AR054818A1 - Proceso para preparar rosuvastatina e intermediarios - Google Patents

Proceso para preparar rosuvastatina e intermediarios

Info

Publication number
AR054818A1
AR054818A1 ARP060102897A ARP060102897A AR054818A1 AR 054818 A1 AR054818 A1 AR 054818A1 AR P060102897 A ARP060102897 A AR P060102897A AR P060102897 A ARP060102897 A AR P060102897A AR 054818 A1 AR054818 A1 AR 054818A1
Authority
AR
Argentina
Prior art keywords
formula
alkyl
compound
intermediaries
independently selected
Prior art date
Application number
ARP060102897A
Other languages
English (en)
Original Assignee
Astrazeneca Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd
Publication of AR054818A1 publication Critical patent/AR054818A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Abstract

También se describen compuestos intermedios y procesos para su preparacion. Reivindicacion 1: Un proceso para la manufactura de un compuesto de formula (5) que comprende a) reaccion de un compuesto de formula (2), donde cada R1 se selecciona independientemente de alquilo C1-6, y R se selecciona de alquilo C1-6, cicloalquilo C3-6 o arilalquilo C1-6; con un compuesto de formula (3) en presencia de un catalizador de titanio (IV) de formula (4) (donde cada R2 se selecciona independientemente entre alquilo C1-6 y la porcion binaftilo está en la configuracion S), una sal haluro de metal alcalino y una amina, en un disolvente inerte.
ARP060102897A 2005-07-08 2006-07-05 Proceso para preparar rosuvastatina e intermediarios AR054818A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0514078.5A GB0514078D0 (en) 2005-07-08 2005-07-08 Chemical process

Publications (1)

Publication Number Publication Date
AR054818A1 true AR054818A1 (es) 2007-07-18

Family

ID=34896960

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102897A AR054818A1 (es) 2005-07-08 2006-07-05 Proceso para preparar rosuvastatina e intermediarios

Country Status (17)

Country Link
US (1) US20100228028A1 (es)
EP (1) EP1904456A1 (es)
JP (1) JP2009500388A (es)
KR (1) KR20080024538A (es)
CN (1) CN101218210B (es)
AR (1) AR054818A1 (es)
AU (1) AU2006268024B2 (es)
BR (1) BRPI0612851A2 (es)
CA (1) CA2614281A1 (es)
GB (1) GB0514078D0 (es)
IL (1) IL188201A0 (es)
MX (1) MX2008000362A (es)
NO (1) NO20076660L (es)
NZ (1) NZ564609A (es)
TW (1) TW200726754A (es)
WO (1) WO2007007119A1 (es)
ZA (1) ZA200711085B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) * 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
DK1417180T3 (da) 2001-07-13 2007-04-10 Astrazeneca Uk Ltd Fremstilling af aminopyrimidinforbindelser
GB0218781D0 (en) * 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
GB0312896D0 (en) * 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
CA2657076A1 (en) 2003-08-28 2005-03-17 Teva Pharmaceutical Industries Ltd. Process for the preparation of rosuvastatin calcium
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
CA2546701C (en) 2003-11-24 2010-07-27 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
ATE507209T1 (de) 2003-12-02 2011-05-15 Teva Pharma Referenzstandard zur charakterisierung von rosuvastatin
US7851624B2 (en) 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
TWI353981B (en) 2005-02-22 2011-12-11 Teva Pharma Preparation of rosuvastatin
US7868169B2 (en) 2005-08-16 2011-01-11 Teva Pharmaceutical Industries, Ltd. Crystalline rosuvastatin intermediate
WO2008053334A2 (en) 2006-10-31 2008-05-08 Aurobindo Pharma Limited An improved process for preparing rosuvastatin calcium
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process
US8212034B2 (en) 2006-12-13 2012-07-03 Aurobindo Pharma Ltd. Process for preparing rosuvastatin calcium
EP2125754B1 (en) 2007-02-08 2012-04-11 Aurobindo Pharma Limited Process for preparation of rosuvastatin calcium
EP1978020A1 (en) * 2007-04-03 2008-10-08 LEK Pharmaceuticals D.D. Processes for the preparation of statins, particularly rosuvastatin, and intermediates for the preparation thereof
WO2008119810A2 (en) 2007-04-03 2008-10-09 Lek Pharmaceuticals D.D. Processes for the preparation of statins, particularly rosuvastatin, and intermediates for the preparation thereof
CN101323597B (zh) * 2007-06-11 2012-09-05 安徽省庆云医药化工有限公司 4-(4-氟苯基)-6-异丙基-2-(n-甲基-n-甲磺酰氨基)嘧啶-5-甲醛的制备方法
US20110295005A1 (en) * 2007-08-20 2011-12-01 Ratiopharm Gmbh Process for preparing pyrimidine derivatives
WO2010038124A1 (en) * 2008-09-30 2010-04-08 Aurobindo Pharma Limited An improved process for preparing pyrimidine propenaldehyde
KR101157314B1 (ko) * 2009-06-05 2012-06-15 주식회사종근당 로수바스타틴의 신규한 제조방법, 이 제조에 유용한 중간체 화합물 및 그의 제조방법
US8846915B2 (en) 2009-08-17 2014-09-30 Aurobindo Pharma Ltd. Process for the manufacture of rosuvastatin calcium using crystalline rosuvastatin ethyl ester
US8430207B2 (en) 2010-06-23 2013-04-30 3M Innovative Properties Company Preassembled and pretorqued friction brake and method of making a safety device containing such a friction brake
US8256574B2 (en) 2010-06-23 2012-09-04 3M Innovative Properties Company Centrifugally-operated apparatus
US8430206B2 (en) 2010-06-23 2013-04-30 3M Innovative Properties Company Safety devices comprising a load-bearing composite polymeric housing and a load-bearing anchorage plate
EP2423195A1 (en) 2010-07-26 2012-02-29 LEK Pharmaceuticals d.d. Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
JP2016188175A (ja) * 2013-08-30 2016-11-04 日産化学工業株式会社 光学活性５−ヒドロキシ−３−ケトエステル化合物の製造方法
CN105473542B (zh) * 2013-08-30 2018-12-04 日产化学工业株式会社 光学活性5-羟基-3-酮酯类的制造方法
US9850213B2 (en) * 2013-11-25 2017-12-26 Jiangxi Boya Seehot Pharmaceutical Co., Ltd. Method for preparing rosuvastatin sodium
WO2016056658A1 (ja) * 2014-10-10 2016-04-14 株式会社エーピーアイ コーポレーション スタチン系化合物の精製方法
KR20160126700A (ko) 2015-04-24 2016-11-02 미래파인켐 주식회사 스타틴의 중간체, 이의 제조방법 및 이를 이용한 로수바스타틴의 제조방법

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4645858A (en) * 1982-03-22 1987-02-24 G. D. Searle & Co. Pentanedioic acid derivatives
DE3741509A1 (de) * 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
EP0577040B1 (de) * 1992-07-02 1997-09-24 Hoechst Aktiengesellschaft Verfahren zur Herstellung von (3R,5S)6-Hydroxy-3,5-0-isopropyliden-3,5-dihydroxy-hexansäure-tert.-butylester
US6278001B1 (en) * 1995-11-28 2001-08-21 L'oréal Method for preparing (+) compactin and (+) mevinolin analog compounds having a β-hydroxy-δ-lactone grouping
EP1055671B1 (en) * 1998-12-10 2004-12-01 Kaneka Corporation A process for producing a simvastatin precursor
GB9903472D0 (en) * 1999-02-17 1999-04-07 Zeneca Ltd Chemical process
GB0011120D0 (en) * 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) * 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
ES2214169T1 (es) * 2001-06-06 2004-09-16 Bristol-Myers Squibb Company Procedimiento de preparacion de sulfonas quirales dioles e inhibidores del dihidroxiacido hmg coa reductasa.
SE0102299D0 (sv) * 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
DK1417180T3 (da) * 2001-07-13 2007-04-10 Astrazeneca Uk Ltd Fremstilling af aminopyrimidinforbindelser
US7064209B2 (en) * 2001-11-14 2006-06-20 Nissan Chemical Industries, Ltd. Process for producing optically active oxoheptenoic acid ester
EP1323717A1 (en) * 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
US6835838B2 (en) * 2002-01-28 2004-12-28 Novartis Ag Process for the manufacture of organic compounds
EP1375493A1 (en) * 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
GB0218781D0 (en) * 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
CA2509344C (en) * 2002-12-16 2011-10-04 Astrazeneca Uk Limited Process for the preparation of pyrimidine compounds
GB0312896D0 (en) * 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) * 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) * 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
DE10352659B4 (de) * 2003-11-11 2007-09-13 Ratiopharm Gmbh Verfahren zur Herstellung von Statinen und Tetrahydropyranonderivate zur Verwendung in dem Verfahren
WO2005054207A1 (en) * 2003-12-04 2005-06-16 Glenmark Pharmaceuticals Limited Process for the preparation of pyrimidine derivatives
US7161004B2 (en) * 2004-06-21 2007-01-09 Dr. Reddy's Laboratories Limited Processes to produce intermediates for rosuvastatin
CN1763015B (zh) * 2004-10-22 2011-06-22 四川抗菌素工业研究所有限公司 一种罗舒伐他汀及其药用盐的制备方法及中间体
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
CN100351240C (zh) * 2005-01-19 2007-11-28 安徽省庆云医药化工有限公司 瑞舒伐他汀钙的合成方法
EP1863773A1 (en) * 2005-03-22 2007-12-12 Unichem Laboratories Limited Process for preparation of rosuvastatin
TW200831469A (en) * 2006-12-01 2008-08-01 Astrazeneca Uk Ltd Chemical process

Also Published As

Publication number Publication date
NO20076660L (no) 2008-01-09
TW200726754A (en) 2007-07-16
AU2006268024B2 (en) 2010-07-01
WO2007007119A1 (en) 2007-01-18
US20100228028A1 (en) 2010-09-09
MX2008000362A (es) 2008-03-07
KR20080024538A (ko) 2008-03-18
EP1904456A1 (en) 2008-04-02
CN101218210B (zh) 2011-08-03
CA2614281A1 (en) 2007-01-18
CN101218210A (zh) 2008-07-09
ZA200711085B (en) 2009-09-30
AU2006268024A1 (en) 2007-01-18
NZ564609A (en) 2010-07-30
GB0514078D0 (en) 2005-08-17
IL188201A0 (en) 2008-03-20
JP2009500388A (ja) 2009-01-08
BRPI0612851A2 (pt) 2011-03-01

Similar Documents

Publication Publication Date Title
AR054818A1 (es) Proceso para preparar rosuvastatina e intermediarios
PE20040164A1 (es) Mimeticos de glucocorticoides, procedimientos para su preparacion y composiciones farmaceuticas
AR068359A1 (es) Derivados de quinoleina sustituida, procesos para su preparacion e intermediarios de sintesis, una composicion fungicida que los comprende y un metodo para combatir o controlar hongos fitopatogenicos.
CY1116082T1 (el) Μεθοδος παρασκευης ενωσεων βενζαζεπινης ή αλατων τους
MX2008000255A (es) Activadores de urea glucocinasa.
BRPI0612957B8 (pt) composto, processos de preparação de compostos, composição farmacêutica e uso de um composto
UA106191C2 (ru) Способ получения транс-1-((1r,3s)-6-хлор-3-фенилиндан-1-ил)-3,3-диметилпиперазина
AR046322A1 (es) Compuestos de amidoacetonitrilo, metodos para su preparacion y de sus intermediarios y su uso en composiciones antiparasitarias.
ATE441630T1 (de) Substituierte cyclopenten-verbindungen
ATE441627T1 (de) Verfahren zur herstellung von valsartan
EP1870403A8 (en) Optically active quaternary ammonium salt having axial asymmetry and process for producing alpha-amino acid and derivative thereof with the same
EA200600605A1 (ru) Перегруппированные пентанолы, способ их получения и их применение в качестве противовоспалительных средств
TW200631939A (en) Process for cross coupling indoles
PE20060018A1 (es) Proceso para la preparacion de haluros de aril y hetoaril-alquilsulfonilo
BR0315112A (pt) Sal de adição ácido, e, processo para a preparação de um composto
EA200701163A1 (ru) Способ получения анилинов
HK1099759A1 (en) A process for the resolution of nefopam
IL189527A0 (en) Chemical process
TW200635883A (en) Chemical compounds
BRPI0606861A2 (pt) processo para a produção de anilinas
AR053439A1 (es) Proceso para la preparacion de nitrobenzoles
TW200510401A (en) Process for the preparation of insulin sensitizer
WO2004050604A3 (en) Process for preparing terbinafine by using platinum as catalyst
TH61601A (th) 3-อัลคิเลตเทด-5,5',6,6',7,7',8,8'-ออคตะไฮโดร-2,2'-ไบแนฟธอล และ3,3'-ไดอัลคิเลตเทด-5,5',6,6',7,7'8,8'-ออคตะไฮโดร-2,2'-ไบแนฟธอล และกระบวนการสำหรับการผลิตพวกมัน
EP1857435A3 (en) A process for the preparation of aryloxypropylamines

Legal Events

Date Code Title Description
FA Abandonment or withdrawal