JP2014512364A5 - - Google Patents
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- JP2014512364A5 JP2014512364A5 JP2014504078A JP2014504078A JP2014512364A5 JP 2014512364 A5 JP2014512364 A5 JP 2014512364A5 JP 2014504078 A JP2014504078 A JP 2014504078A JP 2014504078 A JP2014504078 A JP 2014504078A JP 2014512364 A5 JP2014512364 A5 JP 2014512364A5
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- JP
- Japan
- Prior art keywords
- substituted
- group
- monomer
- alkyl
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000178 monomer Substances 0.000 claims description 203
- 125000000217 alkyl group Chemical group 0.000 claims description 126
- 125000000623 heterocyclic group Chemical group 0.000 claims description 72
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 65
- 229910052736 halogen Inorganic materials 0.000 claims description 62
- 150000002367 halogens Chemical class 0.000 claims description 62
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 58
- 125000005843 halogen group Chemical group 0.000 claims description 57
- 229910052739 hydrogen Inorganic materials 0.000 claims description 54
- 125000001931 aliphatic group Chemical group 0.000 claims description 48
- 125000003118 aryl group Chemical group 0.000 claims description 41
- 125000003545 alkoxy group Chemical group 0.000 claims description 40
- 125000001424 substituent group Chemical group 0.000 claims description 40
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 39
- 125000001072 heteroaryl group Chemical group 0.000 claims description 38
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 35
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 34
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims description 29
- 229910052799 carbon Inorganic materials 0.000 claims description 27
- 239000003446 ligand Substances 0.000 claims description 26
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 25
- 239000001257 hydrogen Substances 0.000 claims description 22
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 22
- -1 cyano, amino Chemical group 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 19
- 150000004677 hydrates Chemical class 0.000 claims description 17
- 239000002207 metabolite Substances 0.000 claims description 17
- 125000004043 oxo group Chemical group O=* 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 16
- 125000002252 acyl group Chemical group 0.000 claims description 15
- 125000004429 atom Chemical group 0.000 claims description 13
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims description 13
- 239000000539 dimer Substances 0.000 claims description 11
- 125000003342 alkenyl group Chemical group 0.000 claims description 10
- 125000002947 alkylene group Chemical group 0.000 claims description 9
- 239000012736 aqueous medium Substances 0.000 claims description 9
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims description 9
- 150000001875 compounds Chemical class 0.000 claims description 9
- 239000013638 trimer Substances 0.000 claims description 9
- 125000005647 linker group Chemical group 0.000 claims description 8
- 230000001225 therapeutic effect Effects 0.000 claims description 8
- 238000001727 in vivo Methods 0.000 claims description 7
- 238000006471 dimerization reaction Methods 0.000 claims description 6
- 125000005842 heteroatom Chemical group 0.000 claims description 5
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 4
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims description 4
- OHENQANLQNOMAO-UHFFFAOYSA-N oxaborole Chemical group O1B=CC=C1 OHENQANLQNOMAO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 125000005620 boronic acid group Chemical group 0.000 claims description 3
- 150000002016 disaccharides Chemical class 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 150000002772 monosaccharides Chemical class 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 16
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 0 CC*(C)(CC(C)N)CC(C)(C(C)*)*(C)=C Chemical compound CC*(C)(CC(C)N)CC(C)(C(C)*)*(C)=C 0.000 description 12
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- PWWSSIYVTQUJQQ-UHFFFAOYSA-N distearyl thiodipropionate Chemical group CCCCCCCCCCCCCCCCCCOC(=O)CCSCCC(=O)OCCCCCCCCCCCCCCCCCC PWWSSIYVTQUJQQ-UHFFFAOYSA-N 0.000 description 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 2
- UZPWKTCMUADILM-UHFFFAOYSA-N CC1C=CCCC1 Chemical compound CC1C=CCCC1 UZPWKTCMUADILM-UHFFFAOYSA-N 0.000 description 1
- WGBBUURBHXLGFM-UHFFFAOYSA-N CCCCC(C)N Chemical compound CCCCC(C)N WGBBUURBHXLGFM-UHFFFAOYSA-N 0.000 description 1
- PZJSZBJLOWMDRG-UHFFFAOYSA-N OB(c1ccc[o]1)O Chemical compound OB(c1ccc[o]1)O PZJSZBJLOWMDRG-UHFFFAOYSA-N 0.000 description 1
- QGMPRYMEGNQNIT-UHFFFAOYSA-N OBCc1cc(C2=CC=CC=CC(Cl)=C2Cl)ccc1 Chemical compound OBCc1cc(C2=CC=CC=CC(Cl)=C2Cl)ccc1 QGMPRYMEGNQNIT-UHFFFAOYSA-N 0.000 description 1
- FWXKZJWQZIKBNP-UHFFFAOYSA-N OBc1cc(cccc2)c2[nH]1 Chemical compound OBc1cc(cccc2)c2[nH]1 FWXKZJWQZIKBNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161473093P | 2011-04-07 | 2011-04-07 | |
| US61/473,093 | 2011-04-07 | ||
| PCT/US2012/032809 WO2013058824A1 (en) | 2011-04-07 | 2012-04-09 | Monomers capable of dimerizing in an aqueous solution, and methods of using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014512364A JP2014512364A (ja) | 2014-05-22 |
| JP2014512364A5 true JP2014512364A5 (enExample) | 2015-05-28 |
Family
ID=48141232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014504078A Pending JP2014512364A (ja) | 2011-04-07 | 2012-04-09 | 水溶液中で二量体化できる単量体、およびその使用法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20140194383A1 (enExample) |
| EP (1) | EP2694707B1 (enExample) |
| JP (1) | JP2014512364A (enExample) |
| WO (1) | WO2013058824A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2694707B1 (en) | 2011-04-07 | 2018-08-15 | Cornell University | Monomers capable of dimerizing in an aqueous solution, and methods of using same |
| EP2693883B1 (en) | 2011-04-07 | 2018-12-26 | Cornell University | Silyl monomers capable of multimerizing in an aqueous solution, and methods of using same |
| US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
| US8669207B1 (en) | 2013-01-30 | 2014-03-11 | Dow Agrosciences, Llc. | Compounds and compositions |
| US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
| US9585396B2 (en) | 2013-01-30 | 2017-03-07 | Agrofresh Inc. | Volatile applications against pathogens |
| CA2899317C (en) | 2013-01-30 | 2024-09-10 | Agrofresh Inc. | USE OF BENZOXABOROLES AS VOLATILE ANTIMICROBIAL AGENTS ON MEAT, PLANTS, OR PARTS OF PLANTS |
| CN103880679B (zh) * | 2014-03-13 | 2015-02-11 | 河北科技大学 | 3-乙氧基-4-乙氧羰基苯乙酸的合成方法 |
| CN105017140B (zh) * | 2014-04-28 | 2017-12-29 | 复旦大学 | 邻氨基苯甲酰胺化合物及其制备方法和用途 |
| WO2016115360A1 (en) * | 2015-01-14 | 2016-07-21 | Coferon, Inc. | C-myc ligands capable of dimerizing in an aqueous solution, and methods of using same |
| CA2985823A1 (en) | 2015-05-12 | 2016-11-17 | Blinkbio, Inc. | Silicon based drug conjugates and methods of using same |
| GB201603359D0 (en) * | 2016-02-26 | 2016-04-13 | Binding Site Group The Ltd | Improved assay |
| WO2017155879A1 (en) | 2016-03-07 | 2017-09-14 | Agrofresh Inc. | Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops |
| JP2019517564A (ja) | 2016-06-09 | 2019-06-24 | ブリンクバイオ インコーポレイテッド | シラノール系治療的ペイロード |
| CN107573297A (zh) * | 2017-08-31 | 2018-01-12 | 桂林南药股份有限公司 | 一种利奈唑胺的酸性水解杂质的制备方法 |
| CN109678701B (zh) * | 2019-01-22 | 2021-08-20 | 安徽德信佳生物医药有限公司 | 一种维兰特罗中间体的制备方法 |
| JP7335849B2 (ja) * | 2019-07-17 | 2023-08-30 | 信越化学工業株式会社 | ジメチルシクロブタン環を有するジエステル化合物及びその製造方法、並びにそれから誘導されるジメチルシクロブタン化合物の製造方法 |
| EP3766861B1 (en) * | 2019-07-17 | 2023-05-24 | Shin-Etsu Chemical Co., Ltd. | Diester compound having a dimethylcyclobutane ring, a process for preparing the same, and a process for preparing dimethylcyclobutane compound derived from the diester compound |
| AU2020408039A1 (en) * | 2019-12-20 | 2022-08-18 | Arbutus Biopharma Corporation | Synthetic processes and intermediates |
| JP2023536657A (ja) * | 2020-08-07 | 2023-08-28 | コーネル ユニバーシティー | タンパク質をｅ３リガーゼの媒介によって分解するための、治療上有用なｃｕｒｅ－ｐｒｏ分子、ならびにその作製方法及び使用方法 |
| WO2022031772A1 (en) * | 2020-08-07 | 2022-02-10 | Cornell University | Therapeutic composition of cure-pro compounds for targeted degradation of bet domain proteins, and methods of making and usage |
| CN114315787A (zh) * | 2021-12-30 | 2022-04-12 | 广州佳途科技股份有限公司 | 一种维兰特罗ep杂质2的制备方法及应用 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63222153A (ja) | 1987-03-11 | 1988-09-16 | Kanegafuchi Chem Ind Co Ltd | 新規α−シアノケイ皮酸アミド誘導体 |
| US5236919A (en) | 1989-02-28 | 1993-08-17 | Imperial Chemical Industries Plc | Quinoxalinyl derivatives suitable for use in leukotriene mediated disease |
| DE69839333T2 (de) | 1997-05-30 | 2009-07-09 | Shiseido Co. Ltd. | Zusammensetzung ein copolymer enthaltend das reaktive silyl-gruppen aufweist sowie verfahren zur verwendung |
| KR20000068915A (ko) | 1997-09-05 | 2000-11-25 | 마쓰시다 일렉트릭 인더스트리얼 컴패니 리미티드 | 형광 편광법 |
| US6326478B1 (en) | 1998-07-08 | 2001-12-04 | Isis Pharmaceuticals, Inc. | Process for the synthesis of oligomeric compounds |
| GB0012362D0 (en) * | 2000-05-22 | 2000-07-12 | Aventis Pharma Ltd | Chemical compounds |
| HU227630B1 (hu) | 2000-05-22 | 2011-10-28 | Aventis Pharma Inc | Arilmetilamin-származékok triptáz gátlóként való alkalmazásra és ezeket tartalmazó gyógyszerkészítmények |
| GB0111459D0 (en) | 2001-05-10 | 2001-07-04 | Isis Innovation | Universal fluorescent sensors |
| US20100081792A1 (en) | 2001-06-28 | 2010-04-01 | Smithkline Beecham Corporation | Ligand |
| JP3841398B2 (ja) | 2001-12-17 | 2006-11-01 | 富士写真フイルム株式会社 | ネガ型レジスト組成物 |
| WO2004071641A2 (en) | 2003-02-10 | 2004-08-26 | Pointilliste, Inc. | Self-assembling arrays and uses thereof |
| US8202843B2 (en) | 2004-02-27 | 2012-06-19 | Rib-X Pharmaceuticals, Inc. | Macrocyclic compounds and methods of making and using the same |
| US7511139B2 (en) | 2004-06-04 | 2009-03-31 | Bristol-Myers Squibb Company | Process for the preparation of entecavir and novel intermediates thereof via carbon-silicon oxidation |
| TW200800201A (en) | 2005-11-18 | 2008-01-01 | Lilly Co Eli | Pyrimidinyl benzothiophene compounds |
| US8129366B2 (en) | 2005-12-13 | 2012-03-06 | Daiichi Sankyo Company, Limited | VLA-4 inhibitory drug |
| BRPI0620151A2 (pt) | 2005-12-22 | 2010-06-29 | Wyeth Corp | composto; composição farmacêutica; método de tratar ou inibir o crescimento de células tumorais cancerosas em um mamìfero que deste necessita; método; e processo |
| US8239008B2 (en) | 2007-04-13 | 2012-08-07 | Ethicon Endo-Surgery, Inc. | Sentinel node identification using fluorescent nanoparticles |
| CA2730565A1 (en) * | 2007-07-27 | 2009-02-05 | Ensemble Discovery Corporation | Detection assays and use thereof |
| UA108596C2 (xx) | 2007-11-09 | 2015-05-25 | Інгібітори пептиддеформілази | |
| CA2706391A1 (en) | 2007-11-21 | 2009-05-28 | Janssen Pharmaceutica N.V. | Spiropiperidines for use as tryptase inhibitors |
| WO2009076373A1 (en) | 2007-12-10 | 2009-06-18 | Concert Pharmaceuticals Inc. | Heterocyclic kinase inhibitors |
| AU2009234373B2 (en) | 2008-04-09 | 2015-09-24 | Cornell University | Coferons and methods of making and using them |
| FR2955324A1 (fr) * | 2010-01-15 | 2011-07-22 | Sanofi Aventis | [4-(5-aminomethyl-phenyl)-piperidin-1-yl]-1h-indol-3-yl]-methanones disubstituees |
| CA2774476A1 (en) * | 2009-10-07 | 2011-04-14 | Francis Barany | Coferons and methods of making and using them |
| EP2694707B1 (en) | 2011-04-07 | 2018-08-15 | Cornell University | Monomers capable of dimerizing in an aqueous solution, and methods of using same |
| WO2012154213A1 (en) | 2011-04-07 | 2012-11-15 | Cornell University | Cofluorons and methods of making and using them |
| EP2693883B1 (en) | 2011-04-07 | 2018-12-26 | Cornell University | Silyl monomers capable of multimerizing in an aqueous solution, and methods of using same |
-
2012
- 2012-04-09 EP EP12842368.8A patent/EP2694707B1/en active Active
- 2012-04-09 WO PCT/US2012/032809 patent/WO2013058824A1/en not_active Ceased
- 2012-04-09 US US14/110,056 patent/US20140194383A1/en not_active Abandoned
- 2012-04-09 JP JP2014504078A patent/JP2014512364A/ja active Pending
-
2020
- 2020-07-15 US US16/929,528 patent/US11970448B2/en active Active
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