 1999-06-15 Eli Lilly And Company Compounds having effects on serotonin-related systems
WO1998030548A1 (fr) * 1997-01-13 1998-07-16 Yamanouchi Pharmaceutical Co., Ltd. AGONISTES DU RECEPTEUR 5-HT2c ET DERIVES D'AMINOALKYLINDAZOLE

Also Published As

Publication number Publication date
EA200000068A2 (ru) 2000-08-28
NO20000373D0 (no) 2000-01-25
PL338027A1 (en) 2000-07-31
DE60001591T2 (de) 2003-12-24
CN1155570C (zh) 2004-06-30
FR2788772A1 (fr) 2000-07-28
AU1355300A (en) 2000-07-27
NO20000373L (no) 2000-07-27
EA003146B1 (ru) 2003-02-27
ATE234093T1 (de) 2003-03-15
MXPA00000856A (es) 2002-03-08
NO314801B1 (no) 2003-05-26
DE60001591D1 (de) 2003-04-17
EP1023898A1 (fr) 2000-08-02
AU761084B2 (en) 2003-05-29
US6239129B1 (en) 2001-05-29
EA200000068A3 (ru) 2000-10-30
CN1266057A (zh) 2000-09-13
ES2193923T3 (es) 2003-11-16
JP2000212162A (ja) 2000-08-02
HUP0000308A2 (en) 2002-06-29
NZ502494A (en) 2001-06-29
HU0000308D0 (en) 2000-03-28
ZA200000336B (en) 2000-08-15
SI1023898T1 (en) 2003-06-30
FR2788772B1 (fr) 2001-03-02
CA2297279A1 (fr) 2000-07-26
KR20010006587A (ko) 2001-01-26
DK1023898T3 (da) 2003-06-10
CA2297279C (fr) 2004-05-18
KR100445389B1 (ko) 2004-08-25
HK1029584A1 (en) 2001-04-06
EP1023898B1 (fr) 2003-03-12

Similar Documents

Publication Publication Date Title
BR0213931A (pt) Forma polimórfica de rimonabant, processo para sua preparação e composições farmacêuticas contendo-as
BR9907429A (pt) Composto de hidrazida, processo para sua preparação e composições farmacêuticas contendo os mesmos
BR0209431A (pt) Novos compostos de 4-anilinoquinolino-3-carboxamidas
HRP20041042A2 (en) Novel substituted sulfamate anticonvulsant derivatives
NO20054787L (no) Indenderivater som farmasotiske midler
BR0102607A (pt) Compostos de difeniluréia, um processo para sua preparação e composições farmacêuticas contendo os mesmos
BR0311984A (pt) Difenilazetidinonas substituìdas cationicamente, processo para a sua preparação, medicamentos contendo estes compostos e sua aplicação
BR0000158A (pt) Compostos inibidores de reabsorção de ciano-indol serotonina, processo para sua preparação e composições farmacêuticas contendo os mesmos
BR9805031A (pt) Compostos de naftaleno, processo para sua preparação e composições farmacêuticas contendo os mesmos.
BR0309558A (pt) Derivados de quinazolina e medicamentos
DE602004029355D1 (de) Sulfopyrrolderivate
BR0100234A (pt) Compostos de piperidina-4-sulfonamida, processo para a sua preparação e composições farmacêuticas contendo os mesmos
BR0003313A (pt) Novos compostos diméricos substituìdos, um processo para a preparação dos mesmos e composições farmacêuticas que contêm os mesmos
BRPI0403028A (pt) Compostos heterocìclicos de oxima, processo para sua preparação e composições farmacêuticas contendo os mesmos
HUP9902199A1 (hu) Új nitronszármazékok, ezek előállítási eljárása és ezeket tartalmazó gyógyszerkészítmények
BR0100107A (pt) Compostos de benzenossulfonamida, um processo para sua preparação e composições farmacêuticas que contêm os mesmos
BRPI0601725A (pt) compostos de fenilpiridilpiperazina, um processo para sua preparação e composições farmacêuticas contendo-os
BRPI0401031A (pt) Compostos de isoquinolina, processo para sua preparação e composições farmacêuticas contendo os mesmos
BR9801448A (pt) Compostos heterocìclicos, processo para sua preparação e composições farmacêuticas contendo os mesmos.
BR0005486A (pt) Compostos análogos de camptotecina, processo para a sua preparação e composições farmacêuticas contendo os mesmos
BR0005442A (pt) Composições de aminopirrolina, processo para a sua preparação e composições farmacêuticas contendo os mesmos
BR9815081A (pt) Compostos tricìclicos, um processo para a sua preparação e composições farmacêuticas contendo-os
BRPI0417300A (pt) métodos para a preparação de compostos de tiazolpirimidina
BR0002075A (pt) Compostos 2,3-metano-aminoácidos, um processo para sua preparação e composições farmacêuticas que os contêm
BR0002076A (pt) Compostos 1-aza-2-alquil-6-aril-cicloalcano, um processo para sua preparação e composições farmacêuticas contendo estes

Legal Events

Date Code Title Description
PC Transfer

Free format text: LES LABORATOIRES SERVIER (FR)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8O E 9O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 NA RPI2003 DE 26/05/2009.