JP6193268B2 - Ｃｄｋ８／ｃｄｋ１９選択的阻害剤、ならびに癌のための抗転移および化学防御の方法におけるそれらの使用 - Google Patents

Ｃｄｋ８／ｃｄｋ１９選択的阻害剤、ならびに癌のための抗転移および化学防御の方法におけるそれらの使用 Download PDF

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JP6193268B2
JP6193268B2 JP2014555805A JP2014555805A JP6193268B2 JP 6193268 B2 JP6193268 B2 JP 6193268B2 JP 2014555805 A JP2014555805 A JP 2014555805A JP 2014555805 A JP2014555805 A JP 2014555805A JP 6193268 B2 JP6193268 B2 JP 6193268B2
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pharmaceutical formulation
patient
cdk8
cancer
tumor
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JP2015506376A (ja
JP2015506376A5 (enExample
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ロビンソン，イゴール，ビー．
ポーター，ドナルド，シー．
ウェントランド，マーク，ピー．
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Senex Biotechnology Inc
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Senex Biotechnology Inc
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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JP2014555805A 2012-02-02 2013-02-01 Ｃｄｋ８／ｃｄｋ１９選択的阻害剤、ならびに癌のための抗転移および化学防御の方法におけるそれらの使用 Expired - Fee Related JP6193268B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261594023P 2012-02-02 2012-02-02
US61/594,023 2012-02-02
US201261673419P 2012-07-19 2012-07-19
US61/673,419 2012-07-19
PCT/US2013/024515 WO2013116786A1 (en) 2012-02-02 2013-02-01 Cdk8/cdk19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer

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JP2015506376A JP2015506376A (ja) 2015-03-02
JP2015506376A5 JP2015506376A5 (enExample) 2016-05-19
JP6193268B2 true JP6193268B2 (ja) 2017-09-06

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US (2) US9321737B2 (enExample)
EP (2) EP3431087A1 (enExample)
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KR (1) KR20150023223A (enExample)
CN (1) CN104363913B (enExample)
AU (1) AU2013214783B2 (enExample)
BR (1) BR112014019052A8 (enExample)
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