NO20076660L - Fremgangsmate for fremstilling av rosuvastatin og mellomprodukter - Google Patents
Fremgangsmate for fremstilling av rosuvastatin og mellomprodukterInfo
- Publication number
- NO20076660L NO20076660L NO20076660A NO20076660A NO20076660L NO 20076660 L NO20076660 L NO 20076660L NO 20076660 A NO20076660 A NO 20076660A NO 20076660 A NO20076660 A NO 20076660A NO 20076660 L NO20076660 L NO 20076660L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- rosuvastatin
- intermediates
- useful
- processes
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 2
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 title abstract 2
- 229960000672 rosuvastatin Drugs 0.000 title abstract 2
- 238000005575 aldol reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Det beskrives en fremgangsmåte for fremstilling av en forbindelse med formel (V), anvendelig for fremstilling av rosuvastatin, ved hjelp av en stereoselektiv aldolreaksjon. Nye mellomprodukter og fremgangsmåter for fremstilling av dem er også beskrevet. (V)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0514078.5A GB0514078D0 (en) | 2005-07-08 | 2005-07-08 | Chemical process |
PCT/GB2006/003543 WO2007007119A1 (en) | 2005-07-08 | 2006-07-03 | Processes for the manufacture of rosuvastatin and intermediates |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20076660L true NO20076660L (no) | 2008-01-09 |
Family
ID=34896960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20076660A NO20076660L (no) | 2005-07-08 | 2007-12-28 | Fremgangsmate for fremstilling av rosuvastatin og mellomprodukter |
Country Status (17)
Country | Link |
---|---|
US (1) | US20100228028A1 (no) |
EP (1) | EP1904456A1 (no) |
JP (1) | JP2009500388A (no) |
KR (1) | KR20080024538A (no) |
CN (1) | CN101218210B (no) |
AR (1) | AR054818A1 (no) |
AU (1) | AU2006268024B2 (no) |
BR (1) | BRPI0612851A2 (no) |
CA (1) | CA2614281A1 (no) |
GB (1) | GB0514078D0 (no) |
IL (1) | IL188201A0 (no) |
MX (1) | MX2008000362A (no) |
NO (1) | NO20076660L (no) |
NZ (1) | NZ564609A (no) |
TW (1) | TW200726754A (no) |
WO (1) | WO2007007119A1 (no) |
ZA (1) | ZA200711085B (no) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0011120D0 (en) | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
NL1015744C2 (nl) | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
CA2453505C (en) | 2001-07-13 | 2011-04-19 | Astrazeneca Uk Limited | Preparation of aminopyrimidine compounds |
GB0218781D0 (en) * | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
CA2657076A1 (en) | 2003-08-28 | 2005-03-17 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of rosuvastatin calcium |
GB0324791D0 (en) * | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
CA2546701C (en) | 2003-11-24 | 2010-07-27 | Teva Pharmaceutical Industries Ltd. | Crystalline ammonium salts of rosuvastatin |
WO2005056534A1 (en) | 2003-12-02 | 2005-06-23 | Teva Pharmaceutical Industries Ltd. | Reference standard for characterization of rosuvastatin |
US7851624B2 (en) | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
GB0428328D0 (en) | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
JP4713574B2 (ja) | 2005-02-22 | 2011-06-29 | テバ ファーマシューティカル インダストリーズ リミティド | ロスバスタチンアルキルエーテルを含まないロスバスタチンおよびその塩およびそれらを製造する方法 |
EP1805148A2 (en) | 2005-08-16 | 2007-07-11 | Teva Pharmaceutical Industries Ltd. | Crystalline rosuvastatin intermediate |
WO2008053334A2 (en) | 2006-10-31 | 2008-05-08 | Aurobindo Pharma Limited | An improved process for preparing rosuvastatin calcium |
TW200831469A (en) * | 2006-12-01 | 2008-08-01 | Astrazeneca Uk Ltd | Chemical process |
WO2008072078A1 (en) | 2006-12-13 | 2008-06-19 | Aurobindo Pharma Limited | An improved process for preparing rosuvastatin caclium |
WO2008096257A1 (en) | 2007-02-08 | 2008-08-14 | Aurobindo Pharma Limited | An improved process for preparation of rosuvastatin calcium |
EP1978020A1 (en) * | 2007-04-03 | 2008-10-08 | LEK Pharmaceuticals D.D. | Processes for the preparation of statins, particularly rosuvastatin, and intermediates for the preparation thereof |
US8183397B2 (en) | 2007-04-03 | 2012-05-22 | Lek Pharmaceuticals D.D. | Synthesis of statins |
CN101323597B (zh) * | 2007-06-11 | 2012-09-05 | 安徽省庆云医药化工有限公司 | 4-(4-氟苯基)-6-异丙基-2-(n-甲基-n-甲磺酰氨基)嘧啶-5-甲醛的制备方法 |
EA201000180A1 (ru) * | 2007-08-20 | 2010-10-29 | Рациофарм Гмбх | Способ получения производных пиримидина |
EP2350025A1 (en) * | 2008-09-30 | 2011-08-03 | Aurobindo Pharma Limited | An improved process for preparing pyrimidine propenaldehyde |
KR101157314B1 (ko) * | 2009-06-05 | 2012-06-15 | 주식회사종근당 | 로수바스타틴의 신규한 제조방법, 이 제조에 유용한 중간체 화합물 및 그의 제조방법 |
EP2467363A1 (en) * | 2009-08-17 | 2012-06-27 | Aurobindo Pharma Limited | Process for the manufacture of rosuvastatin calcium using crystalline rosuvastatin ethyl ester |
US8256574B2 (en) | 2010-06-23 | 2012-09-04 | 3M Innovative Properties Company | Centrifugally-operated apparatus |
US8430206B2 (en) | 2010-06-23 | 2013-04-30 | 3M Innovative Properties Company | Safety devices comprising a load-bearing composite polymeric housing and a load-bearing anchorage plate |
US8430207B2 (en) | 2010-06-23 | 2013-04-30 | 3M Innovative Properties Company | Preassembled and pretorqued friction brake and method of making a safety device containing such a friction brake |
EP2423195A1 (en) | 2010-07-26 | 2012-02-29 | LEK Pharmaceuticals d.d. | Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof |
JP2016188175A (ja) * | 2013-08-30 | 2016-11-04 | 日産化学工業株式会社 | 光学活性5−ヒドロキシ−3−ケトエステル化合物の製造方法 |
CN105473542B (zh) * | 2013-08-30 | 2018-12-04 | 日产化学工业株式会社 | 光学活性5-羟基-3-酮酯类的制造方法 |
WO2015074328A1 (zh) * | 2013-11-25 | 2015-05-28 | 复旦大学 | 一种瑞舒伐他汀钠的制备方法 |
JP6649263B2 (ja) * | 2014-10-10 | 2020-02-19 | 株式会社エーピーアイ コーポレーション | スタチン系化合物の精製方法 |
KR20160126700A (ko) | 2015-04-24 | 2016-11-02 | 미래파인켐 주식회사 | 스타틴의 중간체, 이의 제조방법 및 이를 이용한 로수바스타틴의 제조방법 |
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US4645858A (en) * | 1982-03-22 | 1987-02-24 | G. D. Searle & Co. | Pentanedioic acid derivatives |
DE3741509A1 (de) * | 1987-12-08 | 1989-06-22 | Hoechst Ag | Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte |
JP2648897B2 (ja) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
US5278313A (en) * | 1992-03-27 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors |
ATE158579T1 (de) * | 1992-07-02 | 1997-10-15 | Hoechst Ag | Verfahren zur herstellung von (3r,5s)6-hydroxy- 3,5-0-isopropyliden-3,5-dihydroxy-hexansäure- tert.-butylester |
US6278001B1 (en) * | 1995-11-28 | 2001-08-21 | L'oréal | Method for preparing (+) compactin and (+) mevinolin analog compounds having a β-hydroxy-δ-lactone grouping |
ES2234323T3 (es) * | 1998-12-10 | 2005-06-16 | Kaneka Corporation | Procedimiento para producir un precursor de simvastatina. |
GB9903472D0 (en) * | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Chemical process |
GB0011120D0 (en) * | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
NL1015744C2 (nl) * | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
MXPA03011195A (es) * | 2001-06-06 | 2004-03-18 | Bristol Myers Squibb Co | Proceso para preparacion de sulfonas de diol quirales e inhibidores de coa-reductasa del dihidroxiacido hmg. |
SE0102299D0 (sv) * | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
CA2453505C (en) * | 2001-07-13 | 2011-04-19 | Astrazeneca Uk Limited | Preparation of aminopyrimidine compounds |
JP4433156B2 (ja) * | 2001-11-14 | 2010-03-17 | 日産化学工業株式会社 | 光学活性オキソヘプテン酸エステルの製造方法 |
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US6835838B2 (en) * | 2002-01-28 | 2004-12-28 | Novartis Ag | Process for the manufacture of organic compounds |
EP1375493A1 (en) * | 2002-06-17 | 2004-01-02 | Dsm N.V. | Process for the preparation of an dioxane acetic acid ester |
GB0218781D0 (en) * | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
CA2509344C (en) * | 2002-12-16 | 2011-10-04 | Astrazeneca Uk Limited | Process for the preparation of pyrimidine compounds |
GB0312896D0 (en) * | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
UY28501A1 (es) * | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
GB0321827D0 (en) * | 2003-09-18 | 2003-10-15 | Astrazeneca Uk Ltd | Chemical compounds |
GB0324791D0 (en) * | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
DE10352659B4 (de) * | 2003-11-11 | 2007-09-13 | Ratiopharm Gmbh | Verfahren zur Herstellung von Statinen und Tetrahydropyranonderivate zur Verwendung in dem Verfahren |
WO2005054207A1 (en) * | 2003-12-04 | 2005-06-16 | Glenmark Pharmaceuticals Limited | Process for the preparation of pyrimidine derivatives |
US7161004B2 (en) * | 2004-06-21 | 2007-01-09 | Dr. Reddy's Laboratories Limited | Processes to produce intermediates for rosuvastatin |
CN1763015B (zh) * | 2004-10-22 | 2011-06-22 | 四川抗菌素工业研究所有限公司 | 一种罗舒伐他汀及其药用盐的制备方法及中间体 |
GB0428328D0 (en) * | 2004-12-24 | 2005-02-02 | Astrazeneca Uk Ltd | Chemical process |
CN100351240C (zh) * | 2005-01-19 | 2007-11-28 | 安徽省庆云医药化工有限公司 | 瑞舒伐他汀钙的合成方法 |
EP1863773A1 (en) * | 2005-03-22 | 2007-12-12 | Unichem Laboratories Limited | Process for preparation of rosuvastatin |
TW200831469A (en) * | 2006-12-01 | 2008-08-01 | Astrazeneca Uk Ltd | Chemical process |
-
2005
- 2005-07-08 GB GBGB0514078.5A patent/GB0514078D0/en not_active Ceased
-
2006
- 2006-07-03 NZ NZ564609A patent/NZ564609A/en not_active IP Right Cessation
- 2006-07-03 CN CN2006800247173A patent/CN101218210B/zh not_active Expired - Fee Related
- 2006-07-03 KR KR1020087001929A patent/KR20080024538A/ko not_active Application Discontinuation
- 2006-07-03 EP EP06779538A patent/EP1904456A1/en not_active Withdrawn
- 2006-07-03 WO PCT/GB2006/003543 patent/WO2007007119A1/en active Application Filing
- 2006-07-03 US US11/994,925 patent/US20100228028A1/en not_active Abandoned
- 2006-07-03 MX MX2008000362A patent/MX2008000362A/es not_active Application Discontinuation
- 2006-07-03 JP JP2008520005A patent/JP2009500388A/ja not_active Withdrawn
- 2006-07-03 AU AU2006268024A patent/AU2006268024B2/en not_active Ceased
- 2006-07-03 BR BRPI0612851-3A patent/BRPI0612851A2/pt not_active IP Right Cessation
- 2006-07-03 CA CA002614281A patent/CA2614281A1/en not_active Abandoned
- 2006-07-05 AR ARP060102897A patent/AR054818A1/es not_active Application Discontinuation
- 2006-07-07 TW TW095124757A patent/TW200726754A/zh unknown
-
2007
- 2007-12-17 IL IL188201A patent/IL188201A0/en unknown
- 2007-12-19 ZA ZA200711085A patent/ZA200711085B/xx unknown
- 2007-12-28 NO NO20076660A patent/NO20076660L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2006268024B2 (en) | 2010-07-01 |
US20100228028A1 (en) | 2010-09-09 |
AR054818A1 (es) | 2007-07-18 |
TW200726754A (en) | 2007-07-16 |
GB0514078D0 (en) | 2005-08-17 |
NZ564609A (en) | 2010-07-30 |
CA2614281A1 (en) | 2007-01-18 |
KR20080024538A (ko) | 2008-03-18 |
WO2007007119A1 (en) | 2007-01-18 |
IL188201A0 (en) | 2008-03-20 |
EP1904456A1 (en) | 2008-04-02 |
MX2008000362A (es) | 2008-03-07 |
BRPI0612851A2 (pt) | 2011-03-01 |
ZA200711085B (en) | 2009-09-30 |
CN101218210A (zh) | 2008-07-09 |
CN101218210B (zh) | 2011-08-03 |
AU2006268024A1 (en) | 2007-01-18 |
JP2009500388A (ja) | 2009-01-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |