MX2010008290A - Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion terapeutica. - Google Patents

Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion terapeutica.

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Publication number
MX2010008290A
MX2010008290A MX2010008290A MX2010008290A MX2010008290A MX 2010008290 A MX2010008290 A MX 2010008290A MX 2010008290 A MX2010008290 A MX 2010008290A MX 2010008290 A MX2010008290 A MX 2010008290A MX 2010008290 A MX2010008290 A MX 2010008290A
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MX
Mexico
Prior art keywords
alkyl
group
coor5
nr6r7
halogenoalkyl
Prior art date
Application number
MX2010008290A
Other languages
English (en)
Inventor
Alain Braun
Olivier Crespin
Cecile Pascal
Olivier Venier
Christophe Philippo
Eric Nicolai
Claudie Namane
Francois Pacquet
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0800429A external-priority patent/FR2926817B1/fr
Priority claimed from FR0804521A external-priority patent/FR2934858B1/fr
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MX2010008290A publication Critical patent/MX2010008290A/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
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    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40Benzopyrazines
    • C07D241/44Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a compuestos que responden a fórmula (1): en donde A representa un enlace, un átomo de oxígeno o un grupo -O-CH2-; Ar1 representa un grupo fenilo o heteroarilo; Ar2 representa un grupo fenilo, heteroarilo o heterocicloalquilo; Rla,b,c y R2a,b,c, representan cada uno un átomo de hidrógeno o de halógeno o un grupo alquilo, cicloalquilo, -alquil-cicloalquilo sustituido opcionalmente con uno o varios átomos de halógeno, -0R5 (hidroxi o alcoxi), hidroxi-alquilo, alcoxi-alquilo, alcoxi-alcoxi, halógenoalquilo, -0-halógenoalquilo, oxo, -CO-alquilo, -CO-alquilo-NR6R7, -CO-halógenoalquilo, -COOR5, alquil-COOR5, -O-alquil-COOR5, -S02-alquilo, -SO2- cicloalqu ib, -S02-alquil-cicloalquilo, -S02-alquibo-0R5, -SO2- alquil-COOR5, -S02-alquil-NR6R7,-S02-halóg enoalquibo, alquilS0 2-alquilo, -S02-NR6R7, -S02-alquil-O-alquil-0 R5, -CONR6R7, -alquil-CONR6R7 o -O-alquil-NR6R7, o Ria, Rlb, R, están unidos respectivamente a R2a, R 2b, R 2c y al átomo de carbono al que están unidos y representan -O-alquil-O-; R3 representa un átomo de hidrógeno o un grupo alquilo, R4 representa un átomo de hidrógeno o de halógeno o un grupo ciano, -OR5, hidroxi-alquilo, -COOR5, -NR6R7, -CONR6R7, -S02-alquilo ó -S02-NR6R7, -NR6- COOR5, NR6-COR5, -CQ-NR6-alquil-OR5 R5, R6 y R7, representan un átomo de hidrógeno, un grupo alquilo o -alquil-fenibo, y R8 representa un átomo de hidrógeno, un grupo -S02-alquilo o un grupo de fórmula -B-Het, donde B puede estar ausente o representar un enlace, un átomo de oxígeno o un grupo -CO- o -SO2-(CH2) con n igual a 0, 1 6 2 y donde Het representa un heteroarilo o un heterocicloalquilo sustituido opcionalmente por los grupos alquilos, -S02-alquilos y -COOR5. Procedimiento de preparación y aplicación terapéutica.
MX2010008290A 2008-01-28 2009-01-27 Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion terapeutica. MX2010008290A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0800429A FR2926817B1 (fr) 2008-01-28 2008-01-28 Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique
FR0804521A FR2934858B1 (fr) 2008-08-08 2008-08-08 Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique
PCT/FR2009/000083 WO2009112691A2 (fr) 2008-01-28 2009-01-27 Dérivés d'urée de tetrahydroquinoxaline, leur préparation et leur application en thérapeutique j

Publications (1)

Publication Number Publication Date
MX2010008290A true MX2010008290A (es) 2010-08-18

Family

ID=41037885

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MX2010008290A MX2010008290A (es) 2008-01-28 2009-01-27 Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion terapeutica.

Country Status (24)

Country Link
US (2) US8211892B2 (es)
EP (1) EP2238126B1 (es)
JP (1) JP2011510919A (es)
KR (1) KR20100111308A (es)
CN (1) CN101981026A (es)
AR (1) AR070255A1 (es)
AU (1) AU2009224546B2 (es)
BR (1) BRPI0906567A2 (es)
CA (1) CA2713367A1 (es)
CL (1) CL2009000173A1 (es)
CO (1) CO6290672A2 (es)
CR (1) CR11596A (es)
DO (1) DOP2010000230A (es)
EA (1) EA201070895A1 (es)
EC (1) ECSP10010368A (es)
IL (1) IL207195A (es)
MA (1) MA32098B1 (es)
MX (1) MX2010008290A (es)
NI (1) NI201000130A (es)
PA (1) PA8813701A1 (es)
PE (1) PE20091323A1 (es)
TW (1) TW200936136A (es)
UY (1) UY31616A1 (es)
WO (1) WO2009112691A2 (es)

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AU2009224546B2 (en) 2014-01-30
EA201070895A1 (ru) 2011-04-29
CL2009000173A1 (es) 2010-02-12
PE20091323A1 (es) 2009-09-26
CR11596A (es) 2010-09-13
CA2713367A1 (fr) 2009-09-17
CN101981026A (zh) 2011-02-23
KR20100111308A (ko) 2010-10-14
DOP2010000230A (es) 2010-08-31
ECSP10010368A (es) 2010-08-31
PA8813701A1 (es) 2009-09-17
US8530657B2 (en) 2013-09-10
JP2011510919A (ja) 2011-04-07
TW200936136A (en) 2009-09-01
AR070255A1 (es) 2010-03-25
BRPI0906567A2 (pt) 2015-07-07
UY31616A1 (es) 2009-08-31
IL207195A0 (en) 2010-12-30
AU2009224546A1 (en) 2009-09-17
MA32098B1 (fr) 2011-02-01
WO2009112691A2 (fr) 2009-09-17
CO6290672A2 (es) 2011-06-20
US20120245148A1 (en) 2012-09-27
IL207195A (en) 2013-12-31
EP2238126B1 (fr) 2014-11-05
NI201000130A (es) 2010-12-17
WO2009112691A3 (fr) 2010-01-07
US8211892B2 (en) 2012-07-03
EP2238126A2 (fr) 2010-10-13
US20110009391A1 (en) 2011-01-13

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