BR0314263A - Processo para a preparação de derivados de epotilona, derivados de epotilona assim como produtos intermediários para o processo e os métodos de sua preparação - Google Patents
Processo para a preparação de derivados de epotilona, derivados de epotilona assim como produtos intermediários para o processo e os métodos de sua preparaçãoInfo
- Publication number
- BR0314263A BR0314263A BR0314263-9A BR0314263A BR0314263A BR 0314263 A BR0314263 A BR 0314263A BR 0314263 A BR0314263 A BR 0314263A BR 0314263 A BR0314263 A BR 0314263A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- epothilone derivatives
- derivatives
- methods
- intermediates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"PROCESSO PARA A PREPARAçãO DE DERIVADOS DE EPOTILONA, DERIVADOS DE EPOTILONA ASSIM COMO PRODUTOS INTERMEDIáRIOS PARA O PROCESSO E OS MéTODOS DE SUA PREPARAçãO". A presente invenção fornece uma síntese para a preparação de derivados de epotilona de fórmula 9 em que R1 é metila, e R2 possui o significado de uma arila não substituída ou substituída, uma heteroarila não substituída ou substituída ou um radical heterocíclico não substituído ou substituído fundido a um núcleo de benzeno, e sais destes, e intermediários para a síntese de um composto de fórmula 9.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0221312.2A GB0221312D0 (en) | 2002-09-13 | 2002-09-13 | Organic compounds |
PCT/EP2003/010171 WO2004024735A2 (en) | 2002-09-13 | 2003-09-12 | A new process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0314263A true BR0314263A (pt) | 2005-07-05 |
Family
ID=9944042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0314263-9A BR0314263A (pt) | 2002-09-13 | 2003-09-12 | Processo para a preparação de derivados de epotilona, derivados de epotilona assim como produtos intermediários para o processo e os métodos de sua preparação |
Country Status (30)
Country | Link |
---|---|
US (1) | US7470792B2 (pt) |
EP (1) | EP1539768B1 (pt) |
JP (1) | JP4628102B2 (pt) |
KR (1) | KR20050042500A (pt) |
CN (1) | CN100522968C (pt) |
AR (1) | AR041231A1 (pt) |
AT (1) | ATE373663T1 (pt) |
AU (2) | AU2003267349B2 (pt) |
BR (1) | BR0314263A (pt) |
CA (1) | CA2497119C (pt) |
CY (1) | CY1107794T1 (pt) |
DE (1) | DE60316456T2 (pt) |
DK (1) | DK1539768T3 (pt) |
EC (1) | ECSP055652A (pt) |
ES (1) | ES2290489T3 (pt) |
GB (1) | GB0221312D0 (pt) |
HK (1) | HK1078853A1 (pt) |
IL (1) | IL166829A (pt) |
MX (1) | MXPA05002785A (pt) |
MY (1) | MY140442A (pt) |
NO (1) | NO20051794L (pt) |
NZ (1) | NZ538612A (pt) |
PE (1) | PE20050052A1 (pt) |
PL (1) | PL375039A1 (pt) |
PT (1) | PT1539768E (pt) |
RU (2) | RU2343155C2 (pt) |
SG (1) | SG155770A1 (pt) |
TW (1) | TWI289563B (pt) |
WO (1) | WO2004024735A2 (pt) |
ZA (1) | ZA200501008B (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
DK1506203T3 (da) | 2002-08-23 | 2007-05-14 | Sloan Kettering Inst Cancer | Syntese af epothiloner, mellemprodukter deraf, analoger deraf og anvendelser deraf |
MX2012013100A (es) | 2010-05-18 | 2013-01-22 | Cerulean Pharma Inc | Composiciones y metodos para el tratamiento de enfermedades autoinmunes y otras enfermedades. |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6441186B1 (en) * | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
US6498257B1 (en) * | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
GB9810659D0 (en) * | 1998-05-18 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
WO2001007439A2 (en) * | 1999-07-22 | 2001-02-01 | Schering Aktiengesellschaft | Process for the production of epothiolone b and derivatives as well as intermediate products for this process |
US6593115B2 (en) * | 2000-03-24 | 2003-07-15 | Bristol-Myers Squibb Co. | Preparation of epothilone intermediates |
EP1414384A4 (en) | 2000-10-13 | 2005-07-27 | Univ Mississippi | SYNTHESIS OF EPOTHILONES AND RELATED ANALOGS |
AU2003253365A1 (en) * | 2002-07-31 | 2004-02-23 | Schering Ag | New effector conjugates, process for their production and their pharmaceutical use |
-
2002
- 2002-09-13 GB GBGB0221312.2A patent/GB0221312D0/en not_active Ceased
-
2003
- 2003-09-11 PE PE2003000922A patent/PE20050052A1/es not_active Application Discontinuation
- 2003-09-11 AR ARP030103290A patent/AR041231A1/es active IP Right Grant
- 2003-09-12 AU AU2003267349A patent/AU2003267349B2/en not_active Ceased
- 2003-09-12 BR BR0314263-9A patent/BR0314263A/pt not_active IP Right Cessation
- 2003-09-12 PT PT03748015T patent/PT1539768E/pt unknown
- 2003-09-12 CA CA2497119A patent/CA2497119C/en not_active Expired - Fee Related
- 2003-09-12 CN CNB038215837A patent/CN100522968C/zh not_active Expired - Fee Related
- 2003-09-12 ES ES03748015T patent/ES2290489T3/es not_active Expired - Lifetime
- 2003-09-12 WO PCT/EP2003/010171 patent/WO2004024735A2/en active Application Filing
- 2003-09-12 TW TW092125250A patent/TWI289563B/zh not_active IP Right Cessation
- 2003-09-12 MX MXPA05002785A patent/MXPA05002785A/es active IP Right Grant
- 2003-09-12 DK DK03748015T patent/DK1539768T3/da active
- 2003-09-12 RU RU2005110925/04A patent/RU2343155C2/ru not_active IP Right Cessation
- 2003-09-12 SG SG200701814-6A patent/SG155770A1/en unknown
- 2003-09-12 RU RU2008129613/04A patent/RU2404985C2/ru not_active IP Right Cessation
- 2003-09-12 AT AT03748015T patent/ATE373663T1/de active
- 2003-09-12 DE DE60316456T patent/DE60316456T2/de not_active Expired - Lifetime
- 2003-09-12 EP EP03748015A patent/EP1539768B1/en not_active Expired - Lifetime
- 2003-09-12 US US10/526,283 patent/US7470792B2/en not_active Expired - Fee Related
- 2003-09-12 NZ NZ538612A patent/NZ538612A/en not_active IP Right Cessation
- 2003-09-12 PL PL03375039A patent/PL375039A1/xx not_active Application Discontinuation
- 2003-09-12 JP JP2004535499A patent/JP4628102B2/ja not_active Expired - Fee Related
- 2003-09-12 KR KR1020057004237A patent/KR20050042500A/ko not_active Application Discontinuation
- 2003-09-13 MY MYPI20033494A patent/MY140442A/en unknown
-
2005
- 2005-02-03 ZA ZA200501008A patent/ZA200501008B/xx unknown
- 2005-02-10 IL IL166829A patent/IL166829A/en not_active IP Right Cessation
- 2005-03-09 EC EC2005005652A patent/ECSP055652A/es unknown
- 2005-04-12 NO NO20051794A patent/NO20051794L/no not_active Application Discontinuation
- 2005-11-24 HK HK05110670A patent/HK1078853A1/xx not_active IP Right Cessation
-
2007
- 2007-11-08 CY CY20071101447T patent/CY1107794T1/el unknown
-
2008
- 2008-08-01 AU AU2008203451A patent/AU2008203451A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 11A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2271 DE 15/07/2014. |