NO20051794L - Fremgangsmate for fremstilling av epotilonderivater, og nye mellomprodukter for fremgangsmaten, samt fremgangsmater for fremstilling av slike - Google Patents

Fremgangsmate for fremstilling av epotilonderivater, og nye mellomprodukter for fremgangsmaten, samt fremgangsmater for fremstilling av slike

Info

Publication number
NO20051794L
NO20051794L NO20051794A NO20051794A NO20051794L NO 20051794 L NO20051794 L NO 20051794L NO 20051794 A NO20051794 A NO 20051794A NO 20051794 A NO20051794 A NO 20051794A NO 20051794 L NO20051794 L NO 20051794L
Authority
NO
Norway
Prior art keywords
preparation
processes
epothilone derivatives
novel intermediates
optionally substituted
Prior art date
Application number
NO20051794A
Other languages
English (en)
Other versions
NO20051794D0 (no
Inventor
Olivier Loiseleur
Guido Koch
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9944042&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20051794(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20051794D0 publication Critical patent/NO20051794D0/no
Publication of NO20051794L publication Critical patent/NO20051794L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det beskrives en syntese for fremstilling av epotilonderivater med formel 9, der Rier metyl, og R2 betyr en eventuelt substituert aryl-, en eventuelt substituert heteroatyl- eller eventuelt substituert heterocykhsk rest fiisert til en benzen nukleus, og salter derav. Det beskrives videre mellomprodukter for syntese av en forbindelse med formel 9.
NO20051794A 2002-09-13 2005-04-12 Fremgangsmate for fremstilling av epotilonderivater, og nye mellomprodukter for fremgangsmaten, samt fremgangsmater for fremstilling av slike NO20051794L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0221312.2A GB0221312D0 (en) 2002-09-13 2002-09-13 Organic compounds
PCT/EP2003/010171 WO2004024735A2 (en) 2002-09-13 2003-09-12 A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same

Publications (2)

Publication Number Publication Date
NO20051794D0 NO20051794D0 (no) 2005-04-12
NO20051794L true NO20051794L (no) 2005-04-12

Family

ID=9944042

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051794A NO20051794L (no) 2002-09-13 2005-04-12 Fremgangsmate for fremstilling av epotilonderivater, og nye mellomprodukter for fremgangsmaten, samt fremgangsmater for fremstilling av slike

Country Status (30)

Country Link
US (1) US7470792B2 (no)
EP (1) EP1539768B1 (no)
JP (1) JP4628102B2 (no)
KR (1) KR20050042500A (no)
CN (1) CN100522968C (no)
AR (1) AR041231A1 (no)
AT (1) ATE373663T1 (no)
AU (2) AU2003267349B2 (no)
BR (1) BR0314263A (no)
CA (1) CA2497119C (no)
CY (1) CY1107794T1 (no)
DE (1) DE60316456T2 (no)
DK (1) DK1539768T3 (no)
EC (1) ECSP055652A (no)
ES (1) ES2290489T3 (no)
GB (1) GB0221312D0 (no)
HK (1) HK1078853A1 (no)
IL (1) IL166829A (no)
MX (1) MXPA05002785A (no)
MY (1) MY140442A (no)
NO (1) NO20051794L (no)
NZ (1) NZ538612A (no)
PE (1) PE20050052A1 (no)
PL (1) PL375039A1 (no)
PT (1) PT1539768E (no)
RU (2) RU2404985C2 (no)
SG (1) SG155770A1 (no)
TW (1) TWI289563B (no)
WO (1) WO2004024735A2 (no)
ZA (1) ZA200501008B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
ATE350383T1 (de) 2002-08-23 2007-01-15 Sloan Kettering Inst Cancer Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen
EP3566719A1 (en) 2010-05-18 2019-11-13 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6441186B1 (en) * 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
US6498257B1 (en) * 1998-04-21 2002-12-24 Bristol-Myers Squibb Company 2,3-olefinic epothilone derivatives
GB9810659D0 (en) * 1998-05-18 1998-07-15 Ciba Geigy Ag Organic compounds
AU6233600A (en) * 1999-07-22 2001-02-13 Schering Aktiengesellschaft Process for the production of epothiolone b and derivatives as well as intermediate products for this process
US6593115B2 (en) * 2000-03-24 2003-07-15 Bristol-Myers Squibb Co. Preparation of epothilone intermediates
US6989450B2 (en) * 2000-10-13 2006-01-24 The University Of Mississippi Synthesis of epothilones and related analogs
JP2006505627A (ja) * 2002-07-31 2006-02-16 シエーリング アクチエンゲゼルシャフト 新規エフェクター接合体、それらの生成方法及びそれらの医薬使用

Also Published As

Publication number Publication date
NO20051794D0 (no) 2005-04-12
DK1539768T3 (da) 2008-01-07
RU2008129613A (ru) 2010-01-27
RU2005110925A (ru) 2006-01-20
CN100522968C (zh) 2009-08-05
AU2003267349B2 (en) 2008-05-01
CN1681824A (zh) 2005-10-12
ES2290489T3 (es) 2008-02-16
WO2004024735A2 (en) 2004-03-25
SG155770A1 (en) 2009-10-29
BR0314263A (pt) 2005-07-05
US20060106073A1 (en) 2006-05-18
JP2006511469A (ja) 2006-04-06
MY140442A (en) 2009-12-31
MXPA05002785A (es) 2005-06-03
CA2497119C (en) 2011-08-02
AU2008203451A1 (en) 2008-08-21
DE60316456T2 (de) 2008-06-19
PE20050052A1 (es) 2005-03-28
TWI289563B (en) 2007-11-11
CA2497119A1 (en) 2004-03-25
ZA200501008B (en) 2006-12-27
CY1107794T1 (el) 2013-06-19
KR20050042500A (ko) 2005-05-09
ATE373663T1 (de) 2007-10-15
PT1539768E (pt) 2007-12-17
TW200413388A (en) 2004-08-01
PL375039A1 (en) 2005-11-14
ECSP055652A (es) 2005-05-30
WO2004024735A3 (en) 2004-07-22
DE60316456D1 (de) 2007-10-31
GB0221312D0 (en) 2002-10-23
HK1078853A1 (en) 2006-03-24
RU2404985C2 (ru) 2010-11-27
EP1539768A2 (en) 2005-06-15
RU2343155C2 (ru) 2009-01-10
EP1539768B1 (en) 2007-09-19
IL166829A (en) 2011-01-31
US7470792B2 (en) 2008-12-30
NZ538612A (en) 2008-01-31
AR041231A1 (es) 2005-05-11
AU2003267349A1 (en) 2004-04-30
JP4628102B2 (ja) 2011-02-09

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