MX359404B - Derivados del ácido cicloalcanocraboxílico como antagonistas del receptor cxcr3. - Google Patents

Derivados del ácido cicloalcanocraboxílico como antagonistas del receptor cxcr3.

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Publication number
MX359404B
MX359404B MX2014006827A MX2014006827A MX359404B MX 359404 B MX359404 B MX 359404B MX 2014006827 A MX2014006827 A MX 2014006827A MX 2014006827 A MX2014006827 A MX 2014006827A MX 359404 B MX359404 B MX 359404B
Authority
MX
Mexico
Prior art keywords
carboxylic acid
acid derivatives
receptor antagonists
compounds
cxcr3 receptor
Prior art date
Application number
MX2014006827A
Other languages
English (en)
Other versions
MX2014006827A (es
Inventor
Bata Imre
Budzer-Lantos Péter
Vasas Attila
Bartáné Bodor Veronika
Ferenczy György
Tömösközi Zsuzsanna
Szeleczky Gábor
Bátori Sándor
Smrcina Martin
Patek Marcel
Weichsel Aleksandra
s thorpe David
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MX2014006827A publication Critical patent/MX2014006827A/es
Publication of MX359404B publication Critical patent/MX359404B/es

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C—CHEMISTRY; METALLURGY
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

La presente invención se refiere a compuestos de fórmula 1; (ver Fórmula) que son útiles como ingrediente activo de un medicamento para el tratamiento preventivo y/o terapéutico de enfermedades provocadas por la activación anormal de quimiocinas CXCR3. La invención también se refiere a un procedimiento para la preparación de dichos compuestos, a composiciones farmacéuticas que contienen dichos compuestos y a los nuevos intermedios usados en la preparación de dichos compuestos.
MX2014006827A 2011-12-06 2012-12-03 Derivados del ácido cicloalcanocraboxílico como antagonistas del receptor cxcr3. MX359404B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11462023.0A EP2601950A1 (en) 2011-12-06 2011-12-06 Cycloalkane carboxylic acid derivatives as CXCR3 receptor antagonists
PCT/HU2012/000128 WO2013084013A1 (en) 2011-12-06 2012-12-03 Cycloalkane carboxylic acid derivatives as cxcr3 receptor antagonists

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MX2014006827A MX2014006827A (es) 2014-08-01
MX359404B true MX359404B (es) 2018-09-27

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US5703098A (en) * 1994-12-30 1997-12-30 Celgene Corporation Immunotherapeutic imides/amides
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US20040204455A1 (en) * 2003-04-10 2004-10-14 Cody Wayne Livingston Piperidine derivative rennin inhibitors
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US20110034487A1 (en) 2008-01-22 2011-02-10 Amgen Inc. Cxcr3 antagonists
PE20091576A1 (es) 2008-02-19 2009-11-05 Sanofi Aventis DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3

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EP2787992A1 (en) 2014-10-15
EP2787992B1 (en) 2016-08-24
AR089087A1 (es) 2014-07-30
CN103957905A (zh) 2014-07-30
AU2012349866B2 (en) 2017-07-20
UY34489A (es) 2013-07-31
BR112014013590A2 (pt) 2017-06-13
MX2014006827A (es) 2014-08-01
EP2601950A1 (en) 2013-06-12
TW201335137A (zh) 2013-09-01
JP6133887B2 (ja) 2017-05-24
BR112014013590A8 (pt) 2017-06-13
KR20140098852A (ko) 2014-08-08
RU2615993C2 (ru) 2017-04-12
US9073853B2 (en) 2015-07-07
WO2013084013A1 (en) 2013-06-13
RU2014127303A (ru) 2016-02-20
CA2857198A1 (en) 2013-06-13
MY168750A (en) 2018-11-30
IL232985A (en) 2017-02-28
IL232985A0 (en) 2014-07-31
TWI572590B (zh) 2017-03-01
JP2015500272A (ja) 2015-01-05
SG11201402980XA (en) 2014-07-30
US20140288106A1 (en) 2014-09-25
AU2012349866A1 (en) 2014-07-03
CN103957905B (zh) 2017-10-13

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