JP6456823B2 - 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体 - Google Patents

疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体 Download PDF

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JP6456823B2
JP6456823B2 JP2015523576A JP2015523576A JP6456823B2 JP 6456823 B2 JP6456823 B2 JP 6456823B2 JP 2015523576 A JP2015523576 A JP 2015523576A JP 2015523576 A JP2015523576 A JP 2015523576A JP 6456823 B2 JP6456823 B2 JP 6456823B2
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charom
arom
mmol
pain
solution
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JP2015522650A5 (enExample
JP2015522650A (ja
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ピエール、ソコロフ
フレデリック、カシュー
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ピエール、ファーブル、メディカマン
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2015523576A 2012-07-27 2013-07-29 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体 Active JP6456823B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12305922.2 2012-07-27
EP12305922.2A EP2689778A1 (en) 2012-07-27 2012-07-27 Derivatives of azaindoles or diazaindoles for treating pain
PCT/EP2013/065907 WO2014016433A1 (en) 2012-07-27 2013-07-29 Derivatives of azaindazole or diazaindazole type for treating pain

Related Child Applications (1)

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JP2018200317A Division JP6732855B2 (ja) 2012-07-27 2018-10-24 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体

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JP2015522650A JP2015522650A (ja) 2015-08-06
JP2015522650A5 JP2015522650A5 (enExample) 2016-09-15
JP6456823B2 true JP6456823B2 (ja) 2019-01-23

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JP2015523576A Active JP6456823B2 (ja) 2012-07-27 2013-07-29 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体
JP2018200317A Active JP6732855B2 (ja) 2012-07-27 2018-10-24 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体

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US (1) US9381195B2 (enExample)
EP (2) EP2689778A1 (enExample)
JP (2) JP6456823B2 (enExample)
KR (1) KR102120505B1 (enExample)
CN (1) CN104684554B (enExample)
AU (1) AU2013294920B2 (enExample)
BR (1) BR112015001502B1 (enExample)
CA (1) CA2879595C (enExample)
CY (1) CY1118478T1 (enExample)
DK (1) DK2877177T3 (enExample)
ES (1) ES2612349T3 (enExample)
HR (1) HRP20170104T1 (enExample)
HU (1) HUE032919T2 (enExample)
IL (1) IL236917A (enExample)
LT (1) LT2877177T (enExample)
MA (1) MA37866B1 (enExample)
MX (1) MX363605B (enExample)
MY (1) MY183398A (enExample)
NZ (1) NZ705253A (enExample)
PL (1) PL2877177T3 (enExample)
PT (1) PT2877177T (enExample)
RS (1) RS55646B1 (enExample)
RU (1) RU2640046C2 (enExample)
SI (1) SI2877177T1 (enExample)
TN (1) TN2015000034A1 (enExample)
UA (1) UA116107C2 (enExample)
WO (1) WO2014016433A1 (enExample)
ZA (1) ZA201501209B (enExample)

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AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
CN102971322B (zh) 2010-05-20 2016-02-17 阵列生物制药公司 作为trk激酶抑制剂的大环化合物
WO2015143652A1 (en) * 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
AU2015328307B2 (en) * 2014-10-06 2019-11-21 Apm Therapeutics 1, Inc. Triazolopyridine compounds and methods for the treatment of cystic fibrosis
CA2967951C (en) 2014-11-16 2023-11-07 Array Biopharma, Inc. Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate
WO2016096709A1 (en) 2014-12-16 2016-06-23 Eudendron S.R.L. Heterocyclic derivatives modulating activity of certain protein kinases
WO2017075107A1 (en) 2015-10-26 2017-05-04 Nanda Nisha Point mutations in trk inhibitor-resistant cancer and methods relating to the same
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
DK3439662T3 (da) 2016-04-04 2024-09-02 Loxo Oncology Inc Væskeformige formuleringer af (s)-n-(5-((r)-2-(2,5-difluorphenyl)-pyrrolidin-1-yl)-pyrazol[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidin-1-carboxamid
US11214571B2 (en) 2016-05-18 2022-01-04 Array Biopharma Inc. Process for the preparation of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide and salts thereof
WO2018049271A1 (en) * 2016-09-09 2018-03-15 Flx Bio, Inc. Chemokine receptor modulators and uses thereof
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WO2018079759A1 (ja) * 2016-10-31 2018-05-03 塩野義製薬株式会社 ＴｒｋＡ阻害活性を有する縮合複素環および縮合炭素環誘導体
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
CN112313232B (zh) * 2018-05-02 2024-03-08 Jw中外制药公司 新型杂环衍生物
KR102129114B1 (ko) * 2018-07-26 2020-07-02 주식회사 온코파마텍 TrkA 저해 활성을 갖는 화합물 및 이를 유효성분으로 함유하는 통증의 예방 또는 치료용 약학적 조성물
EP3725777A1 (en) * 2019-04-17 2020-10-21 Rottapharm Biotech S.r.l. Benzo- and pyrido-pyrazoles as protein kinase inhibitors
CN110105356B (zh) * 2019-05-31 2022-04-01 四川国康药业有限公司 一种氮杂吲哚类化合物及其制备方法和用途
KR20250173578A (ko) * 2023-05-24 2025-12-10 장춘 진사이언스 파마슈티컬 씨오., 엘티디. Fgfr2/3 선택적 억제제, 약학 조성물 및 이의 용도

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JP2019031542A (ja) * 2012-07-27 2019-02-28 ピエール、ファーブル、メディカマン 疼痛を治療するためのアザインダゾールまたはジアザインダゾール型の誘導体

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BR112015001502A2 (pt) 2017-07-04
MA37866A1 (fr) 2016-05-31
AU2013294920B2 (en) 2017-08-24
JP6732855B2 (ja) 2020-07-29
EP2877177A1 (en) 2015-06-03
HUE032919T2 (hu) 2017-11-28
PL2877177T3 (pl) 2017-04-28
RU2640046C2 (ru) 2017-12-26
DK2877177T3 (en) 2017-02-06
MA37866B1 (fr) 2016-12-30
UA116107C2 (uk) 2018-02-12
MY183398A (en) 2021-02-18
KR102120505B1 (ko) 2020-06-08
HK1207302A1 (en) 2016-01-29
ZA201501209B (en) 2016-03-30
KR20150038295A (ko) 2015-04-08
CN104684554A (zh) 2015-06-03
TN2015000034A1 (en) 2016-06-29
MX2015001009A (es) 2015-06-04
CY1118478T1 (el) 2017-07-12
CA2879595A1 (en) 2014-01-30
SI2877177T1 (sl) 2017-02-28
IL236917A (en) 2016-11-30
RS55646B1 (sr) 2017-06-30
EP2877177B1 (en) 2016-10-26
WO2014016433A1 (en) 2014-01-30
NZ705253A (en) 2017-05-26
LT2877177T (lt) 2017-01-25
EP2689778A1 (en) 2014-01-29
MX363605B (es) 2019-03-26
JP2019031542A (ja) 2019-02-28
PT2877177T (pt) 2017-02-06
HRP20170104T1 (hr) 2017-03-24
CA2879595C (en) 2020-07-28
AU2013294920A1 (en) 2015-03-12
ES2612349T3 (es) 2017-05-16
US20150190394A1 (en) 2015-07-09
US9381195B2 (en) 2016-07-05
CN104684554B (zh) 2017-05-10
JP2015522650A (ja) 2015-08-06
BR112015001502B1 (pt) 2023-03-07
RU2015106434A (ru) 2016-09-20

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