RU2352569C2 - АЗАБИЦИКЛОАЛКИЛЬНЫЕ ЭФИРЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ АГОНИСТОВ АЛЬФА7-nAChR - Google Patents
АЗАБИЦИКЛОАЛКИЛЬНЫЕ ЭФИРЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ АГОНИСТОВ АЛЬФА7-nAChR Download PDFInfo
- Publication number
- RU2352569C2 RU2352569C2 RU2005109913A RU2005109913A RU2352569C2 RU 2352569 C2 RU2352569 C2 RU 2352569C2 RU 2005109913 A RU2005109913 A RU 2005109913A RU 2005109913 A RU2005109913 A RU 2005109913A RU 2352569 C2 RU2352569 C2 RU 2352569C2
- Authority
- RU
- Russia
- Prior art keywords
- azabicyclo
- yloxy
- octane
- pyridazin
- pyrimidin
- Prior art date
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- 239000000556 agonist Substances 0.000 title claims abstract description 7
- 150000002170 ethers Chemical class 0.000 title 1
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- 150000003839 salts Chemical class 0.000 claims description 109
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- 125000003118 aryl group Chemical group 0.000 claims description 30
- 239000002253 acid Substances 0.000 claims description 29
- 229910052736 halogen Inorganic materials 0.000 claims description 27
- 150000002367 halogens Chemical class 0.000 claims description 27
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 24
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- 238000000034 method Methods 0.000 claims description 20
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
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- 125000002541 furyl group Chemical group 0.000 claims description 7
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- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- 125000001544 thienyl group Chemical group 0.000 claims description 7
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- 125000006656 (C2-C4) alkenyl group Chemical class 0.000 claims description 5
- 125000006650 (C2-C4) alkynyl group Chemical class 0.000 claims description 5
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- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims description 3
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- C—CHEMISTRY; METALLURGY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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