ATE240331T1 - Azatricyclo(3.3.1.1)decanderivate und diese enthaltende phrmazeutische zubereitungen - Google Patents

Azatricyclo(3.3.1.1)decanderivate und diese enthaltende phrmazeutische zubereitungen

Info

Publication number
ATE240331T1
ATE240331T1 AT99909806T AT99909806T ATE240331T1 AT E240331 T1 ATE240331 T1 AT E240331T1 AT 99909806 T AT99909806 T AT 99909806T AT 99909806 T AT99909806 T AT 99909806T AT E240331 T1 ATE240331 T1 AT E240331T1
Authority
AT
Austria
Prior art keywords
hydrogen
substituent
decanderivates
azatricyclo
sigma
Prior art date
Application number
AT99909806T
Other languages
English (en)
Inventor
Merouane Bencherif
Patrick Michael Lippiello
Peter Anthony Crooks
Haeil Park
Balwinder Singh Bhatti
William Scott Caldwell
Gary Maurice Dull
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/053,937 external-priority patent/US6057446A/en
Priority claimed from US09/054,175 external-priority patent/US5952339A/en
Application filed by Targacept Inc filed Critical Targacept Inc
Application granted granted Critical
Publication of ATE240331T1 publication Critical patent/ATE240331T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT99909806T 1998-04-02 1999-03-03 Azatricyclo(3.3.1.1)decanderivate und diese enthaltende phrmazeutische zubereitungen ATE240331T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/053,937 US6057446A (en) 1998-04-02 1998-04-02 Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds
US09/054,175 US5952339A (en) 1998-04-02 1998-04-02 Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
PCT/US1999/004728 WO1999051602A1 (en) 1998-04-02 1999-03-03 Azatricyclo[3.3.1.1] decane derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ATE240331T1 true ATE240331T1 (de) 2003-05-15

Family

ID=26732410

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99909806T ATE240331T1 (de) 1998-04-02 1999-03-03 Azatricyclo(3.3.1.1)decanderivate und diese enthaltende phrmazeutische zubereitungen

Country Status (13)

Country Link
EP (1) EP1068208B1 (de)
JP (1) JP2002510690A (de)
KR (1) KR100591805B1 (de)
AT (1) ATE240331T1 (de)
AU (1) AU2892999A (de)
BR (1) BR9907172A (de)
CA (1) CA2317567A1 (de)
DE (1) DE69907894T2 (de)
DK (1) DK1068208T3 (de)
ES (1) ES2199561T3 (de)
MX (1) MXPA00009634A (de)
PT (1) PT1068208E (de)
WO (1) WO1999051602A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6432975B1 (en) * 1998-12-11 2002-08-13 Targacept, Inc. Pharmaceutical compositions and methods for use
US6953855B2 (en) 1998-12-11 2005-10-11 Targacept, Inc. 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
US6809105B2 (en) 2000-04-27 2004-10-26 Abbott Laboratories Diazabicyclic central nervous system active agents
MY137020A (en) * 2000-04-27 2008-12-31 Abbott Lab Diazabicyclic central nervous system active agents
WO2001082978A2 (en) * 2000-05-01 2001-11-08 Targacept, Inc. Imaging of nicotinic acetylcholine receptor subtypes
US7897766B2 (en) 2005-09-23 2011-03-01 Abbott Laboratories Amino-aza-adamantane derivatives and methods of use
US8314119B2 (en) * 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
MX2009010176A (es) 2007-03-23 2009-10-12 Abbott Lab Derivados de aza-adamantano 4-substituidos y metodos de uso de los mismos.
ATE538122T1 (de) * 2007-03-23 2012-01-15 Abbott Lab Acetamid- und carboxamid-derivate von azaadamantan sowie verfahren zu ihrer verwendung
SA08290475B1 (ar) 2007-08-02 2013-06-22 Targacept Inc (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
EP2619205B1 (de) 2010-09-23 2017-05-17 AbbVie Bahamas Ltd. Monohydrat eines azaadamantanderivates
US9724340B2 (en) 2015-07-31 2017-08-08 Attenua, Inc. Antitussive compositions and methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107184A (en) * 1992-10-09 1997-08-14 Abbott Lab Heterocyclic ether compounds that enhance cognitive function
US5597919A (en) * 1995-01-06 1997-01-28 Dull; Gary M. Pyrimidinyl or Pyridinyl alkenyl amine compounds
US5585388A (en) * 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors
US5583140A (en) * 1995-05-17 1996-12-10 Bencherif; Merouane Pharmaceutical compositions for the treatment of central nervous system disorders
JP3510937B2 (ja) * 1995-06-05 2004-03-29 ポリプラスチックス株式会社 耐熱性ポリエステルアミドスルフィド樹脂及びその組成物
EP0842172A1 (de) * 1995-06-29 1998-05-20 Novo Nordisk A/S Substituierte azacyclische oder azabicyclische verbindungen
EP0853621A1 (de) * 1995-09-22 1998-07-22 Novo Nordisk A/S Neue substituierte azazyklische oder azabizyklische verbindungen

Also Published As

Publication number Publication date
AU2892999A (en) 1999-10-25
DE69907894T2 (de) 2004-03-11
KR100591805B1 (ko) 2006-06-26
DK1068208T3 (da) 2003-09-01
CA2317567A1 (en) 1999-10-14
ES2199561T3 (es) 2004-02-16
WO1999051602A1 (en) 1999-10-14
JP2002510690A (ja) 2002-04-09
DE69907894D1 (de) 2003-06-18
EP1068208A1 (de) 2001-01-17
KR20010052173A (ko) 2001-06-25
EP1068208B1 (de) 2003-05-14
PT1068208E (pt) 2003-09-30
BR9907172A (pt) 2000-10-10
MXPA00009634A (es) 2005-06-20

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