MX2010008290A - Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion terapeutica. - Google Patents

Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion terapeutica.

Info

Publication number
MX2010008290A
MX2010008290A MX2010008290A MX2010008290A MX2010008290A MX 2010008290 A MX2010008290 A MX 2010008290A MX 2010008290 A MX2010008290 A MX 2010008290A MX 2010008290 A MX2010008290 A MX 2010008290A MX 2010008290 A MX2010008290 A MX 2010008290A
Authority
MX
Mexico
Prior art keywords
alkyl
group
coor5
nr6r7
halogenoalkyl
Prior art date
Application number
MX2010008290A
Other languages
English (en)
Inventor
Alain Braun
Olivier Crespin
Cecile Pascal
Olivier Venier
Christophe Philippo
Eric Nicolai
Claudie Namane
Francois Pacquet
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0800429A external-priority patent/FR2926817B1/fr
Priority claimed from FR0804521A external-priority patent/FR2934858B1/fr
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MX2010008290A publication Critical patent/MX2010008290A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La invención se refiere a compuestos que responden a fórmula (1): en donde A representa un enlace, un átomo de oxígeno o un grupo -O-CH2-; Ar1 representa un grupo fenilo o heteroarilo; Ar2 representa un grupo fenilo, heteroarilo o heterocicloalquilo; Rla,b,c y R2a,b,c, representan cada uno un átomo de hidrógeno o de halógeno o un grupo alquilo, cicloalquilo, -alquil-cicloalquilo sustituido opcionalmente con uno o varios átomos de halógeno, -0R5 (hidroxi o alcoxi), hidroxi-alquilo, alcoxi-alquilo, alcoxi-alcoxi, halógenoalquilo, -0-halógenoalquilo, oxo, -CO-alquilo, -CO-alquilo-NR6R7, -CO-halógenoalquilo, -COOR5, alquil-COOR5, -O-alquil-COOR5, -S02-alquilo, -SO2- cicloalqu ib, -S02-alquil-cicloalquilo, -S02-alquibo-0R5, -SO2- alquil-COOR5, -S02-alquil-NR6R7,-S02-halóg enoalquibo, alquilS0 2-alquilo, -S02-NR6R7, -S02-alquil-O-alquil-0 R5, -CONR6R7, -alquil-CONR6R7 o -O-alquil-NR6R7, o Ria, Rlb, R, están unidos respectivamente a R2a, R 2b, R 2c y al átomo de carbono al que están unidos y representan -O-alquil-O-; R3 representa un átomo de hidrógeno o un grupo alquilo, R4 representa un átomo de hidrógeno o de halógeno o un grupo ciano, -OR5, hidroxi-alquilo, -COOR5, -NR6R7, -CONR6R7, -S02-alquilo ó -S02-NR6R7, -NR6- COOR5, NR6-COR5, -CQ-NR6-alquil-OR5 R5, R6 y R7, representan un átomo de hidrógeno, un grupo alquilo o -alquil-fenibo, y R8 representa un átomo de hidrógeno, un grupo -S02-alquilo o un grupo de fórmula -B-Het, donde B puede estar ausente o representar un enlace, un átomo de oxígeno o un grupo -CO- o -SO2-(CH2) con n igual a 0, 1 6 2 y donde Het representa un heteroarilo o un heterocicloalquilo sustituido opcionalmente por los grupos alquilos, -S02-alquilos y -COOR5. Procedimiento de preparación y aplicación terapéutica.
MX2010008290A 2008-01-28 2009-01-27 Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion terapeutica. MX2010008290A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0800429A FR2926817B1 (fr) 2008-01-28 2008-01-28 Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique
FR0804521A FR2934858B1 (fr) 2008-08-08 2008-08-08 Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique
PCT/FR2009/000083 WO2009112691A2 (fr) 2008-01-28 2009-01-27 Dérivés d'urée de tetrahydroquinoxaline, leur préparation et leur application en thérapeutique j

Publications (1)

Publication Number Publication Date
MX2010008290A true MX2010008290A (es) 2010-08-18

Family

ID=41037885

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010008290A MX2010008290A (es) 2008-01-28 2009-01-27 Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion terapeutica.

Country Status (24)

Country Link
US (2) US8211892B2 (es)
EP (1) EP2238126B1 (es)
JP (1) JP2011510919A (es)
KR (1) KR20100111308A (es)
CN (1) CN101981026A (es)
AR (1) AR070255A1 (es)
AU (1) AU2009224546B2 (es)
BR (1) BRPI0906567A2 (es)
CA (1) CA2713367A1 (es)
CL (1) CL2009000173A1 (es)
CO (1) CO6290672A2 (es)
CR (1) CR11596A (es)
DO (1) DOP2010000230A (es)
EA (1) EA201070895A1 (es)
EC (1) ECSP10010368A (es)
IL (1) IL207195A (es)
MA (1) MA32098B1 (es)
MX (1) MX2010008290A (es)
NI (1) NI201000130A (es)
PA (1) PA8813701A1 (es)
PE (1) PE20091323A1 (es)
TW (1) TW200936136A (es)
UY (1) UY31616A1 (es)
WO (1) WO2009112691A2 (es)

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Also Published As

Publication number Publication date
CL2009000173A1 (es) 2010-02-12
IL207195A (en) 2013-12-31
CA2713367A1 (fr) 2009-09-17
US20110009391A1 (en) 2011-01-13
US20120245148A1 (en) 2012-09-27
CN101981026A (zh) 2011-02-23
WO2009112691A2 (fr) 2009-09-17
AU2009224546B2 (en) 2014-01-30
JP2011510919A (ja) 2011-04-07
ECSP10010368A (es) 2010-08-31
DOP2010000230A (es) 2010-08-31
PE20091323A1 (es) 2009-09-26
KR20100111308A (ko) 2010-10-14
EP2238126A2 (fr) 2010-10-13
CO6290672A2 (es) 2011-06-20
CR11596A (es) 2010-09-13
AU2009224546A1 (en) 2009-09-17
TW200936136A (en) 2009-09-01
EP2238126B1 (fr) 2014-11-05
EA201070895A1 (ru) 2011-04-29
US8211892B2 (en) 2012-07-03
NI201000130A (es) 2010-12-17
UY31616A1 (es) 2009-08-31
PA8813701A1 (es) 2009-09-17
IL207195A0 (en) 2010-12-30
AR070255A1 (es) 2010-03-25
BRPI0906567A2 (pt) 2015-07-07
WO2009112691A3 (fr) 2010-01-07
MA32098B1 (fr) 2011-02-01
US8530657B2 (en) 2013-09-10

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