EA201792071A2 - Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения - Google Patents
Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их полученияInfo
- Publication number
- EA201792071A2 EA201792071A2 EA201792071A EA201792071A EA201792071A2 EA 201792071 A2 EA201792071 A2 EA 201792071A2 EA 201792071 A EA201792071 A EA 201792071A EA 201792071 A EA201792071 A EA 201792071A EA 201792071 A2 EA201792071 A2 EA 201792071A2
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- glutarimides
- derivatives
- general formula
- methods
- basis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Настоящее изобретение относится к новым биологически активным производным глутаримидов общей формулы (I) или их фармацевтически приемлемым солям, их применению в качестве средств для лечения заболеваний верхних дыхательных путей, фармацевтическим композициям, содержащим производные глутаримидов общей формулы (I), способам получения производных глутаримидов общей формулы (I) нагреванием моноамида дикарбоновой кислоты общей формулы (II) с водоотнимающим агентом.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2013116826A RU2562773C3 (ru) | 2013-04-12 | Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения |
Publications (3)
Publication Number | Publication Date |
---|---|
EA201792071A2 true EA201792071A2 (ru) | 2018-04-30 |
EA201792071A3 EA201792071A3 (ru) | 2018-09-28 |
EA033054B1 EA033054B1 (ru) | 2019-08-30 |
Family
ID=51689819
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201591957A EA031392B1 (ru) | 2013-04-12 | 2014-04-10 | Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения |
EA201792597A EA032938B1 (ru) | 2013-04-12 | 2014-04-10 | Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения |
EA201792071A EA033054B1 (ru) | 2013-04-12 | 2014-04-10 | Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения |
EA201792072A EA032951B1 (ru) | 2013-04-12 | 2014-04-10 | Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201591957A EA031392B1 (ru) | 2013-04-12 | 2014-04-10 | Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения |
EA201792597A EA032938B1 (ru) | 2013-04-12 | 2014-04-10 | Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201792072A EA032951B1 (ru) | 2013-04-12 | 2014-04-10 | Производное глутаримидов, его применение, фармацевтическая композиция на его основе, способ его получения |
Country Status (15)
Country | Link |
---|---|
US (8) | US9815814B2 (ru) |
EP (3) | EP3725785B1 (ru) |
JP (4) | JP6529958B2 (ru) |
KR (3) | KR102254315B1 (ru) |
CN (4) | CN110172055B (ru) |
AU (5) | AU2014251442A1 (ru) |
BR (3) | BR122020010204B1 (ru) |
CA (1) | CA2909057C (ru) |
EA (4) | EA031392B1 (ru) |
IL (4) | IL266301B2 (ru) |
MX (4) | MX2015014336A (ru) |
SG (4) | SG10201802647QA (ru) |
UA (1) | UA121299C2 (ru) |
WO (1) | WO2014168522A1 (ru) |
ZA (3) | ZA201508278B (ru) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023177329A1 (ru) * | 2022-03-18 | 2023-09-21 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Применение 1-(2-(1н-имидазол-4-ил)этил)пиперидин-2,6-диона для лечения кашля, вызванного вирусными инфекциями |
RU2819722C2 (ru) * | 2022-03-18 | 2024-05-23 | Общество С Ограниченной Ответственностью "Валента - Интеллект" | Применение 1-(2-(1н-имидазол-4-ил)этил)пиперидин-2,6-диона для лечения кашля, вызванного вирусными инфекциями |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2015014336A (es) * | 2013-04-12 | 2016-06-07 | Obschestvo S Ogranichennoi Otveststvennostiyu Pharmentpr | Derivados de glutarimida, uso de los mismos, composicion farmaceutica basada en los mismos y metodos para producir derivados de glutarimida. |
RU2552929C1 (ru) | 2013-11-14 | 2015-06-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Фармацевтическая композиция, содержащая производные глутаримидов, и их применение для лечения эозинофильных заболеваний |
RU2628800C2 (ru) * | 2014-03-12 | 2017-08-22 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Амидные соединения, способы получения, применение в качестве средств для лечения и профилактики заболеваний, вызываемых рнк-содержащими вирусами |
CN106539792B (zh) * | 2016-11-07 | 2017-08-25 | 王晓旭 | 一种治疗高血脂症的药物 |
GEP20227354B (en) * | 2017-09-07 | 2022-02-25 | Obschestvo S Ogranichennoi Otvetstvennostiyu Pharmenterprises | Use of a glutarimide derivative to treat diseases related to the aberrant activity of cytokines |
CA3118438A1 (en) * | 2018-11-01 | 2020-05-07 | Ahammune Biosciences Private Limited | Novel imidazole compounds, process for the synthesis and uses thereof |
RU2712281C1 (ru) | 2018-11-23 | 2020-01-28 | Общество С Ограниченной Ответственностью "Хемиммьюн Терапьютикс" | Применение производного глутаримида для преодоления резистентности к стероидам и терапии заболеваний, ассоциированных с аберрантным сигналингом интерферона гамма |
BR112022026356A2 (pt) * | 2020-06-26 | 2023-01-17 | Valenta Intellekt Ltd | Uso de um derivado de glutarimida para tratar doenças associadas à atividade aberrante da interleucina-6 |
WO2023121519A1 (ru) * | 2021-12-23 | 2023-06-29 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Применение 1-[2-(1-метилимидазол-4-ил)-этил]пергидроазин-2,6-диона для лечения covid-19 |
WO2023191666A1 (ru) * | 2022-03-29 | 2023-10-05 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Кристаллическая форма 1-(2-(1н-имидазол-4-ил)этил)пиперидин-2,6-диона и ее применение |
WO2023249516A1 (ru) * | 2022-06-24 | 2023-12-28 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Новая кристаллическая форма 1-[2-(1-метилимидазол-4-ил)этил]пергидроазин-2,6-диона и ее фармацевтическое применение |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3081308A (en) * | 1959-12-29 | 1963-03-12 | Searle & Co | 5-carbocyclic-3-imidomethyloxazolidines and process |
US3171839A (en) * | 1961-05-18 | 1965-03-02 | Searle & Co | 4-alkyl-1-(cyclic imidoalkyl) piperidines |
GB1033251A (en) * | 1961-09-07 | 1966-06-22 | Distillers Co Yeast Ltd | Glutarimide derivatives |
US3963691A (en) * | 1974-10-07 | 1976-06-15 | Merck & Co., Inc. | Synthetic antigens of luteinizing hormone releasing hormone |
US4261990A (en) * | 1979-03-09 | 1981-04-14 | Ciba-Geigy Corporation | N-alkyleneiminoalkyl-dicarboximides as antiallergics and antiasthmatics |
JPS606686A (ja) * | 1983-06-27 | 1985-01-14 | Kissei Pharmaceut Co Ltd | チオフエン誘導体及びその製造方法 |
JPS6066686A (ja) | 1983-09-19 | 1985-04-16 | Toshiba Corp | ライン駆動電動機の速度制御装置 |
SE8600261D0 (sv) * | 1986-01-21 | 1986-01-21 | Lundblad Leif | Indolokinoxaliner med substituenter i 6-position som innehaller cykliska grupper |
SU1836365A3 (ru) * | 1991-01-24 | 1993-08-23 | Физиko-Xиmичeckий Иhctиtуt Иm.A.B.Бoгatckoгo;Hии@ Фapmakoлoгии Poccийckoй Amh | Способ получения ν-0-пиперазинил)бутилглутаримидов |
FR2737725B1 (fr) | 1995-08-08 | 1997-10-31 | Valentonine | Nouveaux derives acyles de la melatonine et d'analogues melatoninergiques, leur procede de preparation et leur utilisation en tant que medicament |
RU2141483C1 (ru) | 1997-07-04 | 1999-11-20 | Небольсин Владимир Евгеньевич | Производные пептидов или их фармацевтически приемлемые соли, способ их получения, применение и фармацевтическая композиция |
EP1020447A4 (en) * | 1997-09-11 | 2000-11-15 | Nissan Chemical Ind Ltd | PYRAZOLE-BASED COMPOUNDS AND PLANT DISEASE CONTROL AGENT |
ITMI991578A1 (it) * | 1999-07-15 | 2001-01-15 | Recordati Ind Chimica E Farma | Amidi e imidi cicliche dotate di attivita' antagonista selettiva per il recettore adrenergico |
US6413428B1 (en) | 1999-09-16 | 2002-07-02 | Berger Instruments, Inc. | Apparatus and method for preparative supercritical fluid chromatography |
DE10002509A1 (de) * | 2000-01-21 | 2001-07-26 | Gruenenthal Gmbh | Substituierte Glutarimide |
US7030150B2 (en) * | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
AU2003263393A1 (en) * | 2002-09-04 | 2004-03-29 | Glenmark Pharmaceuticals Limited | New heterocyclic amide compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them |
EP1636205A1 (en) * | 2003-06-12 | 2006-03-22 | Novo Nordisk A/S | Pyridinyl carbamates as hormone-sensitive lipase inhibitors |
CN1260218C (zh) * | 2003-11-06 | 2006-06-21 | 天津药物研究院 | 一类pdf酶抑制剂-异羟肟酸系列化合物及其合成方法与用途 |
WO2006040646A1 (en) * | 2004-10-14 | 2006-04-20 | Pfizer, Inc. | Benzimidazole or indole amides as inhibitors of pin1 |
BRPI0607062A2 (pt) * | 2005-02-28 | 2009-08-04 | Japan Tobacco Inc | composto de aminopiridina com atividade inibidora de syk, composição farmacêutica e agente terapêutico compreendendo os mesmos |
EP1741709A1 (en) * | 2005-06-28 | 2007-01-10 | Sanofi-Aventis Deutschland GmbH | Heteroaryl-substituted amides comprising a saturated linker group, and their use as pharmaceuticals |
WO2007007054A1 (en) * | 2005-07-08 | 2007-01-18 | Cancer Research Technology Limited | Phthalamides, succinimides and related compounds and their use as pharmaceuticals |
US20120157387A1 (en) * | 2006-11-28 | 2012-06-21 | Apotex Technologies Inc. | Orally bioavailable d-gamma-glutamyl-d-tryptophan |
US8557836B2 (en) * | 2008-09-16 | 2013-10-15 | The Trustees Of The University Of Pennsylvania | Spiro-piperidine inhibitors |
AU2011241478B2 (en) * | 2010-04-15 | 2016-12-01 | Biota Scientific Management Pty Ltd | Compound for treatment of respiratory condition or disease |
TW201217312A (en) * | 2010-09-22 | 2012-05-01 | Gruenenthal Gmbh | Substituted benzamide compounds |
US20120157382A1 (en) * | 2010-12-21 | 2012-06-21 | Siegfried Krimmer | Pharmaceutical glp-1 compositions having an improved release profile |
RU2665688C2 (ru) * | 2013-04-12 | 2018-09-04 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения |
MX2015014336A (es) * | 2013-04-12 | 2016-06-07 | Obschestvo S Ogranichennoi Otveststvennostiyu Pharmentpr | Derivados de glutarimida, uso de los mismos, composicion farmaceutica basada en los mismos y metodos para producir derivados de glutarimida. |
RU2552929C1 (ru) * | 2013-11-14 | 2015-06-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Фармацевтическая композиция, содержащая производные глутаримидов, и их применение для лечения эозинофильных заболеваний |
-
2014
- 2014-04-10 MX MX2015014336A patent/MX2015014336A/es unknown
- 2014-04-10 KR KR1020207016268A patent/KR102254315B1/ko active IP Right Grant
- 2014-04-10 EA EA201591957A patent/EA031392B1/ru unknown
- 2014-04-10 SG SG10201802647QA patent/SG10201802647QA/en unknown
- 2014-04-10 US US14/783,911 patent/US9815814B2/en active Active
- 2014-04-10 CA CA2909057A patent/CA2909057C/en active Active
- 2014-04-10 EP EP20178488.1A patent/EP3725785B1/en active Active
- 2014-04-10 SG SG11201508394UA patent/SG11201508394UA/en unknown
- 2014-04-10 AU AU2014251442A patent/AU2014251442A1/en not_active Abandoned
- 2014-04-10 UA UAA201511008A patent/UA121299C2/uk unknown
- 2014-04-10 MX MX2020005736A patent/MX2020005736A/es unknown
- 2014-04-10 EA EA201792597A patent/EA032938B1/ru not_active IP Right Cessation
- 2014-04-10 CN CN201910437243.4A patent/CN110172055B/zh active Active
- 2014-04-10 EP EP14782170.6A patent/EP2985282A4/en not_active Withdrawn
- 2014-04-10 KR KR1020207016274A patent/KR102296182B1/ko active IP Right Grant
- 2014-04-10 WO PCT/RU2014/000264 patent/WO2014168522A1/ru active Application Filing
- 2014-04-10 BR BR122020010204-7A patent/BR122020010204B1/pt active IP Right Grant
- 2014-04-10 EP EP20178489.9A patent/EP3722290B1/en active Active
- 2014-04-10 MX MX2020005735A patent/MX2020005735A/es unknown
- 2014-04-10 EA EA201792071A patent/EA033054B1/ru unknown
- 2014-04-10 CN CN201480032755.8A patent/CN106061962B/zh not_active Expired - Fee Related
- 2014-04-10 EA EA201792072A patent/EA032951B1/ru unknown
- 2014-04-10 BR BR112015025804-2A patent/BR112015025804B1/pt not_active IP Right Cessation
- 2014-04-10 CN CN201910437241.5A patent/CN110229140B/zh active Active
- 2014-04-10 CN CN201910437242.XA patent/CN110128406B/zh active Active
- 2014-04-10 JP JP2016507512A patent/JP6529958B2/ja active Active
- 2014-04-10 SG SG10201802650WA patent/SG10201802650WA/en unknown
- 2014-04-10 KR KR1020157032457A patent/KR102255929B1/ko active IP Right Grant
- 2014-04-10 SG SG10201802648SA patent/SG10201802648SA/en unknown
- 2014-04-10 IL IL266301A patent/IL266301B2/en unknown
- 2014-04-10 MX MX2020005738A patent/MX2020005738A/es unknown
- 2014-04-10 BR BR122020010210-1A patent/BR122020010210B1/pt not_active IP Right Cessation
-
2015
- 2015-10-11 IL IL241998A patent/IL241998B/en active IP Right Grant
- 2015-11-10 ZA ZA2015/08278A patent/ZA201508278B/en unknown
-
2016
- 2016-05-10 ZA ZA2016/03108A patent/ZA201603108B/en unknown
- 2016-05-10 ZA ZA2016/03109A patent/ZA201603109B/en unknown
-
2017
- 2017-09-28 US US15/718,316 patent/US10155747B2/en active Active
- 2017-09-28 US US15/718,226 patent/US10155744B2/en active Active
- 2017-09-28 US US15/718,252 patent/US10155745B2/en active Active
- 2017-09-28 US US15/718,295 patent/US10155746B2/en active Active
- 2017-09-28 US US15/718,274 patent/US10196377B2/en active Active
- 2017-09-28 US US15/718,207 patent/US10155743B2/en active Active
-
2018
- 2018-09-27 AU AU2018236805A patent/AU2018236805C1/en not_active Ceased
- 2018-11-07 JP JP2018209573A patent/JP6627039B2/ja active Active
- 2018-11-07 JP JP2018209574A patent/JP6620324B2/ja active Active
- 2018-11-07 JP JP2018209575A patent/JP6843103B2/ja active Active
- 2018-11-15 US US16/192,065 patent/US10377739B2/en active Active
-
2019
- 2019-04-29 IL IL266300A patent/IL266300B/en unknown
- 2019-04-29 IL IL266302A patent/IL266302B/en unknown
-
2020
- 2020-06-02 AU AU2020203632A patent/AU2020203632B2/en active Active
- 2020-06-02 AU AU2020203630A patent/AU2020203630B2/en active Active
- 2020-06-15 AU AU2020203968A patent/AU2020203968B2/en not_active Ceased
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023177329A1 (ru) * | 2022-03-18 | 2023-09-21 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Применение 1-(2-(1н-имидазол-4-ил)этил)пиперидин-2,6-диона для лечения кашля, вызванного вирусными инфекциями |
RU2819722C2 (ru) * | 2022-03-18 | 2024-05-23 | Общество С Ограниченной Ответственностью "Валента - Интеллект" | Применение 1-(2-(1н-имидазол-4-ил)этил)пиперидин-2,6-диона для лечения кашля, вызванного вирусными инфекциями |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201792597A3 (ru) | Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения | |
CY1124882T1 (el) | Αναλογα 1,4-διϋποκατεστημενης πυριδαζινης και μεθοδοι για την θεραπευτικη αγωγη καταστασεων συναφων με ανεπαρκεια smn | |
CY1120832T1 (el) | Τροποποιητες πυρηνικης μεταφορας και χρησεις αυτων | |
CY1119490T1 (el) | Παραγωγα πυραζολοπυρρολιδινης και η χρηση τους στην θεραπεια νοσηματων | |
EA201592256A1 (ru) | Производные имидазопирролидинона и их применение при лечении заболеваний | |
CY1124000T1 (el) | Υποκατεστημενες 5-φθορο-1η-πυραζολοπυριδινες σε κρυσταλλικη μορφη | |
EA201490647A1 (ru) | Производные бензотиазол-6-илуксусной кислоты и их применение для лечения вич-инфекции | |
GEP20207105B (en) | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2yl carbamate derivatives as magl inhibitors | |
EA201592255A1 (ru) | Производные пиразолопирролидин-4-она в качестве ингибиторов вет и их применение при лечении заболевания | |
PH12014502524B1 (en) | Carboxylic acid compounds | |
NZ703989A (en) | Alkoxy pyrazoles as soluble guanylate cyclase activators | |
EA201490774A1 (ru) | Новые производные оксазина и их применение при лечении заболевания | |
EA201690247A1 (ru) | Аминометилбиарильные производные-ингибиторы фактора d комплемента и их применения | |
SG10201806565SA (en) | Heterocyclic carboxylic acids as activators of soluble guanylate cyclase | |
EA201492023A1 (ru) | Регуляторы пути комплемента и их применение | |
EA201690072A1 (ru) | Состав, содержащий гиполипидемическое средство | |
TR201902057T4 (tr) | Tetrasiklin bileşikleri. | |
PH12016500577A1 (en) | Piperazine derivatives and the use thereof as medicament | |
EA201691058A1 (ru) | Производные пирролопирролона и их применение для лечения заболеваний | |
EA201591487A1 (ru) | Производные замещенной бисфенилбутановой кислоты в качестве ингибиторов nep с улучшенной in vivo эффективностью | |
MX359404B (es) | Derivados del ácido cicloalcanocraboxílico como antagonistas del receptor cxcr3. | |
TH166328B (th) | แอลคอกซิ พิแรโซล เป็นกูแอนิเลท ไซเคลส แอคติเวเตอร์ ที่ละลายได้ |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
QB4A | Registration of a licence in a contracting state | ||
QZ4A | Registered corrections and amendments in a licence | ||
PC4A | Registration of transfer of a eurasian patent by assignment |