AR070255A1 - Derivados de urea de tetrahidroquinoxalina, su preparacion, composiciones farmaceuticas que los contienen y su uso en la modulacion de la actividad de 11-beta hd1 (hidroxiesteroide deshidrogenasa de tipo 1) - Google Patents
Derivados de urea de tetrahidroquinoxalina, su preparacion, composiciones farmaceuticas que los contienen y su uso en la modulacion de la actividad de 11-beta hd1 (hidroxiesteroide deshidrogenasa de tipo 1)Info
- Publication number
- AR070255A1 AR070255A1 ARP090100229A ARP090100229A AR070255A1 AR 070255 A1 AR070255 A1 AR 070255A1 AR P090100229 A ARP090100229 A AR P090100229A AR P090100229 A ARP090100229 A AR P090100229A AR 070255 A1 AR070255 A1 AR 070255A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- coor5
- nr6r7
- alkoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Reivindicacion 1: Compuesto que responde a la formula (1) en la que A representa un enlace, un átomo de oxigeno o un grupo -O-CH2-, Ar1 representa un grupo fenilo o heteroarilo, Ar2 representa un grupo fenilo, un grupo heteroarilo o un grupo heterocicloalquilo, R1a, b, c y R2a, b, c, idénticos, o diferentes, representan cada uno un átomo de hidrogeno o de halogeno o un grupo alquilo, cicloalquilo, -alquil-cicloalquilo sustituido opcionalmente con uno o varios átomos de halogeno, -OR5 (hidroxi o alcoxi), hidroxialquilo, alcoxi-alquilo, alcoxi-alcoxi, halogenoalquilo, -O-halogenoalquilo, oxo, -CO-alquilo, -CO-alquilo-NR6R7, -CO-halogenoalquilo, -COOR5, alquil-COOR5, -O-alquil-COOR5, -SO2-alquilo, -SO2-cicIoalquilo, -SO2-alquil-cicloalquilo, -SO2-alquilo-OR5, -SO2-aIquil-COOR5, -SO2-alquil-NR6R7, -SO2-halogenoalquilo, alquil-SO2-alquilo, -SO2-NR6R7, -SO2-alquil-alcoxi-alcoxi, -CONR6R7, -alquil-CONR6R7 o -O-alquil-NR6R7, o R1a, R1b, R1c están unidos respectivamente a R2a, R2b, R2c y al átomo de carbono al que están unidos y representan -O-alquil-O-; R3 representa un átomo de hidrogeno o un grupo alquilo, R4 representa un átomo de hidrogeno o de halogeno o un grupo ciano, -OR5, hidroxi-alquilo, -COOR5, -NR6R7, -CONR6R7, -SO2-alquilo o -SO2-NR6R7, -NR6-COOR5, -NR6-COR5, -CO-NR6-alquil-OR5; R5, R6 y R7, idénticos o diferentes, representan cada uno un átomo de hidrogeno, un grupo alquilo o un grupo -alquil-fenilo, y R8 representa un átomo de hidrogeno, un grupo alquilo o un grupo de formula -B-Het, en la que B puede estar ausente o representar un enlace, un átomo de oxígeno o un grupo -CO- o -SO2-(CH2)n con n igual a 0, 1 o 2 y en la que Het representa un heteroarilo o un heterocicloalquilo sustituido opcionalmente con 1 a 3 grupos elegidos entre los grupos alquilos, -SO2-alquilos y -COOR5, en el estado de base o de ácido o de sal de adicion a un ácido o a una base. Reivindicacion 21: Compuestos de formulas (2) y (4) en las que A, Ar1, Ar2, R1a, b, c, R2a, b, c y R8 son tales como se han definido en una cualquiera de las reivindicaciones 1 a 6 y 9 a 12 y Lg representa un grupo saliente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0800429A FR2926817B1 (fr) | 2008-01-28 | 2008-01-28 | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
FR0804521A FR2934858B1 (fr) | 2008-08-08 | 2008-08-08 | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
AR070255A1 true AR070255A1 (es) | 2010-03-25 |
Family
ID=41037885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090100229A AR070255A1 (es) | 2008-01-28 | 2009-01-26 | Derivados de urea de tetrahidroquinoxalina, su preparacion, composiciones farmaceuticas que los contienen y su uso en la modulacion de la actividad de 11-beta hd1 (hidroxiesteroide deshidrogenasa de tipo 1) |
Country Status (24)
Country | Link |
---|---|
US (2) | US8211892B2 (es) |
EP (1) | EP2238126B1 (es) |
JP (1) | JP2011510919A (es) |
KR (1) | KR20100111308A (es) |
CN (1) | CN101981026A (es) |
AR (1) | AR070255A1 (es) |
AU (1) | AU2009224546B2 (es) |
BR (1) | BRPI0906567A2 (es) |
CA (1) | CA2713367A1 (es) |
CL (1) | CL2009000173A1 (es) |
CO (1) | CO6290672A2 (es) |
CR (1) | CR11596A (es) |
DO (1) | DOP2010000230A (es) |
EA (1) | EA201070895A1 (es) |
EC (1) | ECSP10010368A (es) |
IL (1) | IL207195A (es) |
MA (1) | MA32098B1 (es) |
MX (1) | MX2010008290A (es) |
NI (1) | NI201000130A (es) |
PA (1) | PA8813701A1 (es) |
PE (1) | PE20091323A1 (es) |
TW (1) | TW200936136A (es) |
UY (1) | UY31616A1 (es) |
WO (1) | WO2009112691A2 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
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US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
EA030606B1 (ru) | 2006-05-04 | 2018-08-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Способы приготовления лекарственного средства, содержащего полиморфы |
PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
TW200936136A (en) * | 2008-01-28 | 2009-09-01 | Sanofi Aventis | Tetrahydroquinoxaline urea derivatives, their preparation and their therapeutic application |
PE20140960A1 (es) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
BRPI0923121A2 (pt) | 2008-12-23 | 2015-08-11 | Boehringer Ingelheim Int | Formas salinas de compostos orgânico |
TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
FR2948369B1 (fr) * | 2009-07-27 | 2013-04-12 | Sanofi Aventis | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
FR2948370B1 (fr) * | 2009-07-27 | 2013-04-05 | Sanofi Aventis | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
CA2778175A1 (en) | 2009-11-11 | 2011-05-19 | Yoshihiro Horiuchi | 8-azabicyclo[3.2.1]octane-8-carboxamide derivative |
ES2760917T3 (es) | 2009-11-27 | 2020-05-18 | Boehringer Ingelheim Int | Tratamiento de pacientes diabéticos genotipificados con inhibidores DPP-IV como la linagliptina |
US8796468B2 (en) | 2009-12-22 | 2014-08-05 | Shionogi & Co., Ltd. | Adamantanamine derivative |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
JP6034781B2 (ja) | 2010-05-05 | 2016-11-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 併用療法 |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
EA201991014A1 (ru) | 2010-06-24 | 2019-09-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Лечение диабета |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TWI511958B (zh) | 2010-08-09 | 2015-12-11 | Shionogi & Co | 胺基金剛烷胺基甲酸酯衍生物之製造方法 |
WO2012029942A1 (ja) | 2010-09-03 | 2012-03-08 | 大日本住友製薬株式会社 | 環状アミド誘導体 |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
MX366629B (es) | 2011-07-15 | 2019-07-17 | Boehringer Ingelheim Int | Quinazolinas sustituidas, su preparación y su uso en composiciones farmacéuticas. |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
JP6399660B2 (ja) * | 2012-04-10 | 2018-10-03 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | 癌治療用組成物および方法 |
EP3685839A1 (en) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin for use in the treatment of albuminuria and kidney related diseases |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
US9526728B2 (en) | 2014-02-28 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Medical use of a DPP-4 inhibitor |
JP6043767B2 (ja) * | 2014-09-26 | 2016-12-14 | 株式会社アステム | 番組出力装置、補助情報管理サーバ、番組と補助情報の出力方法、及びプログラム |
JP2019517542A (ja) | 2016-06-10 | 2019-06-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | リナグリプチンおよびメトホルミンの組合せ |
KR102177304B1 (ko) * | 2018-07-23 | 2020-11-10 | 제이투에이치바이오텍 (주) | 비알콜성 지방간염의 예방 또는 치료용 약학 조성물 |
CN109956958B (zh) * | 2019-04-02 | 2020-06-16 | 河北合佳医药科技集团股份有限公司 | 一种7-氨基-3-甲氧基甲基-3-头孢烯-4-羧酸合成方法 |
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WO2004056744A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
GB0505541D0 (en) * | 2005-03-17 | 2005-04-27 | Novartis Ag | Organic compounds |
TW200811158A (en) * | 2006-06-27 | 2008-03-01 | Sanofi Aventis | Piperidine or pyrrolidine urea derivatives, their preparation and their therapeutic application |
TW200811170A (en) * | 2006-06-27 | 2008-03-01 | Sanofi Aventis | Urea derivatives of tropane, their preparation and their therapeutic application |
WO2009001817A1 (ja) * | 2007-06-27 | 2008-12-31 | Taisho Pharmaceutical Co., Ltd. | 11β-HSD1阻害活性を有する化合物 |
WO2009020140A1 (ja) * | 2007-08-06 | 2009-02-12 | Dainippon Sumitomo Pharma Co., Ltd. | アダマンチルウレア誘導体 |
TW200936136A (en) * | 2008-01-28 | 2009-09-01 | Sanofi Aventis | Tetrahydroquinoxaline urea derivatives, their preparation and their therapeutic application |
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2009
- 2009-01-23 TW TW098103125A patent/TW200936136A/zh unknown
- 2009-01-26 PE PE2009000105A patent/PE20091323A1/es not_active Application Discontinuation
- 2009-01-26 AR ARP090100229A patent/AR070255A1/es not_active Application Discontinuation
- 2009-01-27 PA PA20098813701A patent/PA8813701A1/es unknown
- 2009-01-27 AU AU2009224546A patent/AU2009224546B2/en not_active Ceased
- 2009-01-27 WO PCT/FR2009/000083 patent/WO2009112691A2/fr active Application Filing
- 2009-01-27 BR BRPI0906567-9A patent/BRPI0906567A2/pt not_active IP Right Cessation
- 2009-01-27 JP JP2010543545A patent/JP2011510919A/ja active Pending
- 2009-01-27 CA CA2713367A patent/CA2713367A1/fr not_active Abandoned
- 2009-01-27 EP EP09720707.0A patent/EP2238126B1/fr active Active
- 2009-01-27 CN CN2009801113945A patent/CN101981026A/zh active Pending
- 2009-01-27 MX MX2010008290A patent/MX2010008290A/es active IP Right Grant
- 2009-01-27 EA EA201070895A patent/EA201070895A1/ru unknown
- 2009-01-27 KR KR1020107019130A patent/KR20100111308A/ko active Search and Examination
- 2009-01-28 UY UY031616A patent/UY31616A1/es not_active Application Discontinuation
- 2009-01-28 CL CL2009000173A patent/CL2009000173A1/es unknown
-
2010
- 2010-07-23 EC EC2010010368A patent/ECSP10010368A/es unknown
- 2010-07-25 IL IL207195A patent/IL207195A/en not_active IP Right Cessation
- 2010-07-26 US US12/843,124 patent/US8211892B2/en not_active Expired - Fee Related
- 2010-07-26 NI NI201000130A patent/NI201000130A/es unknown
- 2010-07-27 CR CR11596A patent/CR11596A/es not_active Application Discontinuation
- 2010-07-27 DO DO2010000230A patent/DOP2010000230A/es unknown
- 2010-07-28 CO CO10092048A patent/CO6290672A2/es not_active Application Discontinuation
- 2010-08-23 MA MA33110A patent/MA32098B1/fr unknown
-
2012
- 2012-05-30 US US13/483,710 patent/US8530657B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2009224546B2 (en) | 2014-01-30 |
EP2238126B1 (fr) | 2014-11-05 |
TW200936136A (en) | 2009-09-01 |
CO6290672A2 (es) | 2011-06-20 |
KR20100111308A (ko) | 2010-10-14 |
AU2009224546A1 (en) | 2009-09-17 |
CR11596A (es) | 2010-09-13 |
BRPI0906567A2 (pt) | 2015-07-07 |
EA201070895A1 (ru) | 2011-04-29 |
US8530657B2 (en) | 2013-09-10 |
ECSP10010368A (es) | 2010-08-31 |
WO2009112691A3 (fr) | 2010-01-07 |
CL2009000173A1 (es) | 2010-02-12 |
UY31616A1 (es) | 2009-08-31 |
US20110009391A1 (en) | 2011-01-13 |
PE20091323A1 (es) | 2009-09-26 |
US20120245148A1 (en) | 2012-09-27 |
IL207195A0 (en) | 2010-12-30 |
US8211892B2 (en) | 2012-07-03 |
MX2010008290A (es) | 2010-08-18 |
CA2713367A1 (fr) | 2009-09-17 |
WO2009112691A2 (fr) | 2009-09-17 |
MA32098B1 (fr) | 2011-02-01 |
EP2238126A2 (fr) | 2010-10-13 |
NI201000130A (es) | 2010-12-17 |
DOP2010000230A (es) | 2010-08-31 |
CN101981026A (zh) | 2011-02-23 |
IL207195A (en) | 2013-12-31 |
PA8813701A1 (es) | 2009-09-17 |
JP2011510919A (ja) | 2011-04-07 |
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