FR2934858B1 - Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique - Google Patents

Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique

Info

Publication number
FR2934858B1
FR2934858B1 FR0804521A FR0804521A FR2934858B1 FR 2934858 B1 FR2934858 B1 FR 2934858B1 FR 0804521 A FR0804521 A FR 0804521A FR 0804521 A FR0804521 A FR 0804521A FR 2934858 B1 FR2934858 B1 FR 2934858B1
Authority
FR
France
Prior art keywords
preparation
therapeutic use
urea derivatives
tetrahydroquinoxaline
tetrahydroquinoxaline urea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0804521A
Other languages
English (en)
Other versions
FR2934858A1 (fr
Inventor
Alain Braun
Olivier Crespin
Claudie Namane
Eric Nicolai
Francois Pacquet
Cecile Pascal
Christophe Philippo
Olivier Venier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0804521A priority Critical patent/FR2934858B1/fr
Priority to TW098103125A priority patent/TW200936136A/zh
Priority to PE2009000105A priority patent/PE20091323A1/es
Priority to ARP090100229A priority patent/AR070255A1/es
Priority to EP09720707.0A priority patent/EP2238126B1/fr
Priority to CA2713367A priority patent/CA2713367A1/fr
Priority to CN2009801113945A priority patent/CN101981026A/zh
Priority to JP2010543545A priority patent/JP2011510919A/ja
Priority to MX2010008290A priority patent/MX2010008290A/es
Priority to EA201070895A priority patent/EA201070895A1/ru
Priority to PCT/FR2009/000083 priority patent/WO2009112691A2/fr
Priority to PA20098813701A priority patent/PA8813701A1/es
Priority to KR1020107019130A priority patent/KR20100111308A/ko
Priority to AU2009224546A priority patent/AU2009224546B2/en
Priority to BRPI0906567-9A priority patent/BRPI0906567A2/pt
Priority to CL2009000173A priority patent/CL2009000173A1/es
Priority to UY031616A priority patent/UY31616A1/es
Publication of FR2934858A1 publication Critical patent/FR2934858A1/fr
Priority to EC2010010368A priority patent/ECSP10010368A/es
Priority to IL207195A priority patent/IL207195A/en
Priority to US12/843,124 priority patent/US8211892B2/en
Priority to NI201000130A priority patent/NI201000130A/es
Priority to CR11596A priority patent/CR11596A/es
Priority to DO2010000230A priority patent/DOP2010000230A/es
Priority to CO10092048A priority patent/CO6290672A2/es
Priority to MA33110A priority patent/MA32098B1/fr
Application granted granted Critical
Publication of FR2934858B1 publication Critical patent/FR2934858B1/fr
Priority to US13/483,710 priority patent/US8530657B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0804521A 2008-01-28 2008-08-08 Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique Expired - Fee Related FR2934858B1 (fr)

Priority Applications (26)

Application Number Priority Date Filing Date Title
FR0804521A FR2934858B1 (fr) 2008-08-08 2008-08-08 Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique
TW098103125A TW200936136A (en) 2008-01-28 2009-01-23 Tetrahydroquinoxaline urea derivatives, their preparation and their therapeutic application
ARP090100229A AR070255A1 (es) 2008-01-28 2009-01-26 Derivados de urea de tetrahidroquinoxalina, su preparacion, composiciones farmaceuticas que los contienen y su uso en la modulacion de la actividad de 11-beta hd1 (hidroxiesteroide deshidrogenasa de tipo 1)
PE2009000105A PE20091323A1 (es) 2008-01-28 2009-01-26 Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion en terapeutica
CA2713367A CA2713367A1 (fr) 2008-01-28 2009-01-27 Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique
CN2009801113945A CN101981026A (zh) 2008-01-28 2009-01-27 四氢喹喔啉脲衍生物、它们的制备及它们的治疗应用
JP2010543545A JP2011510919A (ja) 2008-01-28 2009-01-27 テトラヒドロキノキサリン尿素誘導体、これらの調製、および治療的適用
MX2010008290A MX2010008290A (es) 2008-01-28 2009-01-27 Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion terapeutica.
EA201070895A EA201070895A1 (ru) 2008-01-28 2009-01-27 Карбамидные производные тетрагидрохиноксалина, их получение и их применение в терапии
PCT/FR2009/000083 WO2009112691A2 (fr) 2008-01-28 2009-01-27 Dérivés d'urée de tetrahydroquinoxaline, leur préparation et leur application en thérapeutique j
PA20098813701A PA8813701A1 (es) 2008-01-28 2009-01-27 Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion en terapeutica
KR1020107019130A KR20100111308A (ko) 2008-01-28 2009-01-27 테트라히드로퀴녹살린 우레아의 유도체, 그의 제법 및 그의 치료학적 용도
AU2009224546A AU2009224546B2 (en) 2008-01-28 2009-01-27 Derivatives of tetrahydroquinoxaline urea, preparation thereof and therapeutic application thereof
BRPI0906567-9A BRPI0906567A2 (pt) 2008-01-28 2009-01-27 Derivados de ureia de tetra-hidroquinoxalina, o respectivo preparo e a respectiva aplicação em terapêutica j
EP09720707.0A EP2238126B1 (fr) 2008-01-28 2009-01-27 Dérivés d'urée de tetrahydroquinoxaline, leur préparation et leur application en thérapeutique
UY031616A UY31616A1 (es) 2008-01-28 2009-01-28 Derivados de urea de tetrahidroquinoxalina, su preparación y su aplicación en terapéutica
CL2009000173A CL2009000173A1 (es) 2008-01-28 2009-01-28 Compuestos derivados de urea-tetrahidroxiquinoxalina; procedimiento de preparacion; compuestos intermediarios; composicion farmaceutica; y uso para el tratamiento y la prevencion de la obesidad y la diabetes, resistencia a la insulina, sindrome metabolico, entre otros.
EC2010010368A ECSP10010368A (es) 2008-01-28 2010-07-23 Derivados de urea de tetrahidroquinoxalina, su preparación
IL207195A IL207195A (en) 2008-01-28 2010-07-25 Tetrahydroquinoxaline derivatives ore, their preparation and therapeutic application
US12/843,124 US8211892B2 (en) 2008-01-28 2010-07-26 Tetrahydroquinoxaline urea derivatives
NI201000130A NI201000130A (es) 2008-01-28 2010-07-26 Derivados de urea de tetrahidroquinoxalina, su preparación y su aplicación en terapéutica.
CR11596A CR11596A (es) 2008-01-28 2010-07-27 Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion en terapeutica
DO2010000230A DOP2010000230A (es) 2008-01-28 2010-07-27 Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion en terapeutica
CO10092048A CO6290672A2 (es) 2008-01-28 2010-07-28 Derivados de urea de tetrahidroquinoxalina su preparacion aplicacion en terapeutica
MA33110A MA32098B1 (fr) 2008-01-28 2010-08-23 Dérivés d'urée de tetrahydroquinoxaline, leur préparation et leur application en thérapeutique
US13/483,710 US8530657B2 (en) 2008-01-28 2012-05-30 Substituted adamantanes and their therapeutic application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0804521A FR2934858B1 (fr) 2008-08-08 2008-08-08 Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2934858A1 FR2934858A1 (fr) 2010-02-12
FR2934858B1 true FR2934858B1 (fr) 2010-08-27

Family

ID=40344779

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0804521A Expired - Fee Related FR2934858B1 (fr) 2008-01-28 2008-08-08 Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique

Country Status (1)

Country Link
FR (1) FR2934858B1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056744A1 (fr) * 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides utilises comme inhibiteurs de la hydroxysteroide deshydrogenase
TW200811170A (en) * 2006-06-27 2008-03-01 Sanofi Aventis Urea derivatives of tropane, their preparation and their therapeutic application

Also Published As

Publication number Publication date
FR2934858A1 (fr) 2010-02-12

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Effective date: 20160429