FR2902791B1 - Derives d'urees de tropane,leur preparation et leur application en therapeutique - Google Patents

Derives d'urees de tropane,leur preparation et leur application en therapeutique

Info

Publication number
FR2902791B1
FR2902791B1 FR0605785A FR0605785A FR2902791B1 FR 2902791 B1 FR2902791 B1 FR 2902791B1 FR 0605785 A FR0605785 A FR 0605785A FR 0605785 A FR0605785 A FR 0605785A FR 2902791 B1 FR2902791 B1 FR 2902791B1
Authority
FR
France
Prior art keywords
urees
tropane
derivatives
preparation
therapeutic application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0605785A
Other languages
English (en)
Other versions
FR2902791A1 (fr
Inventor
Michel Aletru
Alain Jean Braun
Stefan Gussregen
Patrick Roger Mougenot
Claudie Suzanne Yvette Namane
Eric Nicolai
Christophe Philippo
Olivier Claude George Venier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0605785A priority Critical patent/FR2902791B1/fr
Priority to TW096122891A priority patent/TW200811170A/zh
Priority to PE2007000811A priority patent/PE20080344A1/es
Priority to KR1020087031631A priority patent/KR20090021193A/ko
Priority to PL07803782T priority patent/PL2046791T3/pl
Priority to AT07803782T priority patent/ATE461930T1/de
Priority to CA002648769A priority patent/CA2648769A1/fr
Priority to MX2008016492A priority patent/MX277822B/es
Priority to PT07803782T priority patent/PT2046791E/pt
Priority to ES07803782T priority patent/ES2342793T3/es
Priority to SI200730258T priority patent/SI2046791T1/sl
Priority to BRPI0713462-2A priority patent/BRPI0713462A2/pt
Priority to PCT/FR2007/001070 priority patent/WO2008000951A2/fr
Priority to CNA2007800241970A priority patent/CN101479265A/zh
Priority to DE602007005487T priority patent/DE602007005487D1/de
Priority to ARP070102821A priority patent/AR061642A1/es
Priority to JP2009517319A priority patent/JP2009541464A/ja
Priority to CL2007001885A priority patent/CL2007001885A1/es
Priority to EP07803782A priority patent/EP2046791B1/fr
Priority to RU2009102535/04A priority patent/RU2009102535A/ru
Priority to AU2007264792A priority patent/AU2007264792A1/en
Priority to DK07803782.7T priority patent/DK2046791T3/da
Priority to UY30447A priority patent/UY30447A1/es
Publication of FR2902791A1 publication Critical patent/FR2902791A1/fr
Application granted granted Critical
Publication of FR2902791B1 publication Critical patent/FR2902791B1/fr
Priority to IL195510A priority patent/IL195510A0/en
Priority to US12/332,547 priority patent/US7897773B2/en
Priority to CY20101100571T priority patent/CY1110132T1/el
Priority to US12/871,403 priority patent/US20100324084A1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
FR0605785A 2006-06-27 2006-06-27 Derives d'urees de tropane,leur preparation et leur application en therapeutique Expired - Fee Related FR2902791B1 (fr)

Priority Applications (27)

Application Number Priority Date Filing Date Title
FR0605785A FR2902791B1 (fr) 2006-06-27 2006-06-27 Derives d'urees de tropane,leur preparation et leur application en therapeutique
PE2007000811A PE20080344A1 (es) 2006-06-27 2007-06-25 Compuestos 8-azabiciclo[3.2.1]oct-8-il-1,2,3,4-tetrahidroquinolina sustituidos como inhibidores 11b-hsd1
TW096122891A TW200811170A (en) 2006-06-27 2007-06-25 Urea derivatives of tropane, their preparation and their therapeutic application
EP07803782A EP2046791B1 (fr) 2006-06-27 2007-06-26 Dérivés d'urees de tropane, leur préparation et leur application en thérapeutique
AT07803782T ATE461930T1 (de) 2006-06-27 2007-06-26 Harnstoffderivate von tropan, ihre herstellung und ihre therapeutische anwendung
CA002648769A CA2648769A1 (fr) 2006-06-27 2007-06-26 Derives d'urees de tropane, leur preparation et leur application en therapeutique
MX2008016492A MX277822B (es) 2006-06-27 2007-06-26 Derivados de urea de tropano, su preparacion y su aplicacion terapeutica.
PT07803782T PT2046791E (pt) 2006-06-27 2007-06-26 Derivados de ureias de tropano, sua preparação e sua aplicação em terapêutica
ES07803782T ES2342793T3 (es) 2006-06-27 2007-06-26 Derivados de ureas de tropano, su preparacion y su aplicacion en terapeutica.
SI200730258T SI2046791T1 (sl) 2006-06-27 2007-06-26 Sečninski derivati tropana, njihova priprava in njihova terapevtska uporaba
BRPI0713462-2A BRPI0713462A2 (pt) 2006-06-27 2007-06-26 derivado de uréias de tropano , a respectiva preparação e a respectiva aplicação em terapeutica
PCT/FR2007/001070 WO2008000951A2 (fr) 2006-06-27 2007-06-26 Dérivés d'urees de tropane, leur préparation et leur application en thérapeutique
CNA2007800241970A CN101479265A (zh) 2006-06-27 2007-06-26 拓烷尿素衍生物，它们的制备与治疗应用
DE602007005487T DE602007005487D1 (de) 2006-06-27 2007-06-26 Harnstoffderivate von tropan, ihre herstellung und ihre therapeutische anwendung
KR1020087031631A KR20090021193A (ko) 2006-06-27 2007-06-26 트로판의 우레아 유도체, 그의 제법 및 그의 치료 용도
JP2009517319A JP2009541464A (ja) 2006-06-27 2007-06-26 トロパンの尿素誘導体、その調製およびその治療用途
CL2007001885A CL2007001885A1 (es) 2006-06-27 2007-06-26 Compuestos derivados de urea de tropano, moduladores de la actividad de la 11betahsd1; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento de enfermedades tales como obesidad, diabetes, hipertension, aterosclerosis, demencia y osteoporosis.
PL07803782T PL2046791T3 (pl) 2006-06-27 2007-06-26 Mocznikowe pochodne tropanu, ich wytwarzanie i ich zastosowanie w lecznictwie
RU2009102535/04A RU2009102535A (ru) 2006-06-27 2007-06-26 Производные карбамидов тропана, их получение и их применение в терапии
AU2007264792A AU2007264792A1 (en) 2006-06-27 2007-06-26 Urea derivatives of tropane, their preparation and their therapeutic application
DK07803782.7T DK2046791T3 (da) 2006-06-27 2007-06-26 Ureaderivater af tropan, fremstilling deraf og terepeutisk anvendelse deraf
ARP070102821A AR061642A1 (es) 2006-06-27 2007-06-26 Derivados de ureas de tropano, su preparacion y su aplicacion en terapeu-tica, procesos de obtencion y composiciones farmaceuticas
UY30447A UY30447A1 (es) 2006-06-27 2007-06-27 Derivados de ureas de tropano, su preparacion y su aplicacion en terapéutica
IL195510A IL195510A0 (en) 2006-06-27 2008-11-25 Urea derivatives of tropane, their preparation and their therapeutic application
US12/332,547 US7897773B2 (en) 2006-06-27 2008-12-11 Urea derivatives of tropane, their preparation and their therapeutic application
CY20101100571T CY1110132T1 (el) 2006-06-27 2010-06-21 Παραγωγα ουριας τροπανιου, η παρασκευη τους και οι εφαρμογες τους στη θεραπευτικη
US12/871,403 US20100324084A1 (en) 2006-06-27 2010-08-30 Urea derivatives of tropane, their preparation and their therapeutic application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0605785A FR2902791B1 (fr) 2006-06-27 2006-06-27 Derives d'urees de tropane,leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2902791A1 FR2902791A1 (fr) 2007-12-28
FR2902791B1 true FR2902791B1 (fr) 2008-08-22

Family

ID=37714658

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0605785A Expired - Fee Related FR2902791B1 (fr) 2006-06-27 2006-06-27 Derives d'urees de tropane,leur preparation et leur application en therapeutique

Country Status (3)

Country Link
CN (1) CN101479265A (fr)
BR (1) BRPI0713462A2 (fr)
FR (1) FR2902791B1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2937641A1 (fr) * 2008-10-28 2010-04-30 Sanofi Aventis Derives d'urees de tropane, leur preparation et leur application en therapeutique
CN102596949B (zh) 2009-11-11 2015-08-19 大日本住友制药株式会社 8-氮杂双环[3.2.1]辛烷-8-甲酰胺衍生物
CN109422740B (zh) * 2017-08-27 2020-04-21 中南民族大学 一类莨菪烷型生物碱及其合成方法
CN109422729B (zh) * 2017-08-27 2020-06-09 中南民族大学 一类手性氮杂多环生物碱及其合成方法
CN111440162A (zh) * 2020-04-01 2020-07-24 邱曲真 噻唑二氢萘类衍生物及其在代谢性疾病中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0202001A2 (hu) * 2002-06-14 2005-08-29 Sanofi-Aventis DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
ATE482747T1 (de) * 2003-04-11 2010-10-15 High Point Pharmaceuticals Llc Neue amide derivate und deren pharmazeutische verwendungen

Also Published As

Publication number Publication date
FR2902791A1 (fr) 2007-12-28
CN101479265A (zh) 2009-07-08
BRPI0713462A2 (pt) 2012-01-24

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20120229