JP2015506376A5 - - Google Patents
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- Publication number
- JP2015506376A5 JP2015506376A5 JP2014555805A JP2014555805A JP2015506376A5 JP 2015506376 A5 JP2015506376 A5 JP 2015506376A5 JP 2014555805 A JP2014555805 A JP 2014555805A JP 2014555805 A JP2014555805 A JP 2014555805A JP 2015506376 A5 JP2015506376 A5 JP 2015506376A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- patient
- cancer
- administering
- cdk8
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 41
- 206010028980 Neoplasm Diseases 0.000 claims 20
- 238000000034 method Methods 0.000 claims 20
- 201000011510 cancer Diseases 0.000 claims 10
- 102100024456 Cyclin-dependent kinase 8 Human genes 0.000 claims 8
- 101000980937 Homo sapiens Cyclin-dependent kinase 8 Proteins 0.000 claims 8
- 206010006187 Breast cancer Diseases 0.000 claims 6
- 208000026310 Breast neoplasm Diseases 0.000 claims 6
- 150000003384 small molecules Chemical class 0.000 claims 6
- 206010033128 Ovarian cancer Diseases 0.000 claims 5
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 5
- 102100033145 Cyclin-dependent kinase 19 Human genes 0.000 claims 4
- 101000944345 Homo sapiens Cyclin-dependent kinase 19 Proteins 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 102100024170 Cyclin-C Human genes 0.000 claims 3
- 239000012623 DNA damaging agent Substances 0.000 claims 3
- 101000980770 Homo sapiens Cyclin-C Proteins 0.000 claims 3
- 238000009098 adjuvant therapy Methods 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- YQGHJCYLMLPCCB-UHFFFAOYSA-N 2,4-diaminopyrimidin-5-ol Chemical compound NC1=NC=C(O)C(N)=N1 YQGHJCYLMLPCCB-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- -1 small molecule compound Chemical class 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 108060000903 Beta-catenin Proteins 0.000 claims 1
- 102000015735 Beta-catenin Human genes 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 208000031886 HIV Infections Diseases 0.000 claims 1
- 208000037357 HIV infectious disease Diseases 0.000 claims 1
- 206010064390 Tumour invasion Diseases 0.000 claims 1
- 206010002022 amyloidosis Diseases 0.000 claims 1
- 230000009400 cancer invasion Effects 0.000 claims 1
- 230000002113 chemopreventative effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 208000016261 weight loss Diseases 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261594023P | 2012-02-02 | 2012-02-02 | |
| US61/594,023 | 2012-02-02 | ||
| US201261673419P | 2012-07-19 | 2012-07-19 | |
| US61/673,419 | 2012-07-19 | ||
| PCT/US2013/024515 WO2013116786A1 (en) | 2012-02-02 | 2013-02-01 | Cdk8/cdk19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015506376A JP2015506376A (ja) | 2015-03-02 |
| JP2015506376A5 true JP2015506376A5 (enExample) | 2016-05-19 |
| JP6193268B2 JP6193268B2 (ja) | 2017-09-06 |
Family
ID=47716178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555805A Expired - Fee Related JP6193268B2 (ja) | 2012-02-02 | 2013-02-01 | Ｃｄｋ８／ｃｄｋ１９選択的阻害剤、ならびに癌のための抗転移および化学防御の方法におけるそれらの使用 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9321737B2 (enExample) |
| EP (2) | EP2809324B1 (enExample) |
| JP (1) | JP6193268B2 (enExample) |
| KR (1) | KR20150023223A (enExample) |
| CN (1) | CN104363913B (enExample) |
| AU (1) | AU2013214783B2 (enExample) |
| BR (1) | BR112014019052A8 (enExample) |
| CL (1) | CL2014002062A1 (enExample) |
| CO (1) | CO7151516A2 (enExample) |
| EA (2) | EA028595B1 (enExample) |
| GE (1) | GEP201706688B (enExample) |
| MY (1) | MY165446A (enExample) |
| PH (1) | PH12014501862A1 (enExample) |
| SG (1) | SG11201404596UA (enExample) |
| UA (1) | UA117342C2 (enExample) |
| WO (1) | WO2013116786A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102127025B1 (ko) | 2012-07-27 | 2020-06-25 | 비오겐 엠에이 아이엔씨. | S1p 조절제 및/또는 atx 조절제인 화합물들 |
| MX2015002310A (es) * | 2012-08-23 | 2015-06-05 | Hoffmann La Roche | Nuevas amidas de fenil-piridina/pirazina para el tratamiento de cancer. |
| US9636342B2 (en) | 2012-11-01 | 2017-05-02 | University Of South Carolina | Method for treating prostate cancer |
| WO2014134169A1 (en) * | 2013-02-26 | 2014-09-04 | Senex Biotechnology, Inc. | Inhibitors of cdk8/19 for use in treating estrogen receptor positive breast cancer |
| CN110183461A (zh) | 2013-12-24 | 2019-08-30 | 哈佛学院院长等 | 皮质抑素类似物及其合成和用途 |
| JP6529085B2 (ja) * | 2014-04-18 | 2019-06-12 | 武田薬品工業株式会社 | 複素環化合物 |
| EP3154952A4 (en) * | 2014-06-10 | 2018-03-14 | University of South Carolina | Methods and compositions for treatment of her-positive cancers |
| EP3233086B1 (en) | 2014-12-18 | 2023-02-15 | University of South Carolina | Suppression of neointimal formation following vascular surgery using cdk8 inhibitors |
| WO2016182904A1 (en) * | 2015-05-08 | 2016-11-17 | President And Fellows Of Harvard College | Targeted selection of patients for treatment with cortistatin derivatives |
| EP3294298A4 (en) | 2015-05-08 | 2018-10-17 | President and Fellows of Harvard College | Cortistatin analogues, syntheses, and uses thereof |
| WO2017004411A1 (en) | 2015-07-01 | 2017-01-05 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses and uses thereof |
| EP3370720A1 (en) * | 2015-11-03 | 2018-09-12 | Lu License AB | Compounds for treatment of hypoproliferative disorders |
| WO2017091836A1 (en) * | 2015-11-25 | 2017-06-01 | University Of South Carolina | Enhancement of cytarabine activity by inhibiting cdk8/19 |
| JP7198489B2 (ja) * | 2016-03-23 | 2023-01-04 | 国立大学法人 岡山大学 | リン酸化ｓａｒｍ１、抗体、ｓａｒｍ１リン酸化阻害剤、神経変性疾患の予防又は治療薬、スクリーニング方法、ｓａｒｍ１改変体及び使用 |
| WO2018027082A1 (en) | 2016-08-03 | 2018-02-08 | The Broad Institute, Inc. | Use of cdk8 inhibitors to treat diseases of inflammation and autoimmunity |
| ES3004107T3 (en) * | 2017-01-30 | 2025-03-11 | Univ Kyoto | Novel compound, and method for producing regulatory t cells |
| WO2018151633A1 (ru) * | 2017-02-20 | 2018-08-23 | Закрытое Акционерное Общество "Биокад" | Способы получения производных 4-(((нафталин-2-ил)алкил)амино)хинозалин-6-карбонитрилов |
| US20220040179A1 (en) * | 2017-02-23 | 2022-02-10 | University Of South Carolina | Use of cdk8/19 inhibitors for treatment of established colon cancer hepatic metastasis |
| WO2018159805A1 (ja) | 2017-03-03 | 2018-09-07 | 国立大学法人京都大学 | 膵前駆細胞の製造方法 |
| JP7152784B2 (ja) * | 2017-04-03 | 2022-10-13 | 京都薬品工業株式会社 | 新規サイクリン依存性キナーゼ８及び／又は１９阻害剤 |
| RU2641001C1 (ru) * | 2017-04-03 | 2018-01-15 | Закрытое Акционерное Общество "Биокад" | Соли 4-((2-(6-(4-метилпиперазин-1-карбонил)нафталин-2-ил)этил)амино)хиназолин-6-карбонитрила и фармацевтическая композиция |
| WO2019055977A1 (en) | 2017-09-18 | 2019-03-21 | Chan Zuckerberg Biohub, Inc. | METHODS OF TREATING NEGATIVE TRIPLE BREAST CANCER |
| WO2019068613A1 (en) | 2017-10-02 | 2019-04-11 | Boehringer Ingelheim International Gmbh | NOVEL [1,6] NAPHTHYRIDINE COMPOUNDS AND DERIVATIVES AS CDK8 / CDK19 INHIBITORS |
| RU2763347C2 (ru) * | 2018-03-01 | 2021-12-28 | Закрытое Акционерное Общество "Биокад" | Новые ингибиторы cdk8/19 |
| US12281080B2 (en) | 2018-08-21 | 2025-04-22 | University Of South Carolina | Quinoline-based compounds and methods of inhibiting CDK8/19 |
| US11014906B2 (en) | 2018-08-21 | 2021-05-25 | University Of South Carolina | Quinoline-based compounds and methods of inhibiting CDK8/19 |
| CN113677341B (zh) | 2019-02-01 | 2024-07-05 | 南卡罗莱纳大学 | 双环吡啶组合物及其用于癌症治疗的方法 |
| CN116391028A (zh) | 2020-11-20 | 2023-07-04 | 千纸鹤治疗公司 | 促熟剂 |
| WO2022172960A1 (ja) | 2021-02-09 | 2022-08-18 | オリヅルセラピューティクス株式会社 | 成熟化剤 |
| CA3214794A1 (en) * | 2021-03-25 | 2022-09-29 | University Of South Carolina | Cdk8/19 inhibitors for the treatment of cytokine storm |
| AU2022349176A1 (en) | 2021-09-27 | 2024-04-11 | Kyoto University | Method for producing t cell |
| JPWO2023095802A1 (enExample) | 2021-11-24 | 2023-06-01 | ||
| TW202330911A (zh) | 2021-11-24 | 2023-08-01 | 日商雷格細胞股份有限公司 | 人類誘導性控制性ｔ細胞及其製作方法 |
| CN119256076A (zh) | 2022-03-23 | 2025-01-03 | 国立大学法人京都大学 | 用于产生调节性t细胞的方法 |
| KR20250006874A (ko) | 2022-04-25 | 2025-01-13 | 오리즈루 세라퓨틱스 가부시키가이샤 | Alk5 저해 활성과 cdk8/19 저해 활성을 갖는 성숙화제 |
| AU2023307842A1 (en) | 2022-07-14 | 2025-02-06 | Orizuru Therapeutics, Inc. | Fibrin gel sheet for cell transplantation |
| CN119948155A (zh) | 2022-09-26 | 2025-05-06 | 雷格细胞股份有限公司 | 含有嵌合抗原受体（car）的诱导性调节性t细胞 |
| JPWO2024071010A1 (enExample) | 2022-09-26 | 2024-04-04 | ||
| KR20250140618A (ko) | 2023-02-08 | 2025-09-25 | 레그셀 가부시키가이샤 | 천포창을 치료 또는 예방하기 위한 의약 조성물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6046206A (en) * | 1995-06-07 | 2000-04-04 | Cell Pathways, Inc. | Method of treating a patient having a precancerous lesions with amide quinazoline derivatives |
| CA2306082A1 (en) * | 1997-10-27 | 1999-05-06 | Agouron Pharmaceuticals, Inc. | Substituted 4-amino-thiazol-2-y compounds as cdks inhibitors |
| US6440959B1 (en) * | 1999-04-21 | 2002-08-27 | Hoffman-La Roche Inc. | Pyrazolobenzodiazepines |
| US20040180844A1 (en) | 2003-03-10 | 2004-09-16 | Fesik Stephen W. | Method of killing cancer cells |
| US20040180848A1 (en) | 2003-03-10 | 2004-09-16 | Fesik Stephen W. | Method of killing cancer cells |
| JP2006522794A (ja) * | 2003-04-10 | 2006-10-05 | ファイザー株式会社 | Ｎｒ２ｂ受容体拮抗物質としての二環系化合物 |
| EP2021019A4 (en) * | 2006-05-15 | 2009-12-09 | Senex Biotechnology Inc | IDENTIFICATION OF CDKI PATH HAZARD |
| US8598344B2 (en) | 2009-11-30 | 2013-12-03 | Senex Biotechnology | CDKI pathway inhibitors and uses thereof |
-
2013
- 2013-02-01 EP EP13704538.1A patent/EP2809324B1/en not_active Not-in-force
- 2013-02-01 SG SG11201404596UA patent/SG11201404596UA/en unknown
- 2013-02-01 JP JP2014555805A patent/JP6193268B2/ja not_active Expired - Fee Related
- 2013-02-01 UA UAA201409643A patent/UA117342C2/uk unknown
- 2013-02-01 US US13/757,682 patent/US9321737B2/en active Active
- 2013-02-01 MY MYPI2014002269A patent/MY165446A/en unknown
- 2013-02-01 AU AU2013214783A patent/AU2013214783B2/en not_active Ceased
- 2013-02-01 WO PCT/US2013/024515 patent/WO2013116786A1/en not_active Ceased
- 2013-02-01 EA EA201491399A patent/EA028595B1/ru not_active IP Right Cessation
- 2013-02-01 EA EA201791284A patent/EA032429B1/ru not_active IP Right Cessation
- 2013-02-01 CN CN201380017703.9A patent/CN104363913B/zh not_active Expired - Fee Related
- 2013-02-01 GE GEAP201313566A patent/GEP201706688B/en unknown
- 2013-02-01 KR KR1020147024672A patent/KR20150023223A/ko not_active Ceased
- 2013-02-01 EP EP18186536.1A patent/EP3431087A1/en not_active Withdrawn
- 2013-02-01 BR BR112014019052A patent/BR112014019052A8/pt not_active Application Discontinuation
-
2014
- 2014-08-01 CL CL2014002062A patent/CL2014002062A1/es unknown
- 2014-08-18 PH PH12014501862A patent/PH12014501862A1/en unknown
- 2014-08-30 CO CO14191136A patent/CO7151516A2/es unknown
-
2016
- 2016-03-09 US US15/065,083 patent/US10993945B2/en active Active
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