ATE467633T1 - 2-aryl-6-phenylimidazoä1,2-aüpyridin-derivate, ihre herstellung und therapeutische verwendung - Google Patents

2-aryl-6-phenylimidazoä1,2-aüpyridin-derivate, ihre herstellung und therapeutische verwendung

Info

Publication number
ATE467633T1
ATE467633T1 AT07848251T AT07848251T ATE467633T1 AT E467633 T1 ATE467633 T1 AT E467633T1 AT 07848251 T AT07848251 T AT 07848251T AT 07848251 T AT07848251 T AT 07848251T AT E467633 T1 ATE467633 T1 AT E467633T1
Authority
AT
Austria
Prior art keywords
aüpyridine
aryl
derivatives
preparation
therapeutic use
Prior art date
Application number
AT07848251T
Other languages
English (en)
Inventor
Garcia Antonio Almario
Patrick Lardenois
Anne Olivier
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Application granted granted Critical
Publication of ATE467633T1 publication Critical patent/ATE467633T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT07848251T 2006-09-22 2007-09-19 2-aryl-6-phenylimidazoä1,2-aüpyridin-derivate, ihre herstellung und therapeutische verwendung ATE467633T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0608350A FR2906250B1 (fr) 2006-09-22 2006-09-22 Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique
PCT/FR2007/001517 WO2008034974A1 (fr) 2006-09-22 2007-09-19 DERIVES DE 2-ARYL-6-PHENYL-IMIDAZO[1,2-α]PYRIDINES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (1)

Publication Number Publication Date
ATE467633T1 true ATE467633T1 (de) 2010-05-15

Family

ID=37841968

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07848251T ATE467633T1 (de) 2006-09-22 2007-09-19 2-aryl-6-phenylimidazoä1,2-aüpyridin-derivate, ihre herstellung und therapeutische verwendung

Country Status (43)

Country Link
US (1) US7915284B2 (de)
EP (1) EP2069342B1 (de)
JP (1) JP5336378B2 (de)
KR (1) KR101470039B1 (de)
CN (1) CN101516881B (de)
AR (1) AR062897A1 (de)
AT (1) ATE467633T1 (de)
AU (1) AU2007298856B2 (de)
BR (1) BRPI0718517A2 (de)
CA (1) CA2662848C (de)
CL (1) CL2007002733A1 (de)
CO (1) CO6160308A2 (de)
CR (1) CR10643A (de)
CY (1) CY1110232T1 (de)
DE (1) DE602007006525D1 (de)
DK (1) DK2069342T3 (de)
EA (1) EA017442B1 (de)
ES (1) ES2345016T3 (de)
FR (1) FR2906250B1 (de)
GT (1) GT200900049A (de)
HN (1) HN2009000502A (de)
HR (1) HRP20100408T1 (de)
IL (1) IL197352A (de)
JO (1) JO2643B1 (de)
MA (1) MA30792B1 (de)
ME (1) ME00615B (de)
MX (1) MX2009002802A (de)
MY (1) MY145603A (de)
NI (1) NI200900037A (de)
NO (1) NO20091562L (de)
NZ (1) NZ575337A (de)
PE (1) PE20080671A1 (de)
PL (1) PL2069342T3 (de)
PT (1) PT2069342E (de)
RS (1) RS51412B (de)
SI (1) SI2069342T1 (de)
SV (1) SV2009003193A (de)
TN (1) TN2009000081A1 (de)
TW (1) TWI381837B (de)
UA (1) UA95976C2 (de)
UY (1) UY30603A1 (de)
WO (1) WO2008034974A1 (de)
ZA (1) ZA200901551B (de)

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FR2928924B1 (fr) 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
FR2928922B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
FR2928921B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines, leur preparation et leur application en therapeutique
FR2928923B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques
FR2933609B1 (fr) * 2008-07-10 2010-08-27 Fournier Lab Sa Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson.
FR2950344B1 (fr) * 2009-09-18 2011-11-25 Sanofi Aventis Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique.
FR2950345B1 (fr) * 2009-09-18 2011-09-23 Sanofi Aventis Derives acetyleniques de 5-phenyl-pyrazolopyridine, leur preparation et leur application en therapeutique
FR2953520B1 (fr) * 2009-12-04 2011-11-25 Sanofi Aventis Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique
RU2644949C2 (ru) * 2012-11-29 2018-02-15 Ф. Хоффманн-Ля Рош Аг Производные имидазопиридина, стимулирующие нейрогенез
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
US9079866B2 (en) 2013-02-04 2015-07-14 Janssen Pharmaceutica Nv Flap modulators
CN105745208A (zh) * 2013-08-02 2016-07-06 韩国巴斯德研究所 一种抗感染化合物
CN107531693B (zh) 2015-04-10 2021-07-06 百济神州有限公司 作为吲哚胺、色氨酸二加氧酶抑制剂的5或8-取代的咪唑并[1，5-a]吡啶
US20170107216A1 (en) 2015-10-19 2017-04-20 Incyte Corporation Heterocyclic compounds as immunomodulators
AU2016358100B2 (en) 2015-11-19 2021-05-27 Incyte Corporation Heterocyclic compounds as immunomodulators
TW201726623A (zh) 2015-12-17 2017-08-01 英塞特公司 作為免疫調節劑之雜環化合物
TWI850624B (zh) 2015-12-22 2024-08-01 美商英塞特公司 作為免疫調節劑之雜環化合物
TW201808950A (zh) 2016-05-06 2018-03-16 英塞特公司 作為免疫調節劑之雜環化合物
US20170342060A1 (en) 2016-05-26 2017-11-30 Incyte Corporation Heterocyclic compounds as immunomodulators
DK3472167T3 (da) 2016-06-20 2022-09-05 Incyte Corp Heterocykliske forbindelser som immunomodulatorer
EP3484866B1 (de) 2016-07-14 2022-09-07 Incyte Corporation Heterocyclische verbindungen als immunmodulatoren
EP3504198B1 (de) 2016-08-29 2023-01-25 Incyte Corporation Heterocyclische verbindungen als immunmodulatoren
US10882856B2 (en) 2016-09-24 2021-01-05 Beigene, Ltd. 5 or 8-substituted imidazo [1,5-a] pyridines as selective inhibitors of indoleamine and/or tryptophane 2,3-dioxygenases
IL295660A (en) 2016-12-22 2022-10-01 Incyte Corp Benzooxazole derivatives as immunomodulators
ES2929193T3 (es) 2016-12-22 2022-11-25 Incyte Corp Derivados de tetrahidro imidazo[4,5-c]piridina como inductores de la internalización de PD-L1
EP3558963B1 (de) 2016-12-22 2022-03-23 Incyte Corporation Bicyclische heteroaromatische verbindungen als immunmodulatoren
ES2874756T3 (es) 2016-12-22 2021-11-05 Incyte Corp Derivados de triazolo[1,5-A]piridina como inmunomoduladores
EP3558973B1 (de) 2016-12-22 2021-09-15 Incyte Corporation Pyridinderivate als immunmodulatoren
WO2019101188A1 (en) 2017-11-25 2019-05-31 Beigene, Ltd. Novel benzoimidazoles as selective inhibitors of indoleamine 2, 3-dioxygenases
RS64055B1 (sr) 2018-03-30 2023-04-28 Incyte Corp Heterociklična jedinjenja kao imunomodulatori
EP4219492B1 (de) 2018-05-11 2024-11-27 Incyte Corporation Heterocyclische verbindungen als immunmodulatoren
JP7665593B2 (ja) 2019-08-09 2025-04-21 インサイト・コーポレイション Ｐｄ－１／ｐｄ－ｌ１阻害剤の塩
EP4037773A1 (de) 2019-09-30 2022-08-10 Incyte Corporation Pyrido[3,2-d]pyrimidin-verbindungen als immunmodulatoren
BR112022009031A2 (pt) 2019-11-11 2022-10-11 Incyte Corp Sais e formas cristalinas de um inibidor de pd-1/pd-l1
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US11760756B2 (en) 2020-11-06 2023-09-19 Incyte Corporation Crystalline form of a PD-1/PD-L1 inhibitor
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Also Published As

Publication number Publication date
CN101516881A (zh) 2009-08-26
JP2010504309A (ja) 2010-02-12
EA200970311A1 (ru) 2009-08-28
KR101470039B1 (ko) 2014-12-05
DE602007006525D1 (de) 2010-06-24
HN2009000502A (es) 2011-07-11
NO20091562L (no) 2009-04-20
CA2662848C (fr) 2014-12-23
HK1135388A1 (en) 2010-06-04
CR10643A (es) 2009-04-29
NZ575337A (en) 2011-12-22
AU2007298856B2 (en) 2012-08-09
IL197352A (en) 2014-11-30
HRP20100408T1 (hr) 2010-09-30
ZA200901551B (en) 2010-06-30
UY30603A1 (es) 2008-05-02
TWI381837B (zh) 2013-01-11
CL2007002733A1 (es) 2008-04-11
AU2007298856A1 (en) 2008-03-27
DK2069342T3 (da) 2010-08-23
BRPI0718517A2 (pt) 2013-11-19
MEP10709A (en) 2011-12-20
FR2906250A1 (fr) 2008-03-28
CO6160308A2 (es) 2010-05-20
NI200900037A (es) 2014-02-20
EA017442B1 (ru) 2012-12-28
TW200833329A (en) 2008-08-16
EP2069342A1 (de) 2009-06-17
SV2009003193A (es) 2010-02-01
JO2643B1 (en) 2012-06-17
RS51412B (sr) 2011-02-28
CY1110232T1 (el) 2015-01-14
PE20080671A1 (es) 2008-07-14
PT2069342E (pt) 2010-07-19
PL2069342T3 (pl) 2010-10-29
US7915284B2 (en) 2011-03-29
MY145603A (en) 2012-03-15
AR062897A1 (es) 2008-12-10
WO2008034974A1 (fr) 2008-03-27
CA2662848A1 (fr) 2008-03-27
MX2009002802A (es) 2009-04-01
KR20090054449A (ko) 2009-05-29
JP5336378B2 (ja) 2013-11-06
FR2906250B1 (fr) 2008-10-31
UA95976C2 (en) 2011-09-26
MA30792B1 (fr) 2009-10-01
IL197352A0 (en) 2009-12-24
ES2345016T3 (es) 2010-09-13
GT200900049A (es) 2010-03-04
ME00615B (me) 2011-12-20
CN101516881B (zh) 2012-07-18
TN2009000081A1 (en) 2010-08-19
SI2069342T1 (sl) 2010-09-30
US20090253735A1 (en) 2009-10-08
EP2069342B1 (de) 2010-05-12

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