WO2009001817A1 - １１β－ＨＳＤ１阻害活性を有する化合物 - Google Patents

１１β－ＨＳＤ１阻害活性を有する化合物 Download PDF

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WO2009001817A1
WO2009001817A1 PCT/JP2008/061452 JP2008061452W WO2009001817A1 WO 2009001817 A1 WO2009001817 A1 WO 2009001817A1 JP 2008061452 W JP2008061452 W JP 2008061452W WO 2009001817 A1 WO2009001817 A1 WO 2009001817A1
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group
compound
inhibitory activity
hydrogen atom
atom
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PCT/JP2008/061452
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French (fr)
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Ryo Suzuki
Ayako Mikami
Hiroaki Tanaka
Hiroshi Fukushima
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Taisho Pharmaceutical Co., Ltd.
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Priority to EP08790584A priority Critical patent/EP2172453A4/en
Priority to JP2009520591A priority patent/JP5223864B2/ja
Priority to US12/666,802 priority patent/US8222417B2/en
Publication of WO2009001817A1 publication Critical patent/WO2009001817A1/ja

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Abstract

優れた１１β－ＨＳＤ１阻害活性を有する化合物を提供する。 下記式（I） ［式（I）中、 Ｘ1は、酸素原子、又は式－（ＣＲ11Ｒ12）p－等を示し、 Ｙ1は、水素原子、ヒドロキシル基、等を示し、 Ｚ1は、酸素原子、又は式－（ＮＲ14）－を示し、 Ｒ1は、水素原子、ハロゲン原子、シアノ基、Ｃ1-4アルキル基、１～３個のハロゲン原子で置換されたＣ1-4アルキル基、Ｃ1-4アルコキシ基、Ｃ1-4アルコキシカルボニル基、カルボキシル基、カルバモイル基、又はアミノ基を示し、ｍは、１又は２の整数を示し、 Ｒ2は、水素原子、又はＣ1-4アルキル基を示し、ｎは、１又は２の整数を示す。］ で表される化合物。
PCT/JP2008/061452 2007-06-27 2008-06-24 １１β－ＨＳＤ１阻害活性を有する化合物 WO2009001817A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08790584A EP2172453A4 (en) 2007-06-27 2008-06-24 COMPOUND HAVING 11 ß-HSD1 INHIBITION ACTIVITY
JP2009520591A JP5223864B2 (ja) 2007-06-27 2008-06-24 １１β−ＨＳＤ１阻害活性を有する化合物
US12/666,802 US8222417B2 (en) 2007-06-27 2008-06-24 Compound having 11β-HSD1 inhibitory activity

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JP2007-315236 2007-05-12
JP2007169824 2007-06-27
JP2007-169824 2007-06-27
JP2007207294 2007-08-08
JP2007-207294 2007-08-08
JP2007315236 2007-12-05

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EP (1) EP2172453A4 (ja)
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WO (1) WO2009001817A1 (ja)

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JP2011510919A (ja) * 2008-01-28 2011-04-07 サノフイ−アベンテイス テトラヒドロキノキサリン尿素誘導体、これらの調製、および治療的適用
WO2011059021A1 (ja) * 2009-11-11 2011-05-19 大日本住友製薬株式会社 ８－アザビシクロ［３．２．１］オクタン－８－カルボキサミド誘導体
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
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US8222417B2 (en) 2012-07-17
US20100179325A1 (en) 2010-07-15
EP2172453A1 (en) 2010-04-07
JPWO2009001817A1 (ja) 2010-08-26
JP5223864B2 (ja) 2013-06-26

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