AU2013214783B2 - CDK8/CDK19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer - Google Patents

CDK8/CDK19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer Download PDF

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Publication number
AU2013214783B2
AU2013214783B2 AU2013214783A AU2013214783A AU2013214783B2 AU 2013214783 B2 AU2013214783 B2 AU 2013214783B2 AU 2013214783 A AU2013214783 A AU 2013214783A AU 2013214783 A AU2013214783 A AU 2013214783A AU 2013214783 B2 AU2013214783 B2 AU 2013214783B2
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patient
cdk8
cancer
small molecule
molecule compound
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AU2013214783A1 (en
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Donald C. Porter
Igor B. Robinson
Mark P. Wentland
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Senex Biotechnology Inc
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Senex Biotechnology Inc
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57515—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the breast
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    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4739—Cyclin; Prad 1
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    • G01N2333/91—Transferases (2.)
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AU2013214783A 2012-02-02 2013-02-01 CDK8/CDK19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer Ceased AU2013214783B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261594023P 2012-02-02 2012-02-02
US61/594,023 2012-02-02
US201261673419P 2012-07-19 2012-07-19
US61/673,419 2012-07-19
PCT/US2013/024515 WO2013116786A1 (en) 2012-02-02 2013-02-01 Cdk8/cdk19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer

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AU2013214783A1 AU2013214783A1 (en) 2014-08-28
AU2013214783B2 true AU2013214783B2 (en) 2017-07-06

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US (2) US9321737B2 (enExample)
EP (2) EP3431087A1 (enExample)
JP (1) JP6193268B2 (enExample)
KR (1) KR20150023223A (enExample)
CN (1) CN104363913B (enExample)
AU (1) AU2013214783B2 (enExample)
BR (1) BR112014019052A8 (enExample)
CL (1) CL2014002062A1 (enExample)
CO (1) CO7151516A2 (enExample)
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