CL2015000787A1 - Derivados de 1,2,4-triazina para el tratamiento de infecciones virales. - Google Patents

Derivados de 1,2,4-triazina para el tratamiento de infecciones virales.

Info

Publication number
CL2015000787A1
CL2015000787A1 CL2015000787A CL2015000787A CL2015000787A1 CL 2015000787 A1 CL2015000787 A1 CL 2015000787A1 CL 2015000787 A CL2015000787 A CL 2015000787A CL 2015000787 A CL2015000787 A CL 2015000787A CL 2015000787 A1 CL2015000787 A1 CL 2015000787A1
Authority
CL
Chile
Prior art keywords
treatment
viral infections
triazine derivatives
triazine
tlr8
Prior art date
Application number
CL2015000787A
Other languages
English (en)
Inventor
Vincent Gembus
Philippe Jubault
Christophe Hoarau
Vincent Levacher
Gowan David Graig Mc
Jerome Emile Georges Guillemont
Jean-Francois Bonfanti
Original Assignee
Univ Rouen
Inst Nat Sciences Appliq
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rouen, Inst Nat Sciences Appliq, Centre Nat Rech Scient filed Critical Univ Rouen
Publication of CL2015000787A1 publication Critical patent/CL2015000787A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPUESTOS DERIVADOS DE 1,2,4-TRIAZINA; COMPOSICION FARMACEUTICA QUE LOS COMPRENDE; Y SU USO PARA EL TRATAMIENTO DE UN TRASTORNO EN EL CUAL LA MODULACION DE TLR7 Y/O TLR8 ESTA IMPLICADA, TAL COMO INFECCIONES VIRALES Y TRASTORNOS INMUNES O INFLAMATORIOS.
CL2015000787A 2012-10-01 2015-03-30 Derivados de 1,2,4-triazina para el tratamiento de infecciones virales. CL2015000787A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12306196.2A EP2712866A1 (en) 2012-10-01 2012-10-01 1,2,4-triazine derivatives for the treatment of viral infections

Publications (1)

Publication Number Publication Date
CL2015000787A1 true CL2015000787A1 (es) 2015-10-02

Family

ID=46982496

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015000787A CL2015000787A1 (es) 2012-10-01 2015-03-30 Derivados de 1,2,4-triazina para el tratamiento de infecciones virales.

Country Status (22)

Country Link
US (1) US9416114B2 (es)
EP (2) EP2712866A1 (es)
JP (1) JP6298998B2 (es)
KR (1) KR102138393B1 (es)
CN (1) CN104812747B (es)
AU (1) AU2013326579B2 (es)
BR (1) BR112015007310B1 (es)
CA (1) CA2886630C (es)
CL (1) CL2015000787A1 (es)
EA (1) EA026236B1 (es)
ES (1) ES2616496T3 (es)
HK (1) HK1208223A1 (es)
IL (1) IL237871A (es)
IN (1) IN2015DN03327A (es)
MX (1) MX348229B (es)
MY (1) MY182558A (es)
NZ (1) NZ706354A (es)
PH (1) PH12015500724B1 (es)
SG (1) SG11201502522WA (es)
UA (1) UA114644C2 (es)
WO (1) WO2014053516A1 (es)
ZA (1) ZA201502240B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2887303T3 (es) 2011-04-08 2021-12-22 Janssen Sciences Ireland Unlimited Co Derivados de pirimidina para el tratamiento de infecciones víricas
EA036645B1 (ru) 2011-11-09 2020-12-03 Янссен Сайенсиз Айрлэнд Юси Производные пурина для лечения вирусных инфекций
KR102207888B1 (ko) 2012-07-13 2021-01-26 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 바이러스 감염증의 치료를 위한 거대환식 푸린
MX365114B (es) 2012-10-10 2019-05-23 Janssen Sciences Ireland Uc Derivados pirrolo[3,2-d]pirimidinicos para el tratamiento de infecciones viricas y otras enfermedades.
AU2013346793B2 (en) 2012-11-16 2018-03-08 Janssen Sciences Ireland Uc Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
EA035174B1 (ru) 2013-02-21 2020-05-12 Янссен Сайенсиз Айрлэнд Юси Производные 2-аминопиримидина в качестве модуляторов толл-подобных рецепторов tlr7 и/или tlr8
CA2902837C (en) 2013-03-29 2021-09-07 Janssen Sciences Ireland Uc Macrocyclic deaza-purinones for the treatment of viral infections
DK3004074T3 (da) 2013-05-24 2018-01-29 Janssen Sciences Ireland Uc Pyridonderivater til behandling af virusinfektioner og yderligere sygdomme
CN105473592B (zh) 2013-06-27 2018-10-26 爱尔兰詹森科学公司 用于治疗病毒感染和其他疾病的吡咯并[3,2-d]嘧啶衍生物
WO2015014815A1 (en) 2013-07-30 2015-02-05 Janssen R&D Ireland THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
CN109476675B (zh) 2016-07-01 2022-12-09 爱尔兰詹森科学公司 用于治疗病毒性感染的二氢吡喃并嘧啶衍生物
EP3519406B1 (en) * 2016-09-29 2022-02-23 Janssen Sciences Ireland Unlimited Company Pyrimidine prodrugs for the treatment of viral infections and further diseases
TW201945003A (zh) 2018-03-01 2019-12-01 愛爾蘭商健生科學愛爾蘭無限公司 ２，４－二胺基喹唑啉衍生物及其醫學用途
BR112021015577A2 (pt) 2019-02-08 2021-10-05 Research & Business Foundation Sungkyunkwan University Complexo-colesterol agonista do receptor toll-like 7 ou 8 e uso do mesmo
WO2021177679A1 (ko) 2020-03-02 2021-09-10 성균관대학교산학협력단 병원균 외벽 성분 기반 생병원체 모방 나노 입자 및 그 제조 방법
EP4194008A1 (en) 2020-08-04 2023-06-14 Progeneer Inc. Kinetically acting adjuvant ensemble
JP2023536954A (ja) 2020-08-04 2023-08-30 プロジェニア インコーポレイテッド 活性化部位が一時的に不活性化したトール様受容体７または８作用薬と機能性薬物の結合体およびその用途
CN116322751A (zh) 2020-08-04 2023-06-23 蛋白科技先锋 包含能够动力学控制的佐剂的mRNA疫苗

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2485531A1 (fr) * 1980-06-25 1981-12-31 Fabre Sa Pierre Nouveaux n-oxydes de diaryl-5,6 as triazines 1-2-4, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
ES2232871T3 (es) 1996-07-03 2005-06-01 Sumitomo Pharmaceuticals Company, Limited Nuevos derivados de purina.
ES2205573T3 (es) 1997-11-28 2004-05-01 Sumitomo Pharmaceuticals Company, Limited Nuevo compuestos heterociclicos.
US7923554B2 (en) * 2004-08-10 2011-04-12 Janssen Pharmaceutica N.V. HIV inhibiting 1,2,4-triazin-6-one derivatives
AU2006242920A1 (en) 2005-05-04 2006-11-09 Pfizer Limited 2-amido-6-amino-8-oxopurine derivatives as Toll-Like receptor modulators for the treatment of cancer and viral infections, such as hepatitis C
JP4850911B2 (ja) * 2005-09-01 2012-01-11 エフ．ホフマン−ラ ロシュ アーゲー Ｐ２ｘ３およびｐ２ｘ２／３モジュレーターとしてのジアミノピリミジン
RU2352565C1 (ru) * 2007-10-08 2009-04-20 Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" 3-амино-6-ароилметил-5-гидрокси-1,2,4-триазины и способ их получения
PE20091236A1 (es) * 2007-11-22 2009-09-16 Astrazeneca Ab Derivados de pirimidina como immunomoduladores de tlr7
WO2012067269A1 (en) * 2010-11-19 2012-05-24 Dainippon Sumitomo Pharma Co., Ltd. Aminoalkoxyphenyl compounds and their use in the treatment of disease

Also Published As

Publication number Publication date
KR102138393B1 (ko) 2020-08-14
EP2903976A1 (en) 2015-08-12
CA2886630A1 (en) 2014-04-10
ES2616496T3 (es) 2017-06-13
IL237871A (en) 2017-04-30
IN2015DN03327A (es) 2015-10-09
EP2712866A1 (en) 2014-04-02
JP2015535839A (ja) 2015-12-17
BR112015007310B1 (pt) 2022-07-19
BR112015007310A2 (pt) 2017-08-08
CN104812747B (zh) 2017-03-08
SG11201502522WA (en) 2015-05-28
EP2903976B1 (en) 2016-12-07
CA2886630C (en) 2021-01-26
AU2013326579A1 (en) 2015-04-09
AU2013326579B2 (en) 2017-04-27
ZA201502240B (en) 2016-05-25
JP6298998B2 (ja) 2018-03-28
KR20150084791A (ko) 2015-07-22
US20150336907A1 (en) 2015-11-26
MY182558A (en) 2021-01-25
HK1208223A1 (en) 2016-02-26
UA114644C2 (uk) 2017-07-10
MX2015004160A (es) 2016-02-05
PH12015500724A1 (en) 2015-06-01
US9416114B2 (en) 2016-08-16
NZ706354A (en) 2018-08-31
CN104812747A (zh) 2015-07-29
EA026236B1 (ru) 2017-03-31
EA201500383A1 (ru) 2015-07-30
PH12015500724B1 (en) 2015-06-01
MX348229B (es) 2017-05-31
WO2014053516A1 (en) 2014-04-10

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