BR9907172A - Derivados de azatriciclo[3.3.1.1] decano e composições farmacêuticas contendo-os - Google Patents

Derivados de azatriciclo[3.3.1.1] decano e composições farmacêuticas contendo-os

Info

Publication number
BR9907172A
BR9907172A BR9907172-0A BR9907172A BR9907172A BR 9907172 A BR9907172 A BR 9907172A BR 9907172 A BR9907172 A BR 9907172A BR 9907172 A BR9907172 A BR 9907172A
Authority
BR
Brazil
Prior art keywords
hydrogen
substituent
azathricycle
decane
derivatives
Prior art date
Application number
BR9907172-0A
Other languages
English (en)
Inventor
Merouane Bencherif
Patrick Michael Lippiello
Peter Anthony Crooks
Haelil Park
Balwinder Singh Bhatti
William Scott Caldwell
Gary Maurice Dull
Original Assignee
Reynolds Tobacco Co R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/054,175 external-priority patent/US5952339A/en
Priority claimed from US09/053,937 external-priority patent/US6057446A/en
Application filed by Reynolds Tobacco Co R filed Critical Reynolds Tobacco Co R
Publication of BR9907172A publication Critical patent/BR9907172A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS DE AZATRICICLO[3.3.1.1] DECANO E COMPOSIçõES FARMACêUTICAS CONTENDO-OS"<D>. Uma composição farmacêutica incorporando um antagonista nicotínico é fornecida. A composição é uma quantidade eficaz de um composto de fórmula (I). onde X' é nitrogênio ou carbono ligado a uma espécie substituinte caracterizada como tendo um valor sigma m maior do que 0, menor do que 0 ou 0; A, A' e A" são individualmente espécies substituintes caracterizadas como tendo um valor sigma m maior do que 0, menor do que 0 ou 0; Z' é de outra maneira um substituinte de hidrogênio; j é um número inteiro de 0 a 5; e a linha ondulada na estrutura indica que o composto pode existir na forma de um enantiómero ou um diasterómero; Z" é hidrogênio ou um substituinte de outra maneira hidrogênio; Y é C=O, C(OH)R' ou C-A, onde R' é hidrogênio o alquila inferior.
BR9907172-0A 1998-04-02 1999-03-03 Derivados de azatriciclo[3.3.1.1] decano e composições farmacêuticas contendo-os BR9907172A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/054,175 US5952339A (en) 1998-04-02 1998-04-02 Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
US09/053,937 US6057446A (en) 1998-04-02 1998-04-02 Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds
PCT/US1999/004728 WO1999051602A1 (en) 1998-04-02 1999-03-03 Azatricyclo[3.3.1.1] decane derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
BR9907172A true BR9907172A (pt) 2000-10-10

Family

ID=26732410

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9907172-0A BR9907172A (pt) 1998-04-02 1999-03-03 Derivados de azatriciclo[3.3.1.1] decano e composições farmacêuticas contendo-os

Country Status (13)

Country Link
EP (1) EP1068208B1 (pt)
JP (1) JP2002510690A (pt)
KR (1) KR100591805B1 (pt)
AT (1) ATE240331T1 (pt)
AU (1) AU2892999A (pt)
BR (1) BR9907172A (pt)
CA (1) CA2317567A1 (pt)
DE (1) DE69907894T2 (pt)
DK (1) DK1068208T3 (pt)
ES (1) ES2199561T3 (pt)
MX (1) MXPA00009634A (pt)
PT (1) PT1068208E (pt)
WO (1) WO1999051602A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432975B1 (en) * 1998-12-11 2002-08-13 Targacept, Inc. Pharmaceutical compositions and methods for use
US6953855B2 (en) 1998-12-11 2005-10-11 Targacept, Inc. 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
MY145722A (en) * 2000-04-27 2012-03-30 Abbott Lab Diazabicyclic central nervous system active agents
US6809105B2 (en) 2000-04-27 2004-10-26 Abbott Laboratories Diazabicyclic central nervous system active agents
WO2001082978A2 (en) * 2000-05-01 2001-11-08 Targacept, Inc. Imaging of nicotinic acetylcholine receptor subtypes
US7897766B2 (en) 2005-09-23 2011-03-01 Abbott Laboratories Amino-aza-adamantane derivatives and methods of use
US8314119B2 (en) 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
JP5394939B2 (ja) 2007-03-23 2014-01-22 アッヴィ・インコーポレイテッド ４−置換アザアダマンタン誘導体およびそれの使用方法
ATE538122T1 (de) * 2007-03-23 2012-01-15 Abbott Lab Acetamid- und carboxamid-derivate von azaadamantan sowie verfahren zu ihrer verwendung
SA08290475B1 (ar) 2007-08-02 2013-06-22 Targacept Inc (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
UA110802C2 (uk) 2010-09-23 2016-02-25 Еббві Бахамаз Лтд. Моногідрат похідного азаадамантану
US9724340B2 (en) 2015-07-31 2017-08-08 Attenua, Inc. Antitussive compositions and methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107184A (en) * 1992-10-09 1997-08-14 Abbott Lab Heterocyclic ether compounds that enhance cognitive function
US5597919A (en) * 1995-01-06 1997-01-28 Dull; Gary M. Pyrimidinyl or Pyridinyl alkenyl amine compounds
US5585388A (en) * 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
US5583140A (en) * 1995-05-17 1996-12-10 Bencherif; Merouane Pharmaceutical compositions for the treatment of central nervous system disorders
JP3510937B2 (ja) * 1995-06-05 2004-03-29 ポリプラスチックス株式会社 耐熱性ポリエステルアミドスルフィド樹脂及びその組成物
EP0842172A1 (en) * 1995-06-29 1998-05-20 Novo Nordisk A/S Novel substituted azacyclic or azabicyclic compounds
EP0853621A1 (en) * 1995-09-22 1998-07-22 Novo Nordisk A/S Novel substituted azacyclic or azabicyclic compounds

Also Published As

Publication number Publication date
DK1068208T3 (da) 2003-09-01
ES2199561T3 (es) 2004-02-16
ATE240331T1 (de) 2003-05-15
PT1068208E (pt) 2003-09-30
JP2002510690A (ja) 2002-04-09
MXPA00009634A (es) 2005-06-20
DE69907894T2 (de) 2004-03-11
CA2317567A1 (en) 1999-10-14
EP1068208B1 (en) 2003-05-14
EP1068208A1 (en) 2001-01-17
KR100591805B1 (ko) 2006-06-26
DE69907894D1 (de) 2003-06-18
KR20010052173A (ko) 2001-06-25
AU2892999A (en) 1999-10-25
WO1999051602A1 (en) 1999-10-14

Similar Documents

Publication Publication Date Title
EP1254659A4 (en) STABLE EMULSION PREPARATIONS
AU2003222450A1 (en) Stabilized ascorbic acid derivatives
BR9907172A (pt) Derivados de azatriciclo[3.3.1.1] decano e composições farmacêuticas contendo-os
CA2113229A1 (en) Anti-fibrotic quinazolinone-containing compositions and methods for the use thereof
HK1075197A1 (en) New composition containing taxane derivatives as major component
IL129768A0 (en) Antithrombotic organic nitrates
AP9701039A0 (en) Derivatives of 2- (2-oxo-ethlidene)-imidazolidin-4-one.
UA37230C2 (uk) Полі-1-н-алкенаміни та склади палива або мастильного засобу, що їх містять
HK1044936A1 (zh) 凝血酶抑制劑
WO2003082798A8 (es) Compuestos naturales y derivados de éstos para la prevención y el tratamiento de enfermedades cardiovasculares, hepáticas, renales y para aplicaciones cosméticas
CA2199128A1 (en) Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
AU2267495A (en) Benzamide derivatives as vasopressin antagonists
MX9604483A (es) Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas.
IL136359A0 (en) Dihydrobenzofuran derivatives and pharmaceutical compositions containing the same
AU4705200A (en) Cosmetic compositions
DK1066287T3 (da) Azatricykliske forbindelser
IL127379A0 (en) Dihydrobenzopyran and related compounds useful as anti-inflammatory agents
WO2001009093A8 (en) Benzenamine derivatives as anti-coagulants
CA2191850A1 (en) Cancerous metastasis inhibitor
EP1182192A4 (en) 4-HYDROXYPIPERIDINE DERIVATIVES WITH ANTI-ARRHYTHMIC EFFECT
EP0335979A4 (en) Thienopyrimidine derivatives
CA2191947A1 (en) Pirydyl Imidazole Derivatives and Processes for the Preparation Thereof
AU8889998A (en) Water soluble analogs and prodrugs of paclitaxel
WO2001051004A3 (en) Anti-cancer agent containing naphthoquinone compound
EP0790247A4 (en) TETRAHYDROISOCHINOLINE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM

Legal Events

Date Code Title Description
PC Transfer

Free format text: TARGACEPT, INC. (US)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT. CL: A61K31/439, C07D471/18

Ipc: C07D 471/18 (2008.04), A61K 31/435 (2008.04)

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.