NO20081859L - Fremgangsmate for fremstillingen av sartanderivater og mellomprodukter som er nyttige i slike fremgangsmater - Google Patents
Fremgangsmate for fremstillingen av sartanderivater og mellomprodukter som er nyttige i slike fremgangsmaterInfo
- Publication number
- NO20081859L NO20081859L NO20081859A NO20081859A NO20081859L NO 20081859 L NO20081859 L NO 20081859L NO 20081859 A NO20081859 A NO 20081859A NO 20081859 A NO20081859 A NO 20081859A NO 20081859 L NO20081859 L NO 20081859L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- preparation
- processes
- derivative
- intermediates useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Oppfinnelsen tilveiebringer en fremgangsmåte for fremstillingen av et sartanderivat ifølge formel (I) der substituentene har betydningen som er indikert i beskrivelsen, eller et farmasøytisk akseptabelt salt derav, som omfatter å reagere 2-cyanofenylborsyre eller et derivat derav med et p-halobenzyl-1H-imidazolderivat ifølge formel (VI) der X, Y, R1, og R2 er som definert ovenfor, og Z er I, Br eller Cl, i nærvær av en transisjonsmetallkatalysator og en uorganisk eller organisk base. Oppfinnelsen tilveiebringer også nye mellomprodukter ifølge formel (V), der M er et alkalimetall eller en NR4R5R6R7-gruppe, og av formel (II).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05020493A EP1764365A1 (en) | 2005-09-20 | 2005-09-20 | A process for the preparation of sartan derivates and intermediates useful in such process |
PCT/EP2006/009159 WO2007039117A2 (en) | 2005-09-20 | 2006-09-20 | A process for the preparation of sartan derivatives and intermediates useful in such process |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20081859L true NO20081859L (no) | 2008-04-17 |
Family
ID=35464233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20081859A NO20081859L (no) | 2005-09-20 | 2008-04-17 | Fremgangsmate for fremstillingen av sartanderivater og mellomprodukter som er nyttige i slike fremgangsmater |
Country Status (7)
Country | Link |
---|---|
US (1) | US7868180B2 (no) |
EP (2) | EP1764365A1 (no) |
CN (1) | CN101268066B (no) |
EA (1) | EA014691B1 (no) |
NO (1) | NO20081859L (no) |
UA (1) | UA94591C2 (no) |
WO (1) | WO2007039117A2 (no) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20061848A1 (it) * | 2006-09-27 | 2008-03-28 | Dipharma Spa | Procedimento per la preparazione di composti feniltetrazolici |
SI22488A (sl) * | 2007-04-24 | 2008-10-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Kristalni 1-(cikloheksiloksikarboniloksi)etil 1-((2'-cianobifenil-4-il)metil) - 2-etoksi-1h-benz(d)imidazol -7-karboksilat in proces za njegovo pripravo |
DK2451767T3 (da) * | 2009-07-07 | 2019-11-11 | Bayer Cropscience Ag | Fremgangsmåde til fremstilling af (2,4 dimethylbiphenyl 3 yl)eddikesyrer, deres estere samt mellemforbindelser |
KR101526249B1 (ko) * | 2013-11-14 | 2015-06-10 | 동방에프티엘(주) | 올메사탄 메독소밀 유도체의 개선된 제조방법 |
CN109748905B (zh) * | 2019-01-23 | 2021-08-17 | 珠海润都制药股份有限公司 | 一种叠氮离子的处理方法及无基因毒性杂质沙坦类原料药及其中间体 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL95975A (en) * | 1989-10-24 | 1997-06-10 | Takeda Chemical Industries Ltd | N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them |
IL102183A (en) * | 1991-06-27 | 1999-11-30 | Takeda Chemical Industries Ltd | The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them |
US5484955A (en) * | 1992-07-06 | 1996-01-16 | Takeda Chemical Industries, Ltd. | Tri-higher alkyl tin azide and its use |
JP3671266B2 (ja) * | 1996-03-21 | 2005-07-13 | 東洋化成工業株式会社 | 5−置換テトラゾール類の製造方法 |
CN1164587A (zh) | 1997-05-07 | 1997-11-12 | 刘辉 | 多层织物的编织方法 |
US6162922A (en) * | 1998-01-30 | 2000-12-19 | Bristol-Myers Squibb Co. | Method for preparing N-substituted heterocyclic derivatives using a phase-transfer catalyst |
CN1164587C (zh) * | 2002-05-17 | 2004-09-01 | 浙江省医学科学院 | 一种新的奥美沙坦的制备方法 |
ES2281312T3 (es) * | 2003-01-16 | 2008-08-01 | Teva Pharmaceutical Industries Ltd. | Nueva sintesis de irbesartan. |
ITMI20032267A1 (it) * | 2003-11-21 | 2005-05-22 | Dinamite Dipharma S P A In Forma A Bbreviata Diph | Procdimento per la preparzione di valsartan e suoi intermedi |
WO2005051929A1 (en) * | 2003-11-28 | 2005-06-09 | Ranbaxy Laboratories Limited | Conversion of aromatic nitriles into tetrazoles |
EP1751123A4 (en) | 2004-05-20 | 2010-06-30 | Reddys Lab Ltd Dr | PROCESS FOR PREPARING IRBESARTAN |
ES2259909B1 (es) | 2005-02-28 | 2007-06-16 | Inke, S.A. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo y de su intermedio de sintesis. |
-
2005
- 2005-09-20 EP EP05020493A patent/EP1764365A1/en not_active Withdrawn
-
2006
- 2006-09-20 EA EA200800633A patent/EA014691B1/ru not_active IP Right Cessation
- 2006-09-20 WO PCT/EP2006/009159 patent/WO2007039117A2/en active Application Filing
- 2006-09-20 US US12/067,612 patent/US7868180B2/en not_active Expired - Fee Related
- 2006-09-20 EP EP06792188A patent/EP1931655A2/en not_active Withdrawn
- 2006-09-20 UA UAA200803548A patent/UA94591C2/ru unknown
- 2006-09-20 CN CN2006800345903A patent/CN101268066B/zh not_active Expired - Fee Related
-
2008
- 2008-04-17 NO NO20081859A patent/NO20081859L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EA014691B1 (ru) | 2010-12-30 |
WO2007039117A2 (en) | 2007-04-12 |
CN101268066B (zh) | 2012-03-21 |
CN101268066A (zh) | 2008-09-17 |
WO2007039117A3 (en) | 2007-06-21 |
US7868180B2 (en) | 2011-01-11 |
EP1764365A1 (en) | 2007-03-21 |
US20080312451A1 (en) | 2008-12-18 |
EP1931655A2 (en) | 2008-06-18 |
EA200800633A1 (ru) | 2008-08-29 |
UA94591C2 (ru) | 2011-05-25 |
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Legal Events
Date | Code | Title | Description |
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |