JP2011026326A5 - - Google Patents
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- Publication number
- JP2011026326A5 JP2011026326A5 JP2010200674A JP2010200674A JP2011026326A5 JP 2011026326 A5 JP2011026326 A5 JP 2011026326A5 JP 2010200674 A JP2010200674 A JP 2010200674A JP 2010200674 A JP2010200674 A JP 2010200674A JP 2011026326 A5 JP2011026326 A5 JP 2011026326A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- hydrogen
- alkylcarbonyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 3
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000005093 alkyl carbonyl alkyl group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000005243 carbonyl alkyl group Chemical group 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 2
- 125000004967 formylalkyl group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000004995 haloalkylthio group Chemical group 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 125000005358 mercaptoalkyl group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004419 alkynylene group Chemical group 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/079,324 US20030158188A1 (en) | 2002-02-20 | 2002-02-20 | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| US10/364,210 US7074805B2 (en) | 2002-02-20 | 2003-02-11 | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569203A Division JP4614662B2 (ja) | 2002-02-20 | 2003-02-11 | バニロイド受容体サブタイプ１（ｖｒ１）受容体を阻害する縮合アザ二環式化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011026326A JP2011026326A (ja) | 2011-02-10 |
| JP2011026326A5 true JP2011026326A5 (enExample) | 2011-11-24 |
Family
ID=27759931
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569203A Expired - Fee Related JP4614662B2 (ja) | 2002-02-20 | 2003-02-11 | バニロイド受容体サブタイプ１（ｖｒ１）受容体を阻害する縮合アザ二環式化合物 |
| JP2010200674A Pending JP2011026326A (ja) | 2002-02-20 | 2010-09-08 | バニロイド受容体サブタイプ１（ｖｒ１）受容体を阻害する縮合アザ二環式化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569203A Expired - Fee Related JP4614662B2 (ja) | 2002-02-20 | 2003-02-11 | バニロイド受容体サブタイプ１（ｖｒ１）受容体を阻害する縮合アザ二環式化合物 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1478363B1 (enExample) |
| JP (2) | JP4614662B2 (enExample) |
| AT (1) | ATE420644T1 (enExample) |
| CA (1) | CA2476936A1 (enExample) |
| DE (1) | DE60325834D1 (enExample) |
| ES (1) | ES2319886T3 (enExample) |
| MX (1) | MXPA04008073A (enExample) |
| WO (1) | WO2003070247A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE416168T1 (de) * | 2002-02-15 | 2008-12-15 | Glaxo Group Ltd | Modulatoren des vanilloidrezeptors |
| DE60325834D1 (de) * | 2002-02-20 | 2009-03-05 | Abbott Lab | Kondensierte azabicyclischeverbindungen als inhibitoren des vanilloid-rezeptors 1 (vr1) |
| US7074805B2 (en) | 2002-02-20 | 2006-07-11 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| GB0206876D0 (en) * | 2002-03-22 | 2002-05-01 | Merck Sharp & Dohme | Therapeutic agents |
| US7183411B2 (en) * | 2002-07-12 | 2007-02-27 | Janssen Pharmaceutica N.V. | Naphthol, quinoline and isoquinoline-derived urea modulators of vanilloid VR1 receptor |
| EP2426122A1 (en) * | 2002-10-24 | 2012-03-07 | Merck Patent GmbH | Methylene urea derivative as RAF kinasse inhibitors |
| US6933311B2 (en) * | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| US7375126B2 (en) | 2003-06-12 | 2008-05-20 | Abbott Laboratories | Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| US7015233B2 (en) | 2003-06-12 | 2006-03-21 | Abbott Laboratories | Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor |
| PT1658269E (pt) * | 2003-06-12 | 2009-01-09 | Abbott Lab | Compostos condensados que inibem o receptor vanilóide de subtipo 1 (vr1) |
| TW200524909A (en) * | 2003-08-05 | 2005-08-01 | Abbott Lab | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| GB0319150D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
| GB0322016D0 (en) * | 2003-09-19 | 2003-10-22 | Merck Sharp & Dohme | New compounds |
| EP1679296A4 (en) | 2003-10-14 | 2007-12-26 | Ajinomoto Kk | DERIVE ETHERE |
| EP1678123A1 (en) * | 2003-10-15 | 2006-07-12 | Bayer HealthCare AG | Tetrahydro-naphthalene and urea derivatives |
| WO2005044802A2 (en) | 2003-11-08 | 2005-05-19 | Bayer Healthcare Ag | Tetrahydro-quinolinylurea derivatives as vrl antagonists |
| KR101042490B1 (ko) * | 2004-07-15 | 2011-06-16 | 니뽄 다바코 산교 가부시키가이샤 | 축합 벤즈아미드 화합물 및 바닐로이드 수용체 1형(ｖｒ1)활성 저해제 |
| KR20060087386A (ko) | 2005-01-28 | 2006-08-02 | 주식회사 대웅제약 | 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물 |
| US7402596B2 (en) * | 2005-03-24 | 2008-07-22 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| DE102005023943A1 (de) | 2005-05-20 | 2006-11-23 | Grünenthal GmbH | Pentafluorsulfanyl-substituierte Verbindung und deren Verwendung zur Herstellung von Arzneimitteln |
| US7906508B2 (en) | 2005-12-28 | 2011-03-15 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity |
| AU2007238071B2 (en) * | 2006-04-18 | 2012-06-07 | Abbvie Inc. | Antagonists of the vanilloid receptor subtype 1 (VR1) and uses thereof |
| CA2661898A1 (en) | 2006-08-25 | 2008-02-28 | Abbott Laboratories | Indazole derivatives that inhibit trpv1 and uses thereof |
| JP2010513557A (ja) | 2006-12-20 | 2010-04-30 | アボット・ラボラトリーズ | 疼痛治療のためのｔｒｐｖ１バニロイド受容体アンタゴニストとしてのｎ−（５，６，７，８−テトラヒドロナフタレン−１−イル）尿素誘導体および関連化合物 |
| US8093265B2 (en) | 2007-03-09 | 2012-01-10 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| AU2008238250B2 (en) * | 2007-04-16 | 2013-01-24 | Grunenthal Gmbh | Novel vanilloid receptor ligands and the use thereof for the production of pharmaceuticals |
| DE102007018149A1 (de) | 2007-04-16 | 2008-10-23 | Grünenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
| WO2009096701A2 (en) | 2008-01-28 | 2009-08-06 | Amorepacific Corporation | Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same |
| US8232411B2 (en) | 2008-03-20 | 2012-07-31 | Abbott Laboratories | Methods for making central nervous system agents that are TRPV1 antagonists |
| CN101983197B (zh) | 2008-04-18 | 2015-04-22 | 大熊制药株式会社 | 新型苯并噁嗪苯并咪唑衍生物、含有该衍生物的药物组合物及其用途 |
| JP5438103B2 (ja) | 2008-07-02 | 2014-03-12 | アモーレパシフィック コーポレイション | バニロイド受容体アンタゴニストとしての新規化合物、その異性体またはその薬学的に許容される塩、並びにそれを含む医薬組成物 |
| KR101605061B1 (ko) | 2009-05-29 | 2016-03-21 | 라퀄리아 파마 인코포레이티드 | 칼슘 또는 나트륨 채널 차단제로서의 아릴 치환된 카복사미드 유도체 |
| KR101293384B1 (ko) | 2010-10-13 | 2013-08-05 | 주식회사 대웅제약 | 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도 |
| NZ627750A (en) | 2012-01-06 | 2016-11-25 | Abide Therapeutics Inc | Carbamate compounds and of making and using same |
| WO2015091965A2 (en) * | 2013-12-19 | 2015-06-25 | Lanxess Deutschland Gmbh | Process for the production of phthalimides |
| US10450302B2 (en) * | 2015-05-11 | 2019-10-22 | Lundbeck La Jolla Research Center, Inc. | Methods of treating inflammation or neuropathic pain |
| CN107033087B (zh) * | 2016-02-04 | 2020-09-04 | 西华大学 | 1h-吲唑-4-胺类化合物及其作为ido抑制剂的用途 |
| CN105906564B (zh) * | 2016-05-05 | 2018-11-30 | 海南省药物研究所 | 化合物、制备方法及其用途 |
| CA3043609A1 (en) | 2016-11-16 | 2018-05-24 | Abide Therapeutics, Inc. | Pharmaceutical formulations |
| PL3541807T3 (pl) | 2016-11-16 | 2022-01-17 | H. Lundbeck A/S | Krystaliczna postać inhibitora magl |
| US10696638B2 (en) * | 2017-12-26 | 2020-06-30 | Industrial Technology Research Institute | Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same |
| DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3043694A (en) * | 1960-05-23 | 1962-07-10 | Eastman Kodak Co | Novel class of 3-indazolinone developing agent |
| FR1344579A (fr) * | 1961-11-23 | 1963-11-29 | Sandoz Sa | Nouveaux dérivés de l'indole et leur préparation |
| JPS5587771A (en) * | 1978-12-27 | 1980-07-02 | Teikoku Hormone Mfg Co Ltd | 1-phenylisoquinoline derivative |
| DE3430310A1 (de) * | 1984-08-15 | 1986-02-27 | Schering AG, Berlin und Bergkamen, 1000 Berlin | Neue dopamin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPS62116559A (ja) * | 1985-11-18 | 1987-05-28 | Sagami Chem Res Center | ４−アシルメチリデン−４，５，６，７−テトラヒドロインド−ル誘導体及びその製造方法 |
| US4788206A (en) * | 1987-07-10 | 1988-11-29 | Hoffmann-La Roche Inc. | Pentadieneamides |
| US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
| US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
| WO1991004027A1 (en) * | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
| JPH05504968A (ja) * | 1990-03-07 | 1993-07-29 | ローン―プーラン・ロレ・ソシエテ・アノニム | グリシンアミド誘導体、その製造及びそれを含む医薬品 |
| GB9307833D0 (en) * | 1993-04-15 | 1993-06-02 | Glaxo Inc | Modulators of cholecystokinin and gastrin |
| JPH1087629A (ja) * | 1996-09-18 | 1998-04-07 | Fujisawa Pharmaceut Co Ltd | 新規イソキノリン誘導体、およびその医薬用途 |
| EP1154989B1 (en) * | 1999-02-22 | 2005-12-14 | Pacific Corporation | Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof |
| JP2001122895A (ja) * | 1999-10-20 | 2001-05-08 | Hamari Chemicals Ltd | 新規なオピオイドペプチド誘導体 |
| KR20030010589A (ko) * | 2000-03-09 | 2003-02-05 | 오노 야꾸힝 고교 가부시키가이샤 | 인돌 유도체, 그 제조 방법 및 용도 |
| AU2001271357A1 (en) * | 2000-06-21 | 2002-01-02 | Dupont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| IL153884A0 (en) * | 2000-07-20 | 2003-07-31 | Neurogen Corp | Capsaicin receptor ligands |
| TWI239942B (en) * | 2001-06-11 | 2005-09-21 | Dainippon Pharmaceutical Co | N-arylphenylacetamide derivative and pharmaceutical composition containing the same |
| JP2005501873A (ja) * | 2001-07-31 | 2005-01-20 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | アミン誘導体 |
| MY138086A (en) * | 2001-09-13 | 2009-04-30 | Smithkline Beecham Plc | Novel urea derivative as vanilloid receptor-1 antagonist |
| JP2004339061A (ja) * | 2001-09-28 | 2004-12-02 | Takeda Chem Ind Ltd | ベンゼン誘導体、その製造法および用途 |
| MXPA04005427A (es) * | 2001-12-10 | 2005-04-19 | Amgen Inc | Ligandos de receptor vainilloide y su uso en tratamientos. |
| GB0130550D0 (en) * | 2001-12-20 | 2002-02-06 | Smithkline Beecham Plc | Novel compounds |
| JP2003192587A (ja) * | 2001-12-26 | 2003-07-09 | Bayer Ag | 尿素誘導体 |
| JP2003192659A (ja) * | 2001-12-26 | 2003-07-09 | Bayer Ag | フェニル尿素誘導体 |
| DE60325834D1 (de) * | 2002-02-20 | 2009-03-05 | Abbott Lab | Kondensierte azabicyclischeverbindungen als inhibitoren des vanilloid-rezeptors 1 (vr1) |
| US6933311B2 (en) * | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
-
2003
- 2003-02-11 DE DE60325834T patent/DE60325834D1/de not_active Expired - Lifetime
- 2003-02-11 CA CA002476936A patent/CA2476936A1/en not_active Abandoned
- 2003-02-11 JP JP2003569203A patent/JP4614662B2/ja not_active Expired - Fee Related
- 2003-02-11 ES ES03716014T patent/ES2319886T3/es not_active Expired - Lifetime
- 2003-02-11 WO PCT/US2003/004187 patent/WO2003070247A1/en not_active Ceased
- 2003-02-11 MX MXPA04008073A patent/MXPA04008073A/es active IP Right Grant
- 2003-02-11 EP EP03716014A patent/EP1478363B1/en not_active Expired - Lifetime
- 2003-02-11 AT AT03716014T patent/ATE420644T1/de not_active IP Right Cessation
-
2010
- 2010-09-08 JP JP2010200674A patent/JP2011026326A/ja active Pending
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