PE20091323A1 - Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- PE20091323A1 PE20091323A1 PE2009000105A PE2009000105A PE20091323A1 PE 20091323 A1 PE20091323 A1 PE 20091323A1 PE 2009000105 A PE2009000105 A PE 2009000105A PE 2009000105 A PE2009000105 A PE 2009000105A PE 20091323 A1 PE20091323 A1 PE 20091323A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- ilamide
- adamantan
- quinoxaline
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
REFERIDA A DERIVADOS DE UREA DE TETRAHIDROQUINOXALINA DE FORMULA (I) DONDE A ES UN ENLACE, O, -O-CH2-; Ar1 ES FENILO O HETEROARILO; Ar2 ES FENILO, HETEROARILO, HETEROCICLOALQUILO; R1a; R1b; R1c; R2a; R2b y R2c SON CADA UNO H, HALO, ALQUILO, ENTRE OTROS; R3 ES H O ALQUILO; R8 ES H, ALQUILO, B-Het; B ESTA AUSENTE O ES UN ENLACE, O, -CO-, ENTRE OTROS; Het ES HETEROARILO, HETEROCICLOALQUILO, ENTRE OTROS. SON COMPUESTOS SELECCIONADOS: ADAMANTAN-2-ILAMIDA DEL ACIDO 4-(4-PIRIDIN-2-IL-FENIL)-3,4-DIHIDRO-2H-QUINOXALINA-1-CARBOXILICO, ADAMANTAN-2-ILAMIDA DEL ACIDO 4-{4-[1-(TETRAHIDRO-PIRAN-4-CARBONIL)-PIPERIDIN-4-ILOXI]-FENIL}-3,4-DIHIDRO-2H-QUINOXALINA-1-CARBOXILICO, ADAMANTAN-2-ILAMIDA DEL ACIDO 4-[4-(PIRIMIDIN-2-ILMETOXI)-FENIL}-3,4-DIHIDRO-2H-QUINOXALINA-1-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LA 11BETA-HIDROXIESTEROIDE DESHIDROGENASA DE TIPO 1, SIENDO UTILES PARA EL TRATAMIENTO DE LA OBESIDAD, DIABETES, RESISTENCIA A LA INSULINA, ENTRE OTROS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0800429A FR2926817B1 (fr) | 2008-01-28 | 2008-01-28 | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
FR0804521A FR2934858B1 (fr) | 2008-08-08 | 2008-08-08 | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091323A1 true PE20091323A1 (es) | 2009-09-26 |
Family
ID=41037885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009000105A PE20091323A1 (es) | 2008-01-28 | 2009-01-26 | Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion en terapeutica |
Country Status (24)
Country | Link |
---|---|
US (2) | US8211892B2 (es) |
EP (1) | EP2238126B1 (es) |
JP (1) | JP2011510919A (es) |
KR (1) | KR20100111308A (es) |
CN (1) | CN101981026A (es) |
AR (1) | AR070255A1 (es) |
AU (1) | AU2009224546B2 (es) |
BR (1) | BRPI0906567A2 (es) |
CA (1) | CA2713367A1 (es) |
CL (1) | CL2009000173A1 (es) |
CO (1) | CO6290672A2 (es) |
CR (1) | CR11596A (es) |
DO (1) | DOP2010000230A (es) |
EA (1) | EA201070895A1 (es) |
EC (1) | ECSP10010368A (es) |
IL (1) | IL207195A (es) |
MA (1) | MA32098B1 (es) |
MX (1) | MX2010008290A (es) |
NI (1) | NI201000130A (es) |
PA (1) | PA8813701A1 (es) |
PE (1) | PE20091323A1 (es) |
TW (1) | TW200936136A (es) |
UY (1) | UY31616A1 (es) |
WO (1) | WO2009112691A2 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
CA2810522A1 (en) | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim International Gmbh | Polymorphs |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
TW200936136A (en) * | 2008-01-28 | 2009-09-01 | Sanofi Aventis | Tetrahydroquinoxaline urea derivatives, their preparation and their therapeutic application |
PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
AU2009331471B2 (en) | 2008-12-23 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Salt forms of organic compound |
AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
FR2948369B1 (fr) * | 2009-07-27 | 2013-04-12 | Sanofi Aventis | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
FR2948370B1 (fr) * | 2009-07-27 | 2013-04-05 | Sanofi Aventis | Derives d'uree de tetrahydroquinoxaline, leur preparation et leur application en therapeutique |
CN102596949B (zh) * | 2009-11-11 | 2015-08-19 | 大日本住友制药株式会社 | 8-氮杂双环[3.2.1]辛烷-8-甲酰胺衍生物 |
KR102668834B1 (ko) | 2009-11-27 | 2024-05-24 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 dpp-iv 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
JP5686413B2 (ja) * | 2009-12-22 | 2015-03-18 | 塩野義製薬株式会社 | アダマンタンアミン誘導体 |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
CN102946875A (zh) | 2010-05-05 | 2013-02-27 | 贝林格尔.英格海姆国际有限公司 | 组合疗法 |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
NZ603319A (en) | 2010-06-24 | 2015-04-24 | Boehringer Ingelheim Int | Diabetes therapy |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
US8901316B2 (en) | 2010-08-09 | 2014-12-02 | Shionogi & Co., Ltd. | Process for preparing aminoadamantyl carbamate derivatives |
KR20130102065A (ko) | 2010-09-03 | 2013-09-16 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 고리형 아미드 유도체 |
AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
US8962636B2 (en) | 2011-07-15 | 2015-02-24 | Boehringer Ingelheim International Gmbh | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
WO2013155223A1 (en) * | 2012-04-10 | 2013-10-17 | The Regents Of The University Of California | Compositions and methods for treating cancer |
EP3685839A1 (en) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin for use in the treatment of albuminuria and kidney related diseases |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
ES2950384T3 (es) | 2014-02-28 | 2023-10-09 | Boehringer Ingelheim Int | Uso médico de un inhibidor de DPP-4 |
JP6043767B2 (ja) * | 2014-09-26 | 2016-12-14 | 株式会社アステム | 番組出力装置、補助情報管理サーバ、番組と補助情報の出力方法、及びプログラム |
MX2018015089A (es) | 2016-06-10 | 2019-05-13 | Boehringer Ingelheim Int | Combinacion de linagliptina y metformina. |
KR102177304B1 (ko) * | 2018-07-23 | 2020-11-10 | 제이투에이치바이오텍 (주) | 비알콜성 지방간염의 예방 또는 치료용 약학 조성물 |
CN109956958B (zh) * | 2019-04-02 | 2020-06-16 | 河北合佳医药科技集团股份有限公司 | 一种7-氨基-3-甲氧基甲基-3-头孢烯-4-羧酸合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004056744A1 (en) * | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
GB0505541D0 (en) * | 2005-03-17 | 2005-04-27 | Novartis Ag | Organic compounds |
TW200811170A (en) * | 2006-06-27 | 2008-03-01 | Sanofi Aventis | Urea derivatives of tropane, their preparation and their therapeutic application |
PE20080212A1 (es) * | 2006-06-27 | 2008-04-25 | Sanofi Aventis | Derivados de ureas de piperidina o pirrolidina como moduladores de la 11b-hidroxiesteroide deshidrogenasa tipo 1 (11bhsd1) |
JP5223864B2 (ja) * | 2007-06-27 | 2013-06-26 | 大正製薬株式会社 | 11β−HSD1阻害活性を有する化合物 |
WO2009020140A1 (ja) * | 2007-08-06 | 2009-02-12 | Dainippon Sumitomo Pharma Co., Ltd. | アダマンチルウレア誘導体 |
TW200936136A (en) * | 2008-01-28 | 2009-09-01 | Sanofi Aventis | Tetrahydroquinoxaline urea derivatives, their preparation and their therapeutic application |
-
2009
- 2009-01-23 TW TW098103125A patent/TW200936136A/zh unknown
- 2009-01-26 PE PE2009000105A patent/PE20091323A1/es not_active Application Discontinuation
- 2009-01-26 AR ARP090100229A patent/AR070255A1/es not_active Application Discontinuation
- 2009-01-27 MX MX2010008290A patent/MX2010008290A/es active IP Right Grant
- 2009-01-27 PA PA20098813701A patent/PA8813701A1/es unknown
- 2009-01-27 CA CA2713367A patent/CA2713367A1/fr not_active Abandoned
- 2009-01-27 KR KR1020107019130A patent/KR20100111308A/ko active Search and Examination
- 2009-01-27 EA EA201070895A patent/EA201070895A1/ru unknown
- 2009-01-27 BR BRPI0906567-9A patent/BRPI0906567A2/pt not_active IP Right Cessation
- 2009-01-27 AU AU2009224546A patent/AU2009224546B2/en not_active Ceased
- 2009-01-27 WO PCT/FR2009/000083 patent/WO2009112691A2/fr active Application Filing
- 2009-01-27 JP JP2010543545A patent/JP2011510919A/ja active Pending
- 2009-01-27 CN CN2009801113945A patent/CN101981026A/zh active Pending
- 2009-01-27 EP EP09720707.0A patent/EP2238126B1/fr active Active
- 2009-01-28 CL CL2009000173A patent/CL2009000173A1/es unknown
- 2009-01-28 UY UY031616A patent/UY31616A1/es not_active Application Discontinuation
-
2010
- 2010-07-23 EC EC2010010368A patent/ECSP10010368A/es unknown
- 2010-07-25 IL IL207195A patent/IL207195A/en not_active IP Right Cessation
- 2010-07-26 US US12/843,124 patent/US8211892B2/en not_active Expired - Fee Related
- 2010-07-26 NI NI201000130A patent/NI201000130A/es unknown
- 2010-07-27 CR CR11596A patent/CR11596A/es not_active Application Discontinuation
- 2010-07-27 DO DO2010000230A patent/DOP2010000230A/es unknown
- 2010-07-28 CO CO10092048A patent/CO6290672A2/es not_active Application Discontinuation
- 2010-08-23 MA MA33110A patent/MA32098B1/fr unknown
-
2012
- 2012-05-30 US US13/483,710 patent/US8530657B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2011510919A (ja) | 2011-04-07 |
MA32098B1 (fr) | 2011-02-01 |
CL2009000173A1 (es) | 2010-02-12 |
CN101981026A (zh) | 2011-02-23 |
US20110009391A1 (en) | 2011-01-13 |
UY31616A1 (es) | 2009-08-31 |
IL207195A (en) | 2013-12-31 |
MX2010008290A (es) | 2010-08-18 |
AR070255A1 (es) | 2010-03-25 |
CR11596A (es) | 2010-09-13 |
WO2009112691A3 (fr) | 2010-01-07 |
BRPI0906567A2 (pt) | 2015-07-07 |
TW200936136A (en) | 2009-09-01 |
US8211892B2 (en) | 2012-07-03 |
AU2009224546B2 (en) | 2014-01-30 |
EP2238126A2 (fr) | 2010-10-13 |
DOP2010000230A (es) | 2010-08-31 |
EA201070895A1 (ru) | 2011-04-29 |
WO2009112691A2 (fr) | 2009-09-17 |
NI201000130A (es) | 2010-12-17 |
US20120245148A1 (en) | 2012-09-27 |
KR20100111308A (ko) | 2010-10-14 |
ECSP10010368A (es) | 2010-08-31 |
CO6290672A2 (es) | 2011-06-20 |
CA2713367A1 (fr) | 2009-09-17 |
IL207195A0 (en) | 2010-12-30 |
EP2238126B1 (fr) | 2014-11-05 |
US8530657B2 (en) | 2013-09-10 |
PA8813701A1 (es) | 2009-09-17 |
AU2009224546A1 (en) | 2009-09-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20091323A1 (es) | Derivados de urea de tetrahidroquinoxalina, su preparacion y su aplicacion en terapeutica | |
CY1114662T1 (el) | Ημιφουμαρικο αλας του 1-[4-[1-(4-κυκλοεξυλο-3-τριφθορομεθυλο-βενζυλοξυιμινο)-αιθυλο]-2-αιθυλο-βενζυλο]-αζετιδινο-3-καρβοξυλικου οξεος | |
PE20091842A1 (es) | Pirrolidinonas como activadores de glucoquinasa | |
PE20121732A1 (es) | Derivados de ciclohexano espiro-condensado como inhibidores de hsl utiles en el tratamiento de la diabetes | |
BRPI0915592A2 (pt) | composto agonista do receptor de gpr119, processo para a preparação do composto, composição farmacêutica que o compreende, uso do mesmo e método para o tratamento ou profilaxia de diabetes mellitus do tipo ii | |
PE20120355A1 (es) | DERIVADOS DE PIRAZOL COMO INHIBIDORES DE LA ENZIMA 11ßHSD1 | |
ATE557024T1 (de) | Piperidinverbindungen als gpcr-agonisten | |
BRPI0914206A2 (pt) | Composições herbicidas ternárias, uso das composições, método para controlar vegetação indesejável, e, formulação herbicida | |
PE20120690A1 (es) | Derivados de 5-fluoropirimidinona | |
NO20071593L (no) | Pyrimidinderivater | |
PE20091002A1 (es) | Analogos dipeptidos como inhibidores del factor de coagulacion | |
PE20141307A1 (es) | Aril dihidropiridinona y piperidinona como inhibidores de monoacilglicerol aciltransferasa (mgat2) | |
PE20140826A1 (es) | Compuestos sustituidos fungicidas de 2-[2-halogenalquil-4-(fenoxi)-fenil]-1-[1,2,4]triazol-1-il-etanol | |
NO20084307L (no) | Heterocykliske GPCR agonister | |
NZ593906A (en) | Gpr120 receptor agonists and uses thereof | |
ATE557023T1 (de) | Piperidinylverbindungen als gpcr-agonisten | |
BRPI0909315A2 (pt) | Composição herbicida, uso das composições, método para controlar vegetação indesejada, e, formulação herbicida | |
PE20142282A1 (es) | Nuevos derivados de aril-quinolina | |
PE20140831A1 (es) | Nuevo derivado de 1,2,3,4-tetrahidroquinolina util para el tratamiento de diabetes | |
BR112012001943A8 (pt) | 4-(3-alquiltiobenzoil) pirazóis,composição herbecida, método para controle de plantas indesejadas e uso dos 4-(3-alquiltiobenzoil)pirazóis | |
NZ596681A (en) | Pyrazinylpyrazoles | |
PE20091576A1 (es) | DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3 | |
SG10201407430TA (en) | N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate | |
PE20061316A1 (es) | Derivados de pirazol como antagonistas del receptor de progesterona | |
PE20110928A1 (es) | Derivados de 4-azetidinil-1-heteroaril-ciclohexanol como antagonistas de ccr2 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |