WO2009020137A1 - アミノピラゾールアミド誘導体 - Google Patents
アミノピラゾールアミド誘導体 Download PDFInfo
- Publication number
- WO2009020137A1 WO2009020137A1 PCT/JP2008/064085 JP2008064085W WO2009020137A1 WO 2009020137 A1 WO2009020137 A1 WO 2009020137A1 JP 2008064085 W JP2008064085 W JP 2008064085W WO 2009020137 A1 WO2009020137 A1 WO 2009020137A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hydrogen atom
- aminopyrazole
- amide derivative
- formula
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009526467A JPWO2009020137A1 (ja) | 2007-08-06 | 2008-08-06 | アミノピラゾールアミド誘導体 |
AU2008284746A AU2008284746A1 (en) | 2007-08-06 | 2008-08-06 | Aminopyrazole amide derivative |
BRPI0815112-1A BRPI0815112A2 (pt) | 2007-08-06 | 2008-08-06 | Derivado de aminopirazol amida |
CN200880110520A CN101827820A (zh) | 2007-08-06 | 2008-08-06 | 氨基吡唑酰胺衍生物 |
EP08826977A EP2189449A4 (en) | 2007-08-06 | 2008-08-06 | AMINOPYRAZOLE AMIDE DERIVATIVE |
CA2695437A CA2695437A1 (en) | 2007-08-06 | 2008-08-06 | Aminopyrazole amide derivative |
MX2010001566A MX2010001566A (es) | 2007-08-06 | 2008-08-06 | Derivado de aminopirazolamida. |
US12/672,236 US20110071289A1 (en) | 2007-08-06 | 2008-08-06 | Aminopyrazole amide derivative |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007204739 | 2007-08-06 | ||
JP2007-204739 | 2007-08-06 | ||
JP2008074895 | 2008-03-24 | ||
JP2008-074895 | 2008-03-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009020137A1 true WO2009020137A1 (ja) | 2009-02-12 |
Family
ID=40341369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/064085 WO2009020137A1 (ja) | 2007-08-06 | 2008-08-06 | アミノピラゾールアミド誘導体 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20110071289A1 (ja) |
EP (1) | EP2189449A4 (ja) |
JP (1) | JPWO2009020137A1 (ja) |
KR (1) | KR20100044829A (ja) |
CN (1) | CN101827820A (ja) |
AU (1) | AU2008284746A1 (ja) |
BR (1) | BRPI0815112A2 (ja) |
CA (1) | CA2695437A1 (ja) |
MX (1) | MX2010001566A (ja) |
RU (1) | RU2010108325A (ja) |
WO (1) | WO2009020137A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013157511A1 (ja) * | 2012-04-16 | 2013-10-24 | 大日本住友製薬株式会社 | アリールアミノピラゾール誘導体 |
WO2015068773A1 (ja) * | 2013-11-08 | 2015-05-14 | 石原産業株式会社 | 含窒素飽和複素環化合物 |
JP2016512243A (ja) * | 2013-03-15 | 2016-04-25 | ヴァーセオン コーポレイション | トロンビン阻害剤としてのハロゲノピラゾール |
JP2016520115A (ja) * | 2013-05-28 | 2016-07-11 | レデックス ファーマ ピーエルシーRedx Pharma Plc | ヘッジホッグシグナル伝達経路阻害剤としての複素環化合物 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101955691B1 (ko) | 2010-03-30 | 2019-03-07 | 베르선 코포레이션 | 트롬빈 억제제로서의 다중치환된 방향족 화합물 |
CN102633659B (zh) * | 2012-02-23 | 2013-12-04 | 浙江普洛康裕制药有限公司 | 一种反式4-氨基-1-羟基金刚烷盐酸盐的合成方法 |
RU2019101889A (ru) | 2013-03-15 | 2019-03-28 | Версеон Корпорейшн | Полизамещенные ароматические соединения в качестве ингибиторов сериновых протеаз |
CA2960790A1 (en) | 2014-09-17 | 2016-03-24 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
US10532995B2 (en) | 2015-02-27 | 2020-01-14 | Verseon Corporation | Substituted pyrazole compounds as serine protease inhibitors |
CN111548317A (zh) * | 2020-04-28 | 2020-08-18 | 苏州纪元康生物科技有限公司 | 一种依法韦伦合成方法及制备其中间体方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004089470A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | New amide derivatives and pharmaceutical use thereof |
WO2005016877A2 (en) | 2003-08-07 | 2005-02-24 | Merck & Co., Inc. | Pyrazole carboxamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 |
WO2005095350A1 (en) * | 2004-03-23 | 2005-10-13 | Amgen Inc. | Pyrazole compounds and uses related thereto |
WO2006024627A2 (en) * | 2004-08-30 | 2006-03-09 | Janssen Pharmaceutica N.V. | N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7393842B2 (en) * | 2001-08-31 | 2008-07-01 | University Of Connecticut | Pyrazole analogs acting on cannabinoid receptors |
US8084467B2 (en) * | 1999-10-18 | 2011-12-27 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
JP2004502642A (ja) * | 2000-02-11 | 2004-01-29 | ブリストル−マイヤーズ スクイブ カンパニー | カンナビノイドレセプターモジュレーター、それらの製造方法、および呼吸系および非呼吸系疾患の処置のためのカンナビノイドレセプターモジュレーターの使用 |
US7880001B2 (en) * | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
-
2008
- 2008-08-06 MX MX2010001566A patent/MX2010001566A/es not_active Application Discontinuation
- 2008-08-06 RU RU2010108325/04A patent/RU2010108325A/ru not_active Application Discontinuation
- 2008-08-06 CA CA2695437A patent/CA2695437A1/en not_active Abandoned
- 2008-08-06 CN CN200880110520A patent/CN101827820A/zh active Pending
- 2008-08-06 JP JP2009526467A patent/JPWO2009020137A1/ja active Pending
- 2008-08-06 EP EP08826977A patent/EP2189449A4/en not_active Withdrawn
- 2008-08-06 US US12/672,236 patent/US20110071289A1/en not_active Abandoned
- 2008-08-06 BR BRPI0815112-1A patent/BRPI0815112A2/pt not_active IP Right Cessation
- 2008-08-06 KR KR1020107002725A patent/KR20100044829A/ko not_active Application Discontinuation
- 2008-08-06 WO PCT/JP2008/064085 patent/WO2009020137A1/ja active Application Filing
- 2008-08-06 AU AU2008284746A patent/AU2008284746A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004089470A2 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | New amide derivatives and pharmaceutical use thereof |
WO2005016877A2 (en) | 2003-08-07 | 2005-02-24 | Merck & Co., Inc. | Pyrazole carboxamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 |
WO2005095350A1 (en) * | 2004-03-23 | 2005-10-13 | Amgen Inc. | Pyrazole compounds and uses related thereto |
WO2006024627A2 (en) * | 2004-08-30 | 2006-03-09 | Janssen Pharmaceutica N.V. | N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
Non-Patent Citations (6)
Title |
---|
"Greene's Protective Groups in Organic Synthesis", 1981, JOHN WILEY & SONS INC. |
"The Experimental Chemistry", vol. 22, MARUZEN |
C. D. JONES; M. KASELJ ET AL., J. ORG. CHEM., vol. 63, 1998, pages 2758 - 2760 |
R.C. LAROCK, COMPREHENSIVE ORGANIC TRANSFORMATIONS, 1989 |
See also references of EP2189449A4 * |
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 48, 1983, pages 1099 |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013157511A1 (ja) * | 2012-04-16 | 2013-10-24 | 大日本住友製薬株式会社 | アリールアミノピラゾール誘導体 |
JP2016512243A (ja) * | 2013-03-15 | 2016-04-25 | ヴァーセオン コーポレイション | トロンビン阻害剤としてのハロゲノピラゾール |
JP2016520115A (ja) * | 2013-05-28 | 2016-07-11 | レデックス ファーマ ピーエルシーRedx Pharma Plc | ヘッジホッグシグナル伝達経路阻害剤としての複素環化合物 |
WO2015068773A1 (ja) * | 2013-11-08 | 2015-05-14 | 石原産業株式会社 | 含窒素飽和複素環化合物 |
Also Published As
Publication number | Publication date |
---|---|
MX2010001566A (es) | 2010-03-15 |
US20110071289A1 (en) | 2011-03-24 |
EP2189449A1 (en) | 2010-05-26 |
KR20100044829A (ko) | 2010-04-30 |
AU2008284746A1 (en) | 2009-02-12 |
RU2010108325A (ru) | 2011-09-20 |
JPWO2009020137A1 (ja) | 2010-11-04 |
CN101827820A (zh) | 2010-09-08 |
BRPI0815112A2 (pt) | 2015-08-25 |
EP2189449A4 (en) | 2011-10-19 |
CA2695437A1 (en) | 2009-02-12 |
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