JP2011026326A5 - - Google Patents
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- Publication number
- JP2011026326A5 JP2011026326A5 JP2010200674A JP2010200674A JP2011026326A5 JP 2011026326 A5 JP2011026326 A5 JP 2011026326A5 JP 2010200674 A JP2010200674 A JP 2010200674A JP 2010200674 A JP2010200674 A JP 2010200674A JP 2011026326 A5 JP2011026326 A5 JP 2011026326A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- hydrogen
- alkylcarbonyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 3
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000005093 alkyl carbonyl alkyl group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000005243 carbonyl alkyl group Chemical group 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 2
- 125000004967 formylalkyl group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000004995 haloalkylthio group Chemical group 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 125000005358 mercaptoalkyl group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004419 alkynylene group Chemical group 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/079,324 US20030158188A1 (en) | 2002-02-20 | 2002-02-20 | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| US10/364,210 US7074805B2 (en) | 2002-02-20 | 2003-02-11 | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569203A Division JP4614662B2 (ja) | 2002-02-20 | 2003-02-11 | バニロイド受容体サブタイプ１（ｖｒ１）受容体を阻害する縮合アザ二環式化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011026326A JP2011026326A (ja) | 2011-02-10 |
| JP2011026326A5 true JP2011026326A5 (enExample) | 2011-11-24 |
Family
ID=27759931
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569203A Expired - Fee Related JP4614662B2 (ja) | 2002-02-20 | 2003-02-11 | バニロイド受容体サブタイプ１（ｖｒ１）受容体を阻害する縮合アザ二環式化合物 |
| JP2010200674A Pending JP2011026326A (ja) | 2002-02-20 | 2010-09-08 | バニロイド受容体サブタイプ１（ｖｒ１）受容体を阻害する縮合アザ二環式化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003569203A Expired - Fee Related JP4614662B2 (ja) | 2002-02-20 | 2003-02-11 | バニロイド受容体サブタイプ１（ｖｒ１）受容体を阻害する縮合アザ二環式化合物 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1478363B1 (enExample) |
| JP (2) | JP4614662B2 (enExample) |
| AT (1) | ATE420644T1 (enExample) |
| CA (1) | CA2476936A1 (enExample) |
| DE (1) | DE60325834D1 (enExample) |
| ES (1) | ES2319886T3 (enExample) |
| MX (1) | MXPA04008073A (enExample) |
| WO (1) | WO2003070247A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2033953A1 (en) * | 2002-02-15 | 2009-03-11 | Glaxo Group Limited | Vanilloid receptor modulators |
| CA2476936A1 (en) * | 2002-02-20 | 2003-08-28 | Chih-Hung Lee | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor |
| US7074805B2 (en) | 2002-02-20 | 2006-07-11 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| GB0206876D0 (en) | 2002-03-22 | 2002-05-01 | Merck Sharp & Dohme | Therapeutic agents |
| AU2003251828A1 (en) * | 2002-07-12 | 2004-02-02 | Janssen Pharmaceutica N.V. | Naphthol, quinoline and isoquinoline-derivatives as modulators of vanilloid vr1 receptor |
| EP2426122A1 (en) * | 2002-10-24 | 2012-03-07 | Merck Patent GmbH | Methylene urea derivative as RAF kinasse inhibitors |
| US6933311B2 (en) * | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| US7375126B2 (en) | 2003-06-12 | 2008-05-20 | Abbott Laboratories | Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
| US7015233B2 (en) | 2003-06-12 | 2006-03-21 | Abbott Laboratories | Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor |
| PL2017265T3 (pl) * | 2003-06-12 | 2011-11-30 | Abbvie Inc | Związki z pierścieniami skondensowanymi hamujące receptor waniloidowy podtypu 1 (VR1) |
| CA2743534A1 (en) * | 2003-08-05 | 2005-02-24 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor |
| GB0319150D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
| GB0322016D0 (en) * | 2003-09-19 | 2003-10-22 | Merck Sharp & Dohme | New compounds |
| JP4935073B2 (ja) * | 2003-10-14 | 2012-05-23 | 味の素株式会社 | エーテル誘導体 |
| JP2007509846A (ja) * | 2003-10-15 | 2007-04-19 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | テトラヒドロ−ナフタレンおよび尿素誘導体 |
| US7683076B2 (en) | 2003-11-08 | 2010-03-23 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydro-quinolinylurea derivatives |
| CA2571133C (en) * | 2004-07-15 | 2011-04-19 | Japan Tobacco Inc. | Fused benzamide compound and vanilloid receptor 1 (vr1) activity inhibitor |
| KR20060087386A (ko) | 2005-01-28 | 2006-08-02 | 주식회사 대웅제약 | 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물 |
| US7297700B2 (en) * | 2005-03-24 | 2007-11-20 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| DE102005023943A1 (de) | 2005-05-20 | 2006-11-23 | Grünenthal GmbH | Pentafluorsulfanyl-substituierte Verbindung und deren Verwendung zur Herstellung von Arzneimitteln |
| US7906508B2 (en) | 2005-12-28 | 2011-03-15 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity |
| BRPI0710507A2 (pt) * | 2006-04-18 | 2011-08-16 | Abbott Lab | Antagonistas do receptor vanilóide de subtipo 1 (vr1) e usos destes |
| ATE553093T1 (de) | 2006-08-25 | 2012-04-15 | Abbott Lab | Indazolderivate zur hemmung von trpv1 und verwendungen davon |
| CN101563318A (zh) | 2006-12-20 | 2009-10-21 | 艾博特公司 | 作为trpv1香草素受体拮抗剂用于治疗疼痛的n-(5,6,7,8-四氢萘-1-基)脲衍生物以及相关化合物 |
| DK2124562T3 (en) | 2007-03-09 | 2016-08-01 | Second Genome Inc | BICYCLOHETEROARYLFORBINDELSER AS P2X7 modulators and uses thereof |
| KR20100016593A (ko) * | 2007-04-16 | 2010-02-12 | 그뤼넨탈 게엠베하 | 신규한 바닐로이드 수용체 리간드 및 약제의 제조를 위한 이의 용도 |
| DE102007018149A1 (de) | 2007-04-16 | 2008-10-23 | Grünenthal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
| KR101619341B1 (ko) | 2008-01-28 | 2016-05-11 | (주)아모레퍼시픽 | 바닐로이드 수용체 길항체로서의 신규 화합물, 이의 이성질체 또는 약제학적으로 허용가능한 염, 및 이를 함유하는 약학 조성물 |
| CA2719018A1 (en) | 2008-03-20 | 2009-09-24 | Abbott Laboratories | Methods for making central nervous system agents that are trpv1 antagonists |
| NZ587771A (en) | 2008-04-18 | 2011-05-27 | Dae Woong Pharma | Novel benzoxazine benzimidazole derivatives, pharmaceutical composition comprising same, and a use thereof |
| US8691855B2 (en) | 2008-07-02 | 2014-04-08 | Amorepacific Corporation | Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist and pharmaceutical compositions containing the same |
| JP5685203B2 (ja) * | 2009-05-29 | 2015-03-18 | ラクオリア創薬株式会社 | カルシウムチャネル遮断薬またはナトリウムチャネル遮断薬としてのアリール置換カルボキサミド誘導体 |
| KR101293384B1 (ko) | 2010-10-13 | 2013-08-05 | 주식회사 대웅제약 | 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도 |
| PL2800565T3 (pl) | 2012-01-06 | 2020-09-21 | Lundbeck La Jolla Research Center, Inc. | Związki karbaminianowe i sposoby ich wytwarzania oraz zastosowanie |
| US9701632B2 (en) * | 2013-12-19 | 2017-07-11 | Lanxess Deutschland Gmbh | Process for the production of phthalimides |
| AU2016262459A1 (en) * | 2015-05-11 | 2017-12-21 | H. Lundbeck A/S. | Methods of treating inflammation or neuropathic pain |
| CN107033087B (zh) * | 2016-02-04 | 2020-09-04 | 西华大学 | 1h-吲唑-4-胺类化合物及其作为ido抑制剂的用途 |
| CN105906564B (zh) * | 2016-05-05 | 2018-11-30 | 海南省药物研究所 | 化合物、制备方法及其用途 |
| CA3043610A1 (en) | 2016-11-16 | 2018-05-24 | Abide Therapeutics, Inc. | Crystalline forms of a magl inhibitor |
| BR112019009992A2 (pt) | 2016-11-16 | 2019-08-27 | Abide Therapeutics Inc | formulações farmacêuticas |
| US10696638B2 (en) * | 2017-12-26 | 2020-06-30 | Industrial Technology Research Institute | Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same |
| DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3043694A (en) * | 1960-05-23 | 1962-07-10 | Eastman Kodak Co | Novel class of 3-indazolinone developing agent |
| FR1344579A (fr) * | 1961-11-23 | 1963-11-29 | Sandoz Sa | Nouveaux dérivés de l'indole et leur préparation |
| JPS5587771A (en) * | 1978-12-27 | 1980-07-02 | Teikoku Hormone Mfg Co Ltd | 1-phenylisoquinoline derivative |
| DE3430310A1 (de) * | 1984-08-15 | 1986-02-27 | Schering AG, Berlin und Bergkamen, 1000 Berlin | Neue dopamin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPS62116559A (ja) * | 1985-11-18 | 1987-05-28 | Sagami Chem Res Center | ４−アシルメチリデン−４，５，６，７−テトラヒドロインド−ル誘導体及びその製造方法 |
| US4788206A (en) * | 1987-07-10 | 1988-11-29 | Hoffmann-La Roche Inc. | Pentadieneamides |
| US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
| US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
| WO1991004027A1 (en) * | 1989-09-15 | 1991-04-04 | Pfizer Inc. | New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
| WO1991013874A1 (fr) * | 1990-03-07 | 1991-09-19 | Rhone-Poulenc Rorer S.A. | Derives de glycinamide, leur preparation et les medicaments les contenant |
| GB9307833D0 (en) * | 1993-04-15 | 1993-06-02 | Glaxo Inc | Modulators of cholecystokinin and gastrin |
| JPH1087629A (ja) * | 1996-09-18 | 1998-04-07 | Fujisawa Pharmaceut Co Ltd | 新規イソキノリン誘導体、およびその医薬用途 |
| WO2000050387A1 (en) * | 1999-02-22 | 2000-08-31 | Pacific Corporation | Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof |
| JP2001122895A (ja) * | 1999-10-20 | 2001-05-08 | Hamari Chemicals Ltd | 新規なオピオイドペプチド誘導体 |
| NZ521192A (en) * | 2000-03-09 | 2005-01-28 | Ono Pharmaceutical Co | Indole derivatives, process for preparation of the same and use thereof |
| JP2004517803A (ja) * | 2000-06-21 | 2004-06-17 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | ケモカイン受容体活性調節剤としてのｎ−ウレイドアルキル−ピペリジン |
| EP1301484A2 (en) * | 2000-07-20 | 2003-04-16 | Neurogen Corporation | Capsaicin receptor ligands |
| TWI239942B (en) * | 2001-06-11 | 2005-09-21 | Dainippon Pharmaceutical Co | N-arylphenylacetamide derivative and pharmaceutical composition containing the same |
| AU2002325381A1 (en) * | 2001-07-31 | 2003-02-24 | Bayer Healthcare Ag | Naphthylurea and naphthylacetamide derivatives as vanilloid receptor 1 (vr1) antagonists |
| TWI283665B (en) * | 2001-09-13 | 2007-07-11 | Smithkline Beecham Plc | Novel urea compound, pharmaceutical composition containing the same and its use |
| JP2004339061A (ja) * | 2001-09-28 | 2004-12-02 | Takeda Chem Ind Ltd | ベンゼン誘導体、その製造法および用途 |
| PL373484A1 (en) * | 2001-12-10 | 2005-09-05 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| GB0130550D0 (en) * | 2001-12-20 | 2002-02-06 | Smithkline Beecham Plc | Novel compounds |
| JP2003192587A (ja) * | 2001-12-26 | 2003-07-09 | Bayer Ag | 尿素誘導体 |
| JP2003192659A (ja) * | 2001-12-26 | 2003-07-09 | Bayer Ag | フェニル尿素誘導体 |
| CA2476936A1 (en) * | 2002-02-20 | 2003-08-28 | Chih-Hung Lee | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor |
| US6933311B2 (en) * | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
-
2003
- 2003-02-11 CA CA002476936A patent/CA2476936A1/en not_active Abandoned
- 2003-02-11 DE DE60325834T patent/DE60325834D1/de not_active Expired - Lifetime
- 2003-02-11 EP EP03716014A patent/EP1478363B1/en not_active Expired - Lifetime
- 2003-02-11 AT AT03716014T patent/ATE420644T1/de not_active IP Right Cessation
- 2003-02-11 MX MXPA04008073A patent/MXPA04008073A/es active IP Right Grant
- 2003-02-11 ES ES03716014T patent/ES2319886T3/es not_active Expired - Lifetime
- 2003-02-11 WO PCT/US2003/004187 patent/WO2003070247A1/en not_active Ceased
- 2003-02-11 JP JP2003569203A patent/JP4614662B2/ja not_active Expired - Fee Related
-
2010
- 2010-09-08 JP JP2010200674A patent/JP2011026326A/ja active Pending
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