UA114644C2 - Похідні 1,2,4-триазину для лікування вірусних інфекцій - Google Patents

Похідні 1,2,4-триазину для лікування вірусних інфекцій

Info

Publication number
UA114644C2
UA114644C2 UAA201504222A UAA201504222A UA114644C2 UA 114644 C2 UA114644 C2 UA 114644C2 UA A201504222 A UAA201504222 A UA A201504222A UA A201504222 A UAA201504222 A UA A201504222A UA 114644 C2 UA114644 C2 UA 114644C2
Authority
UA
Ukraine
Prior art keywords
viral infections
treatment
triazine derivatives
triazine
derivatives
Prior art date
Application number
UAA201504222A
Other languages
English (en)
Inventor
Венсан Жамбю
Філіп Жюбо
Крістоф Оаро
Венсан Лєваше
Жан-Франсуа Бонфанті
Ґован Дейвід Ґрейґ Мак
Жером Еміль Жорж Ґійємон
Original Assignee
Сантр Насьональ Де Ля Решерш Сьєнтіфік (Снрс)
Юніверсіте Де Руан
Енстітю Насьональ Де Сьянс Апліке Де Руан (Інса)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сантр Насьональ Де Ля Решерш Сьєнтіфік (Снрс), Юніверсіте Де Руан, Енстітю Насьональ Де Сьянс Апліке Де Руан (Інса) filed Critical Сантр Насьональ Де Ля Решерш Сьєнтіфік (Снрс)
Publication of UA114644C2 publication Critical patent/UA114644C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Даний винахід належить до похідних 1,2,4-триазину, способів їх одержання, фармацевтичних композицій і їх застосування для лікування вірусних інфекцій.
UAA201504222A 2012-10-01 2013-10-01 Похідні 1,2,4-триазину для лікування вірусних інфекцій UA114644C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12306196.2A EP2712866A1 (en) 2012-10-01 2012-10-01 1,2,4-triazine derivatives for the treatment of viral infections
PCT/EP2013/070488 WO2014053516A1 (en) 2012-10-01 2013-10-01 1,2,4-triazine derivatives for the treatment of viral infections.

Publications (1)

Publication Number Publication Date
UA114644C2 true UA114644C2 (uk) 2017-07-10

Family

ID=46982496

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201504222A UA114644C2 (uk) 2012-10-01 2013-10-01 Похідні 1,2,4-триазину для лікування вірусних інфекцій

Country Status (22)

Country Link
US (1) US9416114B2 (uk)
EP (2) EP2712866A1 (uk)
JP (1) JP6298998B2 (uk)
KR (1) KR102138393B1 (uk)
CN (1) CN104812747B (uk)
AU (1) AU2013326579B2 (uk)
BR (1) BR112015007310B1 (uk)
CA (1) CA2886630C (uk)
CL (1) CL2015000787A1 (uk)
EA (1) EA026236B1 (uk)
ES (1) ES2616496T3 (uk)
HK (1) HK1208223A1 (uk)
IL (1) IL237871A (uk)
IN (1) IN2015DN03327A (uk)
MX (1) MX348229B (uk)
MY (1) MY182558A (uk)
NZ (1) NZ706354A (uk)
PH (1) PH12015500724B1 (uk)
SG (1) SG11201502522WA (uk)
UA (1) UA114644C2 (uk)
WO (1) WO2014053516A1 (uk)
ZA (1) ZA201502240B (uk)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME03782B (me) 2011-04-08 2021-04-20 Janssen Sciences Ireland Unlimited Co Derivati pirimidina za tretman virusnih infekcija
CN107011346B (zh) 2011-11-09 2020-06-16 爱尔兰詹森科学公司 用于治疗病毒感染的嘌呤衍生物
BR112015000615B1 (pt) 2012-07-13 2022-05-31 Janssen Sciences Ireland Uc Purinas macrocíclicas para o tratamento de infecções virais e composição farmacêutica que as compreende
CN104837840B (zh) 2012-10-10 2017-08-08 爱尔兰詹森科学公司 用于治疗病毒感染及其他疾病的吡咯并[3，2‑d]嘧啶衍生物
AU2013346793B2 (en) 2012-11-16 2018-03-08 Janssen Sciences Ireland Uc Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
KR102300861B1 (ko) 2013-02-21 2021-09-10 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 바이러스 감염의 치료를 위한 2-아미노피리미딘 유도체
JP6336036B2 (ja) 2013-03-29 2018-06-06 ヤンセン・サイエンシズ・アイルランド・ユーシー ウイルス感染治療のための大環状デアザプリノン
JP6377139B2 (ja) 2013-05-24 2018-08-22 ヤンセン・サイエンシズ・アイルランド・ユーシー ウイルス感染症およびさらなる疾患の処置のためのピリドン誘導体
PL3030563T3 (pl) 2013-06-27 2018-01-31 Janssen Sciences Ireland Uc Pochodne pirolo [3,2-d] pirymidyny do leczenia zakażeń wirusowych i innych chorób
MX368625B (es) 2013-07-30 2019-10-08 Janssen Sciences Ireland Uc Derivados de tieno[3,2-d]pirimidinas para el tratamiento de infecciones virales.
WO2018002319A1 (en) 2016-07-01 2018-01-04 Janssen Sciences Ireland Uc Dihydropyranopyrimidines for the treatment of viral infections
ES2912945T3 (es) * 2016-09-29 2022-05-30 Janssen Sciences Ireland Unlimited Co Profármacos de pirimidina para el tratamiento de infecciones virales y otras enfermedades
TW201945003A (zh) 2018-03-01 2019-12-01 愛爾蘭商健生科學愛爾蘭無限公司 ２，４－二胺基喹唑啉衍生物及其醫學用途
JP7287708B2 (ja) 2019-02-08 2023-06-06 プロジェニア インコーポレイテッド Ｔｏｌｌ－ｌｉｋｅ受容体７または８アゴニストとコレステロールの結合体およびその用途
CN115666637A (zh) 2020-03-02 2023-01-31 蛋白科技先锋 基于病原体细胞壁骨架的模拟活病原体的纳米粒子及其制备方法
WO2022031011A1 (ko) 2020-08-04 2022-02-10 성균관대학교산학협력단 동력학적으로 작용하는 아주번트 앙상블
JP2023536954A (ja) 2020-08-04 2023-08-30 プロジェニア インコーポレイテッド 活性化部位が一時的に不活性化したトール様受容体７または８作用薬と機能性薬物の結合体およびその用途
EP4194006A1 (en) 2020-08-04 2023-06-14 Progeneer Inc. Mrna vaccine comprising adjuvant capable of kinetic control

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2485531A1 (fr) * 1980-06-25 1981-12-31 Fabre Sa Pierre Nouveaux n-oxydes de diaryl-5,6 as triazines 1-2-4, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
TW552261B (en) 1996-07-03 2003-09-11 Japan Energy Corp Novel purine derivative
NZ504800A (en) 1997-11-28 2001-10-26 Sumitomo Pharma 6-Amino-9-benzyl-8-hydroxy-purine derivatives and interferon inducers, antiviral agents, anticancer agents and therapeutic agents for immunologic diseases thereof
US7923554B2 (en) * 2004-08-10 2011-04-12 Janssen Pharmaceutica N.V. HIV inhibiting 1,2,4-triazin-6-one derivatives
BRPI0611435A2 (pt) 2005-05-04 2010-09-08 Pfizer Ltd derivados de 2-amido-6-amino-8-oxopurina, composições farmacêuticas, uso e processo de preparo dos mesmos
CN101296907B (zh) * 2005-09-01 2013-03-27 弗·哈夫曼-拉罗切有限公司 作为p2x3和p2x2/3调节剂的二氨基嘧啶类
RU2352565C1 (ru) * 2007-10-08 2009-04-20 Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" 3-амино-6-ароилметил-5-гидрокси-1,2,4-триазины и способ их получения
PE20091236A1 (es) * 2007-11-22 2009-09-16 Astrazeneca Ab Derivados de pirimidina como immunomoduladores de tlr7
WO2012067269A1 (en) * 2010-11-19 2012-05-24 Dainippon Sumitomo Pharma Co., Ltd. Aminoalkoxyphenyl compounds and their use in the treatment of disease

Also Published As

Publication number Publication date
PH12015500724A1 (en) 2015-06-01
EP2712866A1 (en) 2014-04-02
SG11201502522WA (en) 2015-05-28
EP2903976A1 (en) 2015-08-12
EA201500383A1 (ru) 2015-07-30
ES2616496T3 (es) 2017-06-13
CA2886630A1 (en) 2014-04-10
WO2014053516A1 (en) 2014-04-10
NZ706354A (en) 2018-08-31
KR102138393B1 (ko) 2020-08-14
JP2015535839A (ja) 2015-12-17
ZA201502240B (en) 2016-05-25
CL2015000787A1 (es) 2015-10-02
MX348229B (es) 2017-05-31
IN2015DN03327A (uk) 2015-10-09
CN104812747B (zh) 2017-03-08
CN104812747A (zh) 2015-07-29
MY182558A (en) 2021-01-25
US9416114B2 (en) 2016-08-16
EP2903976B1 (en) 2016-12-07
HK1208223A1 (en) 2016-02-26
EA026236B1 (ru) 2017-03-31
PH12015500724B1 (en) 2015-06-01
US20150336907A1 (en) 2015-11-26
AU2013326579A1 (en) 2015-04-09
AU2013326579B2 (en) 2017-04-27
MX2015004160A (es) 2016-02-05
IL237871A (en) 2017-04-30
JP6298998B2 (ja) 2018-03-28
BR112015007310B1 (pt) 2022-07-19
CA2886630C (en) 2021-01-26
BR112015007310A2 (pt) 2017-08-08
KR20150084791A (ko) 2015-07-22

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