JP2006528617A5 - - Google Patents
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- Publication number
- JP2006528617A5 JP2006528617A5 JP2006520897A JP2006520897A JP2006528617A5 JP 2006528617 A5 JP2006528617 A5 JP 2006528617A5 JP 2006520897 A JP2006520897 A JP 2006520897A JP 2006520897 A JP2006520897 A JP 2006520897A JP 2006528617 A5 JP2006528617 A5 JP 2006528617A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- group
- optionally
- aryl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 2
- 125000005488 carboaryl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 1
- -1 4-phenyl-phenyl Chemical group 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 230000003042 antagnostic effect Effects 0.000 claims 1
- 230000008485 antagonism Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0317346A GB0317346D0 (en) | 2003-07-24 | 2003-07-24 | 5-ht2b receptor antagonists |
| US49028603P | 2003-07-28 | 2003-07-28 | |
| PCT/GB2004/003184 WO2005012263A1 (en) | 2003-07-24 | 2004-07-23 | 5-ht2b receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006528617A JP2006528617A (ja) | 2006-12-21 |
| JP2006528617A5 true JP2006528617A5 (enExample) | 2007-09-06 |
Family
ID=34117640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006520897A Withdrawn JP2006528617A (ja) | 2003-07-24 | 2004-07-23 | ５−ｈｔ２ｂ受容体アンタゴニスト |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090018150A1 (enExample) |
| EP (1) | EP1648876A1 (enExample) |
| JP (1) | JP2006528617A (enExample) |
| CA (1) | CA2532505A1 (enExample) |
| WO (1) | WO2005012263A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005097113A2 (en) * | 2004-04-08 | 2005-10-20 | Pharmagene Laboratories Limited | 5-ht2b receptor antagonists |
| US8569352B2 (en) | 2005-06-27 | 2013-10-29 | Exelixis Patent Company Llc | Imidazole based LXR modulators |
| SG162803A1 (en) * | 2005-06-27 | 2010-07-29 | Exelixis Inc | Imidazole based lxr modulators |
| JO3019B1 (ar) | 2006-04-19 | 2016-09-05 | Janssen Pharmaceutica Nv | ثلاثي مستبدل 4،2،1-ثلاثي زولات |
| CN101679297B (zh) | 2006-12-08 | 2012-01-11 | 埃克塞利希斯股份有限公司 | Lxr和fxr调节剂 |
| EP2053920B1 (en) | 2007-01-26 | 2014-04-30 | North Carolina State University | Inhibition of bacterial biofilms with imidazole derivatives |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
| ES2424023T3 (es) | 2007-10-18 | 2013-09-26 | Janssen Pharmaceutica N.V. | 1,2,4-triazoles trisustituidos |
| EP2224809A4 (en) | 2007-11-27 | 2014-06-11 | Univ North Carolina State | INHIBITION OF BIOFILMS IN PLANTS WITH IMIDAZOLE DERIVATIVES |
| MY152486A (en) | 2008-03-19 | 2014-10-15 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4 - triazoles as nicotinic acetylcholine receptor modulators |
| US9005643B2 (en) | 2008-04-04 | 2015-04-14 | North Carolina State University | Inhibition of bacterial biofilms with imidazole-phenyl derivatives |
| WO2009131654A2 (en) | 2008-04-21 | 2009-10-29 | North Carolina State University | Inhibition and dispersion of bacterial biofilms with imidazole-triazole derivatives |
| US8779158B2 (en) | 2008-05-09 | 2014-07-15 | Janssen Pharmaceutica Nv | Trisubstituted pyrazoles as acetylcholine receptor modulators |
| WO2010017902A1 (de) * | 2008-08-14 | 2010-02-18 | Bayer Cropscience Aktiengesellschaft | Insektizide 4-phenyl-1h-pyrazole |
| US20110294668A1 (en) | 2008-12-08 | 2011-12-01 | North Carolina State University | Inhibition and dispersion of biofilms in plants with imidazole-triazole derivatives |
| WO2010144686A1 (en) | 2009-06-10 | 2010-12-16 | North Carolina State University | Inhibition and dispersion of bacterial biofilms with benzimidazole derivatives |
| WO2011015524A2 (en) * | 2009-08-03 | 2011-02-10 | Bayer Cropscience Ag | Fungicide heterocycles derivatives |
| EP2513064B1 (en) | 2009-12-17 | 2018-07-04 | Katholieke Universiteit Leuven K.U. Leuven R&D | Compounds, compositions and methods for controlling biofilms |
| WO2012135016A2 (en) | 2011-03-25 | 2012-10-04 | North Carolina State University | Inhibition of bacterial biofilms and microbial growth with imidazole derivatives |
| US20140010783A1 (en) * | 2012-07-06 | 2014-01-09 | Hoffmann-La Roche Inc. | Antiviral compounds |
| US20160002180A1 (en) * | 2013-03-05 | 2016-01-07 | Hoffmann-La Roche Inc. | Antiviral compounds |
| JP6163214B2 (ja) | 2013-03-06 | 2017-07-12 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 抗ウイルス化合物 |
| EP3119394B1 (en) | 2014-03-19 | 2021-05-12 | Curza Global LLC | Compositions and methods comprising 2-(acylamino)imidazoles |
| JP6552061B2 (ja) | 2014-06-10 | 2019-07-31 | サンフォード−バーンハム メディカル リサーチ インスティテュート | 代謝型グルタミン酸受容体の負のアロステリックモジュレーター（ｎａｍｓ）とその使用 |
| WO2018184019A1 (en) | 2017-03-31 | 2018-10-04 | Curza Global, Llc | Compositions and methods comprising substituted 2-aminoimidazoles |
| TWI782504B (zh) * | 2020-05-08 | 2022-11-01 | 美商美國禮來大藥廠 | (三氟甲基)嘧啶-2-胺化合物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE492033A (enExample) * | 1948-11-05 | |||
| GB696692A (en) * | 1950-12-06 | 1953-09-09 | Ici Ltd | New quinazoline derivatives |
| US3464987A (en) * | 1966-02-21 | 1969-09-02 | Upjohn Co | 1,2-dihydro-1-hydroxy-2-imino-6-(lower alkyl)pyrimidines |
| EP0658559A1 (de) * | 1993-12-14 | 1995-06-21 | Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. | Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren |
| US5733932A (en) * | 1995-01-06 | 1998-03-31 | The Picower Institute For Medical Research | Compounds and methods of use to derivatize neighboring lysine residues in proteins under physiological conditions |
| US5958934A (en) * | 1996-05-23 | 1999-09-28 | Syntex (U.S.A.) Inc. | Aryl pyrimidine derivatives and uses thereof |
| US5952331A (en) * | 1996-05-23 | 1999-09-14 | Syntex (Usa) Inc. | Aryl pyrimidine derivatives |
| TW440563B (en) * | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
| CA2445003A1 (en) * | 2001-05-16 | 2002-11-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | Diarylurea derivatives useful as anti-inflammatory agents |
| GB0203412D0 (en) * | 2002-02-13 | 2002-04-03 | Pharmagene Lab Ltd | 5-HT 2B receptor antagonists |
| US6995181B2 (en) * | 2002-07-18 | 2006-02-07 | Bristol-Myers Squibb Co. | Modulators of the glucocorticoid receptor and method |
| AU2003251969A1 (en) * | 2002-07-18 | 2004-02-09 | Bristol-Myers Squibb Company | Compositions and methods involving nuclear hormone receptor site ii |
| DE60328035D1 (de) * | 2002-11-29 | 2009-07-30 | Banyu Pharma Co Ltd | Neue azolderivate |
-
2004
- 2004-07-23 CA CA002532505A patent/CA2532505A1/en not_active Abandoned
- 2004-07-23 JP JP2006520897A patent/JP2006528617A/ja not_active Withdrawn
- 2004-07-23 WO PCT/GB2004/003184 patent/WO2005012263A1/en not_active Ceased
- 2004-07-23 EP EP04743517A patent/EP1648876A1/en not_active Withdrawn
- 2004-07-23 US US10/564,010 patent/US20090018150A1/en not_active Abandoned