NO20082005L - Syntese av renininhibitorer omfattende en cyklotilfoyelsesreaksjon - Google Patents

Syntese av renininhibitorer omfattende en cyklotilfoyelsesreaksjon

Info

Publication number
NO20082005L
NO20082005L NO20082005A NO20082005A NO20082005L NO 20082005 L NO20082005 L NO 20082005L NO 20082005 A NO20082005 A NO 20082005A NO 20082005 A NO20082005 A NO 20082005A NO 20082005 L NO20082005 L NO 20082005L
Authority
NO
Norway
Prior art keywords
synthesis
renin inhibitors
cyclot
addition reaction
compound
Prior art date
Application number
NO20082005A
Other languages
English (en)
Inventor
Wolfgang Marterer
Stuart John Mickel
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35394904&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20082005(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20082005L publication Critical patent/NO20082005L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)

Abstract

Foreliggende oppfinnelsen angår en ny fremgangsmåte, nye fremgangsmatetrinn og nye intermediater anvendelige ved syntese av farmasøytisk aktive forbindelser, særlig renin inhibitorer, slik som Aliskiren. Blant annet angår oppfinnelsen en fremgangsmåte for fremstilling av en forbindelse med formel III, hvori R, Ri og R' er som i beskrivelsen eller et salt derav, og en forbindelse med formel IV, hvori R, Ri, R2 og R' er som definert i beskrivelsen og fremgangsmåter for fremstilling av disse
NO20082005A 2005-09-28 2008-04-28 Syntese av renininhibitorer omfattende en cyklotilfoyelsesreaksjon NO20082005L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0519764.5A GB0519764D0 (en) 2005-09-28 2005-09-28 Organic compounds
PCT/EP2006/009323 WO2007039183A1 (en) 2005-09-28 2006-09-26 Sythesis of renin inhibitors involving a cycloaddition reaction

Publications (1)

Publication Number Publication Date
NO20082005L true NO20082005L (no) 2008-06-24

Family

ID=35394904

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082005A NO20082005L (no) 2005-09-28 2008-04-28 Syntese av renininhibitorer omfattende en cyklotilfoyelsesreaksjon

Country Status (27)

Country Link
US (2) US7973175B2 (no)
EP (2) EP2287153A1 (no)
JP (1) JP2009509990A (no)
KR (1) KR20080048042A (no)
CN (1) CN101273012A (no)
AR (1) AR057137A1 (no)
AT (1) ATE492533T1 (no)
AU (1) AU2006299097B2 (no)
BR (1) BRPI0616707A2 (no)
CA (1) CA2623495A1 (no)
DE (1) DE602006019114D1 (no)
EC (1) ECSP088319A (no)
ES (1) ES2358536T3 (no)
GB (1) GB0519764D0 (no)
GT (1) GT200600427A (no)
IL (1) IL189763A0 (no)
MA (1) MA29852B1 (no)
MY (1) MY143251A (no)
NO (1) NO20082005L (no)
NZ (1) NZ566429A (no)
PE (1) PE20070488A1 (no)
PL (1) PL1931629T3 (no)
PT (1) PT1931629E (no)
RU (1) RU2423348C2 (no)
TN (1) TNSN08142A1 (no)
TW (1) TW200730480A (no)
WO (1) WO2007039183A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2062874B1 (en) 2007-11-20 2014-12-17 KRKA, tovarna zdravil, d.d., Novo mesto Process and intermediates for the preparation of aliskiren
SI2189442T1 (sl) 2008-11-20 2015-03-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek in intermediati za pripravo aliskirena
WO2011051853A1 (en) 2009-10-29 2011-05-05 CarboDesign LLC Manufacturing process for preparing enaniomerically pure 8- aryloctanoic acid derivatives such as aliskiren
CN101774986B (zh) * 2010-01-06 2012-03-28 浙江天宇药业股份有限公司 一种制备阿利克伦及其中间体的方法
CN101863796B (zh) * 2010-05-12 2011-08-24 海南美兰史克制药有限公司 一种阿利克仑化合物及其制法
EP2551260A1 (en) 2011-07-28 2013-01-30 Chemo Ibérica, S.A. Chemical process for opening ring compounds
US8703976B2 (en) 2011-10-02 2014-04-22 Milan Soukup Manufacturing process for 8-aryloctanoic acids such as Aliskiren

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3421295A1 (de) 1984-06-08 1985-12-12 Basf Ag, 6700 Ludwigshafen Neue pyrrolidincarbonsaeurederivative, verfahren zu ihrer herstellung
MY119161A (en) 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
PL212898B1 (pl) 2000-07-05 2012-12-31 Speedel Pharma Ag Sposób otrzymywania podstawionych amidów oktanoilowych oraz zwiazki posrednie wykorzystane w tym sposobie
DE10116816A1 (de) * 2001-04-04 2002-10-17 Basf Ag Verfahren zur Herstellung von N-Benzylaminen
GB0419361D0 (en) 2004-08-31 2004-10-06 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
ES2358536T3 (es) 2011-05-11
RU2423348C2 (ru) 2011-07-10
US20080255369A1 (en) 2008-10-16
BRPI0616707A2 (pt) 2011-06-28
EP1931629B1 (en) 2010-12-22
ATE492533T1 (de) 2011-01-15
PE20070488A1 (es) 2007-06-13
MY143251A (en) 2011-04-15
GB0519764D0 (en) 2005-11-09
US7973175B2 (en) 2011-07-05
AU2006299097A1 (en) 2007-04-12
JP2009509990A (ja) 2009-03-12
KR20080048042A (ko) 2008-05-30
TW200730480A (en) 2007-08-16
EP1931629A1 (en) 2008-06-18
AR057137A1 (es) 2007-11-21
TNSN08142A1 (en) 2009-07-14
AU2006299097B2 (en) 2010-11-04
MA29852B1 (fr) 2008-10-03
IL189763A0 (en) 2008-08-07
EP2287153A1 (en) 2011-02-23
DE602006019114D1 (de) 2011-02-03
PT1931629E (pt) 2011-03-09
CN101273012A (zh) 2008-09-24
PL1931629T3 (pl) 2011-05-31
GT200600427A (es) 2007-04-30
RU2008116317A (ru) 2009-11-10
CA2623495A1 (en) 2007-04-12
WO2007039183A1 (en) 2007-04-12
NZ566429A (en) 2010-10-29
ECSP088319A (es) 2008-04-28
US20110230665A1 (en) 2011-09-22

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Legal Events

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