SI2069342T1 - Derivati aril fenil imidazo a piridinov njihova priprava in njihova terapevtska uporaba - Google Patents

Derivati aril fenil imidazo a piridinov njihova priprava in njihova terapevtska uporaba

Info

Publication number
SI2069342T1
SI2069342T1 SI200730316T SI200730316T SI2069342T1 SI 2069342 T1 SI2069342 T1 SI 2069342T1 SI 200730316 T SI200730316 T SI 200730316T SI 200730316 T SI200730316 T SI 200730316T SI 2069342 T1 SI2069342 T1 SI 2069342T1
Authority
SI
Slovenia
Prior art keywords
åpyridine
phenylimidazo
aryl
derivatives
preparation
Prior art date
Application number
SI200730316T
Other languages
English (en)
Inventor
Garcia Antonio Almario
Patrick Lardenois
Anne Olivier
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of SI2069342T1 publication Critical patent/SI2069342T1/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI200730316T 2006-09-22 2007-09-19 Derivati aril fenil imidazo a piridinov njihova priprava in njihova terapevtska uporaba SI2069342T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0608350A FR2906250B1 (fr) 2006-09-22 2006-09-22 Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique
PCT/FR2007/001517 WO2008034974A1 (fr) 2006-09-22 2007-09-19 DERIVES DE 2-ARYL-6-PHENYL-IMIDAZO[1,2-α]PYRIDINES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
EP07848251A EP2069342B1 (fr) 2006-09-22 2007-09-19 Derives de 2-aryl-6-phenyl-imidazo[1,2-a]pyridines, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
SI2069342T1 true SI2069342T1 (sl) 2010-09-30

Family

ID=37841968

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200730316T SI2069342T1 (sl) 2006-09-22 2007-09-19 Derivati aril fenil imidazo a piridinov njihova priprava in njihova terapevtska uporaba

Country Status (43)

Country Link
US (1) US7915284B2 (sl)
EP (1) EP2069342B1 (sl)
JP (1) JP5336378B2 (sl)
KR (1) KR101470039B1 (sl)
CN (1) CN101516881B (sl)
AR (1) AR062897A1 (sl)
AT (1) ATE467633T1 (sl)
AU (1) AU2007298856B2 (sl)
BR (1) BRPI0718517A2 (sl)
CA (1) CA2662848C (sl)
CL (1) CL2007002733A1 (sl)
CO (1) CO6160308A2 (sl)
CR (1) CR10643A (sl)
CY (1) CY1110232T1 (sl)
DE (1) DE602007006525D1 (sl)
DK (1) DK2069342T3 (sl)
EA (1) EA017442B1 (sl)
ES (1) ES2345016T3 (sl)
FR (1) FR2906250B1 (sl)
GT (1) GT200900049A (sl)
HN (1) HN2009000502A (sl)
HR (1) HRP20100408T1 (sl)
IL (1) IL197352A (sl)
JO (1) JO2643B1 (sl)
MA (1) MA30792B1 (sl)
ME (1) ME00615B (sl)
MX (1) MX2009002802A (sl)
MY (1) MY145603A (sl)
NI (1) NI200900037A (sl)
NO (1) NO20091562L (sl)
NZ (1) NZ575337A (sl)
PE (1) PE20080671A1 (sl)
PL (1) PL2069342T3 (sl)
PT (1) PT2069342E (sl)
RS (1) RS51412B (sl)
SI (1) SI2069342T1 (sl)
SV (1) SV2009003193A (sl)
TN (1) TN2009000081A1 (sl)
TW (1) TWI381837B (sl)
UA (1) UA95976C2 (sl)
UY (1) UY30603A1 (sl)
WO (1) WO2008034974A1 (sl)
ZA (1) ZA200901551B (sl)

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FR2928924B1 (fr) 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
FR2928922B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
FR2928921B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines, leur preparation et leur application en therapeutique
FR2928923B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques
FR2933609B1 (fr) * 2008-07-10 2010-08-27 Fournier Lab Sa Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson.
FR2950344B1 (fr) * 2009-09-18 2011-11-25 Sanofi Aventis Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique.
FR2950345B1 (fr) * 2009-09-18 2011-09-23 Sanofi Aventis Derives acetyleniques de 5-phenyl-pyrazolopyridine, leur preparation et leur application en therapeutique
FR2953520B1 (fr) * 2009-12-04 2011-11-25 Sanofi Aventis Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique
RU2644949C2 (ru) * 2012-11-29 2018-02-15 Ф. Хоффманн-Ля Рош Аг Производные имидазопиридина, стимулирующие нейрогенез
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
US9079866B2 (en) 2013-02-04 2015-07-14 Janssen Pharmaceutica Nv Flap modulators
CN105745208A (zh) * 2013-08-02 2016-07-06 韩国巴斯德研究所 一种抗感染化合物
CN107531693B (zh) 2015-04-10 2021-07-06 百济神州有限公司 作为吲哚胺、色氨酸二加氧酶抑制剂的5或8-取代的咪唑并[1，5-a]吡啶
US20170107216A1 (en) 2015-10-19 2017-04-20 Incyte Corporation Heterocyclic compounds as immunomodulators
AU2016358100B2 (en) 2015-11-19 2021-05-27 Incyte Corporation Heterocyclic compounds as immunomodulators
TW201726623A (zh) 2015-12-17 2017-08-01 英塞特公司 作為免疫調節劑之雜環化合物
TWI850624B (zh) 2015-12-22 2024-08-01 美商英塞特公司 作為免疫調節劑之雜環化合物
TW201808950A (zh) 2016-05-06 2018-03-16 英塞特公司 作為免疫調節劑之雜環化合物
US20170342060A1 (en) 2016-05-26 2017-11-30 Incyte Corporation Heterocyclic compounds as immunomodulators
DK3472167T3 (da) 2016-06-20 2022-09-05 Incyte Corp Heterocykliske forbindelser som immunomodulatorer
EP3484866B1 (en) 2016-07-14 2022-09-07 Incyte Corporation Heterocyclic compounds as immunomodulators
EP3504198B1 (en) 2016-08-29 2023-01-25 Incyte Corporation Heterocyclic compounds as immunomodulators
US10882856B2 (en) 2016-09-24 2021-01-05 Beigene, Ltd. 5 or 8-substituted imidazo [1,5-a] pyridines as selective inhibitors of indoleamine and/or tryptophane 2,3-dioxygenases
IL295660A (en) 2016-12-22 2022-10-01 Incyte Corp Benzooxazole derivatives as immunomodulators
ES2929193T3 (es) 2016-12-22 2022-11-25 Incyte Corp Derivados de tetrahidro imidazo[4,5-c]piridina como inductores de la internalización de PD-L1
EP3558963B1 (en) 2016-12-22 2022-03-23 Incyte Corporation Bicyclic heteroaromatic compounds as immunomodulators
ES2874756T3 (es) 2016-12-22 2021-11-05 Incyte Corp Derivados de triazolo[1,5-A]piridina como inmunomoduladores
EP3558973B1 (en) 2016-12-22 2021-09-15 Incyte Corporation Pyridine derivatives as immunomodulators
WO2019101188A1 (en) 2017-11-25 2019-05-31 Beigene, Ltd. Novel benzoimidazoles as selective inhibitors of indoleamine 2, 3-dioxygenases
RS64055B1 (sr) 2018-03-30 2023-04-28 Incyte Corp Heterociklična jedinjenja kao imunomodulatori
EP4219492B1 (en) 2018-05-11 2024-11-27 Incyte Corporation Heterocyclic compounds as immunomodulators
JP7665593B2 (ja) 2019-08-09 2025-04-21 インサイト・コーポレイション Ｐｄ－１／ｐｄ－ｌ１阻害剤の塩
EP4037773A1 (en) 2019-09-30 2022-08-10 Incyte Corporation Pyrido[3,2-d]pyrimidine compounds as immunomodulators
BR112022009031A2 (pt) 2019-11-11 2022-10-11 Incyte Corp Sais e formas cristalinas de um inibidor de pd-1/pd-l1
WO2021097243A1 (en) * 2019-11-13 2021-05-20 Aprinoia Therapeutics Inc. Compounds for degrading tau protein aggregates and uses thereof
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US11760756B2 (en) 2020-11-06 2023-09-19 Incyte Corporation Crystalline form of a PD-1/PD-L1 inhibitor
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JP4041624B2 (ja) * 1999-07-21 2008-01-30 三井化学株式会社 有機電界発光素子
AU2001249672A1 (en) * 2000-03-31 2001-10-15 Ortho-Mcneil Pharmaceutical, Inc. Method for using 2- or 3-aryl substituted imidazo(1,2-a) pyridines as h3 antagonists
GB0119911D0 (en) * 2001-08-15 2001-10-10 Novartis Ag Organic Compounds
ATE378336T1 (de) * 2002-09-19 2007-11-15 Schering Corp Imidazopyridine als hemmstoffe cyclin abhängiger kinasen
GB0303503D0 (en) * 2003-02-14 2003-03-19 Novartis Ag Organic compounds
CN1930159A (zh) * 2004-03-08 2007-03-14 北卡罗来纳大学查珀尔希尔分校 作为抗原生动物药的新的双阳离子咪唑并[1,2－a]吡啶和5,6,7,8－四氢－咪唑并[1,2－a]吡啶化合物

Also Published As

Publication number Publication date
CN101516881A (zh) 2009-08-26
JP2010504309A (ja) 2010-02-12
EA200970311A1 (ru) 2009-08-28
ATE467633T1 (de) 2010-05-15
KR101470039B1 (ko) 2014-12-05
DE602007006525D1 (de) 2010-06-24
HN2009000502A (es) 2011-07-11
NO20091562L (no) 2009-04-20
CA2662848C (fr) 2014-12-23
HK1135388A1 (en) 2010-06-04
CR10643A (es) 2009-04-29
NZ575337A (en) 2011-12-22
AU2007298856B2 (en) 2012-08-09
IL197352A (en) 2014-11-30
HRP20100408T1 (hr) 2010-09-30
ZA200901551B (en) 2010-06-30
UY30603A1 (es) 2008-05-02
TWI381837B (zh) 2013-01-11
CL2007002733A1 (es) 2008-04-11
AU2007298856A1 (en) 2008-03-27
DK2069342T3 (da) 2010-08-23
BRPI0718517A2 (pt) 2013-11-19
MEP10709A (en) 2011-12-20
FR2906250A1 (fr) 2008-03-28
CO6160308A2 (es) 2010-05-20
NI200900037A (es) 2014-02-20
EA017442B1 (ru) 2012-12-28
TW200833329A (en) 2008-08-16
EP2069342A1 (fr) 2009-06-17
SV2009003193A (es) 2010-02-01
JO2643B1 (en) 2012-06-17
RS51412B (sr) 2011-02-28
CY1110232T1 (el) 2015-01-14
PE20080671A1 (es) 2008-07-14
PT2069342E (pt) 2010-07-19
PL2069342T3 (pl) 2010-10-29
US7915284B2 (en) 2011-03-29
MY145603A (en) 2012-03-15
AR062897A1 (es) 2008-12-10
WO2008034974A1 (fr) 2008-03-27
CA2662848A1 (fr) 2008-03-27
MX2009002802A (es) 2009-04-01
KR20090054449A (ko) 2009-05-29
JP5336378B2 (ja) 2013-11-06
FR2906250B1 (fr) 2008-10-31
UA95976C2 (en) 2011-09-26
MA30792B1 (fr) 2009-10-01
IL197352A0 (en) 2009-12-24
ES2345016T3 (es) 2010-09-13
GT200900049A (es) 2010-03-04
ME00615B (me) 2011-12-20
CN101516881B (zh) 2012-07-18
TN2009000081A1 (en) 2010-08-19
US20090253735A1 (en) 2009-10-08
EP2069342B1 (fr) 2010-05-12

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