ECSP088319A - Síntesis de inhibidores de renina que involucra una reacción de cicloadición - Google Patents
Síntesis de inhibidores de renina que involucra una reacción de cicloadiciónInfo
- Publication number
- ECSP088319A ECSP088319A EC2008008319A ECSP088319A ECSP088319A EC SP088319 A ECSP088319 A EC SP088319A EC 2008008319 A EC2008008319 A EC 2008008319A EC SP088319 A ECSP088319 A EC SP088319A EC SP088319 A ECSP088319 A EC SP088319A
- Authority
- EC
- Ecuador
- Prior art keywords
- synthesis
- cycloadition
- renina
- reaction
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
Abstract
La invención se refiere a un proceso novedoso, a pasos de proceso novedosos, y a intermediarios novedosos útiles en la síntesis de compuestos farmacéuticamente activos, en especial inhibidores de renina, tales como alisquireno. Entre otras cosas, la invención se refiere a un proceso para la fabricación de un compuesto de la Fórmula III, en donde R, R1, y R' son como se definen en la memoria descriptiva, o una sal del mismo, y un compuesto de la Fórmula IV, en donde R, R1, R2, y R' son como se definen en la memoria descriptiva, y a procesos para la fabricación de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0519764.5A GB0519764D0 (en) | 2005-09-28 | 2005-09-28 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP088319A true ECSP088319A (es) | 2008-04-28 |
Family
ID=35394904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2008008319A ECSP088319A (es) | 2005-09-28 | 2008-03-27 | Síntesis de inhibidores de renina que involucra una reacción de cicloadición |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7973175B2 (es) |
| EP (2) | EP2287153A1 (es) |
| JP (1) | JP2009509990A (es) |
| KR (1) | KR20080048042A (es) |
| CN (1) | CN101273012A (es) |
| AR (1) | AR057137A1 (es) |
| AT (1) | ATE492533T1 (es) |
| AU (1) | AU2006299097B2 (es) |
| BR (1) | BRPI0616707A2 (es) |
| CA (1) | CA2623495A1 (es) |
| DE (1) | DE602006019114D1 (es) |
| EC (1) | ECSP088319A (es) |
| ES (1) | ES2358536T3 (es) |
| GB (1) | GB0519764D0 (es) |
| GT (1) | GT200600427A (es) |
| IL (1) | IL189763A0 (es) |
| MA (1) | MA29852B1 (es) |
| MY (1) | MY143251A (es) |
| NO (1) | NO20082005L (es) |
| NZ (1) | NZ566429A (es) |
| PE (1) | PE20070488A1 (es) |
| PL (1) | PL1931629T3 (es) |
| PT (1) | PT1931629E (es) |
| RU (1) | RU2423348C2 (es) |
| TN (1) | TNSN08142A1 (es) |
| TW (1) | TW200730480A (es) |
| WO (1) | WO2007039183A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2062874B1 (en) | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Process and intermediates for the preparation of aliskiren |
| SI2189442T1 (sl) | 2008-11-20 | 2015-03-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek in intermediati za pripravo aliskirena |
| WO2011051853A1 (en) | 2009-10-29 | 2011-05-05 | CarboDesign LLC | Manufacturing process for preparing enaniomerically pure 8- aryloctanoic acid derivatives such as aliskiren |
| CN101863796B (zh) * | 2010-05-12 | 2011-08-24 | 海南美兰史克制药有限公司 | 一种阿利克仑化合物及其制法 |
| EP2551260A1 (en) | 2011-07-28 | 2013-01-30 | Chemo Ibérica, S.A. | Chemical process for opening ring compounds |
| US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3421295A1 (de) | 1984-06-08 | 1985-12-12 | Basf Ag, 6700 Ludwigshafen | Neue pyrrolidincarbonsaeurederivative, verfahren zu ihrer herstellung |
| MY119161A (en) | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| DE60138099D1 (de) | 2000-07-05 | 2009-05-07 | Speedel Pharma Ag | Verfahren zur herstellung von substituierten octanoyl-amiden |
| DE10116816A1 (de) * | 2001-04-04 | 2002-10-17 | Basf Ag | Verfahren zur Herstellung von N-Benzylaminen |
| GB0419361D0 (en) | 2004-08-31 | 2004-10-06 | Novartis Ag | Organic compounds |
-
2005
- 2005-09-28 GB GBGB0519764.5A patent/GB0519764D0/en not_active Ceased
-
2006
- 2006-09-25 GT GT200600427A patent/GT200600427A/es unknown
- 2006-09-26 RU RU2008116317/04A patent/RU2423348C2/ru not_active IP Right Cessation
- 2006-09-26 EP EP10178025A patent/EP2287153A1/en not_active Withdrawn
- 2006-09-26 US US12/067,055 patent/US7973175B2/en not_active Expired - Fee Related
- 2006-09-26 ES ES06805861T patent/ES2358536T3/es active Active
- 2006-09-26 AT AT06805861T patent/ATE492533T1/de active
- 2006-09-26 CA CA002623495A patent/CA2623495A1/en not_active Abandoned
- 2006-09-26 KR KR1020087007396A patent/KR20080048042A/ko not_active Application Discontinuation
- 2006-09-26 AR ARP060104197A patent/AR057137A1/es not_active Application Discontinuation
- 2006-09-26 NZ NZ566429A patent/NZ566429A/en not_active IP Right Cessation
- 2006-09-26 MY MYPI20080623A patent/MY143251A/en unknown
- 2006-09-26 CN CNA2006800353469A patent/CN101273012A/zh active Pending
- 2006-09-26 PL PL06805861T patent/PL1931629T3/pl unknown
- 2006-09-26 PE PE2006001166A patent/PE20070488A1/es not_active Application Discontinuation
- 2006-09-26 AU AU2006299097A patent/AU2006299097B2/en not_active Ceased
- 2006-09-26 EP EP06805861A patent/EP1931629B1/en not_active Not-in-force
- 2006-09-26 WO PCT/EP2006/009323 patent/WO2007039183A1/en active Application Filing
- 2006-09-26 PT PT06805861T patent/PT1931629E/pt unknown
- 2006-09-26 DE DE602006019114T patent/DE602006019114D1/de active Active
- 2006-09-26 JP JP2008532650A patent/JP2009509990A/ja active Pending
- 2006-09-26 BR BRPI0616707-1A patent/BRPI0616707A2/pt not_active IP Right Cessation
- 2006-09-27 TW TW095135800A patent/TW200730480A/zh unknown
-
2008
- 2008-02-25 IL IL189763A patent/IL189763A0/en unknown
- 2008-03-27 EC EC2008008319A patent/ECSP088319A/es unknown
- 2008-03-27 TN TNP2008000142A patent/TNSN08142A1/en unknown
- 2008-04-04 MA MA30815A patent/MA29852B1/fr unknown
- 2008-04-28 NO NO20082005A patent/NO20082005L/no not_active Application Discontinuation
-
2011
- 2011-05-26 US US13/116,349 patent/US20110230665A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1931629A1 (en) | 2008-06-18 |
| GB0519764D0 (en) | 2005-11-09 |
| TW200730480A (en) | 2007-08-16 |
| ATE492533T1 (de) | 2011-01-15 |
| PL1931629T3 (pl) | 2011-05-31 |
| RU2008116317A (ru) | 2009-11-10 |
| RU2423348C2 (ru) | 2011-07-10 |
| CA2623495A1 (en) | 2007-04-12 |
| JP2009509990A (ja) | 2009-03-12 |
| NO20082005L (no) | 2008-06-24 |
| AU2006299097B2 (en) | 2010-11-04 |
| AU2006299097A1 (en) | 2007-04-12 |
| EP2287153A1 (en) | 2011-02-23 |
| PT1931629E (pt) | 2011-03-09 |
| MA29852B1 (fr) | 2008-10-03 |
| DE602006019114D1 (de) | 2011-02-03 |
| US7973175B2 (en) | 2011-07-05 |
| CN101273012A (zh) | 2008-09-24 |
| EP1931629B1 (en) | 2010-12-22 |
| US20110230665A1 (en) | 2011-09-22 |
| MY143251A (en) | 2011-04-15 |
| PE20070488A1 (es) | 2007-06-13 |
| BRPI0616707A2 (pt) | 2011-06-28 |
| IL189763A0 (en) | 2008-08-07 |
| WO2007039183A1 (en) | 2007-04-12 |
| NZ566429A (en) | 2010-10-29 |
| AR057137A1 (es) | 2007-11-21 |
| GT200600427A (es) | 2007-04-30 |
| US20080255369A1 (en) | 2008-10-16 |
| ES2358536T3 (es) | 2011-05-11 |
| TNSN08142A1 (en) | 2009-07-14 |
| KR20080048042A (ko) | 2008-05-30 |
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