UY34489A - Derivados del ácido cicloalcanocarboxílico como antagonistas del receptor CXCR3 - Google Patents

Derivados del ácido cicloalcanocarboxílico como antagonistas del receptor CXCR3

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Publication number
UY34489A
UY34489A UY0001034489A UY34489A UY34489A UY 34489 A UY34489 A UY 34489A UY 0001034489 A UY0001034489 A UY 0001034489A UY 34489 A UY34489 A UY 34489A UY 34489 A UY34489 A UY 34489A
Authority
UY
Uruguay
Prior art keywords
acid derivatives
receptor antagonists
cxcr3 receptor
cycloalkanecarboxylic acid
cycloalkanecarboxylic
Prior art date
Application number
UY0001034489A
Other languages
English (en)
Inventor
Bata Imre
Peter Buzder-Lantos
Vasas Attila
Veronika Bartane Bodor
Gyoergy Ferenczy
Zsuzsanna Toemoeskoezi
Gabor Szeleczky
Sandor Batori
Smrcina Martin
Patek Marcel
Weichsel Aleksandra
David S Thorpe
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of UY34489A publication Critical patent/UY34489A/es

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/45—Non condensed piperidines, e.g. piperocaine having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

La presente invención se refiere a compuestos de fórmula 1que son útiles como ingrediente activo de un medicamento para el tratamiento preventivo y/o terapéutico de enfermedades provocadas por la activación anormal de quimiocinas CXCR3. La invención también se refiere a un procedimiento para la preparación de dichos compuestos, a composiciones farmacéuticas que contienen dichos compuestos y a los nuevos compuestos intermedios utilizados en la preparación de dichos compuestos.
UY0001034489A 2011-12-06 2012-12-05 Derivados del ácido cicloalcanocarboxílico como antagonistas del receptor CXCR3 UY34489A (es)

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EP11462023.0A EP2601950A1 (en) 2011-12-06 2011-12-06 Cycloalkane carboxylic acid derivatives as CXCR3 receptor antagonists

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US20110034487A1 (en) 2008-01-22 2011-02-10 Amgen Inc. Cxcr3 antagonists
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EP2787992A1 (en) 2014-10-15
TWI572590B (zh) 2017-03-01
IL232985A0 (en) 2014-07-31
RU2014127303A (ru) 2016-02-20
US9073853B2 (en) 2015-07-07
RU2615993C2 (ru) 2017-04-12
EP2787992B1 (en) 2016-08-24
BR112014013590A8 (pt) 2017-06-13
KR20140098852A (ko) 2014-08-08
AR089087A1 (es) 2014-07-30
JP2015500272A (ja) 2015-01-05
CA2857198A1 (en) 2013-06-13
AU2012349866B2 (en) 2017-07-20
MY168750A (en) 2018-11-30
JP6133887B2 (ja) 2017-05-24
AU2012349866A1 (en) 2014-07-03
TW201335137A (zh) 2013-09-01
EP2601950A1 (en) 2013-06-12
MX2014006827A (es) 2014-08-01
CN103957905B (zh) 2017-10-13
BR112014013590A2 (pt) 2017-06-13
WO2013084013A1 (en) 2013-06-13
MX359404B (es) 2018-09-27
US20140288106A1 (en) 2014-09-25
CN103957905A (zh) 2014-07-30
SG11201402980XA (en) 2014-07-30
IL232985A (en) 2017-02-28

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