JP2015509075A5 - - Google Patents
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- Publication number
- JP2015509075A5 JP2015509075A5 JP2014545968A JP2014545968A JP2015509075A5 JP 2015509075 A5 JP2015509075 A5 JP 2015509075A5 JP 2014545968 A JP2014545968 A JP 2014545968A JP 2014545968 A JP2014545968 A JP 2014545968A JP 2015509075 A5 JP2015509075 A5 JP 2015509075A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- salt
- composition
- hydrogen
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 15
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 239000001257 hydrogen Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- 206010012335 Dependence Diseases 0.000 claims description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 2
- 0 CC[C@](C1)C2N3CCC4c5cc(O*)ccc5N(*)C4[C@]2CC1C3 Chemical compound CC[C@](C1)C2N3CCC4c5cc(O*)ccc5N(*)C4[C@]2CC1C3 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161569144P | 2011-12-09 | 2011-12-09 | |
| US61/569,144 | 2011-12-09 | ||
| PCT/US2012/067627 WO2013085849A2 (en) | 2011-12-09 | 2012-12-03 | Sulfate esters of noribogaine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017161033A Division JP2017203046A (ja) | 2011-12-09 | 2017-08-24 | ノルイボガインの硫酸エステル |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015509075A JP2015509075A (ja) | 2015-03-26 |
| JP2015509075A5 true JP2015509075A5 (enExample) | 2016-01-21 |
Family
ID=48575046
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014545968A Pending JP2015509075A (ja) | 2011-12-09 | 2012-12-03 | ノルイボガインの硫酸エステル |
| JP2017161033A Pending JP2017203046A (ja) | 2011-12-09 | 2017-08-24 | ノルイボガインの硫酸エステル |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017161033A Pending JP2017203046A (ja) | 2011-12-09 | 2017-08-24 | ノルイボガインの硫酸エステル |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8853201B2 (enExample) |
| EP (1) | EP2788356A4 (enExample) |
| JP (2) | JP2015509075A (enExample) |
| CA (1) | CA2855990A1 (enExample) |
| WO (1) | WO2013085849A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9045481B2 (en) * | 2012-12-20 | 2015-06-02 | Demerx, Inc. | Substituted noribogaine |
| EP2934541A4 (en) * | 2012-12-20 | 2016-08-03 | Demerx Inc | SUBSTITUTED NORIBOGAIN |
| CA2942638C (en) | 2013-03-15 | 2026-03-10 | Demerx, Inc. | Method for noribogaine treatment of addiction in patients on methadone |
| KR20220044380A (ko) | 2013-04-12 | 2022-04-07 | 이칸 스쿨 오브 메디슨 엣 마운트 시나이 | 외상후 스트레스 장애의 치료 방법 |
| US9561232B2 (en) | 2014-02-18 | 2017-02-07 | Demerx, Inc. | Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use |
| US9591978B2 (en) | 2014-03-13 | 2017-03-14 | Demerx, Inc. | Methods and compositions for pre-screening patients for treatment with noribogaine |
| US9549935B2 (en) | 2014-07-14 | 2017-01-24 | Demerx, Inc. | Methods and compositions for treating migraines using noribogaine |
| ES2867174T3 (es) | 2014-11-26 | 2021-10-20 | Demerx Inc | Métodos y composiciones para potenciar la acción de analgésicos opioides mediante el uso de alcaloides de iboga |
| WO2016134019A1 (en) * | 2015-02-19 | 2016-08-25 | Demerx, Inc. | Methods for treating disorders associated with undesired activity of neuronal nicotinic acetylcholine receptors |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| KR20220008824A (ko) | 2019-04-17 | 2022-01-21 | 컴퍼스 패쓰파인더 리미티드 | 실로시빈으로 불안 장애, 두통 장애 및 섭식 장애를 치료하는 방법 |
| GB2611705B (en) | 2019-07-15 | 2024-03-27 | Demerx Inc | Methods for the non-toxic treatment for opioid drug withdrawal combining noribogaine and cannabinoids |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2813873A (en) * | 1957-11-19 | Derivatives of the ibogaine alkaloids | ||
| US4626539A (en) | 1984-08-10 | 1986-12-02 | E. I. Dupont De Nemours And Company | Trandermal delivery of opioids |
| US4806341A (en) | 1985-02-25 | 1989-02-21 | Rutgers, The State University Of New Jersey | Transdermal absorption dosage unit for narcotic analgesics and antagonists and process for administration |
| JPH0615546B2 (ja) * | 1986-02-24 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
| US5149538A (en) | 1991-06-14 | 1992-09-22 | Warner-Lambert Company | Misuse-resistive transdermal opioid dosage form |
| WO1996003127A1 (en) * | 1994-07-25 | 1996-02-08 | Nda International, Inc. | A method of treating chemical dependency in mammals and a composition therefor |
| WO1997005869A1 (en) * | 1995-08-08 | 1997-02-20 | Albany Medical College | Ibogamine congeners |
| US5616575A (en) * | 1995-12-04 | 1997-04-01 | Regents Of The University Of Minnesota | Bioactive tricyclic ibogaine analogs |
| ES2224430T3 (es) * | 1997-09-04 | 2005-03-01 | Novoneuron Inc | Noribogaina en el tratamiento del dolor y de la toxicomania. |
| US7220737B1 (en) | 1997-09-04 | 2007-05-22 | Novoneuron, Inc | Noribogaine in the treatment of pain and drug addiction |
| TW201018694A (en) * | 2008-09-29 | 2010-05-16 | Abbott Lab | Indole and indoline derivatives and methods of use thereof |
-
2012
- 2012-12-03 CA CA2855990A patent/CA2855990A1/en not_active Abandoned
- 2012-12-03 EP EP12855158.7A patent/EP2788356A4/en not_active Withdrawn
- 2012-12-03 JP JP2014545968A patent/JP2015509075A/ja active Pending
- 2012-12-03 WO PCT/US2012/067627 patent/WO2013085849A2/en not_active Ceased
- 2012-12-07 US US13/708,844 patent/US8853201B2/en active Active
-
2017
- 2017-08-24 JP JP2017161033A patent/JP2017203046A/ja active Pending
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