ATE461930T1 - Harnstoffderivate von tropan, ihre herstellung und ihre therapeutische anwendung - Google Patents
Harnstoffderivate von tropan, ihre herstellung und ihre therapeutische anwendungInfo
- Publication number
- ATE461930T1 ATE461930T1 AT07803782T AT07803782T ATE461930T1 AT E461930 T1 ATE461930 T1 AT E461930T1 AT 07803782 T AT07803782 T AT 07803782T AT 07803782 T AT07803782 T AT 07803782T AT E461930 T1 ATE461930 T1 AT E461930T1
- Authority
- AT
- Austria
- Prior art keywords
- tropan
- production
- therapeutic use
- urea derivatives
- urea
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0605785A FR2902791B1 (fr) | 2006-06-27 | 2006-06-27 | Derives d'urees de tropane,leur preparation et leur application en therapeutique |
FR0700507A FR2911874B1 (fr) | 2007-01-25 | 2007-01-25 | Derives d'urees de tropane, leur preparation et leur application en therapeutique |
PCT/FR2007/001070 WO2008000951A2 (fr) | 2006-06-27 | 2007-06-26 | Dérivés d'urees de tropane, leur préparation et leur application en thérapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE461930T1 true ATE461930T1 (de) | 2010-04-15 |
Family
ID=38820110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07803782T ATE461930T1 (de) | 2006-06-27 | 2007-06-26 | Harnstoffderivate von tropan, ihre herstellung und ihre therapeutische anwendung |
Country Status (23)
Country | Link |
---|---|
US (2) | US7897773B2 (de) |
EP (1) | EP2046791B1 (de) |
JP (1) | JP2009541464A (de) |
KR (1) | KR20090021193A (de) |
AR (1) | AR061642A1 (de) |
AT (1) | ATE461930T1 (de) |
AU (1) | AU2007264792A1 (de) |
CA (1) | CA2648769A1 (de) |
CL (1) | CL2007001885A1 (de) |
CY (1) | CY1110132T1 (de) |
DE (1) | DE602007005487D1 (de) |
DK (1) | DK2046791T3 (de) |
ES (1) | ES2342793T3 (de) |
IL (1) | IL195510A0 (de) |
MX (1) | MX277822B (de) |
PE (1) | PE20080344A1 (de) |
PL (1) | PL2046791T3 (de) |
PT (1) | PT2046791E (de) |
RU (1) | RU2009102535A (de) |
SI (1) | SI2046791T1 (de) |
TW (1) | TW200811170A (de) |
UY (1) | UY30447A1 (de) |
WO (1) | WO2008000951A2 (de) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA200900154B (en) | 2006-06-27 | 2010-03-31 | Takeda Pharmaceutical | Fused cyclic compounds |
WO2008106128A2 (en) | 2007-02-26 | 2008-09-04 | Vitae Pharmaceuticals, Inc. | CYCLIC UREA AND CARBAMATE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1 |
JP5451611B2 (ja) * | 2007-07-26 | 2014-03-26 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1のサイクリックインヒビター |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
JP5769970B2 (ja) | 2007-11-16 | 2015-08-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
US8440658B2 (en) | 2007-12-11 | 2013-05-14 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
TW200934490A (en) * | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
WO2009094169A1 (en) * | 2008-01-24 | 2009-07-30 | Vitae Pharmaceuticals, Inc. | Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
TW200936136A (en) * | 2008-01-28 | 2009-09-01 | Sanofi Aventis | Tetrahydroquinoxaline urea derivatives, their preparation and their therapeutic application |
FR2934858B1 (fr) * | 2008-08-08 | 2010-08-27 | Sanofi Aventis | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
FR2926817B1 (fr) * | 2008-01-28 | 2010-02-26 | Sanofi Aventis | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
JP5538239B2 (ja) * | 2008-02-12 | 2014-07-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベンゾモルファン及び関連骨格の尿素誘導体、そのような化合物を含む医薬ならびにそれらの使用 |
EP2254872A2 (de) * | 2008-02-15 | 2010-12-01 | Vitae Pharmaceuticals, Inc. | Cycloalkyllactamderivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
CA2723034A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
RU2531272C2 (ru) | 2008-05-01 | 2014-10-20 | Вайтаи Фармасьютиклз, Инк. | Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1 |
US8569292B2 (en) | 2008-05-01 | 2013-10-29 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
US8765780B2 (en) | 2008-05-13 | 2014-07-01 | Boehringer Ingelheim International Gmbh | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
JP5777030B2 (ja) | 2008-07-25 | 2015-09-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の阻害剤 |
EP2324018B1 (de) | 2008-07-25 | 2013-09-04 | Boehringer Ingelheim International GmbH | Cyclische inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1 |
CA2735204C (en) * | 2008-08-25 | 2017-06-20 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use |
EP2350068B1 (de) * | 2008-10-23 | 2017-08-30 | Boehringer Ingelheim International GmbH | Harnstoffderivate substituierter nortropane, medikamente, die solche verbindungen enthalten, und ihre verwendung |
US8637505B2 (en) | 2009-02-04 | 2014-01-28 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
UA109255C2 (ru) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1 |
EP2438049B1 (de) | 2009-06-02 | 2014-05-14 | Boehringer Ingelheim International GmbH | Cyclische inhibitoren von 11beta-hydroxysteroiddehydrogenase 1 |
ES2350077B1 (es) | 2009-06-04 | 2011-11-04 | Laboratorios Salvat, S.A. | Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1. |
US8927539B2 (en) | 2009-06-11 | 2015-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure |
JP5749263B2 (ja) | 2009-07-01 | 2015-07-15 | ヴァイティー ファーマシューティカルズ,インコーポレイテッド | 11β−ヒドロキシステロイドデヒドロゲナーゼ1の環状インヒビター |
FR2948369B1 (fr) | 2009-07-27 | 2013-04-12 | Sanofi Aventis | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
FR2948370B1 (fr) * | 2009-07-27 | 2013-04-05 | Sanofi Aventis | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
TWI531571B (zh) * | 2009-11-06 | 2016-05-01 | 維它藥物公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基-及雜芳基羰基衍生物 |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
DK2563780T3 (en) * | 2010-04-29 | 2015-07-27 | Univ Edinburgh | 3,3-DISUBSTITUEREDE- (8-aza-bicyclo [3.2.1] oct-8-yl) - [5- (1H-pyrazol-4-yl) -thiophene-3-yl] -METHANONER as inhibitors of 11 ( BETA) -HSD1 |
US8933072B2 (en) | 2010-06-16 | 2015-01-13 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
EP2585444B1 (de) | 2010-06-25 | 2014-10-22 | Boehringer Ingelheim International GmbH | Azaspirohexanone als 11-beta-hsd1-hemmer zur behandlung von stoffwechselerkrankungen |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
EP2635268A1 (de) | 2010-11-02 | 2013-09-11 | Boehringer Ingelheim International GmbH | Pharmazeutische kombinationen zur behandlung von stoffwechselerkrankungen |
TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基-及雜環芳基羰基衍生物 |
WO2013025664A1 (en) | 2011-08-17 | 2013-02-21 | Boehringer Ingelheim International Gmbh | Indenopyridine derivatives |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
LT3071203T (lt) | 2013-11-18 | 2021-05-25 | Forma Therapeutics, Inc. | Tetrahidrochinolino kompozicijos kaip bet bromodomeno inhibitoriai |
US9422281B2 (en) | 2013-11-18 | 2016-08-23 | Forma Therapeutics, Inc. | Benzopiperazine compositions as BET bromodomain inhibitors |
ES2886766T3 (es) | 2015-03-31 | 2021-12-20 | Enanta Pharm Inc | Derivados del ácido biliar como agonistas de FXR/TGR5 y métodos de uso de estos |
WO2017189652A1 (en) | 2016-04-26 | 2017-11-02 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as fxr agonists and methods of use thereof |
US10080743B2 (en) | 2016-04-26 | 2018-09-25 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use thereof |
WO2017189651A1 (en) | 2016-04-26 | 2017-11-02 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as fxr agonists and methods of use thereof |
WO2017201155A1 (en) | 2016-05-18 | 2017-11-23 | Enanta Pharmaceuticals, Inc. | lSOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF |
WO2017201150A1 (en) | 2016-05-18 | 2017-11-23 | Enanta Pharmaceuticals, Inc. | Isoxazole analogs as fxr agonists and methods of use thereof |
US10138228B2 (en) | 2016-05-18 | 2018-11-27 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use therof |
CN109906223A (zh) | 2016-10-04 | 2019-06-18 | 英安塔制药有限公司 | 异噁唑类似物作为fxr激动剂及其使用方法 |
US10597391B2 (en) | 2016-10-26 | 2020-03-24 | Enanta Pharmaceuticals, Inc. | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof |
US10689391B2 (en) | 2017-12-12 | 2020-06-23 | Enanta Pharmaceuticals, Inc. | Isoxazole analogs as FXR agonists and methods of use thereof |
WO2019160813A1 (en) | 2018-02-14 | 2019-08-22 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as fxr agonists and methods of use thereof |
US11555032B2 (en) | 2019-05-13 | 2023-01-17 | Enanta Pharmaceuticals, Inc. | Isoxazole derivatives as FXR agonists and methods of use thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE38835T1 (de) | 1983-07-05 | 1988-12-15 | Pfizer | Karbonsaeure-derivate verwendbar bei der verhuetung der zersetzung von knorpeln. |
KR100207360B1 (ko) | 1991-06-14 | 1999-07-15 | 돈 더블유. 슈미츠 | 이미다조[1,5,-a]퀸옥살린 |
AU2001256733A1 (en) | 2000-05-16 | 2001-11-26 | Takeda Chemical Industries Ltd. | Melanin-concentrating hormone antagonist |
ITMI20012060A1 (it) | 2001-10-05 | 2003-04-05 | Recordati Chem Pharm | Nuovi eterocilcli n-acilati |
HUP0202001A2 (hu) * | 2002-06-14 | 2005-08-29 | Sanofi-Aventis | DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok |
AU2003269242A1 (en) | 2002-10-11 | 2004-05-04 | Astrazeneca Ab | 1,4-disubstituted piperidine derivatives and their use as 11-betahsd1 inhibitors |
ATE482747T1 (de) * | 2003-04-11 | 2010-10-15 | High Point Pharmaceuticals Llc | Neue amide derivate und deren pharmazeutische verwendungen |
GB0325745D0 (en) | 2003-11-05 | 2003-12-10 | Astrazeneca Ab | Chemical compounds |
WO2006053024A2 (en) | 2004-11-10 | 2006-05-18 | Incyte Corporation | Lactam compounds and their use as pharmaceuticals |
EP1824842A4 (de) | 2004-11-18 | 2009-08-26 | Incyte Corp | Hemmer von 11- hydroxyl steroid dehydrogenase typ 1 und anwendungsverfahren |
WO2006105127A2 (en) | 2005-03-31 | 2006-10-05 | Takeda San Diego, Inc. | Hydroxysteroid dehydrogenase inhibitors |
WO2006132436A1 (ja) | 2005-06-08 | 2006-12-14 | Japan Tobacco Inc. | 複素環化合物 |
-
2007
- 2007-06-25 PE PE2007000811A patent/PE20080344A1/es not_active Application Discontinuation
- 2007-06-25 TW TW096122891A patent/TW200811170A/zh unknown
- 2007-06-26 CA CA002648769A patent/CA2648769A1/fr not_active Abandoned
- 2007-06-26 PT PT07803782T patent/PT2046791E/pt unknown
- 2007-06-26 DE DE602007005487T patent/DE602007005487D1/de active Active
- 2007-06-26 JP JP2009517319A patent/JP2009541464A/ja not_active Withdrawn
- 2007-06-26 MX MX2008016492A patent/MX277822B/es active IP Right Grant
- 2007-06-26 EP EP07803782A patent/EP2046791B1/de active Active
- 2007-06-26 DK DK07803782.7T patent/DK2046791T3/da active
- 2007-06-26 RU RU2009102535/04A patent/RU2009102535A/ru not_active Application Discontinuation
- 2007-06-26 ES ES07803782T patent/ES2342793T3/es active Active
- 2007-06-26 AT AT07803782T patent/ATE461930T1/de active
- 2007-06-26 CL CL2007001885A patent/CL2007001885A1/es unknown
- 2007-06-26 AR ARP070102821A patent/AR061642A1/es not_active Application Discontinuation
- 2007-06-26 SI SI200730258T patent/SI2046791T1/sl unknown
- 2007-06-26 WO PCT/FR2007/001070 patent/WO2008000951A2/fr active Application Filing
- 2007-06-26 PL PL07803782T patent/PL2046791T3/pl unknown
- 2007-06-26 KR KR1020087031631A patent/KR20090021193A/ko not_active Application Discontinuation
- 2007-06-26 AU AU2007264792A patent/AU2007264792A1/en not_active Abandoned
- 2007-06-27 UY UY30447A patent/UY30447A1/es not_active Application Discontinuation
-
2008
- 2008-11-25 IL IL195510A patent/IL195510A0/en unknown
- 2008-12-11 US US12/332,547 patent/US7897773B2/en not_active Expired - Fee Related
-
2010
- 2010-06-21 CY CY20101100571T patent/CY1110132T1/el unknown
- 2010-08-30 US US12/871,403 patent/US20100324084A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
SI2046791T1 (sl) | 2010-07-30 |
MX2008016492A (es) | 2009-01-22 |
CA2648769A1 (fr) | 2008-01-03 |
EP2046791B1 (de) | 2010-03-24 |
AU2007264792A1 (en) | 2008-01-03 |
EP2046791A2 (de) | 2009-04-15 |
IL195510A0 (en) | 2009-09-01 |
MX277822B (es) | 2010-08-03 |
UY30447A1 (es) | 2008-01-31 |
RU2009102535A (ru) | 2010-08-10 |
PL2046791T3 (pl) | 2010-08-31 |
PT2046791E (pt) | 2010-06-23 |
TW200811170A (en) | 2008-03-01 |
JP2009541464A (ja) | 2009-11-26 |
PE20080344A1 (es) | 2008-06-09 |
DE602007005487D1 (de) | 2010-05-06 |
ES2342793T3 (es) | 2010-07-14 |
WO2008000951A2 (fr) | 2008-01-03 |
US7897773B2 (en) | 2011-03-01 |
CY1110132T1 (el) | 2015-01-14 |
US20090170894A1 (en) | 2009-07-02 |
US20100324084A1 (en) | 2010-12-23 |
WO2008000951A3 (fr) | 2008-02-21 |
CL2007001885A1 (es) | 2008-01-25 |
DK2046791T3 (da) | 2010-07-19 |
AR061642A1 (es) | 2008-09-10 |
KR20090021193A (ko) | 2009-02-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE461930T1 (de) | Harnstoffderivate von tropan, ihre herstellung und ihre therapeutische anwendung | |
ATE469131T1 (de) | Sulfonamidderivate, ihre herstellung und ihre therapeutische anwendung | |
ATE467633T1 (de) | 2-aryl-6-phenylimidazoä1,2-aüpyridin-derivate, ihre herstellung und therapeutische verwendung | |
ATE372998T1 (de) | 1-aminophthalazinderivate, deren herstellung und deren therapeutische verwendung | |
ATE441635T1 (de) | 4-cyanopyrazol-3-carbonsäureamidderivate, herstellung und therapeutische anwendung davon | |
DE602006002372D1 (de) | Blockförmige hydroxyethylzellulose, derivate daraus, herstellungsverfahren dafür und verwendungen davon | |
ATE530553T1 (de) | Zytotoxische mittel mit neuen tomamycin-derivaten und ihre therapeutische verwendung | |
ATE453637T1 (de) | N-(aminoheteroaryl)-1h-indol-2-carboxamid- derivate sowie deren herstellung und therapeutische anwendung | |
ATE395342T1 (de) | 2-carbamid-4-phenylthiazol-derivate, deren herstellung und therapeutische verwendung | |
ATE459608T1 (de) | Oxopiperidinderivate, ihre herstellung und therapeutische verwendung | |
ATE502035T1 (de) | 2-amido-4-phenylthiazol-derivate, ihre herstellung und ihre therapeutische verwendung | |
ATE512970T1 (de) | Dimere von artemisininderivaten, deren herstellung und deren therapeutische verwendung | |
ATE423119T1 (de) | Pyridoä2,3-düpyrimidin-derivate sowie deren herstellung und therapeutische anwendung | |
ATE420081T1 (de) | Trifluormethylbenzamidderivate und therapeutische verwendungen dafür | |
ATE412635T1 (de) | Diphenylpyridinderivate, deren herstellung und deren therapeutische anwendung | |
ATE542806T1 (de) | Diarylmethylpiperazinderivate, deren herstellung und deren verwendung | |
ATE451923T1 (de) | N-(arylalkyl)-1h-pyrrolopyridin-2-carboxamid- derivate, ihre herstellung und verwendung | |
ATE548349T1 (de) | In stellung 3 disubstituierte indol-2-on- pyridinderivate, ihre herstellung sowie ihre therapeutische anwendung | |
ATE475661T1 (de) | Triazolopyridin-carboxamid-derivate sowie ihre herstellung und therapeutische verwendung | |
ATE417846T1 (de) | Aminotropanderivate, deren herstellung und deren therapeutische verwendung | |
ATE540023T1 (de) | Neuartige 3-aminoalkyl-1,3-dihydro-2h-indol-2-on- derivate, ihre herstellung und therapeutische verwendung | |
DE602006015675D1 (de) | 6-heteroarylpyridoindolon-derivate, ihre herstellung und ihre therapeutische anwendung | |
DE602005001471D1 (de) | Katalytische Konverter und dessen Herstellung | |
ATE499351T1 (de) | Aryl- und heteroaryl-ethyl-acylguanidinderivate, ihre herstellung und ihre therapeutische anwendung | |
ATE520654T1 (de) | Polypyrrol-derivate, ihre herstellung und ihre therapeutische verwendung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 2046791 Country of ref document: EP |