JP2009143956A5 - - Google Patents
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- Publication number
- JP2009143956A5 JP2009143956A5 JP2009036918A JP2009036918A JP2009143956A5 JP 2009143956 A5 JP2009143956 A5 JP 2009143956A5 JP 2009036918 A JP2009036918 A JP 2009036918A JP 2009036918 A JP2009036918 A JP 2009036918A JP 2009143956 A5 JP2009143956 A5 JP 2009143956A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- substituted
- unsubstituted
- azabicycloalkyl
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000003839 salts Chemical group 0.000 claims 10
- 239000002253 acid Substances 0.000 claims 9
- 239000012458 free base Substances 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- -1 cyano, formyl Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000002541 furyl group Chemical group 0.000 claims 3
- 125000001977 isobenzofuranyl group Chemical group C=1(OC=C2C=CC=CC12)* 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 1
- 206010053643 Neurodegenerative disease Diseases 0.000 claims 1
- 206010037175 Psychiatric disease Diseases 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
Claims (9)
- 遊離塩基またはその酸付加塩形にある請求項1に記載の式Iで示されるアザビシクロアルキル誘導体:
[式中、
XがCH2または一重結合であり;
Yが式:
Rがフェニル、ナフチル、テトラヒドロナフチル、インダニル、チエニル、ベンゾチエニル、フラニル、ベンゾフラニル、イソベンゾフラニルであって、いずれも非置換であるかまたは次の基でモノ−、ジ−もしくはトリ置換されることができる:
ハロゲン、シアノ、ホルミル、アセチル、C1〜C3アルコキシカルボニル、N,N−ジ(C1〜C3アルキル)カルバモイル、フェニル、フェノキシ、メチレンジオキシ、エチレンジオキシ;または
C1〜C4アルキル、C2〜C4アルケニル、C2〜C4アルキニルまたはC1〜C4アルコキシであって、この残基自体も非置換であるかまたはハロゲンでモノ−、ジ−もしくはトリ置換されることができる]。 - 遊離塩基またはその酸付加塩形にある請求項1に記載の式I:
[式中、
XがCH2または一重結合であり;
Yが式:
Rが
(a)非置換フェニルであるか、または
ハロゲン、シアノ、メチレンジオキシ、
非置換であるかハロゲンでモノ−、ジ−もしくはトリ置換されたC1〜C4アルキル、または
非置換であるかハロゲンでモノ−、ジ−もしくはトリ置換されたC1〜C4アルコキシ
でモノ−、ジ−もしくはトリ置換されたフェニルであるか;
(b)ナフチル、インダニル、テトラリニルであるか;または
(c)フラニル、ベンゾフラニル、イソベンゾフラニル、ベンゾチエニルまたはチエニルである]
で示されるアザビシクロアルキル誘導体。 - 医薬として使用するための遊離塩基形または医薬的に許容される酸付加塩形にある請求項1〜4のいずれかに記載のアザビシクロアルキル誘導体。
- 精神疾患および神経変性疾患の予防および処置に使用するための、遊離塩基形または医薬的に許容される酸付加塩形にある請求項1〜4のいずれかに記載のアザビシクロアルキル誘導体。
- 遊離塩基形または医薬的に許容される酸付加塩形にある請求項1〜4のいずれかに記載のアザビシクロアルキル誘導体を医薬的担体または希釈剤と共に含む医薬組成物。
- α7−nAChR活性化が関与するか関連する疾患および病状を処置または予防における使用のための遊離塩基形または医薬的に許容される酸付加塩形にある請求項1〜4のいずれかに記載のアザビシクロアルキル誘導体。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0220581.3 | 2002-09-04 | ||
GB0220581A GB0220581D0 (en) | 2002-09-04 | 2002-09-04 | Organic Compound |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004533455A Division JP4348422B2 (ja) | 2002-09-04 | 2003-09-03 | アザビシクロアルキルエーテルおよびそのα7−NACHRアゴニストとしての使用 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009143956A JP2009143956A (ja) | 2009-07-02 |
JP2009143956A5 true JP2009143956A5 (ja) | 2009-08-13 |
JP5124714B2 JP5124714B2 (ja) | 2013-01-23 |
Family
ID=9943515
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004533455A Expired - Lifetime JP4348422B2 (ja) | 2002-09-04 | 2003-09-03 | アザビシクロアルキルエーテルおよびそのα7−NACHRアゴニストとしての使用 |
JP2009036918A Expired - Fee Related JP5124714B2 (ja) | 2002-09-04 | 2009-02-19 | アザビシクロアルキルエーテルおよびそのα7−NACHRアゴニストとしての使用 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004533455A Expired - Lifetime JP4348422B2 (ja) | 2002-09-04 | 2003-09-03 | アザビシクロアルキルエーテルおよびそのα7−NACHRアゴニストとしての使用 |
Country Status (26)
Country | Link |
---|---|
US (8) | US20060167002A1 (ja) |
EP (3) | EP1537104B1 (ja) |
JP (2) | JP4348422B2 (ja) |
KR (2) | KR20070058027A (ja) |
CN (1) | CN1325493C (ja) |
AT (1) | ATE448225T1 (ja) |
AU (1) | AU2003260486C1 (ja) |
BR (2) | BR122014026685B1 (ja) |
CA (1) | CA2495685C (ja) |
CY (1) | CY1109765T1 (ja) |
DE (1) | DE60330015D1 (ja) |
DK (1) | DK1537104T3 (ja) |
EC (1) | ECSP055621A (ja) |
ES (1) | ES2336099T3 (ja) |
GB (1) | GB0220581D0 (ja) |
HK (2) | HK1077822A1 (ja) |
IL (2) | IL166918A (ja) |
MX (1) | MXPA05002546A (ja) |
NO (1) | NO331556B1 (ja) |
NZ (1) | NZ538534A (ja) |
PL (1) | PL209425B1 (ja) |
PT (1) | PT1537104E (ja) |
RU (1) | RU2352569C2 (ja) |
SI (1) | SI1537104T1 (ja) |
WO (1) | WO2004022556A1 (ja) |
ZA (1) | ZA200500816B (ja) |
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